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Tslp cytokine

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https://www.readbyqxmd.com/read/29222519/virtual-screening-for-inhibitors-of-the-human-tslp-tslpr-interaction
#1
Dries Van Rompaey, Kenneth Verstraete, Frank Peelman, Savvas N Savvides, Koen Augustyns, Pieter Van Der Veken, Hans De Winter
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis. TSLP forms a ternary complex with the TSLP receptor (TSLPR) and the interleukin-7-receptor subunit alpha (IL-7Rα), thereby activating a signaling cascade that culminates in the release of pro-inflammatory mediators. In this study, we conducted an in silico characterization of the TSLP:TSLPR complex to investigate the drugability of this complex...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221590/activit%C3%A3-s-immunomodulatrice-anti-inflammatoire-antiprurigineuse-et-tol%C3%A3-rog%C3%A3-nique-induites-par-i-modulia%C3%A2-un-extrait-issu-de-culture-d%C3%A2-aquaphilus-dolomiae-dans-les-mod%C3%A3-les-pharmacologiques-de-dermatite-atopique-immunomodulatory-anti-inflammatory-anti-pruritus
#2
T Nguyen, N Castex-Rizzi, D Redoulès
Atopic dermatitis (AD) is an inflammatory and pruritic dermatosis of multifactorial origin. Topical steroids are the first line treatment for severe AD however alternatives treatment are increasingly needed. A biological concentrate was elaborated from culture of an Avène aquatic microflora isolate namely Aquaphilus dolomiae. Numerous extracts were evaluated in relevant AD in vitro models with human keratinocytes. Among these extracts, a particular one I-modulia® was found to be remarkable in terms of pharmacological activities: innate immunity modulating by agonizing Toll like receptor (TLR)2, TLR4 and TLR5, induction of anti-microbial peptides, inhibition of cytokines characteristics of T helper (Th)1, Th2 and Th17 responses, inhibition of Protease-activated-receptor (PAR) 2 and Thymic-stromal-lymphopoeitin (TSLP) both being known to be upregulated in pruritus...
January 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29217133/pge2-suppresses-human-group-2-innate-lymphoid-cell-function
#3
Jovana Maric, Avinash Ravindran, Luca Mazzurana, Åsa K Björklund, Aline Van Acker, Anna Rao, Danielle Friberg, Sven-Erik Dahlén, Akos Heinemann, Viktoria Konya, Jenny Mjösberg
BACKGROUND: Group 2 innate lymphoid cells (ILC2) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. PGE2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation. OBJECTIVE: We set out to investigate how PGE2 regulates human ILC2 function. METHODS: The effects of PGE2 on human ILC2 proliferation, intracellular cytokine and transcription factor expression were assessed by flow cytometry...
December 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29204432/caspase-1-deficiency-reduces-eosinophilia-and-interleukin-33-in-an-asthma-exacerbation-model
#4
Mandy Menzel, Hamid Akbarshahi, Irma Mahmutovic Persson, Manoj Puthia, Leif Bjermer, Lena Uller
Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted. Gene expression of caspase-1 was measured in rhinovirus-infected primary bronchial epithelial cells of asthmatic and healthy donors 24 h post-infection...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29186686/testosterone-attenuates-group-2-innate-lymphoid-cell-mediated-airway-inflammation
#5
Jacqueline-Yvonne Cephus, Matthew T Stier, Hubaida Fuseini, Jeffrey A Yung, Shinji Toki, Melissa H Bloodworth, Weisong Zhou, Kasia Goleniewska, Jian Zhang, Sarah L Garon, Robert G Hamilton, Vasiliy V Poloshukin, Kelli L Boyd, R Stokes Peebles, Dawn C Newcomb
Sex hormones regulate many autoimmune and inflammatory diseases, including asthma. As adults, asthma prevalence is 2-fold greater in women compared to men. The number of group 2 innate lymphoid cells (ILC2) is increased in patients with asthma, and we investigate how testosterone attenuates ILC2 function. In patients with moderate to severe asthma, we determine that women have an increased number of circulating ILC2 compared to men. ILC2 from adult female mice have increased IL-2-mediated ILC2 proliferation versus ILC2 from adult male mice, as well as pre-pubescent females and males...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29179209/calycosin-suppresses-epithelial-derived-initiative-key-factors-and-maintains-epithelial-barrier-in-allergic-inflammation-via-tlr4-mediated-nf-%C3%AE%C2%BAb-pathway
