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maternal tolerance

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https://www.readbyqxmd.com/read/29149482/melatonin-alleviates-low-ps-i-limited-carbon-assimilation-under-elevated-co2-and-enhances-the-cold-tolerance-of-offspring-in-chlorophyll-b-deficient-mutant-wheat
#1
Xiangnan Li, Marian Brestic, Dun-Xian Tan, Marek Zivcak, Xiancan Zhu, Shengqun Liu, Fengbin Song, Russel J Reiter, Fulai Liu
Melatonin is involved in the regulation of carbohydrate metabolism and induction of cold tolerance in plants. The objective of this study was to investigate the roles of melatonin in modulation of carbon assimilation of wild type wheat and the Chl b-deficient mutant ANK32B in response to elevated CO2 concentration ([CO2 ]) and the transgenerational effects of application of exogenous melatonin (hereafter identified as melatonin priming) on the cold tolerance in offspring. The results showed that the melatonin priming enhanced the carbon assimilation in ANK32B under elevated [CO2 ], via boosting the activities of ATPase and sucrose synthesis and maintaining a relatively higher level of total chlorophyll concentration in leaves...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29146992/pre-pregnancy-overweight-or-obesity-and-gestational-diabetes-as-predictors-of-body-composition-in-offspring-twenty-years-later-evidence-from-two-birth-cohort-studies
#2
N Kaseva, M Vääräsmäki, H-M Matinolli, M Sipola-Leppänen, M Tikanmäki, K Heinonen, A Lano, D Wolke, S Andersson, M-R Järvelin, K Räikkönen, G Eriksson Johan, E Kajantie
BACKGROUND: Global prevalence of overweight/obesity and gestational diabetes (GDM) is increasing. In pregnant women both conditions affect offspring's later health. Overweight/obesity is a risk factor of GDM; to what extent maternal overweight/obesity explains long-term effects of GDM in offspring is unknown. OBJECTIVE: To evaluate effects of maternal pre-pregnancy overweight/obesity (BMI ⩾25 kg/m(2)) and GDM, occurring together or separately, on body composition among adult offspring...
November 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29123519/two-distinct-myeloid-subsets-at-the-term-human-fetal-maternal-interface
#3
Maria Laura Costa, Michelle L Robinette, Mattia Bugatti, Mark S Longtine, Bryanne N Colvin, Erica Lantelme, William Vermi, Marco Colonna, D Michael Nelson, Marina Cella
During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types. These immune cells play pleiotropic roles, as they control spiral artery remodeling to ensure appropriate blood supply and maintain long-term tolerance to a true allograft; yet, they must be able to mount appropriate immune defenses to pathogens that may threaten the fetus. Whether the same cell type accomplishes all these tasks or if there are dedicated subsets remains controversial...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29118817/maternal-high-fat-diet-impairs-glucose-metabolism-%C3%AE-cell-function-and-proliferation-in-the-second-generation-of-offspring-rats
#4
Yan-Hong Huang, Ting-Ting Ye, Chong-Xiao Liu, Lei Wang, Yuan-Wen Chen, Yan Dong
Background: This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2). Methods: F0 rats were fed with a standard chow (SC) or HF diet for 8 weeks before mating, up to termination of lactation for their first-generation of offspring (F1-SC and F1-HF). F1 females were mated with normal males at the age of week 11, and producing F2 offspring (F2-SC, F2-HF)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29118320/nicotinamide-mononucleotide-nmn-supplementation-ameliorates-the-impact-of-maternal-obesity-in-mice-comparison-with-exercise
#5
Golam Mezbah Uddin, Neil A Youngson, Bronte M Doyle, David A Sinclair, Margaret J Morris
Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD(+)). We have shown that the NAD(+) precursor, nicotinamide mononucleotide (NMN) can reverse some of the negative consequences of high fat diet (HFD) consumption. To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114525/the-effect-of-maternal-forced-exercise-on-offspring-pain-perception-motor-activity-and-anxiety-disorder-the-role-of-5-ht2-and-d2-receptors-and-creb-gene-expression
#6
Ozra Motaghinejad, Majid Motaghinejad, Manijeh Motevalian, Fatemeh Rahimi-Sharbaf, Tabassom Beiranvand
The effect of maternal forced exercise on central disorders in offsprings has been shown but the mechanism is still unclear. In this study, the role of 5-HT2 and D2 receptors in neuroprotective effects of maternal forced exercise on offspring neurodevelopment and neurobehavioral symptoms is evaluated. Sixty pregnant rats were trained by forced exercise and some behavioral and molecular aspects in their offspring were evaluated in presence of 5-HT2 and D2 receptors agonists and antagonists. The results showed that maternal forced exercise causes increase of pain tolerability and increase latency of pain perception in offspring in hot plate test, writhing test and tail flick test...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29114267/the-best-cut-off-value-for-hba1c-as-a-screening-tool-in-iranian-women-with-gestational-diabetes-mellitus
#7
Seyedeh Neda Mousavi, Koorosh Kamali, Motahareh Mirbazel, Maryam Jameshorani
Objective: Gestational diabetes mellitus (GDM) is a prevalent disorder which increases maternal and fetal complications. The oral glucose tolerance test (OGTT) is a traditional, time -consuming and intensive test which is poorly tolerated by pregnant women. To date, increasing evidence considered HbA1c as a screening tool and reported various cut-off values in different populations. In alignment with existing literature, we determined for the first time, the optimal cut-off value for HbA1c in Iranian women with GDM...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29110075/maternal-experience-and-soil-origin-influence-interactions-between-resident-species-and-a-dominant-invasive-species
#8
Gisela C Stotz, Ernesto Gianoli, James F Cahill
Invasive species dominance in invaded communities may not be long-lasting due to regulatory processes, such as plant-soil feedbacks and neighboring species adaptation. Further, the change in species competitive ability may be contingent upon neighbor identity (i.e., specialized response) or consistent across neighbors (i.e., generalized response). Specialized responses can facilitate overall coexistence, while generalized responses may result in competitive exclusion. We set up a greenhouse experiment to test, in three species, the effect of soil conditions (non-invaded vs...
