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Nigel D Toussaint, Lawrence P McMahon, Gregory Dowling, Stephen G Holt, Gillian Smith, Maria Safe, Richard Knight, Kathleen Fair, Leanne Linehan, Rowan G Walker, David A Power
♦ Background: Increased demand for treatment of end-stage kidney disease has largely been accommodated by a costly increase in satellite hemodialysis (SHD) in most jurisdictions. In the Australian State of Victoria, a marked regional variation in the uptake of home-based dialysis suggests that use of home therapies could be increased as an alternative to SHD. An earlier strategy based solely on increased remuneration had failed to increase uptake of home therapies. Therefore, the public dialysis funder adopted the incidence and prevalence of home-based dialysis therapies as a key performance indicator (KPI) for its health services to encourage greater uptake of home therapies...
September 28, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Ami Hale, Nanna Christiansen, Heather Calvert
AIM: To assess the time it takes for paediatric TTA and inpatient orders to be dispensed and sent to ward. This is to establish if the Trust is meeting an operational Key Performance Indicator (KPI). STANDARDS KPIS: ▸ 85% of urgent items (TTAs) dispensed within 1 hour.▸ 85% of non-urgent items (most inpatient orders) dispensed within 3 hrs. METHOD: To audit the time it takes for TTAs and inpatient orders to be screened, sent to dispensary, labelled, dispensed, checked, and leave dispensary...
September 2016: Archives of Disease in Childhood
Achim Escher, Nicolin Hainc, Daniel Boll
Business intelligence (BI) is a worthwhile investment, and will play a significant role in hospital management in the near future. Implementation of BI is challenging and requires resources, skills, and a strategy, but enables management to have easy access to relevant analysis of data and visualization of important key performance indicators (KPI). Modern BI applications will help to overcome shortages of common "hand-made" analysis, save time and money, and will enable even managers to do "self-service" analysis and reporting...
May 2016: Radiology Management
Huihuang H Ding, Steve W Cui, H Douglas Goff, Jie Chen, Qingbin Guo, Qi Wang
The structure of ethanol precipitated fraction from 1M KOH extracted flaxseed kernel polysaccharides (KPI-EPF) was studied for better understanding the molecular structures of flaxseed kernel cell wall polysaccharides. Based on methylation/GC-MS, NMR spectroscopy, and MALDI-TOF-MS analysis, the dominate sugar residues of KPI-EPF fraction comprised of (1,4,6)-linked-β-d-glucopyranose (24.1mol%), terminal α-d-xylopyranose (16.2mol%), (1,2)-α-d-linked-xylopyranose (10.7mol%), (1,4)-β-d-linked-glucopyranose (10...
October 20, 2016: Carbohydrate Polymers
Mahtab Karami, Reza Safdari
OBJECTIVE: The development and implementation of a dashboard of medical imaging department (MID) performance indicators. METHOD: Several articles discussing performance measures of imaging departments were searched for this study. All the related measures were extracted. Then, a panel of imaging experts were asked to rate these measures with an open ended question to seek further potential indicators. A second round was performed to confirm the performance rating...
2016: Applied Clinical Informatics
Tianfang Wang, Parinyaporn Nuurai, Carmel McDougall, Patrick S York, Utpal Bose, Bernard M Degnan, Scott F Cummins
Abalone (Haliotis) undergoes a period of reproductive maturation, followed by the synchronous release of gametes, called broadcast spawning. Field and laboratory studies have shown that the tropical species Haliotis asinina undergoes a two-week spawning cycle, thus providing an excellent opportunity to investigate the presence of endogenous spawning-associated peptides. In female H. asinina, we have isolated a peptide (5145 Da) whose relative abundance in hemolymph increases substantially just prior to spawning and is still detected using reverse-phase high-performance liquid chromatography chromatograms up to 1-day post-spawn...
