keyword
https://read.qxmd.com/read/38472301/risk-factors-for-acute-chest-syndrome-among-children-with-sickle-cell-anemia-hospitalized-for-vaso-occlusive-crises
#21
JOURNAL ARTICLE
Faisal A Alghamdi, Fawaz Al-Kasim, Forat Alshhada, Eatedal Ghareeb, Fauzia R Azmet, Adel Almudaibigh, Lobna Baitalmal, Bedah Alnawfal, Rehab Alluqmani
Sickle cell anemia (SCA) is a globally prevalent inherited condition, with acute chest syndrome (ACS) being one of its most severe complications. ACS frequently leads to hospitalization, requires intensive care unit (ICU) admission, and can even result in death. This study aimed to discern the early indicators of impending ACS in children with SCA who were initially hospitalized due to painful vaso-occlusive crises (VOC). This was a retrospective, case‒control investigation of 120 patients aged 1-14 years seen at the King Saud Medical City in Riyadh, Saudi Arabia from January 2021 to December 2022...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38471800/an-autopsy-proven-case-based-review-of-autoimmune-encephalitis
#22
REVIEW
Yu-Mi Shim, Seong-Ik Kim, So Dug Lim, Kwanghoon Lee, Eric Eunshik Kim, Jae Kyung Won, Sung-Hye Park
Autoimmune encephalitis (AIE) is a type of immunoreactive encephalitic disorder and is recognized as the most prevalent noninfectious encephalitis. Nevertheless, the rarity of definitive AIE diagnosis through biopsy or autopsy represents a significant hurdle to understanding and managing the disease. In this article, we present the pathological findings of AIE and review the literature based on a distinct case of AIE presenting as CD8+ T-lymphocyte predominant encephalitis. We describe the clinical progression, diagnostic imaging, laboratory data, and autopsy findings of an 80-year-old deceased male patient...
February 29, 2024: Experimental Neurobiology
https://read.qxmd.com/read/38471630/a-comprehensive-exdia-trf-lfia-for-simultaneous-quantification-of-gfap-and-nt-probnp-in-distinguishing-ischemic-and-hemorrhagic-stroke
#23
JOURNAL ARTICLE
Minki Lee, Danishmalik Rafiq Sayyed, Hyejeong Kim, Jean-Charles Sanchez, Sung Sik Hong, Sehee Choi, Hyunghoon Kim, Eunhee Han, Hye Won Kang, Jeong Min Kim, Montaner Joan, Hanshin Kim, Hyojin Chae, Jong-Myeon Park
The goal of this study is to create a highly sensitive time-resolved fluorescence lateral flow immunoassay (TRF-LFIA) capable of concurrently measuring glial fibrillary acidic protein (GFAP) and the N-terminal fragment of B-type natriuretic peptide precursor (NT-proBNP). This assay is designed as a diagnostic tool and aims to provide an algorithm for stroke management, specifically for distinguishing between Ischemic stroke (IS) and Hemorrhagic stroke (HS). However, LFIA to quantify simultaneous serum NT-proBNP and GFAP are not yet available...
March 10, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38470003/an-update-on-cardiovascular-disorders-in-systemic-lupus-erythematosus
#24
REVIEW
Ewa Pędzich, Adrian Bednarek, Julita Młynarska, Emilia Włoszek, Dominika Klimczak-Tomaniak, Karolina Gumiężna, Adam Piasecki, Adam Rdzanek, Grażyna Sygitowicz, Marcin Grabowski, Mariusz Tomaniak
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex multifactorial etiology that develops as a result of autoimmune processes, leading to widespread inflammation and malfunction of multiple tissues and organs, and, as a consequence, triggers arterial hypertension, conduction disorders, valvular heart disease, pulmonary hypertension (PH), and venous thromboembolism events (VTE), contributing to increased mortality. Moreover, autoimmune abnormalities can accelerate atherogenesis and lead to many SLE manifestations, including coronary artery disease (CAD) and cerebrovascular events...
March 12, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38469835/indian-academy-of-pediatrics-consensus-statement-on-diagnosis-and-management-of-bone-and-joint-infections-in-children
#25
JOURNAL ARTICLE
Bhaskar Shenoy, Tanu Singhal, Vijay Yewale, Jaydeep Choudhury, Pragalatha Kumar A, Mandar V Agashe, Chandrashekhar Chikkamuniyappa, Seema Janardhan, Bakul Jayant Parekh, G V Basavaraja
JUSTIFICATION: Osteoarticular infections are fairly common in children but often these are associated with underdiagnosis, delayed diagnosis and improper management. This leads to an increased incidence of complications and poor outcomes. Given the paucity of standard protocols for the management of these children in the Indian context, Indian Academy of Pediatrics (IAP) has taken the initiative to formulate guidelines for the early diagnosis and rational management of bone and joint infections (BJIs)...
