keyword
https://read.qxmd.com/read/38513913/isolation-identification-and-characterisation-of-pseudomonas-koreensis-cm-01-isolated-from-diseased-malaysian-mahseer-tor-tambroides
#21
JOURNAL ARTICLE
Melinda Mei Lin Lau, Cindy Jia Yung Kho, Hung Hui Chung, Azham Zulkharnain
Pseudomonas species are one of the most threatening fish pathogens which reside a wide range of environments. In this study, the dominant bacteria were isolated from diseased Malaysian mahseer (Tor tambroides) and tentatively named CM-01. It was identified as Pseudomonas koreensis based on its biochemical, morphological, genetic and physiological information. Its pathogenicity was found to be correlated with twelve virulence genes identified including iron uptake, protease, acylhomoserine lactone synthase gacS/gacA component regulation system, type IV secretion system, hydrogen cyanide production, exolysin, alginate biosynthesis, flagella and pili...
March 19, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38511401/full-dose-challenge-of-moderate-severe-and-unknown-beta-lactam-allergies-in-the-emergency-department
#22
JOURNAL ARTICLE
Adam M Anderson, Stephanie Coallier, Reid E Mitchell, Lisa E Dumkow, Lauren M Wolf
OBJECTIVE: This study aims to assess the outcome of challenging documented moderate, severe, or unknown beta-lactam allergies with full dose administration of a beta-lactam antibiotic in emergency department (ED) patients admitted for acute bacterial infection. METHODS: A single-center, retrospective, descriptive study of adult patients challenged with a full dose of beta-lactam in the ED from January 2021 to December 2022 was conducted. Included patients had at least one documented moderate, severe, or unknown beta-lactam allergy in the electronic medical record (EMR) without documentation of prior tolerance...
March 21, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38500719/impact-of-a-syndrome-based-stewardship-intervention-on-antipseudomonal-beta-lactam-use-antimicrobial-resistance-c-difficile-rates-and-cost-in-a-safety-net-community-hospital
#23
JOURNAL ARTICLE
Alfredo J Mena Lora, Rodrigo Burgos, Aaron E Hunt, Yifan Wang, Dylan Huber, Lawrence Sanchez, Mirza Ali, Candice Krill, Eden Takhsh, Susan C Bleasdale
Broad-spectrum antimicrobials are commonly used without indication and contribute to antimicrobial resistance (AMR). We implemented a syndrome-based stewardship intervention in a community hospital that targeted common infectious syndromes and antipseudomonal beta-lactam (APBL) use. Our intervention successfully reduced AMR, C. difficile rates, use of APBLs, and cost.
2024: Antimicrob Steward Healthc Epidemiol
https://read.qxmd.com/read/38499330/are-skin-tests-useful-after-benign-immediate-reactions-to-beta-lactams-in-children
#24
JOURNAL ARTICLE
Bouchra Mahjoub, Charlotte Marsac, Claude Ponvert, Christophe Delacourt, Hassan Faour, Nicolas Garcelon, Guillaume Lezmi
No abstract text is available yet for this article.
March 18, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38493570/longitudinal-antimicrobial-susceptibility-trends-of-canine-staphylococcus-pseudintermedius
#25
JOURNAL ARTICLE
Caroline Calabro, Ritwik Sadhu, Yuchen Xu, Melissa Aprea, Cassandra Guarino, Casey L Cazer
Antimicrobial resistance within Staphylococcus pseudintermedius poses a significant risk for the treatment of canine pyoderma and as a reservoir for resistance and potential zoonoses, but few studies examine long-term temporal trends of resistance. This study assesses the antimicrobial resistance prevalence and minimum inhibitory concentration (MIC) trends in S. pseudintermedius (n=1804) isolated from canine skin samples at the Cornell University Animal Health Diagnostic Center (AHDC) between 2007 and 2020...
March 12, 2024: Preventive Veterinary Medicine
https://read.qxmd.com/read/38492327/assessing-the-risk-of-exposure-to-antimicrobial-resistance-at-public-beaches-genome-based-insights-into-the-resistomes-mobilomes-and-virulomes-of-beta-lactams-resistant-enterobacteriaceae-from-recreational-beaches-in-lagos-nigeria
#26
JOURNAL ARTICLE
Abolade A Oyelade, Odion O Ikhimiukor, Blessing I Nwadike, Obasola E Fagade, Olawale O Adelowo
The role of recreational water use in the acquisition and transmission of antimicrobial resistance (AMR) is under-explored in low- and middle-income countries (LMICs). We used whole genome sequence analysis to provide insights into the resistomes, mobilomes and virulomes of 14 beta-lactams resistant Enterobacterales isolated from water and wet-sand at four recreational beaches in Lagos, Nigeria. Carriage of multiple beta-lactamase genes was detected in all isolates except two, including six isolates carrying blaNDM-1 ...
