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https://www.readbyqxmd.com/read/28372336/alterations-in-the-balance-of-amyloid-%C3%AE-protein-precursor-species-in-the-cerebrospinal-fluid-of-alzheimer-s-disease-patients
#1
Inmaculada Lopez-Font, Claudia P Boix, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero
We recently demonstrated that soluble forms of the amyloid-β protein precursor (sAβPP) assemble into multimeric complexes in cerebrospinal fluid (CSF), which contributes to the underestimation of specific sAβPP species when assessed by ELISA. To circumvent this issue, we analyzed by SDS-PAGE large fragments of sAβPP and their variants in the CSF from Alzheimer's disease (AD; n = 20) and control (n = 20) subjects, probing with specific antibodies against particular domains. Similar levels of sAβPPα and sAβPPβ protein were found in CSF samples from AD and controls, yet there appeared to be a shift in the balance of the soluble full-length AβPP (sAβPPf) species in AD samples, with a decrease in the proportion of the lower (∼100 kDa) band relative to the upper (∼120 kDa) band...
March 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28219824/characterisation-of-the-first-kpc-2-producing-klebsiella-pneumoniae-st340-from-peru
#2
Gertrudis Horna, Jorge Velasquez, Nathaly Fernández, Jesus Tamariz, Joaquim Ruiz
OBJECTIVES: The aim of this study was to characterise a KPC-carrying Klebsiella pneumoniae isolate from a Peruvian hospital setting. METHODS: The identity of the isolate was confirmed by amplification and sequencing of the 16S rRNA gene, and the antibiotic resistance profile was determined by disk diffusion and automated methods The sequence type (ST) and phylogenetic group were established by PCR. The presence of different β-lactamase genes was determined, including blaMBL, blaKPC, blaCTX-M, blaSHV, blaOXA-1-like, blaOXA-2-like, blaOXA-5-like, blaOXA-48-like and blaTEM and up to six different plasmid-encoded AmpC genes as well as class 1 integrons...
February 20, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28190565/a-kpi-based-process-monitoring-and-fault-detection-framework-for-large-scale-processes
#3
Kai Zhang, Yuri A W Shardt, Zhiwen Chen, Xu Yang, Steven X Ding, Kaixiang Peng
Large-scale processes, consisting of multiple interconnected subprocesses, are commonly encountered in industrial systems, whose performance needs to be determined. A common approach to this problem is to use a key performance indicator (KPI)-based approach. However, the different KPI-based approaches are not developed with a coherent and consistent framework. Thus, this paper proposes a framework for KPI-based process monitoring and fault detection (PM-FD) for large-scale industrial processes, which considers the static and dynamic relationships between process and KPI variables...
February 9, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28164303/process-mining-is-an-underutilized-clinical-research-tool-in-transfusion-medicine
#4
Jason G Quinn, David M Conrad, Calvino K Cheng
BACKGROUND: To understand inventory performance, transfusion services commonly use key performance indicators (KPIs) as summary descriptors of inventory efficiency that are graphed, trended, and used to benchmark institutions. STUDY DESIGN AND METHODS: Here, we summarize current limitations in KPI-based evaluation of blood bank inventory efficiency and propose process mining as an ideal methodology for application to inventory management research to improve inventory flows and performance...
