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https://www.readbyqxmd.com/read/28213685/prasugrel-for-japanese-patients-with-acute-coronary-syndrome-in-short-term-clinical-practice-prasfit-practice-i-a-postmarketing-observational-study
#1
Masato Nakamura, Tomoko Iizuka, Kei Sagawa, Kenji Abe, Shuichi Chikada, Miyuki Arai
: Data on prasugrel use in Japanese patients are limited to phase II/III clinical trials. This early postmarketing observational study evaluated the safety and efficacy of short-term prasugrel use in patients with acute coronary syndrome (ACS) in real-world clinical settings in Japan. From May 2014 to January 2015, we enrolled consecutive patients with ACS requiring percutaneous coronary intervention in each institution. Each patient started prasugrel treatment ≥1 month before the end of the study period...
February 17, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28211910/link-between-plasminogen-activator-inhibitor-1-and-cardiovascular-risk-in-chronic-hepatitis-c-after-viral-clearance
#2
Ming-Ling Chang, Yu-Sheng Lin, Li-Heng Pao, Hsin-Chih Huang, Cheng-Tang Chiu
The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Multivariate analysis demonstrated, before anti-HCV-therapy, platelet count and PAI-1-rs1799889 genotype were associated with PAI-1 levels. Among patients with a sustained virological response (SVR, n = 445), platelet count was associated with PAI-1 level at 24 weeks post-therapy...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211485/association-of-female-reproductive-factors-with-hypertension-diabetes-and-lqtc-in-chinese-women
#3
Bayi Xu, Yequn Chen, Jianping Xiong, Nan Lu, Xuerui Tan
The association of female reproductive factors (FRFs) with cardiovascular risk factors among different population was variable and inconsistent. The objective of this study was to examine the association between FRFs and hypertension, type 2 diabetes mellitus (DM), and long heart-rate-corrected QT interval (LQTc) in Chinese post-menopausal women (Post-MW). A total of 8046 Post-MW from the China Chaoshan Biobank Cohort Study were included for analysis. Logistic regression and general linear regression models were used to estimate the association between FRFs and hypertension, DM, and LQTc...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211138/nocturnal-autonomic-nervous-system-activity-and-morning-proinflammatory-cytokines-in-young-adult-african-americans
#4
Kimberly A Bell, Ihori Kobayashi, Yuanxiu Chen, Thomas A Mellman
Compromised sleep and increased sympathetic nervous system (SNS) activity are implicated in the pathogenesis of, and disparities in, cardiovascular disease. Parasympathetic dominance during sleep may be important for cardiovascular health. Sleep and autonomic balance influence immune activity, which impacts atherogenesis. We evaluated relationships between autonomic balance during sleep and morning levels of the immune activating cytokines, C-reactive protein (CRP) and interleukin (IL)-6. Ninety-four (59 female) young adult African Americans without medical conditions and substance use disorders spent 2 consecutive nights in a clinical research unit for sleep recordings and blood drawing on awakening...
