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Fei Chen, Harendra Arora, Susan M Martinelli
Background: The Accreditation Council for Graduate Medical Education's Next Accreditation System requires residency programs to semiannually submit composite milestone data on each resident's performance. This report describes and evaluates a new assessment review procedure piloted in our departmental Clinical Competency Committee (CCC) semi-annual meeting in June 2016. Methods: A modified Delphi technique was utilized to develop key performance indicators (KPI) linking milestone descriptors to clinical practice...
October 2017: Journal of Education in Perioperative Medicine: JEPM
Ya-Ping Zhang, Run Zhang, Hua-Yuan Zhu, Li Wang, Yu-Jie Wu, Jin-Hua Liang, Wen-Yu Shi, Hong Liu, Wei Xu, Jian-Yong Li
Purpose: Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is a rare subtype of non-Hodgkin lymphoma, and asparaginase-based regimens are the best first-line treatments. Data on the role of specific circulating lymphocyte subsets in the progression of ENKTL are limited. The aim of this study was to investigate the clinical correlation and distribution of circulating absolute CD4+ T-cell counts (ACD4Cs) in ENKTL. Materials and Methods: We retrospectively searched medical records for 70 newly diagnosed ENKTL patients treated with pegaspargase-based regimens...
May 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Maryam Ahmadi, Farid Khorrami, Afsaneh Dehnad, Mohammad H Golchin, Mohsen Azad, Shafei Rahimi
BACKGROUND: The challenges of using health information systems in developing countries are different from developed countries for various reasons such as infrastructure and data culture of organizations. OBJECTIVE: The aim of this study is to assess managers' access to key performance indicators (KPI) via Hospital Information System (HIS) in teaching hospitals of Iran. METHODS: All managers (Census method) of the four teaching hospitals affiliated to Hormozgan University of Medical Sciences (HUMS) were included in this study...
2018: Studies in Health Technology and Informatics
Rahul Jayakar, Emily Yassaie, Christopher Adams
BACKGROUND: Malignant melanoma is the fourth most common cancer in New Zealand. Surgery is the only treatment modality that can achieve high cure rates for regional disease, but is associated with high complication rates. Our study documents the morbidity associated with regional lymphadenectomy; audits nodal harvest numbers and considers nodal harvest targets. METHODS: We retrospectively reviewed regional lymphadenectomies for Stage III melanoma at a single tertiary centre from 2004 to 2014...
May 4, 2018: New Zealand Medical Journal
Christoph Hohenberger, Corinna Schmidt, Julius Höhne, Alexander Brawanski, Florian Zeman, Karl-Michael Schebesch
OBJECTIVE: Space-occupying spinal metastases (SM), commonly diagnosed because of acute neurological deterioration, consequently lead to immediate decompression with tumor removal or debulking. In this study, we analyzed a series of patients with surgically treated spinal metastases and explicitly sought to determine individual predictors of functional outcome. PATIENTS AND METHODS: 94 patients (26 women, 68 men; mean age 64.0 years) with spinal metastases, who had been surgically treated at our department, were included retrospectively...
April 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Natalia Krzyżaniak, Iga Pawłowska, Beata Bajorek
Background Currently, there is no literature describing what a quality level of practice entails in Polish neonatal intensive care units (NICUs), nor are there any means of currently measuring the quality of pharmaceutical care provided to NICU patients. Objective To identify a set of essential pharmacist roles and pharmacy-relevant key performance indicators (KPI's) suitable for Polish neonatal intensive units (NICUs). Setting Polish hospital pharmacies and NICUs. Method Using a modified Delphi technique, potential KPI's structured along Donabedian's domains as well as pharmacy services were presented to an expert panel of stakeholders...