#6
Yu Tao, Yan Wang, Xiaoyu Wang, Can Wang, Kaifang Bao, Lv Ji, Guorong Jiang, Min Hong
BACKGROUND/AIMS: Calycosin is a bioactive component of Astragali Radix, a Chinese herb for treating allergy. We have previously demonstrated that calycosin effectively inhibited allergic inflammation efficiently. The aim of this study was to explore the mechanism of calycosin on epithelial cells in allergic inflammation. METHODS: An initial stage of atopic dermatitis (AD) model in which mice were just sensitized with FITC, was established in vivo and immortalized human keratinocytes (HaCaT cells) were utilized in vitro...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29172841/anti-inflammatory-effects-of-artemisia-scoparia-and-its-active-constituent-3-5-dicaffeoyl-epi-quinic-acid-against-activated-mast-cells
#7
Sun-Young Nam, Na-Ra Han, So-Young Rah, Youngwan Seo, Hyung-Min Kim, Hyun-Ja Jeong
OBJECTIVES: Artemisia scoparia Waldst. et Kit. (AS) has been used to treat inflammation, urticaria and hepatitis. However, the scientific studies of AS and its active compound for inflammatory reactions in activated human mast cell line, HMC-1 cells have not yet been elucidated. MATERIALS AND METHODS: Here, we isolated 3,5-dicaffeoyl-epi-quinic acid (DEQA) from AS butanol fraction. The anti-inflammatory effect of AS and its new active compound, DEQA was examined in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced thymic stromal lymphopoietin (TSLP), tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 secretion and mRNA expression by ELISA and RT-PCR, respectively...
November 27, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29163799/jak2-aberrations-in-childhood-b-cell-precursor-acute-lymphoblastic-leukemia
#8
Elisabeth M P Steeghs, Isabel S Jerchel, Willemieke de Goffau-Nobel, Alex Q Hoogkamer, Judith M Boer, Aurélie Boeree, Cesca van de Ven, Marco J Koudijs, Nicolle J M Besselink, Hester A de Groot-Kruseman, Christian Michel Zwaan, Martin A Horstmann, Rob Pieters, Monique L den Boer
JAK2 abnormalities may serve as target for precision medicines in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In the current study we performed a screening for JAK2 mutations and translocations, analyzed the clinical outcome and studied the efficacy of two JAK inhibitors in primary BCP-ALL cells. Importantly, we identify a number of limitations of JAK inhibitor therapy. JAK2 mutations mainly occurred in the poor prognostic subtypes BCR-ABL1-like and non- BCR-ABL1-like B-other (negative for sentinel cytogenetic lesions)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156718/interleukin-31-and-thymic-stromal-lymphopoietin-expression-in-plasma-and-lymph-node-from-hodgkin-lymphoma-patients
#9
Elisa Ferretti, Stefan Hohaus, Arianna Di Napoli, Beatrice Belmonte, Annarosa Cuccaro, Elisa Cupelli, Eugenio Galli, Vittoria Rufini, Gino Tripodi, Giulio Fraternali-Orcioni, Vito Pistoia, Anna Corcione
Hodgkin Lymphoma (HL) is a tumor of B-cell origin characterized by Hodgkin and Reed-Stenberg (H/RS) cells embedded in an inflammatory tissue where numerous cytokines/chemokines contribute to shape the microenvironment, leading to the typical clinical symptoms. We investigated: i) the expression of Interleukin-IL-31 (IL-31) and Thymic Stromal Lymphopoietin (TSLP), two Th2-related cytokines with tumor-promoting and pruritogenic functions, and of the respective receptors in HL invaded lymph nodes by flow cytometry, and ii) the potential association of IL-31/TSLP plasma concentrations with clinical characteristics by ELISA...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29144463/a-single-cell-survey-of-the-small-intestinal-epithelium
#10
Adam L Haber, Moshe Biton, Noga Rogel, Rebecca H Herbst, Karthik Shekhar, Christopher Smillie, Grace Burgin, Toni M Delorey, Michael R Howitt, Yarden Katz, Itay Tirosh, Semir Beyaz, Danielle Dionne, Mei Zhang, Raktima Raychowdhury, Wendy S Garrett, Orit Rozenblatt-Rosen, Hai Ning Shi, Omer Yilmaz, Ramnik J Xavier, Aviv Regev
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures. We found unexpected diversity in hormone-secreting enteroendocrine cells and constructed the taxonomy of newly identified subtypes, and distinguished between two subtypes of tuft cell, one of which expresses the epithelial cytokine Tslp and the pan-immune marker CD45, which was not previously associated with non-haematopoietic cells...
