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https://www.readbyqxmd.com/read/29132382/early-motor-function-after-local-treatment-of-brain-metastases-in-the-motor-cortex-region-with-stereotactic-radiotherapy-radiosurgery-or-microsurgical-resection-a-retrospective-study-of-two-consecutive-cohorts
#1
Bogdan Pintea, Brigitta Baumert, Thomas Mehari Kinfe, Konstantinos Gousias, Yaroslav Parpaley, Jan Patrick Boström
BACKGROUND: We compared the functional outcome and influential factors of two standard treatment modalities for central cerebral metastases: electrophysiological-controlled microsurgical resection (MSR) and stereotactic radiotherapy/stereotactic radiosurgery (SRT/SRS). METHODS: We performed a database search for central metastasis treatments during the period from January 2008 to September 2012 in two clinical registers: 1) register for intraoperative neuromonitoring (Department of Neurosurgery), and 2) prospective database for SRT/SRS (Department of Radiotherapy)...
November 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29129695/tetrahydroxystilbene-glucoside-modulates-amyloid-precursor-protein-processing-via-activation-of-akt-gsk3%C3%AE-pathway-in-cells-and-in-app-ps1-transgenic-mice
#2
Xiaomin Yin, Chen Chen, Ting Xu, Lin Li, Lan Zhang
Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Aβ) production. Here, we determined the effect of TSG on the AKT-GSK3β pathway. We found GSK3β increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months. We found that the activated the AKT-GSK3β signaling pathway suppressed APP-KPI inclusion...
November 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29054928/the-type-ii-transmembrane-serine-protease-matriptase-cleaves-the-amyloid-precursor-protein-and-reduces-its-processing-to-%C3%AE-amyloid
#3
Erwan Lanchec, Antoine Désilets, François Béliveau, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Denis Gris, Richard Leduc, Christine Lavoie
Recent studies have reported that many proteases, besides the canonical α-, β- and γ-secretases, cleave the amyloid precursor protein (APP) and modulate β amyloid (Aβ) peptide production. Moreover, specific APP isoforms contain Kunitz protease inhibitor (KPI) domains, which regulate the proteolytic activity of serine proteases. This prompted us to investigate the role of matriptase, a member of the type II transmembrane serine protease family, in APP processing. Using qRTPCR, we detected matriptase mRNA in several regions of the human brain, with an enrichment in neurons...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29046678/kunitz-proteinase-inhibitors-limit-water-stress-responses-in-white-clover-trifolium-repens-l-plants
#4
Afsana Islam, Susanna Leung, Aluh Nikmatullah, Paul P Dijkwel, Michael T McManus
The response of plants to water deficiency or drought is a complex process, the perception of which is triggered at the molecular level before any visible morphological responses are detected. It was found that different groups of plant proteinase inhibitors (PIs) are induced and play an active role during abiotic stress conditions such as drought. Our previous work with the white clover (Trifolium repens L.) Kunitz Proteinase Inhibitor (Tr-KPI) gene family showed that Tr-KPIs are differentially regulated to ontogenetic and biotic stress associated cues and that, at least some members of this gene family may be required to maintain cellular homeostasis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29040195/grade-assignment-by-ki-67-proliferative-index-mitotic-count-and-phosphohistone-h3-count-in-surgically-resected-gastrointestinal-and-pancreatic-neuroendocrine-tumors
#5
Claire E Murphy, Kinsey A McCormick, Veena Shankaran, Deepti M Reddi, Paul E Swanson, Melissa P Upton, Antonios Papanicolau-Sengos, Sara Khor, Maria Westerhoff
OBJECTIVES: The aim of this study was to evaluate the concordance in grade assignment for gastroenteropancreatic neuroendocrine tumors using mitotic count (MC), Ki-67 proliferative index (KPI), and phosphohistone H3 count (PHH3C). METHODS: Resected gastroenteropancreatic neuroendocrine tumors were graded based on MC, KPI, and PHH3C. Concordance was determined using a weighted κ statistic. Median survival across each grade category was determined using Kaplan-Meier methods...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28975674/efficient-solar-assisted-o2-reduction-by-a-cofacial-iron-porphyrin-dimer-integrated-to-a-p-cubi2o4-photocathode-prepared-by-a-simple-novel-method
#6
Zaki N Zahran, Eman A Mohamed, Yoshinori Naruta, Ashraf Haleem
A cofacial iron porphyrin hetero-dimer, Fe2TPFPP-TMP showed high electro-catalytic activity, selectivity, and stability for the O2 reduction to H2O both in homogeneous non-aqueous and heterogeneous neutral aqueous solutions. Moreover, when it is integrated to FTO/p-CuBi2O4 (FTO = fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2.
