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https://www.readbyqxmd.com/read/28942804/suicide-attempts-in-juvenile-bipolar-versus-major-depressive-disorders-systematic-review-and-meta-analysis
#1
REVIEW
Franco De Crescenzo, Giulia Serra, Francesco Maisto, Mai Uchida, Hilary Woodworth, Maria Pia Casini, Ross J Baldessarini, Stefano Vicari
OBJECTIVE: Suicide attempts are prevalent in association with major mood disorders, and risk is greater with bipolar disorder (BD) than major depressive disorder (MDD) in adults. There may be similar relationships in juvenile mood disorders, but the evidence has not been compiled systematically and quantitatively. METHOD: We searched for reports of studies comparing rates of suicide attempts in children or adolescents diagnosed with BD or MDD, and applied random-effects meta-analysis...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#2
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28902525/lurasidone-efficacy-and-safety-in-the-treatment-of-psychotic-and-mood-disorders
#3
Maurizio Pompili, Claudio Verzura, Giada Trovini, Andrea Buscajoni, Giulia Falcone, Stefano Naim, Adele Nardella, Serena Sorice, Ross J Baldessarini, Paolo Girardi
Lurasidone ([3aR,4S,7R,7aS]-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1yl-methyl] cyclohexylmethyl]-hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; Latuda® [LRSD]) is a novel benzisothiazole, second-generation antipsychotic drug developed by Dainippon Sumitomo Pharma Corporation in Japan. Similar to other atypical antipsychotics it has a distinctive pharmacodynamic profile, Areas covered: This review updates reported research findings on the efficacy, safety and tolerability of LRSD for treatment of psychotic and major affective disorders, with meta-analyses...
September 13, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28837953/temperaments-in-psychotic-and-major-affective-disorders
#4
Maurizio Pompili, Ross J Baldessarini, Marco Inammorati, Gustavo H Vázquez, Zoltan Rihmer, Xenia Gonda, Alberto Forte, Dorian A Lamis, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi
BACKGROUND: Assessment of affective temperaments with the extensively validated, 110-item TEMPS-A autoquestionnaire has been used to characterize patients with mood disorders, and its scores have been associated consistently with suicidal behavior. Much less has been reported about comparisons of characteristics of such assessments in psychotic and other psychiatric disorders. METHODS: We analyzed results of TEMPS-A assessments in 1081 psychiatrically hospitalized patients in Rome and compared subscale scores (anxious [anx], cyclothymic [cyc], depressive [dep], irritable [irr], hyperthymic [hyp]) and a composite score (anx+cyc+dep+irr - hyp) among diagnoses and subjects with vs...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28758582/potential-novel-treatments-for-bipolar-depression-ketamine-fatty-acids-anti-inflammatory-agents-and-probiotics
#5
G H Vázquez, S Camino, L Tondo, Ross J Baldessarini
BACKGROUND: Treatments for depression in bipolar disorder (BD) are far less well developed than for unipolar major depressive disorder. Several innovative and experimental approaches have been emerging recently, including use of the dissociative anesthetic ketamine and other antagonists of central NMDA glutamate receptors, as well as unsaturated fatty acids, anti-inflammatory agents, and possibly probiotic methods. METHODS: We reviewed relevant reports from the past decade...