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38468351/nonketotic-hyperglycemia-hemichorea-and-hemiballismus-a-case-report
#26
JOURNAL ARTICLE
Abhishek Dixit
BACKGROUND: Diabetic striatopathy, also known as hyperglycemic hemichorea-hemiballismus, is a rare movement disorder associated with nonketotic hyperglycemia in patients with poorly controlled diabetes mellitus. The pathophysiology is not fully elucidated but may involve hyperviscosity, ischemia, and alterations in basal ganglia neurotransmitters. CASE PRESENTATION: We present a case of a 64-year-old Asian female patient with longstanding poorly controlled type 2 diabetes mellitus who developed abrupt-onset right-sided hemichorea-hemiballismus...
March 12, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38468215/derivation-of-the-difficult-airway-physiological-score-daps-in-adults-undergoing-endotracheal-intubation-in-the-emergency-department
#27
JOURNAL ARTICLE
Shahan Waheed, Junaid Abdul Razzak, Nadeemullah Khan, Ahmed Raheem, Asad Iqbal Mian
BACKGROUND: Prediction of serious outcomes among patients with physiological instability is crucial in airway management. In this study, we aim to develop a score to predict serious outcomes following intubation in critically ill adults with physiological instability by using clinical and laboratory parameters collected prior to intubation. METHOD: This single-center analytical cross-sectional study was conducted in the Emergency Department from 2016 to 2020. The airway score was derived using the transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) methodology...
March 12, 2024: BMC Emergency Medicine
https://read.qxmd.com/read/38467710/modeling-multiple-sclerosis-using-mobile-and-wearable-sensor-data
#28
JOURNAL ARTICLE
Shkurta Gashi, Pietro Oldrati, Max Moebus, Marc Hilty, Liliana Barrios, Firat Ozdemir, Veronika Kana, Andreas Lutterotti, Gunnar Rätsch, Christian Holz
Multiple sclerosis (MS) is a neurological disease of the central nervous system that is the leading cause of non-traumatic disability in young adults. Clinical laboratory tests and neuroimaging studies are the standard methods to diagnose and monitor MS. However, due to infrequent clinic visits, it is fundamental to identify remote and frequent approaches for monitoring MS, which enable timely diagnosis, early access to treatment, and slowing down disease progression. In this work, we investigate the most reliable, clinically useful, and available features derived from mobile and wearable devices as well as their ability to distinguish people with MS (PwMS) from healthy controls, recognize MS disability and fatigue levels...
March 11, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38465811/-modern-aspects-of-diagnosis-and-treatment-of-chronic-inflammatory-demyelinating-polyneuropathy-in-children
#29
JOURNAL ARTICLE
A A Kozyreva, R Ts Bembeeva, E S Druzhinina, N N Zavadenko, L M Kolpakchi, S V Pilia
OBJECTIVE: Analysis of demographic, clinical, laboratory, electrophysiological and neuroimaging data and pathogenetic therapy of pediatric patients with chronic inflammatory demyelinating polyneuropathy (CIDP). MATERIAL AND METHODS: Patients ( n =30) were observed in a separate structural unit of the Russian Children's Clinical Hospital of the Russian National Research Medical University named after. N.I. Pirogova Ministry of Health of the Russian Federation in the period from 2006 to 2023...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38464361/effect-of-the-aade7-self-care-behaviors-framework-on-diabetes-education-management-in-a-shared-care-model
#30
JOURNAL ARTICLE
Yunxia Liu, Chenhui Liu
BACKGROUND: Diabetes self-management education (DSME) provides diabetic patients with knowledge of diabetes, requires attention and recording of dietary habits, and increases the frequency and accuracy of blood glucose monitoring. DSME also achieves better blood glucose control, thus benefiting diabetic patients and reducing the risk of diabetes complications. However, few studies have systematically examined whether DSME follows AADE 7 Self-Care Behaviors (AADE7™). Therefore, this study aimed to investigate the control effect of AADE7™-based management on laboratory test indicators of diabetic patients...
2024: International Journal of Endocrinology
https://read.qxmd.com/read/38463384/unusual-coincidence-concurrent-cast-nephropathy-and-lymphoma-infiltration-in-an-influenza-a-associated-acute-kidney-injury
#31
Wan-Ching Lee, Chun-Kuang Tsai, Szu-Yuan Li
Acute kidney injury (AKI) poses a substantial challenge in the management of lymphoma patients and is frequently associated with diverse causative factors. Herein, we report an illustrative case involving a 47-year-old male with influenza A infection who developed severe AKI, which was incongruent with his medical history. Laboratory investigations disclosed aberrant immunoglobulin levels and urinary protein excretion, prompting further evaluation. A renal biopsy revealed the presence of infiltrating lymphoid cells and cast nephropathy, raising suspicion of an underlying hematological disorder...