October 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28931538/modulators-of-actin-myosin-dissociation-basis-for-muscle-type-functional-differences-during-fatigue
#7
Christina Karatzaferi, Nancy Adamek, Michael A Geeves
The muscle types present with variable fatigue tolerance, in part due to the myosin isoform expressed. However, the critical steps that define 'fatigability' in vivo of fast vs slow myosin isoforms, at the molecular level, are not yet fully understood. We examined the modulation of the ATP-induced myosin sub-fragment 1 (S1) dissociation from pyrene-actin by inorganic phosphate (Pi), pH and temperature using a specially modified stopped-flow system that allowed fast kinetics measurements at physiological temperature...
September 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28913504/a-review-and-meta-analysis-of-corneal-cross-linking-for-post-laser-vision-correction-ectasia
#8
REVIEW
Qi Wan, Dan Wang, HongQuan Ye, Jing Tang, Yu Han
PURPOSE: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. METHODS: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28878550/whitham-modulation-theory-for-the-kadomtsev-petviashvili-equation
#9
Mark J Ablowitz, Gino Biondini, Qiao Wang
The genus-1 Kadomtsev-Petviashvili (KP)-Whitham system is derived for both variants of the KP equation; namely the KPI and KPII equations. The basic properties of the KP-Whitham system, including symmetries, exact reductions and its possible complete integrability, together with the appropriate generalization of the one-dimensional Riemann problem for the Korteweg-de Vries equation are discussed. Finally, the KP-Whitham system is used to study the linear stability properties of the genus-1 solutions of the KPI and KPII equations; it is shown that all genus-1 solutions of KPI are linearly unstable, while all genus-1 solutions of KPII are linearly stable within the context of Whitham theory...
August 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28853574/light-induced-surface-reactions-at-the-bismuth-vanadate-potassium-phosphate-interface
#10
Marco Favaro, Fatwa F Abdi, Marlene Lamers, Ethan J Crumlin, Zhi Liu, Roel van de Krol, David E Starr
Bismuth vanadate has recently drawn significant research attention as a light-absorbing photoanode due to its performance for photoelectrochemical water splitting. In this study, we use in situ ambient pressure X-ray photoelectron spectroscopy with "Tender" X-rays (4.0 keV) to investigate a polycrystalline bismuth vanadate (BiVO4) electrode in contact with an aqueous potassium phosphate (KPi) solution at open circuit potential under both dark and light conditions. This is facilitated by the creation of a 25 to 30 nanometers thick electrolyte layer using the "dip-and-pull" method...
August 30, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28756771/prognostic-role-of-abo-blood-type-in-patients-with-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-triple-center-study
#11
Ya-Jun Li, Ping-Yong Yi, Ji-Wei Li, Xian-Ling Liu, Tian Tang, Pei-Ying Zhang, Wen-Qi Jiang
BACKGROUND: The prognostic significance of ABO blood type for lymphoma is largely unknown. We evaluated the prognostic role of ABO blood type in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). METHODS: We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer centers. The prognostic value of ABO blood type was evaluated using Kaplan-Meier curves and Cox proportional hazard models. The prognostic values of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were also evaluated...
July 31, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28734773/epico-4-0-total-quality-in-the-management-of-invasive-candidiasis-in-critically-ill-patients-by-analysing-the-integrated-process
#12
Rafael Zaragoza, Ricard Ferrer, Pedro Llinares, Emilio Maseda, Alejandro Rodríguez, Santiago Grau, Guillermo Quindós
BACKGROUND: A high quality integrated process in the clinical setting of non-neutropenic critically ill patients at risk for invasive candidiasis is a necessary tool to improve the management of these patients. AIMS: To identify the key points on invasive candidiasis in order to develop a set of recommendations with a high level of consensus required for the creation of a total quality integrated process for the management of non-neutropenic critically ill patients at risk of invasive candidiasis...
July 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28687218/keratoconus-screening-indices-and-their-diagnostic-ability-to-distinguish-normal-from-ectatic-corneas
#13
COMPARATIVE STUDY
Rohit Shetty, Harsha Rao, Pooja Khamar, Kanchan Sainani, Krishnapoojita Vunnava, Chaitra Jayadev, Luci Kaweri
PURPOSE: To compare the diagnostic ability of 3 Scheimpflug devices in differentiating normal from ectatic corneas. DESIGN: Comparison of diagnostic instrument accuracy. METHODS: This study included 42 normal, 37 subclinical keratoconic, and 51 keratoconic eyes seen in a tertiary eye care institute. Keratoconus screening indices were evaluated using the Pentacam (Oculus, Wetzlar, Germany), Galilei (Ziemer, Biel, Switzerland), and Sirius (Costruzione Strumenti Oftalmici, Florence, Italy)...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28665668/light-meets-water-in-nonlocal-media-surface-tension-analogue-in-optics
#14
Theodoros P Horikis, Dimitrios J Frantzeskakis
Shallow water wave phenomena find their analogue in optics through a nonlocal nonlinear Schrödinger (NLS) model in 2+1 dimensions. We identify an analogue of surface tension in optics, namely, a single parameter depending on the degree of nonlocality, which changes the sign of dispersion, much like surface tension does in the shallow water wave problem. Using multiscale expansions, we reduce the NLS model to a Kadomtsev-Petviashvili (KP) equation, which is of the KPII (KPI) type, for strong (weak) nonlocality...
