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https://www.readbyqxmd.com/read/28938406/ct-derived-body-fat-distribution-and-incident-cardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#1
Morgana L Mongraw-Chaffin, Matthew A Allison, Gregory L Burke, Michael H Criqui, Kunihiro Matsushita, Pamela Ouyang, Ravi V Shah, Christina M Shay, Cheryl A M Anderson
Background: Visceral fat has been shown to be associated with increased cardiometabolic risk, but the role of subcutaneous fat remains unclear, and evidence from diverse populations is lacking. We hypothesized that visceral, but not subcutaneous fat, would be independently associated with incident cardiovascular disease and all-cause mortality. Methods: Among 1,910 participants from the Multi-Ethnic Study of Atherosclerosis with abdominal fat measurements from computed tomography (CT) scans and followed for an average of 9...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938275/inpatient-treatment-of-patients-admitted-for-dizziness-a-population-based-healthcare-research-study-on-epidemiology-diagnosis-treatment-and-outcome
#2
Vera Renner, Katharina Geißler, Daniel Boeger, Jens Buentzel, Dirk Esser, Kerstin Hoffmann, Peter Jecker, Andreas Mueller, Gerald Radtke, Hubertus Axer, Orlando Guntinas-Lichius
OBJECTIVE: To determine inpatient treatment rates of patients with dizziness with focus on diagnostics, treatment and outcome. STUDY DESIGN: Retrospective population-based study. SETTING: Inpatients in the federal state Thuringia in 2014. PATIENTS: All 1,262 inpatients (62% females, median age: 61 yr) treated for inpatient dizziness were included. MAIN OUTCOME MEASURES: The association between analyzed parameters and probability of improvement and recovery was tested using univariable and multivariable statistics...
September 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28937258/sensitivity-to-perioperative-ischemia-reperfusion-injury-in-male-and-female-donor-myocardium
#3
M Smetana, J Besik, I Netuka, J Maly, J Maluskova, A Lodererova, L Hoskova, J Franeková, E Pokorna, J Pirk, O Szarszoi
Many functions of the cardiovascular apparatus are affected by gender. The aim of our study was find out whether markers of cell death present in the donor myocardium differ in male and female hearts. The study involved 81 patients undergoing heart transplantation from September 2010 to January 2013. Patients were divided into two groups: male allograft (n=49), and female allograft (n=32). Two types of myocardial cell death were analyzed. High-sensitive cardiac troponin T as a necrosis marker and protein bcl-2, caspase 3 and TUNEL as apoptosis markers were measured...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937241/preejection-period-as-a-sympathetic-activity-index-a-role-of-confounding-factors
#4
J Krohova, B Czippelova, Z Turianikova, Z Lazarova, I Tonhajzerova, M Javorka
In previous studies, one of the systolic time intervals - preejection period (PEP) - was used as an index of sympathetic activity reflecting the cardiac contractility. However, PEP could be also influenced by several other cardiovascular variables including preload, afterload and diastolic blood pressure (DBP). The aim of this study was to assess the behavior of the PEP together with other potentially confounding cardiovascular system characteristics in healthy humans during mental and orthostatic stress (head-up tilt test - HUT)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28935756/perinatal-hypercholesterolemia-exacerbates-atherosclerosis-lesions-in-offspring-by-altering-metabolism-of-trimethylamine-n-oxide-and-bile-acids
#5
Charlotte Trenteseaux, Anh-Thu Gaston, Audrey Aguesse, Guillaume Poupeau, Pierre de Coppet, Ramaroson Andriantsitohaina, Jamila Laschet, Valérie Amarger, Michel Krempf, Estelle Nobecourt-Dupuy, Khadija Ouguerram
OBJECTIVE: Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E-deficient mice and the underlying mechanism. APPROACH AND RESULTS: Atherosclerosis and related parameters were studied in adult male or female apolipoprotein E-deficient mice offspring from either normocholesterolemic or hypercholesterolemic mothers and normocholesterolemic fathers...