February 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28210489/arterial-ventricular-coupling-and-parameters-of-vascular-stiffness-in-hypertensive-patients-role-of-gender
#5
Luca Faconti, Rosa Maria Bruno, Simona Buralli, Marta Barzacchi, Elisa Dal Canto, Lorenzo Ghiadoni, Stefano Taddei
OBJECTIVE: Non-invasive estimation of arterial-ventricular coupling has been extensively used for the evaluation of cardiovascular performance, however, a relative small amount of data is available regarding arterial-ventricular coupling and its components in hypertension. The present study was designed to investigate the relationship between left ventricular elastance, arterial elastance, parameters of vascular stiffness and the influence of gender in a population of hypertensive individuals...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28209728/evaluation-of-cell-therapy-on-exercise-performance-and-limb-perfusion-in-peripheral-artery-disease-the-cctrn-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-pace-trial
#6
Emerson C Perin, Michael P Murphy, Keith L March, Roberto Bolli, John Loughran, Phillip C Yang, Nicholas J Leeper, Ronald L Dalman, Jason Q Alexander, Timothy D Henry, Jay H Traverse, Carl J Pepine, R David Anderson, Scott Berceli, James T Willerson, Raja Muthupillai, Amir A Gahremanpour, Ganesh Raveendran, Omaida C Velazquez, Joshua M Hare, Ivonne H Schulman, Vijaykumar S Kasi, William R Hiatt, Bharath Ambale-Venkatesh, João A Lima, Doris A Taylor, Micheline M Resende, Adrian P Gee, April G Durett, Jeannette Bloom, Sara Richman, Patricia G'Sell, Shari Williams, Fouzia Khan, Elsie G Ross, Michelle R Santoso, JoAnne Goldman, Dana Leach, Eileen Handberg, Benjamin Y C Cheong, Nichole A Piece, Darcy DiFede, Barb Bruhn-Ding, Emily Caldwell, Judy Bettencourt, Dejian Lai, Linda B Piller, Lara M Simpson, Michelle Cohen, Shelly L Sayre, Rachel W Vojvodic, Lem Moyé, Ray F Ebert, Robert D Simari, Alan T Hirsch
Background -Atherosclerotic peripheral artery disease (PAD) affects 8-12% of Americans over 65 and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of ischemic amputation. Current treatment strategies for claudication have limitations. PACE is an NHLBI-sponsored, randomized, double-blind, placebo-controlled phase 2, exploratory clinical trial designed to assess safety and efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in PAD patients and to explore associated claudication physiologic mechanisms...
February 16, 2017: Circulation
https://www.readbyqxmd.com/read/28209155/intranasal-oxytocin-reduces-provoked-symptoms-in-female-patients-with-posttraumatic-stress-disorder-despite-exerting-sympathomimetic-and-positive-chronotropic-effects-in-a-randomized-controlled-trial
#7
M Sack, D Spieler, L Wizelman, G Epple, J Stich, M Zaba, U Schmidt
BACKGROUND: Posttraumatic stress disorder (PTSD) is a severe psychiatric disease accompanied by neuroendocrine changes such as adrenergic overdrive and hence an elevated cardiovascular morbidity. Current pharmacotherapeutic options for PTSD are less than suboptimal, necessitating the development of PTSD-specific drugs. Although the neuropeptide oxytocin has been repeatedly suggested to be effective in PTSD treatment, there are, to our knowledge, only three studies that have assessed its efficacy on the intensity of PTSD symptoms in PTSD patients - among them one symptom provocation study in male veterans...
February 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28207791/vitamin-d-and-mortality-individual-participant-data-meta-analysis-of-standardized-25-hydroxyvitamin-d-in-26916-individuals-from-a-european-consortium
#8
Martin Gaksch, Rolf Jorde, Guri Grimnes, Ragnar Joakimsen, Henrik Schirmer, Tom Wilsgaard, Ellisiv B Mathiesen, Inger Njølstad, Maja-Lisa Løchen, Winfried März, Marcus E Kleber, Andreas Tomaschitz, Martin Grübler, Gudny Eiriksdottir, Elias F Gudmundsson, Tamara B Harris, Mary F Cotch, Thor Aspelund, Vilmundur Gudnason, Femke Rutters, Joline W J Beulens, Esther van 't Riet, Giel Nijpels, Jacqueline M Dekker, Diana Grove-Laugesen, Lars Rejnmark, Markus A Busch, Gert B M Mensink, Christa Scheidt-Nave, Michael Thamm, Karin M A Swart, Ingeborg A Brouwer, Paul Lips, Natasja M van Schoor, Christopher T Sempos, Ramón A Durazo-Arvizu, Zuzana Škrabáková, Kirsten G Dowling, Kevin D Cashman, Mairead Kiely, Stefan Pilz
BACKGROUND: Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality. METHODS: In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data...
2017: PloS One
https://www.readbyqxmd.com/read/28205118/association-of-serum-gamma-glutamyltransferase-and-premature-coronary-artery-disease
#9
M Sheikh, M Tajdini, A Shafiee, M Sotoudeh Anvari, A Jalali, H Poorhosseini, A Amirzadegan
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography. METHODS: In this cross-sectional study, we enrolled male subjects aged ≤45 years and female subjects ≤55 years who were candidates for elective coronary angiography due to typical chest pain or a positive non-invasive test...