June 16, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28641638/-change-of-plasma-interleukin-17-level-in-patients-with-extranodal-nk-t-cell-lymphoma-and-its-clinical-significance
#15
Chun-Xiang Shang, Ji-Cheng Ma, Zheng Nan, Ye Li, Wen-Cai He, Xian-Ying Pan
OBJECTIVE: To investigate the clinical significance of interleukin-17 (IL-17) level in patients with extranodal NK/T-cell lymphoma(ENKTL). METHODS: Eighty patients with nasal ENKTL who received radiotherapy, chemotherapy or radiotherapy combined with chemotherapy from January 2011 to January 2012 were enrolled in the study. Eighty healthy volunteers were selected as the controls (control group). About 5 ml of peripheral blood was collected from all patients and controls...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28593815/homogenous-uv-periodate-process-in-treatment-of-p-nitrophenol-aqueous-solutions-under-mild-operating-conditions
#16
Javad Saien, Marzieh Fallah Vahed Bazkiaei
Aqueous solutions of p-nitrophenol (PNP) were treated with UV-activated potassium periodate (UV/KPI) in an efficient photo-reactor. Either periodate or UV alone had little effect; however, their combination led to a significant degradation and mineralization. The response surface methodology was employed for design of experiments and optimization. The optimum conditions for treatment of 30 mg/L of the substrate were determined as [KPI] = 386.3 mg/L, pH = 6.2 and T = 34.6°C, under which 79.5% degradation was achieved after 60 min...
June 20, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28581548/metal-oxide-assisted-surface-treatment-of-polyimide-gate-insulators-for-high-performance-organic-thin-film-transistors
#17
Sohee Kim, Taewook Ha, Sungmi Yoo, Jae-Won Ka, Jinsoo Kim, Jong Chan Won, Dong Hoon Choi, Kwang-Suk Jang, Yun Ho Kim
We developed a facile method for treating polyimide-based organic gate insulator (OGI) surfaces with self-assembled monolayers (SAMs) by introducing metal-oxide interlayers, called the metal-oxide assisted SAM treatment (MAST). To create sites for surface modification with SAM materials on polyimide-based OGI (KPI) surfaces, the metal-oxide interlayer, here amorphous alumina (α-Al2O3), was deposited on the KPI gate insulator using spin-coating via a rapid sol-gel reaction, providing an excellent template for the formation of a high-quality SAM with phosphonic acid anchor groups...
June 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28572091/the-ser-thr-protein-kinase-protein-protein-interaction-map-of-m-tuberculosis
#18
Fan-Lin Wu, Yin Liu, He-Wei Jiang, Yi-Zhao Luan, Hai-Nan Zhang, Xiang He, Zhao-Wei Xu, Jing-Li Hou, Li-Yun Ji, Zhi Xie, Daniel M Czajkowsky, Wei Yan, Jiao-Yu Deng, Li-Jun Bi, Xian-En Zhang, Sheng-Ce Tao
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, the leading cause of death among all infectious diseases. There are 11 eukaryotic-like serine/threonine protein kinases (STPKs) in Mtb, which are thought to play pivotal roles in cell growth, signal transduction and pathogenesis. However, their underlying mechanisms of action remain largely uncharacterized. In this study, using a Mtb proteome microarray, we have globally identified the binding proteins in Mtb for all of the STPKs, and constructed the first STPK protein interaction (KPI) map that includes 492 binding proteins and 1,027 interactions...
August 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28558338/the-challenge-of-sustainability-in-healthcare-systems-frequency-and-cost-of-inappropriate-patterns-of-breast-cancer-care-the-e-pic-a-study
#19
Ilaria Massa, William Balzi, Costanza Burattini, Nicola Gentili, Lauro Bucchi, Oriana Nanni, Davide Gallegati, Andrea Pierini, Dino Amadori, Fabio Falcini, Mattia Altini
OBJECTIVES: In a context of decreasing economic health resources and a rise in health needs, it is urgent to face this sustainability crisis through the analysis of healthcare expenditures. Wastages, deriving from inappropriate interventions, erode resources which could be reallocated to high-value activities. To identify these areas of wastages, we developed a method for combining and analyzing data from multiple sources. Here we report the preliminary results of a retrospective cohort study evaluating the performance of breast cancer (BC) care at IRST, an Italian cancer institute...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28540115/the-benefits-of-streamlined-hip-fracture-management-in-a-regional-hospital
#20
T C Mow, Jen Lukeis, A G Sutherland
INTRODUCTION: Hip fracture is an increasingly common injury in the growing elderly population. The morbidity and mortality associated with this injury can be reduced by minimizing delays to surgical treatment. We describe the impact of a regional hospital service redesign project that utilized the principles of smart simplicity, a management strategy that lays emphasis on collaboration to achieve desired goals. METHODS: Prior to the redesign, patients with hip fractures were taking an average of 72 hours for surgical treatment...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
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