keyword
MENU ▼
Read by QxMD icon Read
search

ross baldessarini

keyword
https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#1
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#2
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29496141/what-can-we-learn-about-brain-donors-use-of-clinical-information-in-human-postmortem-brain-research
#3
Kathleen Sullivan, Harry Pantazopoulos, Elizabeth Liebson, T-U W Woo, Ross J Baldessarini, John Hedreen, Sabina Berretta
Postmortem studies on the human brain reside at the core of investigations on neurologic and psychiatric disorders. Ground-breaking advances continue to be made on the pathologic basis of many of these disorders, at molecular, cellular, and neural connectivity levels. In parallel, there is increasing emphasis on improving methods to extract relevant demographic and clinical information about brain donors and, importantly, translate it into measures that can reliably and effectively be incorporated in the design and data analysis of postmortem human investigations...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29329066/association-of-suicidal-risk-with-ratings-of-affective-temperaments
#4
Leonardo Tondo, Gustavo H Vázquez, Gabriele Sani, Marco Pinna, Ross J Baldessarini
BACKGROUND: Ratings of particular temperament-types with the TEMPS-A autoquestionnaire have been associated with suicidal risk, and combinations of such ratings may enhance the association. However, the predictive value of scores for individual temperaments and combinations remains to be quantified. METHOD: We evaluated associations of TEMPS-A ratings for anxious (anx), cyclothymic (cyc), dysthymic (dys), hyperthymic (hyp) and irritable (irr) temperaments, with a history of suicidal acts or reported suicidal ideation in 882 patients with bipolar (BD; n = 509), major depressive (MDD; n = 268) or anxiety (ANX; n = 105) disorders...
March 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29303918/suicidal-risk-and-affective-temperaments-evaluated-with-the-temps-a-scale-a-systematic-review
#5
Gustavo H Vázquez, Xenia Gonda, María Lolich, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: Among risk factors for suicidal behavior, there is growing interest in associations with stable affective temperament types, particularly based on assessment with the TEMPS-A self-rating scale. AIM: As research on this topic has not been reviewed systematically, we synthesized relevant, reported research findings. METHODS: Systematic searching identified peer-reviewed reports pertaining to associations of suicidal behavior or ideation with affective temperament types evaluated with TEMPS-A...
January 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29303917/clinical-and-environmental-risk-factors-for-bipolar-disorder-review-of-prospective-studies
#6
Ciro Marangoni, Gianni L Faedda, Ross J Baldessarini
After participating in this activity, learners should be better able to:• Evaluate factors that have been identified in prospective studies as predicting the onset of bipolar disorder ABSTRACT: The prodromal phase of bipolar disorder (BD) remains incompletely characterized, limiting early detection of BD and delaying interventions that might limit future morbidity and disability. Retrospective and family-risk studies have consistently found evidence of prodromal psychopathology in subjects later diagnosed with BD...
January 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29215383/mood-stabilizing-anticonvulsants-spina-bifida-and-folate-supplementation-commentary
#7
Neil Patel, Adele C Viguera, Ross J Baldessarini
PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects...
February 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29182075/tricyclic-and-selective-serotonin-reuptake-inhibitor-antidepressants-compared-with-placebo-in-randomized-trials-for-acute-major-depression
#8
Juan Undurraga, Ross J Baldessarini
No abstract text is available yet for this article.
December 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29102381/corrigendum-to-temperaments-in-psychotic-and-major-affective-disorders-j-affect-disord-2018-195-200
#9
Maurizio Pompili, Ross J Baldessarini, Marco Innamorati, Gustavo H Vázquez, Zoltan Rihmer, Xenia Gonda, Alberto Forte, Dorian A Lamis, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi
No abstract text is available yet for this article.
November 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29091781/factors-associated-with-suicide-case-control-study-in-south-tyrol
#10
Giancarlo Giupponi, Marco Innamorati, Ross J Baldessarini, Diego De Leo, Francesca de Giovannelli, Roger Pycha, Andreas Conca, Paolo Girardi, Maurizio Pompili
BACKGROUND: As suicide is related to many factors in addition to psychiatric illness, broad and comprehensive risk-assessment for risk of suicide is required. This study aimed to differentiate nondiagnostic risk factors among suicides versus comparable psychiatric patients without suicidal behavior. METHODS: We carried out a pilot, case-control comparison of 131 cases of suicide in South Tyrol matched for age and sex with 131 psychiatric controls, using psychological autopsy methods to evaluate differences in clinically assessed demographic, social, and clinical factors, using bivariate conditional Odds Risk comparisons followed by conditional regression modeling controlled for ethnicity...
January 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29089008/specialized-police-based-mental-health-crisis-response-the-first-10-years-of-colorado-s-crisis-intervention-team-implementation
#11
Hari-Mandir K Khalsa, Attila C Denes, Diane M Pasini-Hill, Jeffrey C Santelli, Ross J Baldessarini
OBJECTIVE: This study examined the implementation of crisis intervention teams by law enforcement agencies in Colorado. METHODS: Rates of Special Weapons and Tactics (SWAT) use, arrests, use of force, and injuries were assessed during 6,353 incidents involving individuals experiencing a mental health crisis. Relationships among original complaint, psychiatric illness, substance abuse, violence risk, and disposition of crisis calls were analyzed. RESULTS: Rates of SWAT use (<1%), injuries (<1%), arrests (<5%), and use of force (<5%) were low...
