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https://www.readbyqxmd.com/read/28919116/global-regional-and-national-age-sex-specific-mortality-for-264-causes-of-death-1980-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#1
(no author information available yet)
BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. METHODS: We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28916411/3d-fusion-of-coronary-ct-angiography-and-ct-myocardial-perfusion-imaging-intuitive-assessment-of-morphology-and-function
#2
Jochen von Spiczak, Robert Manka, Manoj Mannil, Sabrina Oebel, Sandra Hamada, Kai Higashigaito, Ernst Klotz, Frank Ruschitzka, Hatem Alkadhi
BACKGROUND: The objective of this work was to support three-dimensional fusion of coronary CT angiography (coronary CTA) and CT myocardial perfusion (CT-Perf) data visualizing coronary artery stenoses and corresponding stress-induced myocardial perfusion deficits for diagnostics of coronary artery disease. METHODS: Twelve patients undergoing coronary CTA/CT-Perf after heart transplantation were included (56 ± 12 years, all males). CT image quality was rated. Coronary diameter stenoses >50% were documented for coronary CTA...
September 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28915907/effect-of-a-mother-s-recorded-voice-on-emergence-from-general-anesthesia-in-pediatric-patients-study-protocol-for-a-randomized-controlled-trial
#3
Seok Young Song, Sang Gyu Kwak, Eugene Kim
BACKGROUND: Emergence delirium is a behavioral disturbance after general anesthesia in children and may distress both the patients and the primary caregivers, such as parents and medical staff, looking after the patients. Various medical and emotional interventions have been investigated to reduce emergence delirium; however, none are completely effective. This trial intends to assess whether the mother's recorded voice can reduce this adverse post-anesthesia event and facilitate arousal from general anesthesia...
September 15, 2017: Trials
https://www.readbyqxmd.com/read/28906129/perceptions-of-u-s-veterans-affairs-and-community-healthcare-providers-regarding-cross-system-care-for-heart-failure
#4
Charlene A Pope, Boyd H Davis, Leticia Wine, Lynne S Nemeth, K Sue Haddock, Tom Hartney, R Neal Axon
Objectives This study explores perceptions of US Veterans Affairs (VA) and non-VA healthcare providers caring for Veterans with heart failure (HF) regarding Veteran knowledge and motivations for dual use, provider roles in recommending and coordinating dual use, systems barriers and facilitators, and suggestions for improving cross-system care. Methods Twenty VA and 11 non-VA providers participated in semi-structured interviews, which were analyzed using parallel qualitative content and discourse analysis. Results VA and non-VA providers described variable HF knowledge and self-management among Veterans, and both groups described the need for improved education addressing medication adherence, self-care, and management of acute symptoms...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28905197/systemic-glyceryl-trinitrate-reduces-anal-sphincter-tone-is-there-a-therapeutic-indication
#5
C Connolly, S Tierney, P Grace
BACKGROUND: Nitric oxide (NO) has diverse roles as a biological messenger. [1] Topically applied nitrate donors cause relaxation of the internal anal sphincter (IAS) and facilitate healing of anal fissures [2,3]. Systemic nitrates are commonly used for the treatment of ischaemic heart disease, yet the effects of systemically administered nitrates on the smooth muscle of the IAS are unknown. AIM: Our aim was to test the hypothesis that systemically administered nitrates at a normal dose, cause inhibition of anal sphincter activity...
September 13, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28901573/validation-of-a-novel-cartoseg%C3%A2-segmentation-module-software-for-contrast-enhanced-computed-tomography-guided-radiofrequency-ablation-in-patients-with-atrial-fibrillation
#6
EDITORIAL
Hasan Imanli, Shaun Bhatty, Jean Jeudy, Yousra Ghzally, Kiddy Ume, Rama Vunnam, Refael Itah, Mati Amit, John Duell, Vincent See, Stephen Shorofsky, Timm M Dickfeld
INTRODUCTION: Visualization of left atrial (LA) anatomy using image integration modules has been associated with decreased radiation exposure and improved procedural outcome when used for guidance of pulmonary vein isolation (PVI) in atrial fibrillation (AF) ablation. We evaluated the CARTOSEG™ CT Segmentation Module (Biosense Webster, Inc.) that offers a new CT-specific semi-automatic reconstruction of the atrial endocardium. METHODS: The CARTOSEG™ CT Segmentation Module software was assessed prospectively in 80 patients undergoing AF ablation...