September 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28935680/cardiac-events-during-competitive-recreational-and-daily-activities-in-children-and-adolescents-with-long-qt-syndrome
#6
Kristina D Chambers, Virginie Beausejour Ladouceur, Mark E Alexander, Robyn J Hylind, Laura Bevilacqua, Douglas Y Mah, Vassilios Bezzerides, John K Triedman, Edward P Walsh, Dominic J Abrams
BACKGROUND: The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS: Long QT syndrome patients aged ≥4 years treated with anti-adrenergic therapy were included. Demographics included mechanism of presentation, corrected QT interval pretreatment, symptom history, medication compliance, and administration of QT-prolonging medications...
September 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28935359/disparities-by-sex-tracked-in-the-2015-national-healthcare-quality-and-disparities-report-trends-across-national-quality-strategy-priorities-health-conditions-and-access-measures
#7
Jennifer E Moore, Atlang Mompe, Ernest Moy
INTRODUCTION: Established by the Affordable Care Act, the National Quality Strategy (NQS) is the national policy goals aimed at improving the quality of health care for all Americans. The NQS established six priorities to provide better, more affordable care for individuals and communities. This is the first analysis of data on the NQS and access measures that focus on sex differences, health conditions, trends, and disparities. METHODS: Measures from the 2015 National Healthcare Quality and Disparities Report (QDR) for the four National Quality Strategy priorities (Patient Safety, Person Centered Care, Effective Treatment and Healthy Living), access to care, and health conditions for women were compared to measures for men...
September 19, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28935081/efficacy-and-safety-of-the-absorb-bioresorbable-vascular-scaffold-in-females-and-males-results-of-an-individual-patient-level-pooled-meta-analysis-of-randomized-controlled-trials
#8
Satya Shreenivas, Dean J Kereiakes, Stephen G Ellis, Runlin Gao, Takeshi Kimura, Yoshinobu Onuma, Karine Piard-Ruster, Yunlong Zhang, Kai Koo, Minh-Thien Vu, Patrick W Serruys, Gregg W Stone
OBJECTIVES: Because females are under-represented in coronary trials, this study sought to assess the relative safety and efficacy of Absorb bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) and the Xience everolimus-eluting stent in females compared with males. BACKGROUND: The Absorb everolimus-eluting BVS provides drug delivery and mechanical support similar to a metallic drug-eluting stent, followed by resorption and restoration of more normal vascular structure with the potential to improve late clinical outcomes...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28934312/clinical-characteristics-and-12-month-outcomes-of-patients-with-valvular-and-non-valvular-atrial-fibrillation-in-kenya
#9
Tecla M Temu, Kathleen A Lane, Changyu Shen, Loise Ng'ang'a, Constantine O Akwanalo, Peng-Sheng Chen, Wilfred Emonyi, Susan R Heckbert, Myra M Koech, Imran Manji, Matteo Vatta, Eric J Velazquez, Jennifer Wessel, Sylvester Kimaiyo, Thomas S Inui, Gerald S Bloomfield
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. METHODS: We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates...
2017: PloS One
https://www.readbyqxmd.com/read/28934296/lactobacillus-paracasei-gmnl-32-exerts-a-therapeutic-effect-on-cardiac-abnormalities-in-nzb-w-f1-mice
#10
Wei-Syun Hu, Peramaiyan Rajendran, Bor-Show Tzang, Yu-Lan Yeh, Chia-Yao Shen, Ray-Jade Chen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang
Systemic lupus erythematosus (SLE) is a disease that mostly affects women. Accelerated atherosclerosis is a high-risk factor associated with SLE patients. SLE associated with cardiovascular disease is one of the most important causes of death. In this study, we demonstrated that Lactobacillus paracasei GMNL-32 (GMNL-32), a probiotic species, exhibits anti-fibrosis and anti-apoptotic effects on the cardiac tissue of NZB/WF1 mice. Female NZB/W F1 mice, a well-known and commonly used lupus-prone mouse strain, were treated with or without GMNL-32 administration for 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28933414/association-between-low-serum-bicarbonate-concentrations-and-cardiovascular-disease-in-patients-in-the-end-stage-of-renal-disease
#11
Vaia D Raikou, Despina Kyriaki
BACKGROUND: Metabolic acidosis, a common condition particularly in the end-stage of renal disease patients, results in malnutrition, inflammation and oxidative stress. In this study, we focused on the association between low serum bicarbonate and cardiovascular disease in patients on intermittent dialysis. METHODS: We studied 52 on-line-pre-dilution hemodiafiltration (on-l HDF) patients, 32 males and 20 females, with a mean age of 58.01 ± 15.4 years old. Metabolic acidosis was determined by serum bicarbonate concentrations less than 22 mmol/L...