March 15, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38491069/metagenomic-insights-into-the-wastewater-resistome-before-and-after-purification-at-large%C3%A2-scale-wastewater-treatment-plants-in-the-moscow-city
#27
JOURNAL ARTICLE
Shahjahon Begmatov, Alexey V Beletsky, Alexander G Dorofeev, Nikolai V Pimenov, Andrey V Mardanov, Nikolai V Ravin
Wastewater treatment plants (WWTPs) are considered to be hotspots for the spread of antibiotic resistance genes (ARGs). We performed a metagenomic analysis of the raw wastewater, activated sludge and treated wastewater from two large WWTPs responsible for the treatment of urban wastewater in Moscow, Russia. In untreated wastewater, several hundred ARGs that could confer resistance to most commonly used classes of antibiotics were found. WWTPs employed a nitrification/denitrification or an anaerobic/anoxic/oxic process and enabled efficient removal of organic matter, nitrogen and phosphorus, as well as fecal microbiota...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38487146/ventilator-associated-lower-respiratory-tract-infections-and-their-association-with-covid-19-a-retrospective-cohort-study-in-a-portuguese-intensive-treatment-unit
#28
JOURNAL ARTICLE
André Fernandes, Joao Nuno Patricio, Rita Jorge, Raquel Nazareth, Carlos S Pereira
Introduction Ventilator-associated pneumonia (VAP) is the most common infectious complication related to admission to an Intensive Treatment Unit (ITU). Ventilator-associated lower respiratory tract infection (VA-LRTI) is a broader diagnosis than VAP. By disregarding radiological criteria, it will include both VAP and ventilator-associated tracheobronchitis. This study, conducted in the setting of a Portuguese ITU, aims to study the incidence, microbiology and clinical outcome of VA-LRTI and its association with COVID-19...
February 2024: Curēus
https://read.qxmd.com/read/38484932/cefazolin-dilemma-in-perioperative-setting-balancing-surgical-prophylaxis-and-allergic-reactions
#29
EDITORIAL
Jose Julio Laguna
No abstract text is available yet for this article.
March 12, 2024: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/38484476/rapid-diagnostic-of-multidrug-resistant-sepsis-pathogens-directly-from-blood-culture-bottles-using-maldi-tof-and-the-eucast-rast
#30
JOURNAL ARTICLE
Jesus G M Pariona, Flavio A Oliveira, Patrícia Helena Scoton, Heli J Barrón-Pastor, Eva M M Pariona, Tania R Zaccariotto, Nilton Lincopan, Carlos E Levy
In this study, rapid diagnostic of multidrug-resistant (MDR) sepsis pathogens, directly from positive blood culture (BC) bottles, was evaluated by combining MALDI-TOF and the EUCAST Rapid Antimicrobial Susceptibility Testing (RAST). Carbapenemase production in Escherichia coli and Klebsiella pneumoniae isolates was also evaluated by RAST. From 171 positive BC bottles analyzed, 79 (46 %) MDR species, including E. coli (4/34, 12 %), K. pneumoniae (33/48, 69 %), Pseudomonas aeruginosa (12/12, 100 %), Acinetobacter baumannii (15/15, 100 %), and Staphylococcus aureus (14/37, 38 %) displaying resistance to beta-lactams, fluoroquinolones, aminoglycosides, and/or trimethoprim/sulphamethoxazole, were identified...
March 8, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38482359/multiple-interspecies-recombination-events-documented-by-whole-genome-sequencing-in-multidrug-resistant-haemophilus-influenzae-clinical-isolates
#31
JOURNAL ARTICLE
Charlotte Michel, Maria De Los Angeles Argudín, Magali Wautier, Fedoua Echahidi, Benoit Prevost, Olivier Vandenberg, Delphine Martiny, Marie Hallin
INTRODUCTION: Haemophilus influenzae ( Hi ) was long known as an easy-to-treat bacterium, but increasing resistance against beta-lactams and other critically important antibiotics is now a growing concern. We describe here the whole-genome sequencing (WGS) analysis of three non-typeable Hi isolates received in 2018-2019 by the Belgian National Reference Centre (NRC) for Haemophilus influenzae , as they presented an unusual multi-resistant profile. METHODS: All three isolates were sequenced by WGS and mapped to the reference isolate Hi Rd KW20...