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29114386/suppression-of-inflammation-and-tissue-damage-by-a-hookworm-recombinant-protein-in-experimental-colitis
#11
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29109963/cytokine-profile-of-patients-with-allergic-rhinitis-caused-by-pollen-mite-and-microbial-allergen-sensitization
#12
Yury A Tyurin, Svetlana A Lissovskaya, Rustem S Fassahov, Ilshat G Mustafin, Anton F Shamsutdinov, Marina A Shilova, Albert A Rizvanov
Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 patients with AR was studied...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29084017/antialarmins-for-treatment-of-asthma-future-perspectives
#13
Dhuha Al-Sajee, John-Paul Oliveria, Roma Sehmi, Gail M Gauvreau
PURPOSE OF REVIEW: Recent studies have highlighted the role of alarmins in asthma pathophysiology and tested the roles of these cytokines in asthmatic patients. This review will discuss the recent advances in the role of alarmins in asthma and the potential of future targeted therapies in asthma. RECENT FINDINGS: Epithelial-derived cytokines can be released upon exposure to external stimuli, causing damage to the epithelial barrier and resulting in tissue inflammation...
October 27, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29047096/hypoxia-and-local-inflammation-in-pulmonary-artery-structure-and-function
#14
Michael Thompson, Rodney D Britt, Christina M Pabelick, Y S Prakash
Hypoxia is recognized as a contributor to pulmonary vascular diseases such as pulmonary hypertension. Hypoxia-induced inflammatory changes can enhance structural and functional changes in pulmonary artery (PA) in the context of PH. Accordingly, understanding how hypoxia and inflammation are linked in the context of pulmonary artery structure and function could be relevant towards development of novel therapies for PH. In this regard, factors such as thymic stromal lymphopoietin (TSLP), an inflammatory cytokine, and brain-derived neurotrophic factor (BDNF), a neurotrophin, have been found critical for nonvascular systems such as airway and asthma...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29031394/the-role-of-cysteinyl-leukotrienes-and-their-receptors-in-refractory-nasal-polyps
#15
Jintao Du, Luo Ba, Jiao Zhou, Lingyu Yu, Ruowu Liu, Jie Zhang, Feng Liu, Junming Xian, Shixi Liu, Yafeng Liu
Leukotriene signaling is essential in many diseases, including asthma, allergic rhinitis, atherosclerosis and inflammatory bowel disease. Nevertheless, the expression of cysteinyl leukotrienes (CysLTs) and its receptors (CYSLTRs) in different types of nasal polyps (NPs), and the role of their antagonist in the treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) are not well understood. The following study investigates the expression of CysLTs and CYSLTRs in different types of NPs, as well as the role of leukotriene receptor antagonist (montelukast) in refractory NPs...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29024606/role-of-the-tslp-dc-ox40l-pathway-in-asthma-pathogenesis-and-airway-inflammation-in-mice
#16
Shuang Feng, Li Zhang, Xu-Hua Bian, Ying Luo, Guang-Hui Qin, Rui-Ming Shi
This study aims to explore the effect of the TSLP/DC/OX40L pathway in asthma pathogenesis and airway inflammation in mice. Sixty-five male BALF/c mice were divided into the control, asthma, IgG + asthma (IgG, 500 g/500 l, intratracheal injection of 50 l each time), LY294002 (OX40L inhibitor) + asthma (intratracheal injection of 2 mg/kg LY294002), and anti-TSLP + asthma (intratracheal injection of 500 ug/500 l TSLP antibody, 50 l each time) groups. ELISA was applied to measure the serum levels of IgE, ovalbumin (OVA)-sIgE, interleukin-4 (IL-4), IL-5, IL-13 and interferon-γ (IFN-γ), flow cytometry was employed to detect Treg cells and dendritic cell (DC) and lymphopoiesis...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29017796/anti-inflammatory-effect-of-collagen-tripeptide-in-atopic-dermatitis