November 15, 2016: Diseases (Basel)
https://www.readbyqxmd.com/read/28933132/effects-of-secukinumab-on-serum-adipocytokines-preliminary-data
#12
A Fassio, D Gatti, P Gisondi, G Girolomoni, O Viapiana, A Giollo, M Zamboni, M Rossini, L Idolazzi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Secukinumab is a new monoclonal antibody with a different mechanism of action. This antibody selectively binds to and neutralizes interleukin-17 (IL-17) and it has shown efficacy in the treatment of PsA...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28932938/assessment-of-oral-anticoagulation-control-at-two-pharmacist-managed-clinics-in-brazil
#13
Rogério Guimarães de Lima Silva, Caryne Margotto Bertollo, Isadora Gonçalves Ferreira, Luisa Caldeira Brant, Maria Auxiliadora Parreiras Martins
Background Warfarin remains widely used by patients with cardiovascular diseases. When using warfarin, the quality of oral anticoagulation control is a critical determinant to minimize the risk of bleeding and thromboembolic events. Pharmacist engagement in patient care is relevant towards improving the quality of warfarin therapy. Objective To assess the quality of oral anticoagulation control measured by time in therapeutic range (TTR) at two pharmacist-managed anticoagulation clinics (AC). Method This study included adults with indication of continuous warfarin use...
September 20, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28932733/pectoral-nerve-block-pecs-block-with-sedation-for-breast-conserving-surgery-without-general-anesthesia
#14
Eun-Jin Moon, Seung-Beom Kim, Jun-Young Chung, Jeong-Yoon Song, Jae-Woo Yi
Most regional anesthesia in breast surgeries is performed as postoperative pain management under general anesthesia, and not as the primary anesthesia. Regional anesthesia has very few cardiovascular or pulmonary side-effects, as compared with general anesthesia. Pectoral nerve block is a relatively new technique, with fewer complications than other regional anesthesia. We performed Pecs I and Pec II block simultaneously as primary anesthesia under moderate sedation with dexmedetomidine for breast conserving surgery in a 49-year-old female patient with invasive ductal carcinoma...
September 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28932292/methotrexate-blood-pressure-and-markers-of-arterial-function-in-patients-with-rheumatoid-arthritis-a-repeated-cross-sectional-study
#15
Arduino A Mangoni, Leena R Baghdadi, E Michael Shanahan, Michael D Wiese, Sara Tommasi, David Elliot, Richard J Woodman
BACKGROUND: Methotrexate (MTX) treatment in rheumatoid arthritis (RA) has been associated with lower cardiovascular risk compared to other disease-modifying antirheumatic drugs (DMARDs). We sought to identify whether the MTX-associated cardioprotection involves changes in blood pressure (BP) and/or arterial function. METHODS: Clinic and 24-hour peripheral and central systolic and diastolic BP (SBP and DBP), augmentation index (AIx), pulse wave velocity (PWV) and plasma asymmetric dimethylarginine (ADMA) were assessed in RA patients on stable treatment with either MTX ± other DMARDs (MTX group, n = 56, age 61 ± 13 years, 70% females) or other DMARDs (non-MTX group, n = 30, age 63 ± 12 years, 76% females)...