March 2017: Transfusion
https://www.readbyqxmd.com/read/28077410/health-policies-on-dialysis-modality-selection-a-nationwide-population-cohort-study
#5
Yi-Chun Lin, Yen-Chung Lin, Chih-Chin Kao, Hsi-Hsien Chen, Chih-Cheng Hsu, Mai-Szu Wu
OBJECTIVES: In Taiwan, peritoneal dialysis (PD) and haemodialysis are fully accessible to patients with end-stage renal disease. However, the usage of PD is considered low in Taiwan. Since 2005, 4 major policies have been implemented by Taiwan's Ministry of Health and Welfare, namely a multidisciplinary predialysis care programme and usage increasing the PD incidence as a key performance indicator (KPI) for hospital accreditation, both of which were implemented in 2006; reimbursement of the glucose-free dialysate, icodextrin that was implemented in 2007; and insurance reimbursement for renting automated PD machines that was implemented in 2008...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28047712/su-g-iep3-15-cloud-based-monitoring-of-x-ray-angiography-equipment-performance-based-on-automated-daily-sampling-of-key-performance-indicators
#6
J Sjoeberg, A Omar, R Bujila, P Nowik, I Olafsson, G Poludniowski
PURPOSE: To investigate the feasibility of deploying a novel method for the daily monitoring of x-ray Angiography (XA) equipment performance as a cloud-based service. METHODS: From previous work, we have developed a novel image based method of testing the performance of XA equipment on a daily basis. A pre-programmed protocol on an XA system is used and images are automatically analyzed using software developed in-house, resulting in a set of Key Performance Indicators (KPI's) that can be tracked over time...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28002803/increased-body-mass-index-is-associated-with-improved-overall-survival-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#7
Ya-Jun Li, Ping-Yong Yi, Ji-Wei Li, Xian-Ling Liu, Xi-Yu Liu, Fang Zhou, Zhou OuYang, Zhong-Yi Sun, Li-Jun Huang, Jun-Qiao He, Yuan Yao, Zhou Fan, Tian Tang, Wen-Qi Jiang
OBJECTIVES: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. METHODS: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909912/identification-and-characterization-of-the-lysine-rich-matrix-protein-family-in-pinctada-fucata-indicative-of-roles-in-shell-formation
#8
Jian Liang, Jun Xie, Jing Gao, Chao-Qun Xu, Yi Yan, Gan-Chu Jia, Liang Xiang, Li-Ping Xie, Rong-Qing Zhang
Mantle can secret matrix proteins playing key roles in regulating the process of shell formation. The genes encoding lysine-rich matrix proteins (KRMPs) are one of the most highly expressed matrix genes in pearl oysters. However, the expression pattern of KRMPs is limited and the functions of them still remain unknown. In this study, we isolated and identified six new members of lysine-rich matrix proteins, rich in lysine, glycine and tyrosine, and all of them are basic matrix proteins. Combined with four members of the KRMPs previously reported, all these proteins can be divided into three subclasses according to the results of phylogenetic analyses: KRMP1-3 belong to subclass KPI, KRMP4-5 belong to KPII, and KRMP6-10 belong to KPIII...
December 2, 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27868234/efficient-31-p-band-inversion-transfer-approach-for-measuring-creatine-kinase-activity-atp-synthesis-and-molecular-dynamics-in-the-human-brain-at-7-t
#9
Jimin Ren, A Dean Sherry, Craig R Malloy
PURPOSE: To develop an efficient (31) P magnetic resonance spectroscopy (MRS) method for measuring creatine kinase (CK) activity, adenosine triphosphate (ATP) synthesis, and motion dynamics in the human brain at 7 Tesla (T). METHODS: Three band inversion modules differing in center frequency were used to induce magnetization transfer (MT) effect in three exchange pathways: (i) CK-mediated reaction PCr → γ-ATP; (ii) de novo ATP synthesis Pi → γ-ATP; and (iii) ATP intramolecular (31) P-(31) P cross-relaxation γ-(α-) ↔ β-ATP...
November 20, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27847351/a-comparison-of-mobile-and-fixed-device-access-on-user-engagement-associated-with-women-infants-and-children-wic-online-nutrition-education
#10
John J Brusk, Robert J Bensley
BACKGROUND: Online health education has expanded its reach due to cost-effective implementation and demonstrated effectiveness. However, a limitation exists with the evaluation of online health education implementations and how the impact of the system is attenuated by the extent to which a user engages with it. Moreover, the current online health education research does not consider how this engagement has been affected by the transition from fixed to mobile user access over the last decade...
