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https://www.readbyqxmd.com/read/28641638/-change-of-plasma-interleukin-17-level-in-patients-with-extranodal-nk-t-cell-lymphoma-and-its-clinical-significance
#1
Chun-Xiang Shang, Ji-Cheng Ma, Zheng Nan, Ye Li, Wen-Cai He, Xian-Ying Pan
OBJECTIVE: To investigate the clinical significance of interleukin-17 (IL-17) level in patients with extranodal NK/T-cell lymphoma(ENKTL). METHODS: Eighty patients with nasal ENKTL who received radiotherapy, chemotherapy or radiotherapy combined with chemotherapy from January 2011 to January 2012 were enrolled in the study. Eighty healthy volunteers were selected as the controls (control group). About 5 ml of peripheral blood was collected from all patients and controls...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28593815/homogenous-uv-periodate-process-in-treatment-of-p-nitrophenol-aqueous-solutions-under-mild-operating-conditions
#2
Javad Saien, Marzieh Fallah Vahed Bazkiaei
Aqueous solutions of p-nitrophenol (PNP) were treated with UV-activated potassium periodate (UV/KPI) in an efficient photo-reactor. Either periodate or UV alone had little effect; however, their combination led to a significant degradation and mineralization. The response surface methodology was employed for design of experiments and optimization. The optimum conditions for treatment of 30 mg/L of the substrate were determined as [KPI] = 386.3 mg/L, pH = 6.2 and T = 34.6°C, under which 79.5% degradation was achieved after 60 min...
June 20, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28581548/metal-oxide-assisted-surface-treatment-of-polyimide-gate-insulators-for-high-performance-organic-thin-film-transistors
#3
Sohee Kim, Taewook Ha, Sungmi Yoo, Jae-Won Ka, Jinsoo Kim, Jong Chan Won, Dong Hoon Choi, Kwang-Suk Jang, Yun Ho Kim
We developed a facile method for treating polyimide-based organic gate insulator (OGI) surfaces with self-assembled monolayers (SAMs) by introducing metal-oxide interlayers, called the metal-oxide assisted SAM treatment (MAST). To create sites for surface modification with SAM materials on polyimide-based OGI (KPI) surfaces, the metal-oxide interlayer, here amorphous alumina (α-Al2O3), was deposited on the KPI gate insulator using spin-coating via a rapid sol-gel reaction, providing an excellent template for the formation of a high-quality SAM with phosphonic acid anchor groups...
June 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28572091/the-ser-thr-protein-kinase-protein-protein-interaction-map-of-m-tuberculosis
#4
Fan-Lin Wu, Yin Liu, He-Wei Jiang, Yi-Zhao Luan, Hai-Nan Zhang, Xiang He, Zhao-Wei Xu, Jing-Li Hou, Li-Yun Ji, Zhi Xie, Daniel M Czajkowsky, Wei Yan, Jiao-Yu Deng, Li-Jun Bi, Xian-En Zhang, Sheng-Ce Tao
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, the leading cause of death among all infectious diseases. There are 11 eukaryotic-like serine/threonine protein kinases (STPKs) in Mtb, which are thought to play pivotal roles in cell growth, signal transduction and pathogenesis. However, their underlying mechanisms of action remain largely uncharacterized. In this study, using a Mtb proteome microarray, we have globally identified the binding proteins in Mtb for all of the STPKs, and constructed the first STPK protein interaction (KPI) map that includes 492 binding proteins and 1,027 interactions...
