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indeterminate colitis

David L Suskind, Ghassan Wahbeh, Stanley A Cohen, Christopher J Damman, Jani Klein, Kim Braly, Michele Shaffer, Dale Lee
BACKGROUND: Recent studies suggest that dietary therapy may be effective for patients with inflammatory bowel disease (IBD), but limited published data exist on the usage and efficacy of dietary therapy. AIM: To evaluate the perspective of IBD patients using the specific carbohydrate diet (SCD). METHODS: An anonymous online survey was conducted using REDCap, a Web-based survey tool. Survey links were sent to known Web sites as well as support groups in an attempt to characterize patient utilization of the SCD and perception of efficacy of the SCD...
November 2016: Digestive Diseases and Sciences
Nicholas Horton, Xianrui Wu, Jessica Philpott, Ari Garber, Jean-Paul Achkar, Aaron Brzezinski, Bret A Lashner, Bo Shen
BACKGROUND: Inflammatory bowel diseases (IBDs) are considered immune-mediated disorders with dysregulated innate and adaptive immunities. Secondary immunogloblin deficiency can occur in IBD and its impact on the disease course of IBD is not clear. AIMS: We sought to determine associations between low IgG/G1 levels and poor clinical outcomes in IBD patients. METHODS: This historic cohort study was performed on IBD patients with obtained IgG/IgG1 levels...
November 2016: Digestive Diseases and Sciences
J R Ten Hove, E Mooiweer, E Dekker, A E van der Meulen-de Jong, G J A Offerhaus, C Y Ponsioen, P D Siersema, B Oldenburg
BACKGROUND & AIMS: When dysplastic lesions are encountered during surveillance colonoscopy of patients with inflammatory bowel diseases (IBD), guidelines recommend collection of additional biopsies from the surrounding mucosa, to ensure the lesion has been adequately circumscribed. We aimed to determine the rate of dysplasia in mucosa biopsies collected from tissues surrounding dysplastic lesions during IBD surveillance. METHODS: In a retrospective study, we collected endoscopy and pathology reports from 1065 patients undergoing colonoscopic surveillance for IBD, from 2000 through 2015, at 3 centers in the Netherlands...
September 6, 2016: Clinical Gastroenterology and Hepatology
Monika Fischer, Dina Kao, Colleen Kelly, Aishwarya Kuchipudi, Syed-Mohammed Jafri, Mark Blumenkehl, Douglas Rex, Mark Mellow, Nirmal Kaur, Harry Sokol, Gwen Cook, Matthew J Hamilton, Emmalee Phelps, Brian Sipe, Huiping Xu, Jessica R Allegretti
BACKGROUND: New treatments are needed as Clostridium difficile infection (CDI) is becoming increasingly formidable. Fecal microbiota transplantation (FMT) has a 90% success rate in the treatment of recurrent CDI. However, evidence regarding its safety, efficacy, and effect on disease activity in patients with inflammatory bowel disease (IBD) is lacking. METHODS: This cohort study used data from 8 national and international academic centers. Patients with established IBD who underwent FMT for recurrent CDI were followed for a minimum of 3 months...
October 2016: Inflammatory Bowel Diseases
Noa Krugliak Cleveland, Dylan Rodriquez, Alana Wichman, Isabella Pan, Gil Y Melmed, David T Rubin
BACKGROUND: Current guidelines emphasize vaccination for influenza and pneumococcus for IBD patients and the avoidance of live virus vaccines for those who are on immunosuppressive (ISS) therapy. Given the recent resurgence of measles and pertussis infections, we assessed the immune status of our IBD population in order to advise about these risks. METHODS: We prospectively collected measles and pertussis titers in our IBD patients from February 1-May 1, 2015. Immune status based on standard threshold values was determined: measles antibodies ≤0...
October 2016: Digestive Diseases and Sciences
Pamela L Valentino, Shanna Wiggins, Sarah Harney, Roshan Raza, Christine K Lee, Maureen M Jonas
OBJECTIVES: Data regarding pediatric PSC natural history are limited. We describe a large pediatric PSC cohort with longitudinal follow-up. METHODS: Records review of pediatric PSC patients diagnosed between 1984 and 2014. RESULTS: N = 120 (63% M) aged 1-21y (median 14y) at diagnosis. 27% (31/113) had ASC (autoimmune sclerosing cholangitis), 24% had exclusive small duct PSC, METAVIR stage was F3-F4 in 41%. 81% of PSC patients had IBD; most had ulcerative/indeterminate colitis (72/97), typically pancolitis (40/72)...
