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https://www.readbyqxmd.com/read/27767119/antibiotics-are-not-useful-to-reduce-pain-associated-with-irreversible-pulpitis
#1
Eileen Hoskin, Analia Veitz-Keenan
Data sourcesCochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Clinical Trials.gov and the WHO International Clinical Trials Registry Platform. There were no language restrictions.Study selectionRandomised controlled trials which compared the relief of pain with systemic antibiotics and analgesics against placebo and analgesics in the preoperative phase of irreversible pulpitis. The primary interest was pain control with an antibiotic or without one in the presence of analgesics...
September 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27440277/intestinal-lymphangiectasia-insights-on-management-and-literature-review
#2
Mohamad J Alshikho, Joud M Talas, Salem I Noureldine, Saf Zazou, Aladdin Addas, Haitham Kurabi, Mahmoud Nasser
BACKGROUND Intestinal lymphangiectasia (IL) is a rare disease characterized by a dilatation of the intestinal lymphatics and loss of lymph fluid into the gastrointestinal tract leading to hypoproteinemia, edema, lymphocytopenia, hypogammaglobinemia, and immunological abnormalities. Iron, calcium, and other serum components (e.g., lipids, fat soluble vitamins) may also be depleted. A literature search revealed more than 200 reported cases of IL. Herein, we report our observations of a patient diagnosed with IL; we also present our conclusion for our review of the published literature...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27365868/change-in-prescription-habits-after-federal-rescheduling-of-hydrocodone-combination-products
#3
Susan Seago, Adam Hayek, Jessica Pruszynski, Megan Greene Newman
Nationally, health care providers wrote 259 million prescriptions for narcotic analgesics in 2012, or roughly one bottle of narcotics per US adult (1). In an effort to combat this ever-growing problem, the Drug Enforcement Administration changed the schedule of hydrocodone combination products from schedule III to schedule II on October 6, 2014. Fourteen Baylor Scott & White pharmacies encompassing a 200-mile radius in Central Texas were queried for prescription information on hydrocodone/acetaminophen, morphine, codeine/acetaminophen, and tramadol before and after the rescheduling to evaluate trends in prescription drug usage...
July 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/26886473/antibiotic-use-for-irreversible-pulpitis
#4
REVIEW
Anirudha Agnihotry, Zbys Fedorowicz, Esther J van Zuuren, Allan G Farman, Jassim Hasan Al-Langawi
BACKGROUND: Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain of irreversible pulpitis.This review updates the previous version published in 2013...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26254283/prenatal-acetaminophen-affects-maternal-immune-and-endocrine-adaptation-to-pregnancy-induces-placental-damage-and-impairs-fetal-development-in-mice
#5
Kristin Thiele, M Emilia Solano, Samuel Huber, Richard A Flavell, Timo Kessler, Roja Barikbin, Roman Jung, Khalil Karimi, Gisa Tiegs, Petra C Arck
Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to treat fever or pain and recommended to pregnant women by their physicians. Recent epidemiological studies reveal an association between prenatal APAP use and an increased risk for asthma. Our aim was to identify the effects of APAP in pregnancy using a mouse model. Allogeneically mated C57Bl/6J females were injected i.p. with 50 or 250 mg/kg APAP or phosphate-buffered saline on gestation day 12.5; nonpregnant females served as controls...
October 2015: American Journal of Pathology
https://www.readbyqxmd.com/read/25862546/over-the-counter-relief-from-pains-and-pleasures-alike-acetaminophen-blunts-evaluation-sensitivity-to-both-negative-and-positive-stimuli
#6
Geoffrey R O Durso, Andrew Luttrell, Baldwin M Way
Acetaminophen, an effective and popular over-the-counter pain reliever (e.g., the active ingredient in Tylenol), has recently been shown to blunt individuals' reactivity to a range of negative stimuli in addition to physical pain. Because accumulating research has shown that individuals' reactivity to both negative and positive stimuli can be influenced by a single factor (an idea known as differential susceptibility), we conducted two experiments testing whether acetaminophen blunted individuals' evaluations of and emotional reactions to both negative and positive images from the International Affective Picture System...
June 2015: Psychological Science
https://www.readbyqxmd.com/read/25112303/impact-of-educational-levels-and-health-literacy-on-community-acetaminophen-knowledge
#7
Eric J Ip, Terrill T-L Tang, Vincent Cheng, Junhua Yu, Derren S Cheongsiatmoy
Patient understanding of acetaminophen is important for its safe and appropriate self-use. A cross-sectional survey was conducted in the San Francisco Bay Area to determine the impact of educational level, patient health literacy score, and other demographic characteristics on acetaminophen knowledge. A 17-item, in-person, paper-and-pen questionnaire containing questions about demographics and acetaminophen knowledge was administered to 311 adults outside 5 local grocery stores in varying socioeconomic communities...