June 1, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28558338/the-challenge-of-sustainability-in-healthcare-systems-frequency-and-cost-of-inappropriate-patterns-of-breast-cancer-care-the-e-pic-a-study
#5
Ilaria Massa, William Balzi, Costanza Burattini, Nicola Gentili, Lauro Bucchi, Oriana Nanni, Davide Gallegati, Andrea Pierini, Dino Amadori, Fabio Falcini, Mattia Altini
OBJECTIVES: In a context of decreasing economic health resources and a rise in health needs, it is urgent to face this sustainability crisis through the analysis of healthcare expenditures. Wastages, deriving from inappropriate interventions, erode resources which could be reallocated to high-value activities. To identify these areas of wastages, we developed a method for combining and analyzing data from multiple sources. Here we report the preliminary results of a retrospective cohort study evaluating the performance of breast cancer (BC) care at IRST, an Italian cancer institute...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28540115/the-benefits-of-streamlined-hip-fracture-management-in-a-regional-hospital
#6
T C Mow, Jen Lukeis, A G Sutherland
INTRODUCTION: Hip fracture is an increasingly common injury in the growing elderly population. The morbidity and mortality associated with this injury can be reduced by minimizing delays to surgical treatment. We describe the impact of a regional hospital service redesign project that utilized the principles of smart simplicity, a management strategy that lays emphasis on collaboration to achieve desired goals. METHODS: Prior to the redesign, patients with hip fractures were taking an average of 72 hours for surgical treatment...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28499154/mutation-of-the-kunitz-type-proteinase-inhibitor-domain-in-the-amyloid-%C3%AE-protein-precursor-abolishes-its-anti-thrombotic-properties-in-vivo
#7
Feng Xu, Judianne Davis, Michael Hoos, William E Van Nostrand
INTRODUCTION: Kunitz proteinase inhibitor (KPI) domain-containing forms of the amyloid β-protein precursor (AβPP) inhibit cerebral thrombosis. KPI domain-lacking forms of AβPP are abundant in brain. Regions of AβPP other than the KPI domain may also be involved with regulating cerebral thrombosis. To determine the contribution of the KPI domain to the overall function of AβPP in regulating cerebral thrombosis we generated a reactive center mutant that was devoid of anti-thrombotic activity and studied its anti-thrombotic function in vitro and in vivo...
May 4, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28372336/alterations-in-the-balance-of-amyloid-%C3%AE-protein-precursor-species-in-the-cerebrospinal-fluid-of-alzheimer-s-disease-patients
#8
Inmaculada Lopez-Font, Claudia P Boix, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero
We recently demonstrated that soluble forms of the amyloid-β protein precursor (sAβPP) assemble into multimeric complexes in cerebrospinal fluid (CSF), which contributes to the underestimation of specific sAβPP species when assessed by ELISA. To circumvent this issue, we analyzed by SDS-PAGE large fragments of sAβPP and their variants in the CSF from Alzheimer's disease (AD; n = 20) and control (n = 20) subjects, probing with specific antibodies against particular domains. Similar levels of sAβPPα and sAβPPβ protein were found in CSF samples from AD and controls, yet there appeared to be a shift in the balance of the soluble full-length AβPP (sAβPPf) species in AD samples, with a decrease in the proportion of the lower (∼100 kDa) band relative to the upper (∼120 kDa) band...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28219824/characterisation-of-the-first-kpc-2-producing-klebsiella-pneumoniae-st340-from-peru
#9
Gertrudis Horna, Jorge Velasquez, Nathaly Fernández, Jesus Tamariz, Joaquim Ruiz
OBJECTIVES: The aim of this study was to characterise a KPC-carrying Klebsiella pneumoniae isolate from a Peruvian hospital setting. METHODS: The identity of the isolate was confirmed by amplification and sequencing of the 16S rRNA gene, and the antibiotic resistance profile was determined by disk diffusion and automated methods The sequence type (ST) and phylogenetic group were established by PCR. The presence of different β-lactamase genes was determined, including blaMBL, blaKPC, blaCTX-M, blaSHV, blaOXA-1-like, blaOXA-2-like, blaOXA-5-like, blaOXA-48-like and blaTEM and up to six different plasmid-encoded AmpC genes as well as class 1 integrons...
June 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28190565/a-kpi-based-process-monitoring-and-fault-detection-framework-for-large-scale-processes
#10
Kai Zhang, Yuri A W Shardt, Zhiwen Chen, Xu Yang, Steven X Ding, Kaixiang Peng
Large-scale processes, consisting of multiple interconnected subprocesses, are commonly encountered in industrial systems, whose performance needs to be determined. A common approach to this problem is to use a key performance indicator (KPI)-based approach. However, the different KPI-based approaches are not developed with a coherent and consistent framework. Thus, this paper proposes a framework for KPI-based process monitoring and fault detection (PM-FD) for large-scale industrial processes, which considers the static and dynamic relationships between process and KPI variables...