August 6, 2016: Journal of Pediatric Gastroenterology and Nutrition
Ho-Su Lee, Jaewon Choe, Hyo Jeong Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Kim, Suk-Kyun Yang
BACKGROUND/AIMS: Accurately diagnosing inflammatory bowel disease (IBD) remains a challenge, but is crucial for providing proper management for affected patients. The aim of the present study was to evaluate the frequency of change in diagnosis in Korean patients who were referred to our institution with a diagnosis of IBD. METHODS: We enrolled 1,444 patients diagnosed with ulcerative colitis (UC) and 1,452 diagnosed with Crohn's disease (CD), who had been referred to the Asan Medical Center between January 2010 and December 2014...
July 2016: Intestinal Research
Anet A Soubières, Andrew Poullis
There is currently no single test available to confidently diagnose cases of inflammatory bowel disease (IBD). Physicians rely on a number of diagnostic tools, including clinical evaluation, serum testing, and imaging, which are used on conjunction with endoscopic evaluation. It is often difficult to determine whether patients with abdominal pain and change in bowel habit have functional bowel symptoms or whether they have a true diagnosis of IBD. Even once a diagnosis of IBD has been made, a significant proportion of patients are labeled with the term "indeterminate colitis" where histological sampling cannot confidently subclassify patients as either Crohn's or ulcerative colitis...
August 2016: Inflammatory Bowel Diseases
Mohannad Dugum, Jingmei Lin, Rocio Lopez, Bassam Estfan, Elena Manilich, Luca Stocchi, Bo Shen, Xiuli Liu
BACKGROUND AND AIM: Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC). Studies have shown tumorigenetic and histomorphological differences between IBD-associated CRC and non-IBD CRC, suggesting differences in tumor behavior and response to treatment. We aimed to compare tumor recurrence and survival rates following postoperative chemotherapy in CRC patients with and without IBD. METHODS: Search of the Cleveland Clinic's CRC database revealed 65 patients who had IBD-associated CRC and received postoperative adjuvant chemotherapy between 1994 and 2010...
June 8, 2016: Gastroenterology Report
Edyta Szymańska, Sylwia Szymańska, Michał Szczepański, Piotr Landowski, Grażyna Czaja-Bulsa, Elżbieta Jarocka-Cyrta, Bartosz Korczowski, Elżbieta Krzesiek, Jarosław Kierkuś
INTRODUCTION: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition of the colon and small intestine. The disease is common in young people (children and young adults), but it is rare in children younger than five years of age. Therefore, IBD developing during the first years of life (under the age of 5) is known as an early-onset IBD (EO-IBD), and it is considered to be a specific entity with a distinct phenotype. However, the available data on that issue are still insufficient...
2016: Przegla̜d Gastroenterologiczny
Jessica N Kimmel, Tiffany H Taft, Laurie Keefer
Objective. Patients with inflammatory bowel disease (IBD) are at increased risk from skin cancer. Aims include assessing IBD patients' risk factors and knowledge of skin cancer and current skin protection practices to identify gaps in patient education regarding skin cancer prevention in IBD. Methods. IBD patients ≥ 18 years were recruited to complete an online survey. Results. 164 patients (mean age 43.5 years, 63% female) with IBD (67% Crohn's disease, 31% ulcerative colitis, and 2% indeterminate colitis) were included...
2016: Journal of Skin Cancer
A S Tertychnyi, K H M Akhrieva, O V Zairat'yants, L S Selivanova, T M Birg
AIM: to investigate the specific features of somatostatin receptor expression in the ileal mucosa of patients with inflammatory bowel disease (IBD). MATERIAL AND METHODS: Ileal biopsy specimens from 42 patients aged 22 to 55 years, including 16 patients with Crohn's disease (CD), 14 with indeterminate colitis of IBD unclassified (IBDU), and 12 with the unchanged ileal mucosa (a comparison group). Immunohistochemical examination was performed using anti-somatostatin receptor type 2 (SSTR-2) antibodies (Epitomics, USA)...
January 2016: Arkhiv Patologii
A W Shand, J S Chen, W Selby, M Solomon, C L Roberts
OBJECTIVE: To determine the prevalence of the inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), in pregnant women and determine pregnancy and fetal/neonatal outcomes. DESIGN: Population-based cohort study. SETTING: New South Wales, Australia, 2001-11. POPULATION: A total of 630 742 women who delivered at ≥20 weeks of gestation. METHODS: Descriptive and multivariate regression analyses of perinatal data linked to hospital admission data...
October 2016: BJOG: An International Journal of Obstetrics and Gynaecology
J Murphy, K A Kalkbrenner, J V Blas, J H Pemberton, R G Landmann, T M Young-Fadok, D A Etzioni
AIM: Surgery aims to prevent cancer-related morbidity for patients with ulcerative colitis (UC) associated dysplasia. The literature varies widely regarding the likelihood of dysplastic progression to higher grades of dysplasia or cancer. The aim of this study was to characterize the likelihood of the development of colorectal cancer (CRC) of patients with UC-associated dysplasia who chose to defer surgery. METHOD: A retrospective review was carried out of patients undergoing surgery for UC at the Mayo Clinic, who were diagnosed to have dysplasia between August 1993 and July 2012...