November 6, 2017: Oecologia
https://www.readbyqxmd.com/read/29103944/short-sleep-duration-and-hyperglycemia-in-pregnancy-aggregate-and-individual-patient-data-meta-analysis
#9
REVIEW
Sirimon Reutrakul, Thunyarat Anothaisintawee, Sharon J Herring, Bilgay Izci Balserak, Isabelle Marc, Ammarin Thakkinstian
Short sleep duration has been linked to maternal hyperglycemia. Systematic review and meta-analysis were performed to evaluate the relationship between sleep duration and hyperglycemia in pregnancy or gestational diabetes (GDM). MEDLINE and Scopus were searched until July 2017. Studies that assessed sleep duration and had objective measurements of hyperglycemia during pregnancy were eligible. Aggregate data were available from eight studies, n = 17,308 (seven with self-reported and one with objectively measured sleep duration)...
October 5, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29098391/fetal-sex-influences-maternal-fasting-plasma-glucose-levels-and-basal-%C3%AE-cell-function-in-pregnant-women-with-normal-glucose-tolerance
#10
Xinqian Geng, Lulu Geng, Yinan Zhang, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Minfang Tao, Congrong Wang, Weiping Jia
AIMS: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. METHODS: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29097593/maternal-loading-of-a-small-heat-shock-protein-increases-embryo-thermal-tolerance-in-drosophila-melanogaster
#11
Brent L Lockwood, Cole R Julick, Kristi L Montooth
Maternal investment is likely to have direct effects on offspring survival. In oviparous animals whose embryos are exposed to the external environment, maternal provisioning of molecular factors like mRNAs and proteins may help embryos cope with sudden changes in the environment. Here we sought to modify the maternal mRNA contribution to offspring embryos and test for maternal effects on acute thermal tolerance in early embryos of Drosophila melanogaster We drove in vivo overexpression of a small heat shock protein gene (Hsp23) in female ovaries and measured the effects of acute thermal stress on offspring embryonic survival and larval development...
November 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29092663/high-granulocytic-myeloid-derived-suppressor-cell-levels-in-the-peripheral-blood-predict-a-better-ivf-treatment-outcome
#12
Mengchen Zhu, Xiaomin Huang, Shanling Yi, Haixiang Sun, Jianjun Zhou
OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) have been described as important immunosuppressive cells for maternal immune tolerance. The aim of this study was to detect whether there was any association between the peripheral blood MDSCs level and IVF treatment outcomes. METHODS: This prospective observational study randomly recruited 85 women who underwent IVF treatment from May 2016 to June 2016. The levels of peripheral blood G-MDSC, M-MDSC and their relations to IVF treatment outcomes were analyzed...
November 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29092048/intragenomic-conflict-and-immune-tolerance-do-selfish-x-linked-alleles-drive-skewed-x-chromosome-inactivation
#13
Scott W Roy
In mammalian females, diploid somatic cells contain two X chromosomes, one of which is transcriptionally silenced, in a process termed X chromosome inactivation (XCI). While XCI is largely random in placental females, many women exhibit skewed XCI (SXCI), in which the vast majority cells have the same X chromosome inactivated. SXCI has serious health consequences, associated with conditions ranging from Alzheimer's to various autoimmune disorders. SXCI is also associated with outcomes of pregnancies, with higher rates of recurrent spontaneous abortion in women with SXCI...