2024: Case Reports in Nephrology
https://read.qxmd.com/read/38463110/point-prevalence-and-clinical-profile-of-patients-with-delirium-admitted-in-internal-medicine-department-at-tertiary-care-centre-in-eastern-nepal-a-descriptive-cross-sectional-study
#32
JOURNAL ARTICLE
Tek Nath Yogi, Sujan Puri, Bhupendra Shah, Suraj Nepal, Akshat Mishra
INTRODUCTION: Delirium, marked by acute disturbances in consciousness and cognition, remains underdiagnosed despite its significant impact on morbidity and mortality. This study investigates the point prevalence and clinical profile of delirium in patients at an eastern Nepal tertiary care centre. METHODS: A 1-month descriptive cross-sectional study involved 152 Internal Medicine Department patients at BPKIHS, Dharan. Data, collected through face-to-face interviews and the Confusion Assessment Method (CAM), analyzed demographic details, clinical history, and laboratory findings...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38463081/knee-replacement-surgery-in-a-patient-with-acquired-von-willebrand-disease-a-case-study-with-recommendations-for-patient-management
#33
María Teresa Álvarez Román, María Isabel Rivas Pollmar, Hortensia De la Corte-Rodríguez, Primitivo Gómez-Cardero, E Carlos Rodríguez-Merchán, Mar Gutiérrez-Alvariño, Eduardo García-Pérez, Mónica Martín-Salces, Damaris Zagrean, Nora V Butta-Coll, Víctor Jiménez-Yuste
INTRODUCTION AND IMPORTANCE: Acquired von Willebrand disease (AvWD) is a rare underdiagnosed bleeding disorder caused by alterations in the levels of the major blood-clotting protein von Willebrand factor (vWF). The clinical and laboratory parameters of AvWD are similar to congenital vWD, but it is found in individuals with no positive family history with no underlying genetic basis. The disease remains multifactorial and incompletely understood. Proposed mechanisms include the development of autoantibodies to vWF, absorption of high molecular weight vWF multimers that impair normal function, shear stress induced vWF cleavage and increased proteolysis...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38463079/an-unusual-imaging-presentation-of-pediatric-bacterial-meningoencephalitis-a-case-report-study
#34
Maryam Kachuei, Ramin Zare, Shirin Sayyahfar, Mitra Khalili, Hamidreza Movahedi, Mobin Naghshbandi, Shayan Eghdami
BACKGROUND: Bacterial meningoencephalitis is a serious infection affecting the brain and its surrounding membranes. While imaging studies play a crucial role in diagnosing this condition, the typical radiological findings are well-documented. However, this case report describes an unusual imaging presentation that deviates from the expected patterns, emphasizing the need for awareness of such variations. CASE PRESENTATION: A 7-year-old female with no prior medical history was referred to our hospital with fever, seizure, and loss of Consciousness...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38452137/lower-doses-of-carvedilol-in-japanese-heart-failure-patients-with-reduced-ejection-fraction-could-show-the-potential-to-be-non-inferior-to-higher-doses-in-us-patients-an-international-collaborative-observational-study
#35
JOURNAL ARTICLE
Makiko Maeda, Douglas Humber, Eisuke Hida, Tomohito Ohtani, Guannan Wang, Tong Wu, Shiori Takeda, Jacinta N Situ, Jun Hayashi, Shinpei Nonen, Toshihiro Takeda, Hiroshi Okamoto, Masatsugu Hori, Yasushi Sakata, Yasushi Fujio, Shirley M Tsunoda
The Japanese national guidelines recommend significantly lower doses of carvedilol for heart failure with reduced ejection fraction (HFrEF) management than the US guidelines. Using real-world data, we determined whether initial and target doses of carvedilol in Japanese patients (JPNs) differ from those in US patients (USPs), especially in Asian Americans (ASA) and Caucasians (CA), and investigated differences in outcomes. We collected data from the electronic medical records, including demographics, carvedilol dosing, tolerability, cardiac functional indicators like EF, cardiovascular events including all-cause deaths, and laboratory values from the University of California, San Diego Health and Osaka University...
2024: PloS One
https://read.qxmd.com/read/38449385/a-generalizable-decision-making-framework-for-selecting-onsite-versus-send-out-clinical-laboratory-testing
#36
JOURNAL ARTICLE
Lee F Schroeder, Paul Rebman, Parastu Kasaie, Ernest Kenu, Jon Zelner, David W Dowdy
BACKGROUND: Laboratory networks provide services through onsite testing or through specimen transport to higher-tier laboratories. This decision is based on the interplay of testing characteristics, treatment characteristics, and epidemiological characteristics. OBJECTIVES: Our objective was to develop a generalizable model using the threshold approach to medical decision making to inform test placement decisions. METHODS: We developed a decision model to compare the incremental utility of onsite versus send-out testing for clinical purposes...