July 28, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28633600/direct-comparison-of-tricyclic-and-serotonin-reuptake-inhibitor-antidepressants-in-randomized-head-to-head-trials-in-acute-major-depression-systematic-review-and-meta-analysis
#6
Juan Undurraga, Ross J Baldessarini
BACKGROUND: A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect a selective secular decline of responses after randomization to placebo. Remaining uncertainty encouraged direct comparison of the drug-types in trials involving randomized, head-to-head comparisons. METHODS: We systematically identified reports of randomized trials of TCAs versus SSRIs for major depression in several digital databases, and applied standard meta-analytic and multiple-factor regression methods to analyze and pool the findings...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28503106/depression-and-mania-in-bipolar-disorder
#7
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. METHODS: We reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28480485/long-term-lithium-treatment-in-bipolar-disorder-effects-on-glomerular-filtration-rate-and-other-metabolic-parameters
#8
Leonardo Tondo, Maria Abramowicz, Martin Alda, Michael Bauer, Alberto Bocchetta, Lorenza Bolzani, Cynthia V Calkin, Caterina Chillotti, Diego Hidalgo-Mazzei, Mirko Manchia, Bruno Müller-Oerlinghausen, Andrea Murru, Giulio Perugi, Marco Pinna, Giuseppe Quaranta, Daniela Reginaldi, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, David Saiger, Gabriele Sani, Valerio Selle, Thomas Stamm, Gustavo H Vázquez, Julia Veeh, Eduard Vieta, Ross J Baldessarini
BACKGROUND: Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of decline over time; effects of lithium dose, serum concentration, and duration of treatment; relative effects of lithium exposure vs. aging; and contributions of sex and other factors all remain unclear. METHODS: Accordingly, we acquired data from 12 collaborating international sites and 312 bipolar disorder patients (6142 person-years, 2669 assays) treated with lithium carbonate for 8-48 (mean 18) years and aged 20-89 (mean 56) years...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28236781/antipsychotic-treatment-and-the-rorschach-perceptual-thinking-index-pti-in-psychotic-disorder-patients-effects-of-treatment
#9
Mario Biagiarelli, Martina Curto, Ileana Di Pomponio, Anna Comparelli, Ross J Baldessarini, Stefano Ferracuti
The Rorschach-based Perceptual Thinking Index (PTI) is used to identify and rate features of psychotic disorders, but effects of antipsychotic treatment on such ratings is not clear. Accordingly, we examined potential effects of antipsychotic drugs on PTI measures in 114 patients with a psychotic or bipolar-I disorder. Use and doses of antipsychotic drugs (as chlorpromazine-equivalent [CPZ-eq] mg/day) were unrelated to PTI total or subscale scores in any diagnostic group. PTI scores were independently and significantly associated with psychotic symptomatic severity (PANSS score) and less with female sex...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28183075/morbidity-in-depressive-disorders
#10
EDITORIAL
Ross J Baldessarini, Alberto Forte, Valerio Selle, Kang Sim, Leonardo Tondo, Juan Undurraga, Gustavo H Vázquez
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28152464/arsenic-association-of-regional-concentrations-in-drinking-water-with-suicide-and-natural-causes-of-death-in-italy
#11
Maurizio Pompili, Monica Vichi, Enrico Dinelli, Denise Erbuto, Roger Pycha, Gianluca Serafini, Gloria Giordano, Paolo Valera, Stefano Albanese, Annamaria Lima, Benedetto De Vivo, Domenico Cicchella, Zoltan Rihmer, Andrea Fiorillo, Mario Amore, Paolo Girardi, Ross J Baldessarini
Arsenic, as a toxin, may be associated with higher mortality rates, although its relationship to suicide is not clear. Given this uncertainty, we evaluated associations between local arsenic concentrations in tapwater and mortality in regions of Italy, to test the hypothesis that both natural-cause and suicide death rates would be higher with greater trace concentrations of arsenic. Arsenic concentrations in drinking-water samples from 145 sites were assayed by mass spectrometry, and correlated with local rates of mortality due to suicide and natural causes between 1980 and 2011, using weighted, least-squares univariate and multivariate regression modeling...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28146001/clinical-use-of-mood-stabilizers-with-antidepressants-in-asia-report-from-the-research-on-asian-psychotropic-prescription-patterns-for-antidepressants-reap-ad-projects-in-2004-and-2013
#12
MULTICENTER STUDY
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen F K Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy A Kallivayalil, Andi J Tanra, Margarita M Maramis, Winston W Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
OBJECTIVE: As most reports concerning treatment with combinations of mood stabilizer (MS) with antidepressant (AD) drugs are based in the West, we surveyed characteristics of such cotreatment in 42 sites caring for the mentally ill in 10 Asian countries. METHODS: This cross-sectional, pharmacoepidemiologic study used 2004 and 2013 data from the REAP-AD (Research Study on Asian Psychotropic Prescription Patterns for Antidepressants) to evaluate the rates and doses of MSs given with ADs and associated factors in 4164 psychiatric patients, using standard bivariate methods followed by multivariable logistic regression modeling...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27992854/differential-associations-of-affective-temperaments-and-diagnosis-of-major-affective-disorders-with-suicidal-behavior
#13
Ross J Baldessarini, Marco Innamorati, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi, Maurizio Pompili
BACKGROUND: Affective temperaments are associated with suicidal risk, but their predictive value relative to diagnosis of major affective disorder is uncertain. METHODS: We compared diagnoses, affective-temperament ratings (TEMPS-A), and other potential risk factors in 956 psychiatric inpatients, using bivariate analyses and multivariable logistic regression modeling for associations with suicidal status. RESULTS: Lifetime suicide-attempt rates were high (43...