December 2015: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/25004022/acetaminophen-and-meloxicam-inhibit-platelet-aggregation-and-coagulation-in-blood-samples-from-humans
#8
Angela K Martini, Cassandra M Rodriguez, Andrew P Cap, Wenjun Z Martini, Michael A Dubick
Acetaminophen (Ace) and meloxicam (Mel) are the two types of analgesic and antipyretic medications. This study investigated the dose responses of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples. Blood samples were collected from six healthy humans and processed to make platelet-adjusted (100 × 10 cells/μl) blood samples. Acetaminophen (Tylenol, Q-PAP, 100 mg/ml) was added at the doses of 0 μg/ml (control), 214 μg/ml (the standard dose, 1 ×), 4 ×, 8 ×, 10 ×, 12 ×, 16 ×, and 20 ×...
December 2014: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/24813653/patient-perception-and-knowledge-of-acetaminophen-in-a-large-family-medicine-service
#9
Christopher M Herndon, Dawn M Dankenbring
The use of acetaminophen is currently under increased scrutiny by the US Food and Drug Administration (FDA) due to the risk of intentional and more concerning, unintentional overdose-related hepatotoxicity. Acetaminophen is responsible for an estimated 48% of all acute liver failure diagnoses. The purpose of this study is to evaluate patient perception and knowledge of the safe use and potential toxicity of acetaminophen-containing products. The authors conducted a descriptive, 2-week study using a convenience sample from a large family medicine clinic waiting room...
June 2014: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/24763167/insufficient-evidence-to-assess-the-effectiveness-of-antibiotics-for-irreversible-pulpitis
#10
COMMENT
Roy George
DATA SOURCES: The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the US National Institutes of Health Trials Register. STUDY SELECTION: Randomised controlled trials (RCTs) which compared pain relief with systemic antibiotics and analgesics, against placebo and analgesics in the acute preoperative phase of irreversible pulpitis. DATA EXTRACTION AND SYNTHESIS: Study selection, risk of bias assessment and data extraction were carried out independently by two reviewers...
March 2014: Evidence-based Dentistry
https://www.readbyqxmd.com/read/24628747/randomized-clinical-trial-of-hydrocodone-acetaminophen-versus-codeine-acetaminophen-in-the-treatment-of-acute-extremity-pain-after-emergency-department-discharge
#11
RANDOMIZED CONTROLLED TRIAL
Andrew K Chang, Polly E Bijur, Kevin G Munjal, E John Gallagher
OBJECTIVES: The objective was to test the hypothesis that hydrocodone/acetaminophen (Vicodin [5/500]) provides more efficacious analgesia than codeine/acetaminophen (Tylenol #3 [30/300]) in patients discharged from the emergency department (ED). Both are currently Drug Enforcement Administration (DEA) Schedule III narcotics. METHODS: This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)...
March 2014: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/24604434/a-triple-option-analgesia-plan-for-tactical-combat-casualty-care-tccc-guidelines-change-13-04
#12
Frank K Butler, Russ S Kotwal, Chester C Buckenmaier, Erin P Edgar, Kevin C O'Connor, Harold R Montgomery, Stacy A Shackelford, John V Gandy, Ian S Wedmore, Jeffrey W Timby, Kirby R Gross, Jeffrey A Bailey
Although the majority of potentially preventable fatalities among U.S. combat forces serving in Afghanistan and Iraq have died from hemorrhagic shock, the majority of U.S. medics carry morphine autoinjectors for prehospital battlefield analgesia. Morphine given intramuscularly has a delayed onset of action and, like all opioids, may worsen hemorrhagic shock. Additionally, on a recent assessment of prehospital care in Afghanistan, combat medical personnel noted that Tactical Combat Casualty Care (TCCC) battlefield analgesia recommendations need to be simplified--there are too many options and not enough clear guidance on which medication to use in specific situations...
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/24386516/recent-updates-on-acetaminophen-hepatotoxicity-the-role-of-nrf2-in-hepatoprotection
#13
Sang Il Gum, Min Kyung Cho
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure. Overdose of APAP depletes the hepatic glutathione (GSH) rapidly, and the metabolic intermediate leads to hepatocellular death. This article reviews the mechanisms of hepatotoxicity and provides an overview of current research studies. Pharmacokinetics including metabolism (activation and detoxification), subsequent transport (efflux)-facilitating excretion, and some other aspects related to toxicity are discussed...