November 15, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27822371/improving-admission-medication-reconciliation-compliance-using-the-electronic-tool-in-admitted-medical-patients
#11
Haytham Taha, Dana Abdulhay, Neama Luqman, Samer Ellahham
Sheikh Khalifa Medical City (SKMC) in Abu Dhabi is the main tertiary care referral hospital in the United Arab Emirates (UAE) with 560 bed capacity that is fully occupied most of the time. SKMC senior management has made a commitment to make quality and patient safety a top priority. Our governing body Abu Dhabi Health Services Company has identified medication reconciliation as a critical patient safety measure and key performance indicator (KPI). The medication reconciliation electronic form a computerized decision support tool was introduced to improve medication reconciliation compliance on transition of care at admission, transfer and discharge of patients both in the inpatient and outpatient settings...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27680765/introduction-of-renal-key-performance-indicators-associated-with-increased-uptake-of-peritoneal-dialysis-in-a-publicly-funded-health-service
#12
Nigel D Toussaint, Lawrence P McMahon, Gregory Dowling, Stephen G Holt, Gillian Smith, Maria Safe, Richard Knight, Kathleen Fair, Leanne Linehan, Rowan G Walker, David A Power
♦ Background: Increased demand for treatment of end-stage kidney disease has largely been accommodated by a costly increase in satellite hemodialysis (SHD) in most jurisdictions. In the Australian State of Victoria, a marked regional variation in the uptake of home-based dialysis suggests that use of home therapies could be increased as an alternative to SHD. An earlier strategy based solely on increased remuneration had failed to increase uptake of home therapies. Therefore, the public dialysis funder adopted the incidence and prevalence of home-based dialysis therapies as a key performance indicator (KPI) for its health services to encourage greater uptake of home therapies...
September 28, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27540250/an-audit-to-assess-the-timings-of-ttas-and-inpatient-orders-in-paediatrics-from-writing-to-screening-to-dispensing-and-to-leaving-dispensary
#13
Ami Hale, Nanna Christiansen, Heather Calvert
AIM: To assess the time it takes for paediatric TTA and inpatient orders to be dispensed and sent to ward. This is to establish if the Trust is meeting an operational Key Performance Indicator (KPI). STANDARDS KPIS: ▸ 85% of urgent items (TTAs) dispensed within 1 hour.▸ 85% of non-urgent items (most inpatient orders) dispensed within 3 hrs. METHOD: To audit the time it takes for TTAs and inpatient orders to be screened, sent to dispensary, labelled, dispensed, checked, and leave dispensary...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27514111/business-intelligence-in-hospital-management
#14
Achim Escher, Nicolin Hainc, Daniel Boll
Business intelligence (BI) is a worthwhile investment, and will play a significant role in hospital management in the near future. Implementation of BI is challenging and requires resources, skills, and a strategy, but enables management to have easy access to relevant analysis of data and visualization of important key performance indicators (KPI). Modern BI applications will help to overcome shortages of common "hand-made" analysis, save time and money, and will enable even managers to do "self-service" analysis and reporting...
May 2016: Radiology Management
https://www.readbyqxmd.com/read/27474598/xyloglucans-from-flaxseed-kernel-cell-wall-structural-and-conformational-characterisation
#15
Huihuang H Ding, Steve W Cui, H Douglas Goff, Jie Chen, Qingbin Guo, Qi Wang
The structure of ethanol precipitated fraction from 1M KOH extracted flaxseed kernel polysaccharides (KPI-EPF) was studied for better understanding the molecular structures of flaxseed kernel cell wall polysaccharides. Based on methylation/GC-MS, NMR spectroscopy, and MALDI-TOF-MS analysis, the dominate sugar residues of KPI-EPF fraction comprised of (1,4,6)-linked-β-d-glucopyranose (24.1mol%), terminal α-d-xylopyranose (16.2mol%), (1,2)-α-d-linked-xylopyranose (10.7mol%), (1,4)-β-d-linked-glucopyranose (10...