July 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
Hao Wu, Mingyu Wang, Yuqing Liu, Xinhua Wang, Yunkun Wang, Jinxing Lu, Hai Xu
The prevalence of antimicrobial resistant Klebsiella pneumoniae in poultry products has been a public concern, as it severely endangers food safety and human health. In this study, we investigated 90 antimicrobial resistant Klebsiella strains that were isolated from a commercial broiler slaughter plant in Shandong province of China. Nearly all (89/90) of the isolates were identified as infectious phylogenetic group KpI-type K. pneumoniae. Out of these 90 strains, 87 (96.7%) were multidrug-resistant isolates, and 87 (96...
September 2, 2016: International Journal of Food Microbiology
Anna-Madeleine Beckmann, Konstantin Glebov, Jochen Walter, Olaf Merkel, Martin Mangold, Frederike Schmidt, Christoph Becker-Pauly, Michael Gütschow, Marit Stirnberg
Proteolytic processing of the amyloid precursor protein (APP) leads to amyloid-β (Aβ) peptides. So far, the mechanism of APP processing is insufficiently characterized at the molecular level. Whereas the knowledge of Aβ generation by several proteases has been expanded, the contribution of the Kunitz-type protease inhibitor domain (KPI) present in two major APP isoforms to the complex proteolytic processing of APP is poorly understood. In this study, we have identified KPI-containing APP as a very potent, slow-binding inhibitor for the membrane-bound proteolytic regulator of iron homeostasis matriptase-2 by forming stable complexes with its target protease in HEK cells...
August 1, 2016: Biological Chemistry
Li-Ping Zhao, Tian-Min Xu, Mu-Jie Kan, Ye-Chen Xiao, Man-Hua Cui
Urokinase-type plasminogen activator (uPA) acts by breaking down the basement membrane and is involved in cell proliferation, migration and invasion. These actions are mediated by binding to the uPA receptor (uPAR) via its growth factor domain (GFD). The present study evaluated the effects of uPAg-KPI, a fusion protein of uPA-GFD and a kunitz protease inhibitor (KPI) domain that is present in the amyloid β-protein precursor. Using SKOV-3 cells, an ovarian cancer cell line, we examined cell viability, migration, invasion and also protein expression...
May 2016: International Journal of Molecular Medicine
Jinhee Kim, Jongcheol Lee, Sungchul Kim
[This corrects the article DOI: 10.3831/KPI.2015.18.026.].
December 2015: Journal of Pharmacopuncture
Yajie Wang, Fengyi Wu, Haining Pan, Wenzhong Zheng, Chi Feng, Yunfu Wang, Zixin Deng, Lianrong Wang, Jie Luo, Shi Chen
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain. Aβ plaques are produced through sequential β/γ cleavage of amyloid precursor protein (APP), of which there are three main APP isoforms: APP695, APP751 and APP770. KPI-APPs (APP751 and APP770) are known to be elevated in AD, but the reason remains unclear. Transcription activator-like (TAL) effector nucleases (TALENs) induce mutations with high efficiency at specific genomic loci, and it is thus possible to knock out specific regions using TALENs...
2016: Scientific Reports
Brenda Gannon, Cheryl Jones, Aileen McCabe, Ronan O'Sullivan, Abel Wakai
OBJECTIVES: High quality data is fundamental to using key performance indicators (KPIs) for performance monitoring. However, the resources required to collect high quality data are often significant and should usually be targeted at high priority areas. As part of a study of 11 emergency department (ED) KPIs in Ireland, the primary objective of this study was to estimate the relative cost of collecting the additional minimum data set (MDS) elements for those 11 KPIs. METHODS: An economic cost analysis focused on 12 EDs in the Republic of Ireland...