March 6, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://read.qxmd.com/read/38448679/screening-and-diagnosis-of-primary-aldosteronism-consensus-document-of-all-the-spanish-societies-involved-in-the-management-of-primary-aldosteronism
#37
REVIEW
Marta Araujo-Castro, Jorge Gabriel Ruiz-Sánchez, Paola Parra Ramírez, Patricia Martín Rojas-Marcos, Almudena Aguilera-Saborido, Jorge Francisco Gómez Cerezo, Nieves López Lazareno, María Eugenia Torregrosa Quesada, Jorge Gorrin Ramos, Josep Oriola, Esteban Poch, Anna Oliveras, José Vicente Méndez Monter, Isabel Gómez Muriel, María Rosa Bella-Cueto, Enrique Mercader Cidoncha, Isabelle Runkle, Felicia A Hanzu
Primary aldosteronism (PA) is the most frequent cause of secondary hypertension (HT), and is associated with a higher cardiometabolic risk than essential HT. However, PA remains underdiagnosed, probably due to several difficulties clinicians usually find in performing its diagnosis and subtype classification. The aim of this consensus is to provide practical recommendations focused on the prevalence and the diagnosis of PA and the clinical implications of aldosterone excess, from a multidisciplinary perspective, in a nominal group consensus approach by experts from the Spanish Society of Endocrinology and Nutrition (SEEN), Spanish Society of Cardiology (SEC), Spanish Society of Nephrology (SEN), Spanish Society of Internal Medicine (SEMI), Spanish Radiology Society (SERAM), Spanish Society of Vascular and Interventional Radiology (SERVEI), Spanish Society of Laboratory Medicine (SEQC(ML)), Spanish Society of Anatomic-Pathology, Spanish Association of Surgeons (AEC)...
March 6, 2024: Endocrine
https://read.qxmd.com/read/38446563/association-of-demographic-characteristics-and-laboratory-values-in-diabetic-foot-infections-leading-to-lower-extremity-amputation
#38
JOURNAL ARTICLE
Allen J Kempf, Ellianne M Nasser, Idorenyin F Udoeyo, Isana Fils-Aime
BACKGROUND: Lower-extremity amputations are a common complication of poorly controlled diabetes and contribute to significant morbidity and mortality in diabetic patients. We sought to determine whether objective data points obtained on presentation or hospital admission, including white blood cell (WBC) count, hemoglobin A1c (HbA1c), C-reactive protein (CRP), and descriptive patient demographics allow for the ability to predict optimal amputation levels and outcomes of lower-extremity amputation in the diabetic population...
2024: Journal of the American Podiatric Medical Association
https://read.qxmd.com/read/38446250/transplant-nephrectomy-indication-surgical-approach-and-complications-experiences-from-a-single-transplantation-center
#39
JOURNAL ARTICLE
Josef Mang, Josephine Haag, Lutz Liefeldt, Klemens Budde, Robert Peters, Sebastian L Hofbauer, Matthias Schulz, Sarah Weinberger, Julia Dagnæs-Hansen, Andreas Maxeiner, Bernhard Ralla, Frank Friedersdorff
PURPOSE: Management of a failed kidney allograft, and the question whether it should be removed is a challenging task for clinicians. The reported risks for transplant nephrectomy (TN) vary, and there is no clear recommendation on indications or surgical approach that should be used. This study gives an overview of indications, compares surgical techniques, and identifies risk factors for higher morbidity. METHODS: Retrospective analysis was conducted on all transplant nephrectomies performed between 2005 and 2020 at Charité Hospital Berlin, Department of Urology...
March 6, 2024: World Journal of Urology
https://read.qxmd.com/read/38445122/iron-deficiency-a-silent-threat-in-patients-with-heart-failure-with-reduced-ejection-fraction
#40
JOURNAL ARTICLE
Nitin Sarate, Rahul Sonawane, Vinayak Pai, Shifa Karatela, Alhad Mulkalwar
Background Iron deficiency is a prevalent and clinically significant comorbidity in patients with heart failure with reduced ejection fraction (HFrEF). Despite its high prevalence, its impact on clinical outcomes, mortality, and various physiological parameters remains a subject of ongoing investigation. The findings of this study are anticipated to contribute valuable insights into the management and prognosis of patients with HFrEF, potentially informing future interventions and improving patient outcomes...
February 2024: Curēus
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