keyword
MENU ▼
Read by QxMD icon Read
search

Tslp cytokine

keyword
https://www.readbyqxmd.com/read/28214951/inhibition-of-jak-stat-pathway-restrains-tslp-activated-dendritic-cells-mediated-inflammatory-t-helper-type-2-cell-response-in-allergic-rhinitis
#1
Zhaohui Shi, Weihong Jiang, Min Wang, Xiaocheng Wang, Xiaoyuan Li, Xiaodong Chen, Li Qiao
Thymic stromal lymphopoietin (TSLP) has recently been implicated as a key molecule for initiating allergic rhinitis (AR) at the cell-dendritic cell (DC) interface. Previous studies demonstrated that TSLP activated DCs to express more OX40 ligand (OX40L), which is associated with the initiation of T helper type 2 (Th2) cell responses. STAT phosphorylation has been reported to be promoted by TSLP. Thus, we investigated if the JAK/STAT pathway inhibitor CYT387 could affect TSLP-DC-mediated Th2 cell response in naive T cell and AR mice model...
February 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28199345/impact-of-chronic-rhinosinusitis-on-severe-asthma-patients
#2
Ta-Jen Lee, Chia-Hsiang Fu, Chun-Hua Wang, Chi-Che Huang, Chien-Chia Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Chen Wu, Ching-Lung Wu, Han-Pin Kuo
Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 non-severe and 16 severe) with CRS receiving nasal surgery were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28188409/tipe2-inhibits-the-expression-of-asthma-related-inflammatory-factors-in-hyperstretched-bronchial-epithelial-cells-through-the-wnt-%C3%AE-catenin-pathway
#3
Xinrong Sun, Lu Chen, Wen Yan
Childhood asthma, an airway inflammatory disease, is a serious threat to the child's quality of life. Recently, TIPE2 expression was reported to be decreased in children with asthma. Therefore, additional studies focusing on TIPE2 might provide an approach for treating childhood asthma. In this study, we found that TIPE2 was poorly expressed in hyperstretched human bronchial epithelial cells (BEAS-2B). TIPE2 overexpression also significantly suppressed the stretch-induced secretion of asthma-related inflammatory factors (TNF-α, TSLP, MMP-9, and VEGF)...
February 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28137499/association-of-interleukin-25-levels-with-development-of-aspirin-induced-respiratory-diseases
#4
Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Da-Jeong Bae, Ji-Hye Son, Jong-Sook Park, Jae Sung Choi, Hun Gyu Hwang, Choon-Sik Park
BACKGROUND: Aspirin-exacerbated respiratory diseases (AERD) are caused by ingestion of non-steroidal anti-inflammatory drugs and are characterized by acute bronchospasms and marked infiltration of eosinophils, the latter being attributable to altered synthesis of cysteinyl leukotrienes (LT) and prostaglandins (PG). Recently, the innate Th2 response is revealed to induce eosinophil infiltration in allergic inflammation, however the role of the innate Th2 response has not been studies in AERD...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28134765/dimerized-translationally-controlled-tumor-protein-binding-peptide-ameliorates-atopic-dermatitis-in-nc-nga-mice
#5
Xing-Hai Jin, Juhyeon Lim, Dong Hae Shin, Jeehye Maeng, Kyunglim Lee
Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group...
January 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28131815/sebaceous-gland-rich-skin-is-characterized-by-tslp-expression-and-distinct-immune-surveillance-which-is-disturbed-in-rosacea
#6
Zsolt Dajnoki, Gabriella Béke, Anikó Kapitány, Gábor Mócsai, Krisztián Gáspár, Ralph Rühl, Zoltán Hendrik, István Juhász, Christos C Zouboulis, Attila Bácsi, Tamás Bíró, Dániel Törőcsik, Andrea Szegedi
The microbial community exhibits remarkable diversity on topographically distinct skin regions, which may be accompanied by differences in skin immune characteristics. Our aim was to compare the immune milieu of healthy sebaceous gland rich (SGR) and sebaceous gland poor (SGP) skin areas, and to analyze its changes in an inflammatory disease of SGR skin. For this purpose, immunohistochemical, immunocytochemical and quantitative real-time PCR analyses of thymic stromal lymphopoietin (TSLP) and other cytokines, phenotypic immune cell markers and transcription factors were carried out in samples from SGP, SGR skin and from papulopustular rosacea (PPR)...