July 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Steffen U Thorsen, Christian Jakobsen, Arieh Cohen, Marika Lundqvist, Lau C Thygesen, Christian Pipper, Alberto Ascherio, Jannet Svensson
Objective Basic and epidemiologic studies on inflammatory bowel disease (IBD) have suggested an association between vitamin D and IBD risk. Though, the literature on IBD - especially pediatric-onset IBD - and vitamin D is still in its cradle. We therefore wanted to examine if levels of 25(OH)D at birth were associated with increased risk of developing pediatric-onset IBD. Material and methods A case-cohort study composed of cases diagnosed with Crohn's disease, ulcerative colitis or indeterminate/unclassified colitis and healthy controls...
August 2016: Scandinavian Journal of Gastroenterology
Irene Franceschet, Nora Cazzagon, Teresa Del Ross, Renata D'Incà, Alessandra Buja, Annarosa Floreani
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with a strong association with inflammatory bowel disease (IBD). Medical treatment for PSC is still disappointing, whereas immunomodulators and biologics have been proven to be effective in IBD. AIMS: This study aimed to analyze (i) the natural history of patients with PSC with or without IBD and (ii) the long-term efficacy of biologics in patients with PSC and concomitant IBD or rheumatological disorders...
May 2016: European Journal of Gastroenterology & Hepatology
Kristen Plantz, Elizabeth Maxwell, Petar Mamula, Robert Baldassano, Ronen Stein
BACKGROUND: Iron deficiency anemia (IDA) is a common complication of pediatric inflammatory bowel disease (IBD). The effectiveness of oral iron supplementation in the treatment of IDA is limited by its slow onset of action, daily dosing, gastrointestinal side effects, and potential for exacerbation of intestinal inflammation. Intravenous iron sucrose (IS) is an effective and safe alternative treatment for IDA in adults with IBD, but its role in the treatment of IDA in pediatric IBD is unclear...
March 2016: Inflammatory Bowel Diseases
Miriam F Gasia, Subrata Ghosh, Remo Panaccione, Jose G Ferraz, Gilaad G Kaplan, Yvette Leung, Kerri L Novak, Cynthia H Seow, Marietta Iacucci
BACKGROUND & AIMS: It is unclear what are the best and most appropriate endoscopic procedures for detecting colonic neoplasia in patients with long-term colonic inflammatory bowel disease (IBD). Dye chromoendoscopy (DCE) is the standard used in IBD surveillance colonoscopies. However, studies are needed to determine the optimal endoscopic technique for detecting dysplastic lesions. We investigated current practices used in surveillance colonoscopies by IBD gastroenterologists at a single tertiary center...
May 2016: Clinical Gastroenterology and Hepatology
Ana I Robles, Giovanni Traverso, Ming Zhang, Nicholas J Roberts, Mohammed A Khan, Christine Joseph, Gregory Y Lauwers, Florin M Selaru, Maria Popoli, Meredith E Pittman, Xiquan Ke, Ralph H Hruban, Stephen J Meltzer, Kenneth W Kinzler, Bert Vogelstein, Curtis C Harris, Nickolas Papadopoulos
BACKGROUND & AIMS: A long duration of inflammatory bowel disease (IBD) increases the risk for colorectal cancer. Mutation analysis of limited numbers of genes has indicated that colorectal tumors that develop in patients with IBD differ from those of patients without IBD. We performed whole-exome sequencing analyses to characterize the genetic landscape of these tumors. METHODS: We collected colorectal tumor and non-neoplastic tissues from 31 patients with IBD and colorectal cancer (15 with ulcerative colitis, 14 with Crohn's disease, and 2 with indeterminate colitis) and performed whole-exome sequencing analyses of the microdissected tumor and matched nontumor tissues...
April 2016: Gastroenterology
Carol S Brotherton, Christopher A Martin, Millie D Long, Michael D Kappelman, Robert S Sandler
BACKGROUND & AIMS: Chronic inflammatory bowel diseases (IBDs) have been associated with an abnormal mucosal response to the gastrointestinal microbiota. Although dietary fiber affects the gastrointestinal microbiota, there is limited information on the role of fiber on IBD activity. We investigated factors associated with fiber consumption and whether it was associated with flares in patients with IBD. METHODS: We collected a completed 26-item dietary survey from 1619 participants in the Crohn's and Colitis Foundation of America Partners Internet cohort (Crohn's disease, 1130; ulcerative colitis/indeterminate colitis, 489)...
August 2016: Clinical Gastroenterology and Hepatology
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