September 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28931409/clinical-review-of-24-35%C3%A2-year-olds-conceived-with-and-without-in-vitro-fertilization-study-protocol
#16
Sharon Lewis, Joanne Kennedy, David Burgner, Robert McLachlan, Sarath Ranganathan, Karin Hammarberg, Richard Saffery, David J Amor, Michael M H Cheung, Lex W Doyle, Markus Juonala, Susan Donath, John McBain, Jane Halliday
BACKGROUND: Children conceived by assisted reproductive technologies (ART) currently comprise 4% of Australian births. The manipulation of biological parameters related to fertilization and implantation are integral to successful ART but potentially pose a risk to the longer-term health of the offspring. There is consensus that many common adult health problems (particularly cardiovascular, metabolic and respiratory conditions) have their origins in early life, possibly before birth, and that risk trajectories track through childhood until clinical disease manifests in adulthood...
September 20, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28931072/high-prevalence-of-non-dipping-blood-pressure-and-vascular-stiffness-in-hiv-infected-south-africans-on-antiretrovirals
#17
M S Borkum, J M Heckmann, K Manning, J A Dave, N S Levitt, B L Rayner, N Wearne
BACKGROUND: HIV-infected individuals are at increased risk of tissue inflammation and accelerated vascular aging ('inflamm-aging'). Abnormal diurnal blood pressure (BP) rhythms such as non-dipping may contribute to an increased risk of cardiovascular and cerebrovascular events in HIV infected individuals. However, little data exists on ambulatory blood pressure (ABP) and measures of vascular stiffness in the black African HIV infected population. METHODS: This is a cross-sectional analysis of otherwise well, HIV infected outpatients on ART for >5 years...
2017: PloS One
https://www.readbyqxmd.com/read/28929027/the-role-of-polycarbonate-monomer-bisphenol-a-in-insulin-resistance
#18
Milos Pjanic
Bisphenol A (BPA) is a synthetic unit of polycarbonate polymers and epoxy resins, the types of plastics that could be found in essentially every human population and incorporated into almost every aspect of the modern human society. BPA polymers appear in a wide range of products, from liquid storages (plastic bottles, can and glass linings, water pipes and tanks) and food storages (plastics wraps and containers), to medical and dental devices. BPA polymers could be hydrolyzed spontaneously or in a photo- or temperature-catalyzed process, providing widespread environmental distribution and chronic exposure to the BPA monomer in contemporary human populations...
2017: PeerJ
https://www.readbyqxmd.com/read/28928558/oral-clonidine-premedication-attenuates-hemodynamic-responses-of-ketamine-during-total-intravenous-anesthesia
#19
Pulak Tosh, Sunil Rajan, Nitu Puthenveettil, Lakshmi Kumar
BACKGROUND: The most commonly used drug for total intravenous anesthesia (TIVA) is ketamine which results in cardiovascular stimulation. AIMS: The primary aim of this study was to assess the effect of oral clonidine premedication on attenuating the hemodynamic responses following ketamine administration. SETTINGS AND DESIGNS: This was a prospective, observational, comparative study conducted in a tertiary care institution. SUBJECTS AND METHODS: A total of 40 female patients aged 18-55 years who were posted for elective short gynecological procedures under TIVA were recruited for this study...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28927656/features-and-outcomes-from-a-retrospective-study-of-570%C3%A2-hospitalized-chinese-patients-with-drug-induced-liver-injury
#20
Lili Pang, Wanna Yang, Fengqin Hou
AIMS: To investigate the clinical features and outcomes of hospitalized patients with drug-induced liver injury (DILI). METHODS: The medical records of hospitalized patients with DILI from January 1997 through July 2016 were reviewed. RESULTS: Five hundred seventy cases were reviewed, of which 381 (66.8%) were female. Four hundred fifty-eight cases (80.4%) presented with hepatocellular injury, 53 (9.3%) with cholestatic injury and 59 (10...
September 15, 2017: Clinics and Research in Hepatology and Gastroenterology
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