February 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28942804/suicide-attempts-in-juvenile-bipolar-versus-major-depressive-disorders-systematic-review-and-meta-analysis
#12
REVIEW
Franco De Crescenzo, Giulia Serra, Francesco Maisto, Mai Uchida, Hilary Woodworth, Maria Pia Casini, Ross J Baldessarini, Stefano Vicari
OBJECTIVE: Suicide attempts are prevalent in association with major mood disorders, and risk is greater with bipolar disorder (BD) than major depressive disorder (MDD) in adults. There may be similar relationships in juvenile mood disorders, but the evidence has not been compiled systematically and quantitatively. METHOD: We searched for reports of studies comparing rates of suicide attempts in children or adolescents diagnosed with BD or MDD, and applied random-effects meta-analysis...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#13
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28902525/lurasidone-efficacy-and-safety-in-the-treatment-of-psychotic-and-mood-disorders
#14
REVIEW
Maurizio Pompili, Claudio Verzura, Giada Trovini, Andrea Buscajoni, Giulia Falcone, Stefano Naim, Adele Nardella, Serena Sorice, Ross J Baldessarini, Paolo Girardi
Lurasidone ([3aR,4S,7R,7aS]-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1yl-methyl] cyclohexylmethyl]-hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; Latuda®) is a novel benzisothiazole, second-generation antipsychotic drug developed by Dainippon Sumitomo Pharma Corporation in Japan. Similar to other atypical antipsychotics it has a distinctive pharmacodynamic profile, Areas covered: This review updates reported research findings on the efficacy, safety and tolerability of LRSD for treatment of psychotic and major affective disorders, with meta-analyses...
February 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28837953/temperaments-in-psychotic-and-major-affective-disorders
#15
Maurizio Pompili, Ross J Baldessarini, Marco Innamorati, Gustavo H Vázquez, Zoltan Rihmer, Xenia Gonda, Alberto Forte, Dorian A Lamis, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi
BACKGROUND: Assessment of affective temperaments with the extensively validated, 110-item TEMPS-A autoquestionnaire has been used to characterize patients with mood disorders, and its scores have been associated consistently with suicidal behavior. Much less has been reported about comparisons of characteristics of such assessments in psychotic and other psychiatric disorders. METHODS: We analyzed results of TEMPS-A assessments in 1081 psychiatrically hospitalized patients in Rome and compared subscale scores (anxious [anx], cyclothymic [cyc], depressive [dep], irritable [irr], hyperthymic [hyp]) and a composite score (anx+cyc+dep+irr - hyp) among diagnoses and subjects with vs...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28758582/potential-novel-treatments-for-bipolar-depression-ketamine-fatty-acids-anti-inflammatory-agents-and-probiotics
#16
Gustavo H Vazquez, Sebastian Camino, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: Treatments for depression in bipolar disorder (BD) are far less well developed than for unipolar major depressive disorder. Several innovative and experimental approaches have been emerging recently, including use of the dissociative anesthetic ketamine and other antagonists of central NMDA glutamate receptors, as well as unsaturated fatty acids, anti-inflammatory agents, and possibly probiotic methods. METHOD: We reviewed relevant reports from the past decade...
2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28633600/direct-comparison-of-tricyclic-and-serotonin-reuptake-inhibitor-antidepressants-in-randomized-head-to-head-trials-in-acute-major-depression-systematic-review-and-meta-analysis
#17
Juan Undurraga, Ross J Baldessarini
BACKGROUND: A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect a selective secular decline of responses after randomization to placebo. Remaining uncertainty encouraged direct comparison of the drug-types in trials involving randomized, head-to-head comparisons. METHODS: We systematically identified reports of randomized trials of TCAs versus SSRIs for major depression in several digital databases, and applied standard meta-analytic and multiple-factor regression methods to analyze and pool the findings...
September 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28503106/depression-and-mania-in-bipolar-disorder
#18
REVIEW
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. METHODS: We reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28480485/long-term-lithium-treatment-in-bipolar-disorder-effects-on-glomerular-filtration-rate-and-other-metabolic-parameters
#19
Leonardo Tondo, Maria Abramowicz, Martin Alda, Michael Bauer, Alberto Bocchetta, Lorenza Bolzani, Cynthia V Calkin, Caterina Chillotti, Diego Hidalgo-Mazzei, Mirko Manchia, Bruno Müller-Oerlinghausen, Andrea Murru, Giulio Perugi, Marco Pinna, Giuseppe Quaranta, Daniela Reginaldi, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, David Saiger, Gabriele Sani, Valerio Selle, Thomas Stamm, Gustavo H Vázquez, Julia Veeh, Eduard Vieta, Ross J Baldessarini
BACKGROUND: Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of decline over time; effects of lithium dose, serum concentration, and duration of treatment; relative effects of lithium exposure vs. aging; and contributions of sex and other factors all remain unclear. METHODS: Accordingly, we acquired data from 12 collaborating international sites and 312 bipolar disorder patients (6142 person-years, 2669 assays) treated with lithium carbonate for 8-48 (mean 18) years and aged 20-89 (mean 56) years...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28236781/antipsychotic-treatment-and-the-rorschach-perceptual-thinking-index-pti-in-psychotic-disorder-patients-effects-of-treatment
#20
Mario Biagiarelli, Martina Curto, Ileana Di Pomponio, Anna Comparelli, Ross J Baldessarini, Stefano Ferracuti
The Rorschach-based Perceptual Thinking Index (PTI) is used to identify and rate features of psychotic disorders, but effects of antipsychotic treatment on such ratings is not clear. Accordingly, we examined potential effects of antipsychotic drugs on PTI measures in 114 patients with a psychotic or bipolar-I disorder. Use and doses of antipsychotic drugs (as chlorpromazine-equivalent [CPZ-eq] mg/day) were unrelated to PTI total or subscale scores in any diagnostic group. PTI scores were independently and significantly associated with psychotic symptomatic severity (PANSS score) and less with female sex...
May 2017: Psychiatry Research
keyword
keyword
72480
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"