March 31, 2018: International Journal of Clinical Pharmacy
William P Sheffield, Louise J Eltringham-Smith, Varsha Bhakta
BACKGROUND/AIMS: The Kunitz Protease Inhibitor (KPI) domain of protease nexin 2 (PN2) potently inhibits coagulation factor XIa. Recombinant KPI has been shown to inhibit thrombosis in mouse models, but its clearance from the murine circulation remains uncharacterized. The present study explored the pharmacokinetic and pharmacodynamic effects of fusing KPI to human serum albumin (HSA) in fusion protein KPIHSA. METHODS: Hexahistidine-tagged KPI (63 amino acids) and KPIHSA (656 amino acids) were expressed in Pichia pastoris yeast and purified by nickel-chelate chromatography...
2018: Cellular Physiology and Biochemistry
B Pintea, J A Kandenwein, H Lorenzen, J P Boström, F Daher, V Velazquez, R A Kristof
OBJECTIVE: To describe the patient's self assessed health related quality of life (saHRQoL) based upon the medical outcome study 36-item short form health survey (SF-36) as well as the factors of influence upon the saHRQoL following surgery for petroclival (PCM) and lateral posterior surface of the pyramid (LPPM) meningiomas. PATIENTS AND METHODS: In a series of 78 patients operated consecutively for PCM (n = 46) or LPPM (n = 32) the preoperative, intraoperative and postoperative data were collected retrospectively...
March 2018: Clinical Neurology and Neurosurgery
Christopher E Wing, Anthony N Turner, Chris J Bishop
The purpose of this investigation was to examine the importance of strength and power in relation to key performance indicators (KPI's) within competitive soccer match play. This was achieved through using an experimental approach where fifteen subjects were recruited from a professional soccer club's scholarship squad during the 2013/14 season. Following anthropometric measures, power and strength were assessed across a range of tests which included the squat jump (SJ), countermovement jump (CMJ), 20 metre (m) sprint and arrowhead change of direction test...
January 24, 2018: Journal of Strength and Conditioning Research
Peng-Hao Su, Gregg T Tomy, Chun-Yan Hou, Fang Yin, Dao-Lun Feng, Yong-Sheng Ding, Yi-Fan Li
A size-segregated gas/particle partitioning coefficient KPi was proposed and evaluated in the predicting models on the basis of atmospheric polybrominated diphenyl ether (PBDE) field data comparing with the bulk coefficient KP . Results revealed that the characteristics of atmospheric PBDEs in southeast Shanghai rural area were generally consistent with previous investigations, suggesting that this investigation was representative to the present pollution status of atmospheric PBDEs. KPi was generally greater than bulk KP , indicating an overestimate of TSP (the mass concentration of total suspended particles) in the expression of bulk KP ...
April 2018: Chemosphere
Huaichao Luo, Xiaoying Quan, Xiao-Yu Song, Li Zhang, Yilin Yin, Qiao He, Shaolei Cai, Shi Li, Jian Zeng, Qing Zhang, Yu Gao, Sisi Yu
We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher's exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder...
November 3, 2017: Oncotarget
Bogdan Pintea, Brigitta Baumert, Thomas Mehari Kinfe, Konstantinos Gousias, Yaroslav Parpaley, Jan Patrick Boström
BACKGROUND: We compared the functional outcome and influential factors of two standard treatment modalities for central cerebral metastases: electrophysiological-controlled microsurgical resection (MSR) and stereotactic radiotherapy/stereotactic radiosurgery (SRT/SRS). METHODS: We performed a database search for central metastasis treatments during the period from January 2008 to September 2012 in two clinical registers: 1) register for intraoperative neuromonitoring (Department of Neurosurgery), and 2) prospective database for SRT/SRS (Department of Radiotherapy)...
November 13, 2017: Radiation Oncology
Xiaomin Yin, Chen Chen, Ting Xu, Lin Li, Lan Zhang
Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Aβ) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AKT-GSK3β pathway. We found GSK3β increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months. We found that the activated the AKT-GSK3β signaling pathway suppressed APP-KPI inclusion...