October 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27437043/from-information-management-to-information-visualization-development-of-radiology-dashboards
#16
Mahtab Karami, Reza Safdari
OBJECTIVE: The development and implementation of a dashboard of medical imaging department (MID) performance indicators. METHOD: Several articles discussing performance measures of imaging departments were searched for this study. All the related measures were extracted. Then, a panel of imaging experts were asked to rate these measures with an open ended question to seek further potential indicators. A second round was performed to confirm the performance rating...
2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27352998/identification-of-a-female-spawn-associated-kazal-type-inhibitor-from-the-tropical-abalone-haliotis-asinina
#17
Tianfang Wang, Parinyaporn Nuurai, Carmel McDougall, Patrick S York, Utpal Bose, Bernard M Degnan, Scott F Cummins
Abalone (Haliotis) undergoes a period of reproductive maturation, followed by the synchronous release of gametes, called broadcast spawning. Field and laboratory studies have shown that the tropical species Haliotis asinina undergoes a two-week spawning cycle, thus providing an excellent opportunity to investigate the presence of endogenous spawning-associated peptides. In female H. asinina, we have isolated a peptide (5145 Da) whose relative abundance in hemolymph increases substantially just prior to spawning and is still detected using reverse-phase high-performance liquid chromatography chromatograms up to 1-day post-spawn...
July 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/27289192/characterization-of-antimicrobial-resistance-in-klebsiella-species-isolated-from-chicken-broilers
#18
Hao Wu, Mingyu Wang, Yuqing Liu, Xinhua Wang, Yunkun Wang, Jinxing Lu, Hai Xu
The prevalence of antimicrobial resistant Klebsiella pneumoniae in poultry products has been a public concern, as it severely endangers food safety and human health. In this study, we investigated 90 antimicrobial resistant Klebsiella strains that were isolated from a commercial broiler slaughter plant in Shandong province of China. Nearly all (89/90) of the isolates were identified as infectious phylogenetic group KpI-type K. pneumoniae. Out of these 90 strains, 87 (96.7%) were multidrug-resistant isolates, and 87 (96...
September 2, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27078672/the-intact-kunitz-domain-protects-the-amyloid-precursor-protein-from-being-processed-by-matriptase-2
#19
Anna-Madeleine Beckmann, Konstantin Glebov, Jochen Walter, Olaf Merkel, Martin Mangold, Frederike Schmidt, Christoph Becker-Pauly, Michael Gütschow, Marit Stirnberg
Proteolytic processing of the amyloid precursor protein (APP) leads to amyloid-β (Aβ) peptides. So far, the mechanism of APP processing is insufficiently characterized at the molecular level. Whereas the knowledge of Aβ generation by several proteases has been expanded, the contribution of the Kunitz-type protease inhibitor domain (KPI) present in two major APP isoforms to the complex proteolytic processing of APP is poorly understood. In this study, we have identified KPI-containing APP as a very potent, slow-binding inhibitor for the membrane-bound proteolytic regulator of iron homeostasis matriptase-2 by forming stable complexes with its target protease in HEK cells...
August 1, 2016: Biological Chemistry
https://www.readbyqxmd.com/read/27035617/a-novel-upag-kpi-fusion-protein-inhibits-the-growth-and-invasion-of-human-ovarian-cancer-cells-in-vitro
#20
Li-Ping Zhao, Tian-Min Xu, Mu-Jie Kan, Ye-Chen Xiao, Man-Hua Cui
Urokinase-type plasminogen activator (uPA) acts by breaking down the basement membrane and is involved in cell proliferation, migration and invasion. These actions are mediated by binding to the uPA receptor (uPAR) via its growth factor domain (GFD). The present study evaluated the effects of uPAg-KPI, a fusion protein of uPA-GFD and a kunitz protease inhibitor (KPI) domain that is present in the amyloid β-protein precursor. Using SKOV-3 cells, an ovarian cancer cell line, we examined cell viability, migration, invasion and also protein expression...
May 2016: International Journal of Molecular Medicine
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