September 2013: Toxicological Research
https://www.readbyqxmd.com/read/24353116/antibiotic-use-for-irreversible-pulpitis
#14
REVIEW
Zbys Fedorowicz, Esther J van Zuuren, Allan G Farman, Anirudha Agnihotry, Jassim Hasan Al-Langawi
BACKGROUND: Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain of irreversible pulpitis. OBJECTIVES: To assess the effects of systemic antibiotics for irreversible pulpitis...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23935833/are-all-placebo-effects-equal-placebo-pills-sham-acupuncture-cue-conditioning-and-their-association
#15
RANDOMIZED CONTROLLED TRIAL
Jian Kong, Rosa Spaeth, Amanda Cook, Irving Kirsch, Brian Claggett, Mark Vangel, Randy L Gollub, Jordan W Smoller, Ted J Kaptchuk
Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion and visual cue conditioning by investigating whether responses to different types of placebo treatment, as well as conditioning responses, correlate with one another. Secondarily, this study also examines whether responses to sham acupuncture correlate with responses to genuine acupuncture...
2013: PloS One
https://www.readbyqxmd.com/read/23724283/can-diabetes-i-and-early-blindness-be-prevented-using-a-tylenol-combination-which-inhibits-oxidative-and-nitrosative-stress
#16
Knox Van Dyke, Erica Ghareeb, Robert Hoeldtke, Mark Van Dyke, Chris Van Dyke, David Van Thiel
Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin possibly peroxynitrite, dinitrogen trioxide, dinitrogen tetraoxide and so forth. The toxic compounds damage the DNA causing beta cell death. This prevents insulin synthesis, storage and release. By using antioxidant substances that destroy the nitric-oxide-based toxins (e...
2011: ISRN Toxicology
https://www.readbyqxmd.com/read/23698086/a-unique-case-of-methanol-toxicity
#17
Maria Herrera, Christiane Mbianda
SESSION TYPE: DVT/PE/Pulmonary Hypertension Posters IPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: In patients presenting with volatile alcohol toxicity early diagnosis and treatment is critical to prevent organ damage and death. The goal standard for diagnosing methanol and ethylene glycol (EG) toxicity is gas chromatography. Results can take up to days and many hospitals are not equipped to provide such test. Clinicians must rely on the clinical presentation and other laboratory tests such osmolar gap (OG) to make a diagnosis...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23499469/multimodal-analgesia-reduces-narcotic-requirements-and-antiemetic-rescue-medication-in-laparoscopic-roux-en-y-gastric-bypass-surgery
#18
COMPARATIVE STUDY
Patrick Ziemann-Gimmel, Priscilla Hensel, John Koppman, Robert Marema
BACKGROUND: After bariatric surgery, patients are at risk for narcotic-related side effects. Multimodal pain management strategies should be used when possible to reduce the consumption of narcotic medication. The purpose of this study was to investigate whether multimodal analgesia reduces narcotic consumption and may have an influence on opioid-related side effects in patients undergoing laparoscopic Roux-en-Y gastric bypass surgery (LRYGB). METHODS: In this retrospective data analysis, we examined the data of a total of 181 consecutive patients undergoing LRYGB...
November 2013: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/23432879/acetaminophen-and-pregnancy-short-and-long-term-consequences-for-mother-and-child
#19
REVIEW
Kristin Thiele, Timo Kessler, Petra Arck, Annette Erhardt, Gisa Tiegs
Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks at the top of the list of medications taken prenatally. Insights on an increased risk for pregnancy complications such as miscarriage, stillbirth, preterm birth or fetal malformations upon APAP exposure are rather ambiguous. However, emerging evidence arising from human trials clearly reveals a significant correlation between APAP use during pregnancy and an increased risk for the development of asthma in children later in life...
March 2013: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/23408702/study-on-the-reaction-mechanism-and-the-static-injection-chemiluminescence-method-for-detection-of-acetaminophen
#20
Yongjun Wu, Huili Zhang, Songcheng Yu, Fei Yu, Yanqiang Li, Hongquan Zhang, Lingbo Qu, Peter de B Harrington
Acetaminophen, also called paracetamol, is found in Tylenol, Excedrin and other products as over-the-counter medicines. In this study, acetaminophen as a luminol signal enhancer was used in the chemiluminescence (CL) substrate solution of horseradish peroxidase (HRP) for the first time. The use of acetaminophen in the luminol-HRP-H2O2 system affected not only the intensity of the obtained signal, but also its kinetics. It was shown that acetaminophen was to be a potent enhancer of the luminol-HRP-H2O2 system...
November 2013: Luminescence: the Journal of Biological and Chemical Luminescence
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