#17
Amiko Hakuta, Yukie Yamaguchi, Tomoko Okawa, Shoko Yamamoto, Yasuo Sakai, Michiko Aihara
BACKGROUND: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease in which type 2 allergic inflammation plays an important role. Collagen tripeptide (CTP) is a functional collagen fraction with a high content of Gly-X-Y tripeptides. OBJECTIVE: To examine the effect of CTP on inflammation in AD. METHODS: Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation...
September 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28972901/maternal-exposure-to-environmental-dehp-exacerbated-ova-induced-asthmatic-responses-in-rat-offspring
#18
Bohan Wang, Fangwei Liu, Jing Dong, Mingdan You, Yuanyuan Fu, Chao Li, Yiping Lu, Jie Chen
Di (ethylhexyl) phthalate (DEHP) is a commonly used phthalates (PAEs) compound as plasticizer and becomes a severe environmental pollutant worldwide. Studies show that DEHP, as an environmental endocrine disruptor, has potential adverse effects on human. Epidemiologic studies indicate that DEHP is positively correlated to allergic diseases. Maternal exposure to DEHP may contribute to the increasing incidence of allergic diseases in offspring. However, the role of DEHP and its detailed mechanism in allergic disease of the offspring are still unclear...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28967978/topical-glucose-induces-claudin-1-and-filaggrin-expression-in-a-mouse-model-of-atopic-dermatitis-and-in-keratinocyte-culture-exerting-anti-inflammatory-effects-by-repairing-skin-barrier-function
#19
Kiyoko Yamada, Kenji Matsushita, Wang Jingshu, Takuro Kanekura
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed. This study examined the effect of topical application of high-dose glucose on inflamed skin in a murine model of AD. High-dose glucose treatment on the ear reduced dermatitis scores and ear thicknesses in mite antigen-treated NC/Nga mice. The levels of thymus and activation-regulated chemokine (TARC), Th cytokines (interleukin (IL)-4, IL-5, IL-12, IL-13, and (interferon) IFN-γ), and IgE were decreased in the serum of high-dose glucose-treated mice...
October 2, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28966674/tlr4-antagonist-suppresses-airway-remodeling-in-asthma-by-inhibiting-the-t-helper-2-response
#20
Ming Li, Zhao-Ni Wang, Li-Fen Yang, Yan Yan, Liang-Ming Cai, Ya-Ting Li, Yong-Kang Qiao, Zhuang-Gui Chen
Airway remodeling is a hallmark of bronchial asthma. Our group has previously reported that the thymic stromal lymphopoietin (TSLP), an airway epithelial-derived cytokine, has a central role in the pathogenesis of airway remodeling, and that toll-like receptor (TLR) 4 signaling in epithelial cells may trigger T-helper 2 (Th2) immune responses by overexpression of TSLP. However, it is currently unclear whether TLR4 is a target in the treatment of airway remodeling in asthma. The present study established a house dust mite (HDM)-induced chronic asthmatic model in female BALB/c mice and treated the HDM-exposed mice with 3 mg/kg TAK242, as a TLR4 antagonist, 30 min prior to HDM challenge for up to 2 weeks...
October 2017: Experimental and Therapeutic Medicine
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