December 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27753726/factors-associated-with-antidepressant-dosing-in-asia-findings-from-the-research-on-asian-psychotropic-prescription-study
#14
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J Tanra, Margarita Maramis, Winston Wu-Dien Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27727180/do-atypical-antipsychotics-have-antisuicidal-effects-a-hypothesis-generating-overview
#15
REVIEW
Maurizio Pompili, Ross J Baldessarini, Alberto Forte, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi
Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general...
October 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27703755/long-term-antipsychotic-treatment-in-schizophrenia-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials
#16
Ying Jiao Zhao, Liang Lin, Monica Teng, Ai Leng Khoo, Lay Beng Soh, Toshiaki A Furukawa, Ross J Baldessarini, Boon Peng Lim, Kang Sim
BACKGROUND: For treatment of patients diagnosed with schizophrenia, comparative long-term effectiveness of antipsychotic drugs to reduce relapses when minimising adverse effects is of clinical interest, hence prompting this review. AIMS: To evaluate the comparative long-term effectiveness of antipsychotic drugs. METHOD: We systematically searched electronic databases for reports of randomised controlled trials (RCTs) of antipsychotic monotherapy aimed at reducing relapse risks in schizophrenia...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27673411/child-and-adolescent-clinical-features-preceding-adult-suicide-attempts
#17
Giulia Serra, Athanasios Koukopoulos, Lavinia De Chiara, Flavia Napoletano, Alexia Koukopoulos, Gabriele Sani, Gianni L Faedda, Paolo Girardi, Daniela Reginaldi, Ross J Baldessarini
The objective of this study was to identify the predictive value of juvenile factors for adult suicidal behavior. We reviewed clinical records to compare factors identified in childhood and adolescence between adult suicidal versus nonsuicidal major affective disorder subjects. Suicide attempts occurred in 23.1% of subjects. Age-at-first-symptom was 14.2 vs. 20.2 years among suicidal versus nonsuicidal subjects (p < 0.0001). More prevalent in suicidal versus non-suicidal subjects by multivariate analysis were: depressive symptoms, hyper-emotionality, younger-at-first-affective-episode, family suicide history, childhood mood-swings, and adolescence low self-esteem...
July 3, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/27542851/suicidal-behavior-in-mood-disorders-response-to-pharmacological-treatment
#18
REVIEW
Leonardo Tondo, Ross J Baldessarini
Suicidal behavior is strongly associated with depression, especially if accompanied by behavioral activation, dysphoria, or agitation. It may respond to some treatments, but the design of scientifically sound, ethical trials to test for therapeutic effects on suicidal behavior is highly challenging. In bipolar disorder, and possibly also unipolar major depression, an underprescribed medical intervention with substantial evidence of preventive effects on suicidal behavior is long-term treatment with lithium...
September 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27232651/the-mclean-harvard-first-episode-project-early-course-in-114-cases-of-first-episode-nonaffective-psychoses
#19
Mauricio Tohen, Hari-Mandir K Khalsa, Paola Salvatore, Carlos A Zarate, Stephen M Strakowski, Jesús Pérez Sanchez-Toledo, Ross J Baldessarini
BACKGROUND: Early course in contemporary, clinically treated, nonaffective psychotic disorders other than schizophrenia remains incompletely defined. METHODS: We prospectively, repeatedly, and systematically assessed 114 patients hospitalized for a first episode of DSM-IV-TR nonaffective psychotic illness for ≥ 2 years (1989-1996) using structured (Structured Clinical Interview for DSM-III-R, Patient Edition; Clinical Global Impressions scale; Scale for the Assessment of Negative Symptoms; Scale for the Assessment of Positive Symptoms; and the expanded version of the Brief Psychiatric Rating Scale) and unstructured (best-estimate procedure, life charting) naturalistic follow-up procedures and survival analysis...
June 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27222142/systematic-review-of-clozapine-cardiotoxicity
#20
REVIEW
Martina Curto, Nicoletta Girardi, Luana Lionetto, Giuseppino M Ciavarella, Stefano Ferracuti, Ross J Baldessarini
Clozapine is exceptionally effective in psychotic disorders and can reduce suicidal risk. Nevertheless, its use is limited due to potentially life-threatening adverse effects, including myocarditis and cardiomyopathy. Given their clinical importance, we systematically reviewed research on adverse cardiac effects of clozapine, aiming to improve estimates of their incidence, summarize features supporting their diagnosis, and evaluate proposed monitoring procedures. Incidence of early (≤2 months) myocarditis ranges from <0...
July 2016: Current Psychiatry Reports
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