September 13, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28898668/understanding-the-arbuscule-at-the-heart-of-endomycorrhizal-symbioses-in-plants
#7
REVIEW
Leonie H Luginbuehl, Giles E D Oldroyd
Arbuscular mycorrhizal fungi form associations with most land plants and facilitate nutrient uptake from the soil, with the plant receiving mineral nutrients from the fungus and in return providing the fungus with fixed carbon. This nutrient exchange takes place through highly branched fungal structures called arbuscules that are formed in cortical cells of the host root. Recent discoveries have highlighted the importance of fatty acids, in addition to sugars, acting as the form of fixed carbon transferred from the plant to the fungus and several studies have begun to elucidate the mechanisms that control the plant processes necessary for fungal colonisation and arbuscule development...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28898387/prevalence-and-correlates-of-elder-abuse-in-s%C3%A3-o-paulo-and-rio-de-janeiro
#8
Sergio L Blay, Jerson Laks, Valeska Marinho, Ivan Figueira, Deborah Maia, Evandro S F Coutinho, Ines M Quintana, Marcelo F Mello, Rodrigo A Bressan, Jair J Mari, Sergio B Andreoli
OBJECTIVES: To assess the prevalence of elder abuse and to investigate potential sociodemographic, health behavior, and medical correlates. DESIGN: Cross-sectional data were collected in face-to-face assessments. SETTING: São Paulo and Rio de Janeiro, Brazil. PARTICIPANTS: Individuals aged 60 to 75. MEASUREMENTS: Information on elder abuse was obtained using the Brazil-adapted, nine-item Hwalek-Sengstock Elder Abuse Screening Test...
September 12, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28891183/primary-percutaneous-coronary-intervention-for-inferior-st-segment-elevation-myocardial-infarction-in-a-patient-supported-by-the-heartware-left-ventricular-assist-device
#9
Roberto Spina, Maithri Siriwardena, Nicole Bart, Mayooran Namasivayam, Mark Connellan, Paul Jansz, Philip Spratt, Christopher S Hayward, Eugene Kotlyar, Brendan Gunalingam
A 63-year-old man with an ischaemic cardiomyopathy, supported by the HeartWare left ventricular assist device (LVAD), presented with ventricular tachycardia and inferior ST-elevation myocardial infarction (STEMI) with associated acute right ventricular (RV) dysfunction. He underwent primary percutaneous coronary intervention with balloon angioplasty and placement of three drug-eluting stents in the proximal-to-mid right coronary artery. Post-procedure, ventricular arrhythmias abated, RV systolic dysfunction resolved and RV size normalised...
September 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28889247/guidelines-for-autopsy-investigation-of-sudden-cardiac-death-2017-update-from-the-association-for-european-cardiovascular-pathology
#10
Cristina Basso, Beatriz Aguilera, Jytte Banner, Stephan Cohle, Giulia d'Amati, Rosa Henriques de Gouveia, Cira di Gioia, Aurelie Fabre, Patrick J Gallagher, Ornella Leone, Joaquin Lucena, Lubov Mitrofanova, Pilar Molina, Sarah Parsons, Stefania Rizzo, Mary N Sheppard, Maria Paz Suárez Mier, S Kim Suvarna, Gaetano Thiene, Allard van der Wal, Aryan Vink, Katarzyna Michaud
Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosis of the causes of SCD is now of particular importance. Pathologists are responsible for determining the precise cause and mechanism of sudden death but there is still considerable variation in the way in which they approach this increasingly complex task...
September 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28883048/corp-ultrasound-assessment-of-vascular-function-with-the-passive-leg-movement-technique
#11
Jayson R Gifford, Russell S Richardson
As dysfunction of the vascular system is an early, modifiable step in the progression of many cardiovascular diseases, there is demand for methods to non-invasively monitor the health of the vascular system in clinical and research settings. Validated by very good agreement with more technical assessments of vascular function, like intra-arterial drug infusions and flow mediated dilation (FMD), the passive leg movement (PLM) technique has emerged as a powerful, yet relatively simple, test of peripheral vascular function...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28880807/-my-heart-is-in-his-hands-the-lived-spiritual-experiences-of-congolese-refugee-women-survivors-of-sexual-violence
#12
Melissa A Smigelsky, Alison R Gill, Deb Foshager, Jamie D Aten, Hannah Im
The Democratic Republic of Congo (DRC) has experienced widespread violence, including sexual violence. Sexual violence toward women includes rape, genital mutilation, and sexual slavery. Many Congolese have sought to escape such conditions as refugees in the USA. In the present study, we examined lived spiritual experiences of nine Congolese refugee women survivors of sexual violence. Overall, this study provides new insights into participants' experiences of spirituality in the aftermath of sexual trauma and in living as a refugees...
October 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28877121/begin-again-and-continue-with-life-a-qualitative-study-on-the-experiences-of-cardiac-rehabilitation-patients
#13
Fariba Jokar, Hojatllah Yousefi, Alireza Yousefy, Masoumeh Sadeghi
BACKGROUND: Cardiovascular diseases are a main cause of mortality worldwide. However, new diagnostic techniques and treatments have increased the rate of survival for patients with cardiovascular disease. Cardiac rehabilitation programs aim to maintain and enhance the quality of life of patients and improve the secondary prevention of coronary artery disease. Suboptimal participation in rehabilitation programs, early exit from these programs, and not achieving lasting changes are cardiac rehabilitation challenges that are associated with health issues, including the increased need for medication, repeated hospitalization, failure in the secondary prevention programs, and long waiting lists...