February 9, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28164303/process-mining-is-an-underutilized-clinical-research-tool-in-transfusion-medicine
#11
Jason G Quinn, David M Conrad, Calvino K Cheng
BACKGROUND: To understand inventory performance, transfusion services commonly use key performance indicators (KPIs) as summary descriptors of inventory efficiency that are graphed, trended, and used to benchmark institutions. STUDY DESIGN AND METHODS: Here, we summarize current limitations in KPI-based evaluation of blood bank inventory efficiency and propose process mining as an ideal methodology for application to inventory management research to improve inventory flows and performance...
March 2017: Transfusion
https://www.readbyqxmd.com/read/28077410/health-policies-on-dialysis-modality-selection-a-nationwide-population-cohort-study
#12
Yi-Chun Lin, Yen-Chung Lin, Chih-Chin Kao, Hsi-Hsien Chen, Chih-Cheng Hsu, Mai-Szu Wu
OBJECTIVES: In Taiwan, peritoneal dialysis (PD) and haemodialysis are fully accessible to patients with end-stage renal disease. However, the usage of PD is considered low in Taiwan. Since 2005, 4 major policies have been implemented by Taiwan's Ministry of Health and Welfare, namely a multidisciplinary predialysis care programme and usage increasing the PD incidence as a key performance indicator (KPI) for hospital accreditation, both of which were implemented in 2006; reimbursement of the glucose-free dialysate, icodextrin that was implemented in 2007; and insurance reimbursement for renting automated PD machines that was implemented in 2008...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28047712/su-g-iep3-15-cloud-based-monitoring-of-x-ray-angiography-equipment-performance-based-on-automated-daily-sampling-of-key-performance-indicators
#13
J Sjoeberg, A Omar, R Bujila, P Nowik, I Olafsson, G Poludniowski
PURPOSE: To investigate the feasibility of deploying a novel method for the daily monitoring of x-ray Angiography (XA) equipment performance as a cloud-based service. METHODS: From previous work, we have developed a novel image based method of testing the performance of XA equipment on a daily basis. A pre-programmed protocol on an XA system is used and images are automatically analyzed using software developed in-house, resulting in a set of Key Performance Indicators (KPI's) that can be tracked over time...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28002803/increased-body-mass-index-is-associated-with-improved-overall-survival-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#14
Ya-Jun Li, Ping-Yong Yi, Ji-Wei Li, Xian-Ling Liu, Xi-Yu Liu, Fang Zhou, Zhou OuYang, Zhong-Yi Sun, Li-Jun Huang, Jun-Qiao He, Yuan Yao, Zhou Fan, Tian Tang, Wen-Qi Jiang
OBJECTIVES: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. METHODS: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/27909912/identification-and-characterization-of-the-lysine-rich-matrix-protein-family-in-pinctada-fucata-indicative-of-roles-in-shell-formation
#15
Jian Liang, Jun Xie, Jing Gao, Chao-Qun Xu, Yi Yan, Gan-Chu Jia, Liang Xiang, Li-Ping Xie, Rong-Qing Zhang
Mantle can secret matrix proteins playing key roles in regulating the process of shell formation. The genes encoding lysine-rich matrix proteins (KRMPs) are one of the most highly expressed matrix genes in pearl oysters. However, the expression pattern of KRMPs is limited and the functions of them still remain unknown. In this study, we isolated and identified six new members of lysine-rich matrix proteins, rich in lysine, glycine and tyrosine, and all of them are basic matrix proteins. Combined with four members of the KRMPs previously reported, all these proteins can be divided into three subclasses according to the results of phylogenetic analyses: KRMP1-3 belong to subclass KPI, KRMP4-5 belong to KPII, and KRMP6-10 belong to KPIII...