February 15, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28203292/the-waist-circumference-adjusted-associations-between-hyperuricemia-and-other-lifestyle-related-diseases
#10
Taiju Miyagami, Hirohide Yokokawa, Kazutoshi Fujibayashi, Toshiaki Gunji, Noriko Sasabe, Mitsue Okumura, Kimiko Iijima, Toshio Naito
BACKGROUND: Few studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex. METHODS: This cross-sectional study included 33,498 Japanese individuals, and was conducted at the Center for Preventive Medicine, NTT Kanto Medical Center, Tokyo, from May 2006 to March 2015. Hyperuricemia was defined as a uric acid level of >7 mg/dl in men; >6 mg/dl in women. Metabolic syndrome (Mets) components were defined using the Japanese criteria for Mets...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28202429/virtual-patient-technology-engaging-primary-care-in-quality-improvement-innovations
#11
Amanda C Blok, Christine N May, Rajani S Sadasivam, Thomas K Houston
BACKGROUND: Engaging health care staff in new quality improvement programs is challenging. OBJECTIVE: We developed 2 virtual patient (VP) avatars in the context of a clinic-level quality improvement program. We sought to determine differences in preferences for VPs and the perceived influence of interacting with the VP on clinical staff engagement with the quality improvement program. METHODS: Using a participatory design approach, we developed an older male smoker VP and a younger female smoker VP...
February 15, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28202270/acute-metabolic-and-endocrine-responses-induced-by-glucose-and-fructose-in-healthy-young-subjects-a-double-blinded-randomized-crossover-trial
#12
Wenwen Cai, Jie Li, Jiahui Shi, Bo Yang, Jun Tang, Helen Truby, Duo Li
BACKGROUND AND OBJECTIVE: A rise in fructose consumption has been implicated in the etiology of obesity, diabetes and cardiovascular disease. Serum uric acid (UA) elevates after fructose ingestion, increasing the risk of cardiovascular disease. However, the impact of fructose ingestion on nitric oxide (NO) has not yet been confirmed. The aim of this study was to investigate the postprandial metabolic and endocrine responses following an acute ingestion of fructose and glucose in healthy subjects...
February 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28199497/racial-differences-in-associations-of-blood-pressure-components-in-young-adulthood-with-incident-cardiovascular-disease-by-middle-age-coronary-artery-risk-development-in-young-adults-cardia-study
#13
Yuichiro Yano, Jared P Reis, Yacob G Tedla, David C Goff, David R Jacobs, Stephen Sidney, Hongyan Ning, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones
Importance: Data are sparse regarding which blood pressure (BP) components in young adulthood optimally determine cardiovascular disease (CVD) by middle age. Objectives: To assess which BP components best determine incident CVD events in young adults and determine whether these associations vary by race and age at BP measurement. Design, Setting, and Participants: Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, this study assessed the longitudinal race-stratified associations between BP and cardiovascular outcomes...
February 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28199464/identification-of-patients-with-stable-chest-pain-deriving-minimal-value-from-noninvasive-testing-the-promise-minimal-risk-tool-a-secondary-analysis-of-a-randomized-clinical-trial
#14
Christopher B Fordyce, Pamela S Douglas, Rhonda S Roberts, Udo Hoffmann, Hussein R Al-Khalidi, Manesh R Patel, Christopher B Granger, John Kostis, Daniel B Mark, Kerry L Lee, James E Udelson
Importance: Guidelines recommend noninvasive testing for patients with stable chest pain, although many subsequently have normal test results and no adverse clinical events. Objective: To describe a risk tool developed to use only pretest clinical data to identify patients with chest pain with normal coronary arteries and no clinical events during follow-up (minimal-risk cohort). Design, Setting, and Participants: This secondary analysis of a randomized, pragmatic comparative effectiveness trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain [PROMISE]) includes stable, symptomatic outpatients without known coronary artery disease referred for noninvasive testing at 193 sites in North America...