January 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28129681/effects-of-quercetin-treatment-on-epithelium-derived-cytokines-and-epithelial-cell-apoptosis-in-allergic-airway-inflammation-mice-model
#7
Sule Caglayan Sozmen, Meral Karaman, Serap Cilaker Micili, Sakine Isik, Alper Bagriyanik, Zeynep Arikan Ayyildiz, Nevin Uzuner, Ozden Anal, Ozkan Karaman
Quercetin is a dietary flavonoid which has anti-inflammatory effects. This study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. Twenty-eight BALB/c mice were randomly divided into four groups: Group I (control), Group II (untreated mice with allergic airway inflammation), Group III (allergic airway inflammation quercetin-treated [16mg/kg/day]), Group IV (allergic airway inflammation dexamethasone-treated [1mg/kg/day])...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28124203/the-role-of-allergy-testing-in-eosinophilic-esophagitis-an-update-of-the-evidence
#8
Hamish Philpott, Francis Thien
Allergy testing has been advocated for patients with eosinophilic esophagitis (EoE) as a means of defining food triggers and directing dietary therapy. Several recent and comprehensive studies have demonstrated the futility of skin prick (SPT), skin patch (APT) and serum food antigen specific IgE (SIgE) estimates in this context. Furthermore, if identification of food triggers is the endpoint (as opposed to the ability of an allergy test-directed diet merely to induce remission), previous positive studies have limitations...
January 25, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28121465/topical-application-of-the-anti-microbial-chemical-triclosan-induces-immunomodulatory-responses-through-the-s100a8-a9-tlr4-pathway
#9
Nikki B Marshall, Ewa Lukomska, Ajay P Nayak, Carrie M Long, Justin M Hettick, Stacey E Anderson
The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies report positive associations with urinary triclosan levels and allergic disease. Although not sensitizing, earlier studies previously found that repeated topical application of triclosan augments the allergic response to ovalbumin (OVA) though a thymic stromal lymphopoietin (TSLP) pathway in mice. In the present study, early immunological effects following triclosan exposure were further evaluated following topical application in a murine model...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28115699/similarities-and-differences-in-the-transcriptional-control-of-expression-of-the-mouse-tslp-gene-in-skin-epidermis-and-intestinal-epithelium
#10
Krishna Priya Ganti, Atish Mukherji, Milan Surjit, Mei Li, Pierre Chambon
We previously reported that selective ablation of the nuclear receptors retinoid X receptor (RXR)-α and RXR-β in mouse epidermal keratinocytes (RXR-αβ(ep-/-)) or a topical application of active vitamin D3 (VD3) and/or all-trans retinoic acid (RA) on wild-type mouse skin induces a human atopic dermatitis-like phenotype that is triggered by an increased expression of the thymic stromal lymphopoietin (TSLP) proinflammatory cytokine. We demonstrate here that in epidermal keratinocytes, unliganded heterodimers of vitamin D receptor (VDR)/RXR-α and retinoic acid receptor-γ (RAR-γ)/RXR-β are bound as repressing complexes to their cognate DNA-binding sequence(s) (DBS) in the TSLP promoter regulatory region...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28115217/cysteinyl-leukotriene-e4-activates-human-ilc2s-and-enhances-the-effect-of-prostaglandin-d2-and-epithelial-cytokines
#11
Maryam Salimi, Linda Stöger, Wei Liu, Simei Go, Ian Pavord, Paul Klenerman, Graham Ogg, Luzheng Xue
BACKGROUND: Group 2 innate lymphoid cells (ILC2) are a potential innate source of type-2 cytokines in the pathogenesis of allergic conditions. Epithelial cytokines (IL-33, IL-25 and TSLP) and mast cell mediators (PGD2) are critical activators of ILC2s. Cysteinyl leukotrienes (cysLTs) including leukotriene C4 (LTC4), D4 and E4 are metabolites of arachidonic acid and mediate inflammatory responses. Their role in human ILC2s is still poorly understood. OBJECTIVES: We sought to determine the role of cysLTs and their relationship with other ILC2 stimulators in the activation of human ILC2s...
January 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28108299/mouse-model-of-hydroquinone-hypersensitivity-via-innate-and-acquired-immunity-and-its-promotion-by-combined-reagents
#12
Kanan Bando, Yukinori Tanaka, Toshinobu Kuroishi, Keiichi Sasaki, Teruko Takano-Yamamoto, Shunji Sugawara, Yasuo Endo
We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks. Then, HQ was challenged by painting onto ear-pinnas on days 7 and 14. The CHS after the 2(nd) challenge was markedly greater than that after the 1(st) challenge. Both challenges increased thymic stromal lymphopoietin (TSLP) and Th2 cytokines in ear-pinnas, while IFN-γ (typical Th1 cytokine) was decreased, despite an increase in IL-18 (typical IFN-γ inducer)...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28092372/direct-control-of-regulatory-t-cells-by-keratinocytes
#13
Mariko Kashiwagi, Junichi Hosoi, Jen-Feng Lai, Janice Brissette, Steven F Ziegler, Bruce A Morgan, Katia Georgopoulos
Environmental challenges to epithelial cells trigger gene expression changes that elicit context-appropriate immune responses. We found that the chromatin remodeler Mi-2β controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state. Mi-2β depletion resulted in rapid deployment of both a pro-inflammatory and an immunosuppressive response in the skin. A key target of Mi-2β in keratinocytes is the pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP)...