January 1, 2018: Biochemical and Biophysical Research Communications
Erwan Lanchec, Antoine Désilets, François Béliveau, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Denis Gris, Richard Leduc, Christine Lavoie
Recent studies have reported that many proteases, besides the canonical α-, β-, and γ-secretases, cleave the amyloid precursor protein (APP) and modulate β-amyloid (Aβ) peptide production. Moreover, specific APP isoforms contain Kunitz protease-inhibitory domains, which regulate the proteolytic activity of serine proteases. This prompted us to investigate the role of matriptase, a member of the type II transmembrane serine protease family, in APP processing. Using quantitative RT-PCR, we detected matriptase mRNA in several regions of the human brain with an enrichment in neurons...
December 15, 2017: Journal of Biological Chemistry
Afsana Islam, Susanna Leung, Aluh Nikmatullah, Paul P Dijkwel, Michael T McManus
The response of plants to water deficiency or drought is a complex process, the perception of which is triggered at the molecular level before any visible morphological responses are detected. It was found that different groups of plant proteinase inhibitors (PIs) are induced and play an active role during abiotic stress conditions such as drought. Our previous work with the white clover ( Trifolium repens L.) Kunitz Proteinase Inhibitor ( Tr-KPI ) gene family showed that Tr-KPIs are differentially regulated to ontogenetic and biotic stress associated cues and that, at least some members of this gene family may be required to maintain cellular homeostasis...
2017: Frontiers in Plant Science
Claire E Murphy, Kinsey A McCormick, Veena Shankaran, Deepti M Reddi, Paul E Swanson, Melissa P Upton, Antonios Papanicolau-Sengos, Sara Khor, Maria Westerhoff
OBJECTIVES: The aim of this study was to evaluate the concordance in grade assignment for gastroenteropancreatic neuroendocrine tumors using mitotic count (MC), Ki-67 proliferative index (KPI), and phosphohistone H3 count (PHH3C). METHODS: Resected gastroenteropancreatic neuroendocrine tumors were graded based on MC, KPI, and PHH3C. Concordance was determined using a weighted κ statistic. Median survival across each grade category was determined using Kaplan-Meier methods...
November 2017: Pancreas
Zaki N Zahran, Eman A Mohamed, Yoshinori Naruta, Ashraf Haleem
A cofacial iron porphyrin hetero-dimer, Fe2TPFPP-TMP showed high electro-catalytic activity, selectivity, and stability for the O2 reduction to H2O both in homogeneous non-aqueous and heterogeneous neutral aqueous solutions. Moreover, when it is integrated to FTO/p-CuBi2O4 (FTO = fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2.
October 4, 2017: Chemistry: a European Journal
Christina Karatzaferi, Nancy Adamek, Michael A Geeves
The muscle types present with variable fatigue tolerance, in part due to the myosin isoform expressed. However, the critical steps that define "fatigability" in vivo of fast vs. slow myosin isoforms, at the molecular level, are not yet fully understood. We examined the modulation of the ATP-induced myosin subfragment 1 (S1) dissociation from pyrene-actin by inorganic phosphate (Pi ), pH, and temperature using a specially modified stopped-flow system that allowed fast kinetics measurements at physiological temperature...
December 1, 2017: American Journal of Physiology. Cell Physiology
Qi Wan, Dan Wang, HongQuan Ye, Jing Tang, Yu Han
PURPOSE: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. METHODS: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count...
September 2017: Journal of Current Ophthalmology
Mark J Ablowitz, Gino Biondini, Qiao Wang
The genus-1 Kadomtsev-Petviashvili (KP)-Whitham system is derived for both variants of the KP equation; namely the KPI and KPII equations. The basic properties of the KP-Whitham system, including symmetries, exact reductions and its possible complete integrability, together with the appropriate generalization of the one-dimensional Riemann problem for the Korteweg-de Vries equation are discussed. Finally, the KP-Whitham system is used to study the linear stability properties of the genus-1 solutions of the KPI and KPII equations; it is shown that all genus-1 solutions of KPI are linearly unstable, while all genus-1 solutions of KPII are linearly stable within the context of Whitham theory...
August 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
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