December 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27868234/efficient-31-p-band-inversion-transfer-approach-for-measuring-creatine-kinase-activity-atp-synthesis-and-molecular-dynamics-in-the-human-brain-at-7-t
#16
Jimin Ren, A Dean Sherry, Craig R Malloy
PURPOSE: To develop an efficient (31) P magnetic resonance spectroscopy (MRS) method for measuring creatine kinase (CK) activity, adenosine triphosphate (ATP) synthesis, and motion dynamics in the human brain at 7 Tesla (T). METHODS: Three band inversion modules differing in center frequency were used to induce magnetization transfer (MT) effect in three exchange pathways: (i) CK-mediated reaction PCr → γ-ATP; (ii) de novo ATP synthesis Pi → γ-ATP; and (iii) ATP intramolecular (31) P-(31) P cross-relaxation γ-(α-) ↔ β-ATP...
November 20, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27847351/a-comparison-of-mobile-and-fixed-device-access-on-user-engagement-associated-with-women-infants-and-children-wic-online-nutrition-education
#17
John J Brusk, Robert J Bensley
BACKGROUND: Online health education has expanded its reach due to cost-effective implementation and demonstrated effectiveness. However, a limitation exists with the evaluation of online health education implementations and how the impact of the system is attenuated by the extent to which a user engages with it. Moreover, the current online health education research does not consider how this engagement has been affected by the transition from fixed to mobile user access over the last decade...
November 15, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27822371/improving-admission-medication-reconciliation-compliance-using-the-electronic-tool-in-admitted-medical-patients
#18
Haytham Taha, Dana Abdulhay, Neama Luqman, Samer Ellahham
Sheikh Khalifa Medical City (SKMC) in Abu Dhabi is the main tertiary care referral hospital in the United Arab Emirates (UAE) with 560 bed capacity that is fully occupied most of the time. SKMC senior management has made a commitment to make quality and patient safety a top priority. Our governing body Abu Dhabi Health Services Company has identified medication reconciliation as a critical patient safety measure and key performance indicator (KPI). The medication reconciliation electronic form a computerized decision support tool was introduced to improve medication reconciliation compliance on transition of care at admission, transfer and discharge of patients both in the inpatient and outpatient settings...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27680765/introduction-of-renal-key-performance-indicators-associated-with-increased-uptake-of-peritoneal-dialysis-in-a-publicly-funded-health-service
#19
Nigel D Toussaint, Lawrence P McMahon, Gregory Dowling, Stephen G Holt, Gillian Smith, Maria Safe, Richard Knight, Kathleen Fair, Leanne Linehan, Rowan G Walker, David A Power
♦ Background: Increased demand for treatment of end-stage kidney disease has largely been accommodated by a costly increase in satellite hemodialysis (SHD) in most jurisdictions. In the Australian State of Victoria, a marked regional variation in the uptake of home-based dialysis suggests that use of home therapies could be increased as an alternative to SHD. An earlier strategy based solely on increased remuneration had failed to increase uptake of home therapies. Therefore, the public dialysis funder adopted the incidence and prevalence of home-based dialysis therapies as a key performance indicator (KPI) for its health services to encourage greater uptake of home therapies...
September 28, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27540250/an-audit-to-assess-the-timings-of-ttas-and-inpatient-orders-in-paediatrics-from-writing-to-screening-to-dispensing-and-to-leaving-dispensary
#20
Ami Hale, Nanna Christiansen, Heather Calvert
AIM: To assess the time it takes for paediatric TTA and inpatient orders to be dispensed and sent to ward. This is to establish if the Trust is meeting an operational Key Performance Indicator (KPI). STANDARDS KPIS: ▸ 85% of urgent items (TTAs) dispensed within 1 hour.▸ 85% of non-urgent items (most inpatient orders) dispensed within 3 hrs. METHOD: To audit the time it takes for TTAs and inpatient orders to be screened, sent to dispensary, labelled, dispensed, checked, and leave dispensary...
September 2016: Archives of Disease in Childhood
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