March 2017: Nature Immunology
https://www.readbyqxmd.com/read/28057434/atopic-dermatitis-immune-deviation-barrier-dysfunction-ige-autoreactivity-and-new-therapies
#14
REVIEW
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD...
January 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28049868/expression-of-epithelial-cell-derived-cytokine-genes-in-the-duodenal-and-colonic-mucosae-of-dogs-with-chronic-enteropathy
#15
Hironari Osada, Misato Ogawa, Ayana Hasegawa, Makoto Nagai, Junsuke Shirai, Kazuaki Sasaki, Minoru Shimoda, Hiroshi Itoh, Hirotaka Kondo, Keitaro Ohmori
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs...
December 29, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28005965/formaldehyde-induced-aggravation-of-pruritus-and-dermatitis-is-associated-with-the-elevated-expression-of-th1-cytokines-in-a-rat-model-of-atopic-dermatitis
#16
Rafael Taeho Han, Seung Keun Back, Hyunkyoung Lee, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Heung Sik Na
Atopic dermatitis is a complex disease of heterogeneous pathogenesis, in particular, genetic predisposition, environmental triggers, and their interactions. Indoor air pollution, increasing with urbanization, plays a role as environmental risk factor in the development of AD. However, we still lack a detailed picture of the role of air pollution in the development of the disease. Here, we examined the effect of formaldehyde (FA) exposure on the manifestation of atopic dermatitis and the underlying molecular mechanism in naive rats and in a rat model of atopic dermatitis (AD) produced by neonatal capsaicin treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27992078/basophils-and-mast-cells-are-crucial-for-reactions-due-to-epicutaneous-sensitization-to-ovalbumin
#17
Rie Yu, Ken Igawa, Yutaro Handa, Takichi Munetsugu, Takahiro Satoh, Hiroo Yokozeki
The prevalence of food allergies worldwide has increased recently. Epicutaneous sensitization to antigen could be a method to study food allergy METHODS: To clarify the mechanisms of food allergy, we established a mouse model of epicutaneous sensitization using ovalbumin. BALB/c mice were sensitized by three-time application of ovalbumin to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of ovalbumin undertaken. Rectal temperature was monitored. Blood and tissue (skin and jejunum) of challenged mice were taken...
December 19, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27967302/cutaneous-exposure-to-clinically-relevant-pigeon-pea-cajanus-cajan-proteins-promote-th2-dependent-sensitization-and-ige-mediated-anaphylaxis-in-balb-c-mice
#18
Rinkesh Kumar Gupta, Sandeep Kumar, Kriti Gupta, Akanksha Sharma, Ruchi Roy, Alok Kumar Verma, Bhushan P Chaudhari, Mukul Das, Irfan Ahmad Ansari, Premendra D Dwivedi
Epicutaneous (EC) sensitization to food allergens may occur when the skin has been lightly damaged. The study here tested whether cutaneous exposure to pigeon pea protein(s) may cause allergic sensitization. BALB/c mice were either orally gavaged or epicutaneously sensitized by repeated application of pigeon pea crude protein extract (CPE) on undamaged areas of skin without any adjuvant; afterwards, both groups were orally challenged with the pigeon pea CPE. Anaphylactic symptoms along with measures of body temperature, MCPT-1, TSLP, pigeon pea-specific IgE and IgG1, myeloperoxidase (MPO) activity, TH2 cytokines, TH2 transcription factors (TFs) and filaggrin expression were determined...
November 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27942351/therapeutic-interventions-in-severe-asthma
#19
REVIEW
Giorgio Walter Canonica, Gianenrico Senna, Patrick D Mitchell, Paul M O'Byrne, Giovanni Passalacqua, Gilda Varricchi
The present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospitalizations and Emergency Department accesses as well as expensive treatments. The recent identification of different endotypes of asthma, based on the inflammatory pattern, has led to the development of tailored treatments that target different inflammatory mediators. These are major achievements in the perspective of Precision Medicine: a leading approach to the modern treatment strategy...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27924821/critical-role-of-tslp-responsive-mucosal-dendritic-cells-in-the-induction-of-nasal-antigen-specific-iga-response
#20
S Joo, Y Fukuyama, E J Park, Y Yuki, Y Kurashima, R Ouchida, S F Ziegler, H Kiyono
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7)-like cytokine involved in T helper 2 type immune responses. The primary target of TSLP is myeloid dendritic cells (DCs), however, little is known about the mechanism by which TSLP elicits respiratory IgA immune responses upon mucosal immunization. Here, we found that the levels of TSLP and TSLPR were upregulated in the mucosal DCs of mice nasally immunized with pneumococcal surface protein A (PspA) plus cholera toxin (CT) compared with those immunized with PspA alone...
December 7, 2016: Mucosal Immunology
keyword
keyword
7248
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"