2024: Access microbiology
https://read.qxmd.com/read/38482056/chiral-phthalimides-against-penicillin-binding-protein-2a-of-methicillin-resistant-staphylococcus-aureus-molecular-docking-and-in-vitro-analysis
#32
JOURNAL ARTICLE
Aamina Azam Khan, Momin Khan, Sher Wali Khan, Nayyer Siddique, Rimsha Abid, Shandana Zulfiqar, Sidra Rahman, Muhammad Ali
Staphylococcus aureus ( S. aureus ) is a commensal bacterium and an opportunistic pathogen causing a wide variety of infections ranging from localized skin and soft tissue infections to life-threatening severe bacteremia, osteomyelitis, endocarditis, atopic dermatitis, prosthetic joint infection, staphylococcal food poisoning, medical device-related infections, and pneumonia. It is attributed to an acquired resistant gene, mecA , encoding penicillin-binding protein 2a (PBP2a). PBP2a is an essential protein responsible for the resistivity of methicillin-resistant S...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38476645/isolation-and-molecular-characterization-of-multidrug%C3%A2-resistant-escherichia-coli-from-chicken-meat
#33
JOURNAL ARTICLE
Anugya Jaiswal, Aquib Khan, Akanksha Yogi, Sweta Singh, Arun Kumar Pal, Ramendra Soni, Pooja Tripathi, Jonathan A Lal, Vijay Tripathi
UNLABELLED: Antibiotics in animal farms play a significant role in the proliferation and spread of antibiotic-resistant genes (ARGs) and antibiotic-resistant bacteria (ARB). The dissemination of antibiotic resistance from animal facilities to the nearby environment has become an emerging concern. The present study was focused on the isolation and molecular identification of Escherichia coli ( E. coli ) isolates from broiler chicken meat and further access their antibiotic-resistant profile against different antibiotics...
April 2024: 3 Biotech
https://read.qxmd.com/read/38475927/carbapenem-resistant-hypervirulent-st23-klebsiella-pneumoniae-with-a-highly-transmissible-dual-carbapenemase-plasmid-in-chile
#34
JOURNAL ARTICLE
Matías Gálvez-Silva, Patricio Arros, Camilo Berríos-Pastén, Aura Villamil, Paula I Rodas, Ingrid Araya, Rodrigo Iglesias, Pamela Araya, Juan C Hormazábal, Constanza Bohle, Yahua Chen, Yunn-Hwen Gan, Francisco P Chávez, Rosalba Lagos, Andrés E Marcoleta
BACKGROUND: The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from sequence type 23 (ST23) and having a K1 capsule, have been associated with severe community-acquired invasive infections. Although hvKp were initially restricted to Southeast Asia and primarily antibiotic-sensitive, carbapenem-resistant hvKp infections are reported worldwide...
March 12, 2024: Biological Research
https://read.qxmd.com/read/38472486/comparative-genomic-analysis-of-pseudomonas-aeruginosa-strains-susceptible-and-resistant-to-carbapenems-and-aztreonam-isolated-from-patients-with-healthcare-associated-infections-in-a-mexican-hospital
#35
JOURNAL ARTICLE
María José Martínez-Gallardo, Claudia Villicaña, Martha Yocupicio-Monroy, Sofía Lizeth Alcaraz-Estrada, Juana Salazar-Salinas, Omar Fernando Mendoza-Vázquez, Gabriel Damazo-Hernández, Josefina León-Félix
Pseudomonas aeruginosa (PA) is an important opportunistic pathogen that causes different infections on immunocompromised patients. Within PA accessory genome, differences in virulence, antibiotic resistance and biofilm formation have been described between strains, leading to the emergence of multidrug-resistant strains. The genome sequences of 17 strains isolated from patients with healthcare-associated infections in a Mexican hospital were genomically and phylogenetically analyzed and antibiotic resistance genes, virulence genes, and biofilm formation genes were detected...