February 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28198751/the-role-of-agonistic-striving-in-the-association-between-cortisol-and-high-blood-pressure
#15
Craig K Ewart, Gavin J Elder, Randall S Jorgensen, Sheila T Fitzgerald
OBJECTIVES: A social action theory of chronic stress proposes that agonistic striving (seeking to influence or control others) impairs cardiovascular health by magnifying the impact of high adversity-induced cortisol levels on blood pressure. We tested three predictions of social action theory: (1) the social action theory taxonomy of regulatory strivings characterizes young adults from high-adversity neighborhoods; (2) high cortisol levels predict high blood pressure more reliably in the subgroup with the agonistic striving profile than in subgroups with other profiles; (3) the association of higher cortisol and higher blood pressure with agonistic striving is not explained by negative affect (depressive symptoms/dysphoria, anger, hostility)...
November 3, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28198422/low-density-lipoprotein-cholesterol-and-survival-in-pulmonary-arterial-hypertension
#16
Grzegorz Kopeć, Marcin Waligóra, Anna Tyrka, Kamil Jonas, Michael J Pencina, Tomasz Zdrojewski, Deddo Moertl, Jakub Stokwiszewski, Paweł Zagożdżon, Piotr Podolec
Low-density lipoprotein cholesterol(LDL-C) is a well established metabolic marker of cardiovascular risk, however, its role in pulmonary arterial hypertension (PAH) has not been determined. Therefore we assessed whether LDL-C levels are altered in PAH patients, if they are associated with survival in this group and whether pulmonary hypertension (PH) reversal can influence LDL-C levels. Consecutive 46 PAH males and 94 females were age matched with a representative sample of 1168 males and 1245 females, respectively...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196817/comparison-of-carotid-plaque-score-and-coronary-artery-calcium-score-for-predicting-cardiovascular-disease-events-the-multi-ethnic-study-of-atherosclerosis
#17
Adam D Gepner, Rebekah Young, Joseph A Delaney, Matthew J Budoff, Joseph F Polak, Michael J Blaha, Wendy S Post, Erin D Michos, Joel Kaufman, James H Stein
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown. METHODS AND RESULTS: CVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound-detected plaques in the common, bifurcation, and internal carotid artery segments...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28196738/cholesterol-levels-of-japanese-dyslipidaemic-patients-with-various-comorbidities-biobank-japan
#18
Hiroshi Yokomichi, Hokuto Noda, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yoichiro Kamatani, Yutaka Kiyohara, Koichi Matsuda, Kaori Muto, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata
BACKGROUND: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia. METHODS: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals)...
February 11, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28195680/disparities-in-the-incidence-of-acute-myocardial-infarction-long-term-trends-from-the-hunter-region
#19
Allan J Davies, Crystal Naudin, Mohammed Al Omari, Arshad Khan, Chris Oldmeadow, Mark Jones, Bruce Bastian, Rohan Bhagwandeen, Peter Fletcher, James Leitch, Andrew Boyle
BACKGROUND: Trends in the incidence of Acute Myocardial Infarction (AMI) provide important information for health care providers and can allow for accurate planning of future health needs and targeted interventions in areas with an excess burden of cardiovascular disease AIMS: To investigate the regional variations in AMI incidence in the Hunter region METHODS: Incident cases of AMI identified between 1996 and 2013 from the Hunter New England Health Cardiac and Stroke Outcomes Unit were prospectively collected for this study...
February 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28194628/association-between-ck-mb-area-under-the-curve-and-tranexamic-acid-utilization-in-patients-undergoing-coronary-artery-bypass-surgery
#20
Sean van Diepen, Peter D Merrill, Michel Carrier, Jean-Claude Tardif, Mihai Podgoreanu, John H Alexander, Renato D Lopes
Myonecrosis after coronary artery bypass graft (CABG) surgery is associated with excess mortality. Tranexamic acid (TA), an anti-fibrinolytic agent, has been shown to reduce peri-operative blood loss without increasing the risk of myocardial infarction (MI); however, no large study has examined the association between TA treatment and post-CABG myonecrosis. In the MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery II trial, inverse probability weighting of the propensity to receive TA was used to test for differences among the 656 patients receiving and 770 patients not receiving TA...
February 14, 2017: Journal of Thrombosis and Thrombolysis
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