October 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28875228/myocardial-deformation-assessed-by-longitudinal-strain-chamber-specific-normative-data-for-cmr-feature-tracking-from-the-german-competence-network-for-congenital-heart-defects
#14
Quanliang Shang, Shivani Patel, Michael Steinmetz, Andreas Schuster, David A Danford, Philipp Beerbaum, Samir Sarikouch, Shelby Kutty
PURPOSE: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). METHODS: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions...
September 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28874825/knockout-of-the-atpase-inhibitory-factor-1-protects-the-heart-from-pressure-overload-induced-cardiac-hypertrophy
#15
Kevin Yang, Qinqiang Long, Kamalamma Saja, Fengyuan Huang, Steven M Pogwizd, Lufang Zhou, Masasuke Yoshida, Qinglin Yang
Mitochondrial ATP synthase catalyzes the coupling of oxidative phosphorylation. Under pathological conditions, ATP synthase hydrolyzes ATP to replenish protons from the matrix into the intermembrane space, sustaining mitochondrial membrane potential. ATPase inhibitory factor 1 (IF1) is a nuclear-encoded, ATP synthase-interacting protein that selectively inhibits the hydrolysis activity of ATP synthase, which may render the protective role of IF1 in ischemic hearts. However, the in vivo cardiac function of IF1 and the potential therapeutic application targeting IF1 remain obscure...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872734/xenon-as-an-adjuvant-to-sevoflurane-anesthesia-in-children-younger-than-4%C3%A2-years-of-age-undergoing-interventional-or-diagnostic-cardiac-catheterization-a-randomized-controlled-clinical-trial
#16
Sarah Devroe, Roselien Meeusen, Marc Gewillig, Bjorn Cools, Koen Poesen, Robert Sanders, Steffen Rex
BACKGROUND: Xenon has repeatedly been demonstrated to have only minimal hemodynamic side effects when compared to other anesthetics. Moreover, in experimental models, xenon was found to be neuroprotective and devoid of developmental neurotoxicity. These properties could render xenon attractive for the anesthesia in neonates and infants with congenital heart disease. However, experience with xenon anesthesia in children is scarce. AIMS: We hypothesized that in children undergoing cardiac catheterization, general anesthesia with a combination of sevoflurane with xenon results in superior hemodynamic stability, compared to sevoflurane alone...
September 5, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28870220/the-type-vi-adenylyl-cyclase-protects-cardiomyocytes-from-%C3%AE-adrenergic-stress-by-a-pka-stat3-dependent-pathway
#17
Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen, Yijuang Chern
BACKGROUND: The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1-86). Activation of AC6, rather than AC5, produces cardioprotective effects against heart failure, while the underlying mechanism remains to be unveiled. Using an AC6-null (AC6(-/-)) mouse and a knockin mouse with AC6-N deletion (AC6 (ΔN/ΔN)), we aimed to investigate the cardioprotective mechanism of AC6 in the heart...
September 4, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28867834/estimation-of-leaf-area-index-and-its-sunlit-portion-from-dscovr-epic-data-theoretical-basis
#18
Bin Yang, Yuri Knyazikhin, Matti Mõttus, Miina Rautiainen, Pauline Stenberg, Lei Yan, Chi Chen, Kai Yan, Sungho Choi, Taejin Park, Ranga B Myneni
This paper presents the theoretical basis of the algorithm designed for the generation of leaf area index and diurnal course of its sunlit portion from NASA's Earth Polychromatic Imaging Camera (EPIC) onboard NOAA's Deep Space Climate Observatory (DSCOVR). The Look-up-Table (LUT) approach implemented in the MODIS operational LAI/FPAR algorithm is adopted. The LUT, which is the heart of the approach, has been significantly modified. First, its parameterization incorporates the canopy hot spot phenomenon and recent advances in the theory of canopy spectral invariants...
September 1, 2017: Remote Sensing of Environment
https://www.readbyqxmd.com/read/28867191/aging-related-mitochondrial-dysfunction-facilitates-the-occurrence-of-serious-arrhythmia-after-myocardial-infarction
#19
Florian Stöckigt, Thomas Beiert, Vincent Knappe, Olivier R Baris, Rudolf J Wiesner, Christoph S Clemen, Georg Nickenig, René P Andrié, Jan W Schrickel
BACKGROUND: During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. METHODS AND RESULTS: Myocardial cryoinfarction was performed in 12-month-old transgenic mice with accelerated accumulation of deletions in mitochondrial DNA. Occurrence and pathogenesis of arrhythmia was investigated after two weeks...
September 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28866490/hadamard-encoded-multi-pulses-for-contrast-enhanced-ultrasound-imaging
#20
Ping Gong, Pengfei Song, Shigao Chen
The development of contrast-enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound clinical applications such as myocardial perfusion imaging and abdominal lesion characterization. In CEUS imaging, the contrast agents (i.e., microbubbles) are utilized to improve the contrast between blood and tissue based on their high nonlinearity under low ultrasound pressure. In this paper, we propose a new CEUS pulse sequence by combining Hadamard-encoded multi-pulses (HEM) with fundamental frequency bandpass filter (i...
August 30, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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