January 25, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
Adrian Murphy, Abel Wakai, Cathal Walsh, Fergal Cummins, Ronan O'Sullivan
INTRODUCTION: Key performance indicators (KPIs) are used to monitor and evaluate critical areas of clinical and support functions that influence patient outcome. Traditional prehospital emergency care performance monitoring has focused solely on response time metrics. The landscape of emergency care delivery in Ireland is in the process of significant national reconfiguration. The development of KPIs is therefore considered one of the key priorities in prehospital research. AIMS: The aim of this study was to develop a suite of KPIs for prehospital emergency care in Ireland...
April 2016: Emergency Medicine Journal: EMJ
Coralith García, Lizeth Astocondor, Beatriz Rojo-Bezares, Jan Jacobs, Yolanda Sáenz
Klebsiella pneumoniae (KP) is the most common cause of neonatal sepsis in the low- and middle-income countries. Our objective was to describe the phenotypic and molecular characteristics of extended-spectrum β-lactamase (ESBL)-producer KP in neonatal care centers from Peru. We collected 176 non-duplicate consecutive KP isolates from blood isolates of neonates from eight general public hospitals of Lima, Peru. The overall rate of ESBL production was 73.3% (N = 129). The resistance rates were higher among ESBL-producer isolates when compared with the nonproducers: 85...
February 2016: American Journal of Tropical Medicine and Hygiene
Shen Yin, Xiaochen Xie, James Lam, Kie Chung Cheung, Huijun Gao
The key performance indicator (KPI) has an important practical value with respect to the product quality and economic benefits for modern industry. To cope with the KPI prognosis issue under nonlinear conditions, this paper presents an improved incremental learning approach based on available process measurements. The proposed approach takes advantage of the algorithm overlapping of locally weighted projection regression (LWPR) and partial least squares (PLS), implementing the PLS-based prognosis in each locally linear model produced by the incremental learning process of LWPR...
November 20, 2015: IEEE Transactions on Cybernetics
Tina M George, Peter D Olsen, Nick E Kimber, Jeremy P Shearman, Jamie G Hamilton, Michael J Hamlin
The aim of this study was to investigate whether playing rugby at altitude or after travel (domestic and international) disadvantaged teams. In a retrospective longitudinal study, all matches (N = 125) played in the 2012 Super Rugby Competition were analyzed for key performance indicators (KPI) from coded game data provided by OPTA sports data company. Matches were played in a home-away format in New Zealand, South Africa, and Australia. Teams based at sea level but playing at altitude (1,271-1,753 m) were more likely to miss tackles (mean ± 90% confidence interval, 1...
December 2015: Journal of Strength and Conditioning Research
Jack Weiner, Venugopal Balijepally, Mohan Tanniru
Hospitals have invested and continue to invest heavily in building information systems to support operations at various levels of administration. These systems generate a lot of data but fail to effectively convert these data into actionable information for decision makers. Such ineffectiveness often is attributed to a lack of alignment between strategic planning and information technology (IT) initiatives supporting operational goals. We present a case study that illustrates how the use of digital dashboards at St...
September 2015: Journal of Healthcare Management / American College of Healthcare Executives
Fidelma Fitzpatrick, Mary O Riordan
Public and political pressure for healthcare quality indicator monitoring, specifically healthcare-associated infection (HAI) has intensified the debate regarding the merits of public reporting and target setting as policy approaches. This paper reviews the evidence for these approaches with a focus on HAI, including Clostridium difficile infection (CDI). Healthcare key performance indicators (KPIs) and associated targets have been used widely with little evaluation. While targets are associated with some HAI reductions including CDI, as their control is multi-factorial, it is likely that reductions are due to numerous, concurrent control measures...
February 2016: Anaerobe
Junsang Yu, Seungho Sun, Kwangho Lee, Kirok Kwon
[This corrects the article DOI: 10.3831/KPI.2015.18.018.].
September 2015: Journal of Pharmacopuncture
Woo-Jin Choi, Yoon-Young Cho, Seung-Ho Sun
[This corrects the article DOI: 10.3831/KPI.2015.18.013.].
September 2015: Journal of Pharmacopuncture
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