March 12, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38472028/inhibitory-action-of-antibiotics-on-kluyveromyces-marxianus
#36
JOURNAL ARTICLE
Rafael Lisandro Althaus, Orlando Guillermo Nagel, Dafna Eluk
A bioassay containing Kluyveromyces marxianus in microtiter plates was used to determine the inhibitory action of 28 antibiotics (aminoglycosides, beta-lactams, macrolides, quinolones, tetracyclines and sulfonamides) against this yeast in whey. For this purpose, the dose-response curve for each antibiotic was constructed using 16 replicates of 12 different concentrations of the antibiotic. The plates were incubated at 40°C until the negative samples exhibited their indicator (5-7h). Subsequently, the absorbances of the yeast cells in each plate were measured by the turbidimetric method (λ=600nm) and the logistic regression model was applied...
March 11, 2024: Revista Argentina de Microbiología
https://read.qxmd.com/read/38467165/identification-characterization-and-complete-genome-analysis-of-a-vibrio-anguillarum-isolated-from-sebastes-schlegelii
#37
JOURNAL ARTICLE
Zeyu Li, Yungui Sun, Ruiming Tan, Yingli Gao
Vibrio anguillarum is an important fish pathogen in mariculture, which can infect fish with great economic losses. In this study, a Vibrio anguillarum isolated from Sebastes schlegelii was named VA1 and was identified and characterized from aspects of morphology, physiological and biochemical characteristics, 16SRNA, virulence genes, drug sensitivity, and extracellular enzyme activity. At the same time, The VA1 was investigated at the genomic level. The results showed that a Gram-negative was isolated from the diseased fish...
March 11, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38460199/unexpected-role-of-pig-nostrils-in-the-clonal-and-plasmidic-dissemination-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-at-farm-level
#38
JOURNAL ARTICLE
Sandra Martínez-Álvarez, Pierre Châtre, Pauline François, Idris Nasir Abdullahi, Carmen Simón, Myriam Zarazaga, Jean-Yves Madec, Marisa Haenni, Carmen Torres
The presence of methicillin-resistant or -susceptible S. aureus in pig nostrils has been known for a long time, but the occurrence of extended-spectrum beta-lactamase (ESBL)-producing E. coli has hardly been investigated. Here, we collected 25 E. coli recovered from nasal samples of 40 pigs/10 farmers of four farms. Nine ESBL-producing isolates belonging to ST48, ST117, ST847, ST5440, ST14914 and ST10 were retrieved from seven pigs. All blaESBL genes (blaCTX-M-32, blaCTX-M-14, blaCTX-M-1, blaCTX-M-65, and blaSHV-12 ) were horizontally transferable by conjugation through plasmids belonging to IncI1 (n=3), IncX1 (n=3) and IncHI2 (n=1) types...
March 8, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38459885/safety-of-direct-oral-provocation-test-to-delabel-reported-mild-beta-lactam-allergy-in-infants
#39
JOURNAL ARTICLE
Francisca Cunha, Inês Cunha, Eva Gomes
BACKGROUND: Around 10% of people report a drug allergy and avoid some medications because of fear of allergic reactions. However, only after a proper diagnostic workup can some of these reactions be confirmed as allergic or nonallergic hypersensitivities. Beta-lactams (BLs) are the most common medication suspected of being involved in drug hypersensivity reactions (DHRs) in children. Recently, direct oral provocation tests (DPT) with BLs gained popularity within pediatric populations as a tool for delabeling children with suspected BL allergies...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38458537/changes-in-antimicrobial-resistance-of-escherichia-coli-isolated-from-community-associated-urinary-tract-infection-before-and-during-the-covid-19-pandemic-in-india
#40
JOURNAL ARTICLE
Shwetha Venugopal, Sneha Chunchanur, Rajashree Panigrahy, Vibhor Tak, Manish Yadav, Akanksha Chauhan, Himabindhu Ks, Jayapriya R, Swati Pundir, Satyendra Bhatt, Birasen Behera, Sumanth M, Ambica R, Susmita Chaudhuri, Sarita Mohapatra
PURPOSE: Impact of COVID-19 pandemic on antimicrobial resistance (AMR) is largely studied in healthcare settings, there is a need to understand the fluctuations in AMR during pandemic at the community level. Urinary tract infection (UTI) being one of the most common infections in the community, AMR profile of Community-acquired UTI (CA-UTI) is considered representative AMR at the community level. PATIENTS AND METHODS: The study was taken in cohort of patients with clinical diagnosis of CA-UTI...
March 6, 2024: Journal of Global Antimicrobial Resistance
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