October 30, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29078256/predicting-persistent-impaired-glucose-tolerance-in-gdm-women-the-role-of-hscrp-and-adiponectin
#14
Celeste P Durnwald, Katheryne Downes, Rita Leite, Michal Elovitz, Samuel Parry
BACKGROUND: To evaluate whether maternal serum adiponectin and high-sensitivity C-reactive protein (hsCRP) levels at the time of gestational diabetes (GDM) diagnosis are associated with persistent glucose intolerance in GDM women at 6-12 weeks postpartum. METHODS: This is a secondary analysis of prospective randomized trial of GDM women enrolled in a behavior education program. Women with a GDM diagnosis ≥ 20 weeks were included. At the time of randomization, serum adiponectin and hsCRP levels were drawn...
October 27, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29073617/preimplantation-factor-pif-promotes-hla-g-e-f-c-expression-in-jeg-3-choriocarcinoma-cells-and-endogenous-progesterone-activity
#15
Miya Soukaina Hakam, Jose Maria Miranda-Sayago, Soren Hayrabedyan, Krassimira Todorova, Patrick Simon Spencer, Asma Jabeen, Eytan R Barnea, Nelson Fernandez
BACKGROUND/AIMS: Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of PreImplantation Factor (PIF), a novel peptide secreted by viable embryos, correlate with embryo development, and its early detection in circulation correlates with a favourable pregnancy outcome. PIF enhances endometrial receptivity to promote embryo implantation. Via the p53 pathway, it increases trophoblast invasion, improving cell survival / immune privilege...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29065432/preimplantation-factor-pif-regulates-stress-induced-adrenal-steroidogenesis-and-anti-inflammatory-cytokines-potential-application-for-bioartificial-adrenal-transplant
#16
Mariya Balyura, Evgeny Gelfgat, Enrico Ullmann, Barbara Ludwig, Eytan R Barnea, Stefan R Bornstein
The main treatment algorithm for adrenal insufficiency is hormonal replacement, however, inadequate hormone substitution often leads to severe side effects. Adrenal cell transplantation could be a more effective alternative but would require life-long immune suppressive therapy. PreImplantation Factor (PIF) is an endogenous peptide secreted by viable human embryos that leads to maternal tolerance without immunosuppression. PIF could be effective for xenogeneic cell transplantation such as of bovine adrenocortical cells (BAC), which are used for bioartificial adrenal gland development that may more effectively restore complex adrenal functions...
October 24, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29062316/preterm-birth-affects-the-risk-of-developing-immune-mediated-diseases
#17
Sybelle Goedicke-Fritz, Christoph Härtel, Gabriela Krasteva-Christ, Matthias V Kopp, Sascha Meyer, Michael Zemlin
Prematurity affects approximately 10% of all children, resulting in drastically altered antigen exposure due to premature confrontation with microbes, nutritional antigens, and other environmental factors. During the last trimester of pregnancy, the fetal immune system adapts to tolerate maternal and self-antigens, while also preparing for postnatal immune defense by acquiring passive immunity from the mother. Since the perinatal period is regarded as the most important "window of opportunity" for imprinting metabolism and immunity, preterm birth may have long-term consequences for the development of immune-mediated diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29058058/maternal-early-pregnancy-plasma-concentration-of-25-hydroxyvitamin-d-and-risk-of-gestational-diabetes-mellitus
#18
Changen Xu, He-Hong Ma, Yao Wang
We examined whether 25-Hydroxyvitamin D [25(OH) D] concentrations, measured at the first prenatal visit, would be associated with risk of gestational diabetes mellitus (GDM). From July 2015 to June 2016, consecutive women who admitted to the two-obstetrics center in china were included. Relevant data were collected between 24 and 28 weeks of gestation, including fasting plasma glucose (FPG) and 25(OH) D concentrations at the first prenatal visit and the one-step GDM screened with 75-g oral glucose tolerance test (OGTT)...
October 22, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29055791/the-role-of-decidual-immune-cells-on-human-pregnancy
#19
REVIEW
Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng, Joanne Y H Kwak-Kim
The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8(+) T cells, effector CD4(+) T cells, Foxp3(+) regulatory T cells and CD4(+)HLA-G(+) suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus...
October 18, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29049918/dc-sign-expression-in-hofbauer-cells-may-play-an-important-role-in-immune-tolerance-in-fetal-chorionic-villi-during-the-development-of-preeclampsia
#20
Seung Woo Yang, Eun Hee Cho, So Young Choi, Yun Kyung Lee, Jae Hyun Park, Min Kyung Kim, Jin Yeon Park, Hyeong Jwa Choi, Jeong Ik Lee, Hyun Myung Ko, Seung Hwa Park, Han Sung Hwang, Young Sun Kang
Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of maternal mortality in the field of obstetrics, and the innate immunological role of maternal decidual macrophages is well known. In this study, we assessed the differential phenotypes and marker expression in fetal macrophages, known as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)-positive Hofbauer cells...
September 28, 2017: Journal of Reproductive Immunology
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