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https://www.readbyqxmd.com/read/29780140/fulminant-type-1-diabetes-mellitus-presenting-15-days-after-delivery-diagnosed-in-cooperation-with-obstetricians
#1
Junji Sagawa, Yoko Yoshii, Mitsunobu Kubota
The patient was a 32-year-old Japanese woman who was given a 75-g oral glucose tolerance test at the 35th week of pregnancy and was normoglycemic. She had excessive thirst and polyuria from 15 days after delivery. When she visited for the 1-month postpartum checkup, her plasma glucose level was 479 mg/dL, HbA1c was 7.4%, and urinary C-peptide was 1.1 μg/mL; she was therefore diagnosed with fulminant type 1 diabetes mellitus associated with pregnancy. All physicians should be aware of this disease so as to provide a prompt diagnosis and emergency treatment and consequently improve the maternal prognosis...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29777276/prophylactic-placement-of-internal-iliac-balloons-in-patients-with-abnormal-placental-implantation-maternal-and-foetal-outcomes
#2
Patrick J Nicholson, Owen O'Connor, John Buckley, Liam D Spence, Richard A Greene, David J Tuite
PURPOSE: To report on outcomes following the use of prophylactic internal iliac artery occlusion balloons in patients with abnormal placental implantation. METHODS: A retrospective analysis was undertaken of patients with abnormal placental implantation who underwent prophylactic iliac balloon placement prior to delivery in a University Maternity Hospital. Various clinical and technical factors were analysed, including technical success of balloon placement, blood loss and number of blood units transfused, duration of surgery, length of stay, hysterectomy rates, complications related to the balloon insertion, foetal pH and infant Apgar scores...
May 18, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29773207/poor-sleep-during-early-pregnancy-increases-subsequent-risk-of-gestational-diabetes-mellitus
#3
Chunrong Zhong, Renjuan Chen, Xuezhen Zhou, Shangzhi Xu, Qian Li, Wenli Cui, Weiye Wang, Xiating Li, Jiangyue Wu, Chaoqun Liu, Mei Xiao, Guoqiang Sun, Xuefeng Yang, Liping Hao, Nianhong Yang
OBJECTIVES: To examine the relationship between poor sleep quality during pregnancy and the risk of gestational diabetes mellitus (GDM). METHODS: A total of 4066 singleton pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC) without overt diabetes before pregnancy were analyzed. Sleep quality and duration during early pregnancy were self-reported by enrolled women at their first antenatal care visit before 16 weeks of gestation. Gestational diabetes mellitus (GDM) was assessed with a 75-g, 2-h oral glucose tolerance test at 24-28 weeks of gestation...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29763854/inhibition-of-pregnancy-associated-granulocytic-myeloid-derived-suppressor-cell-expansion-and-arginase-1-production-in-preeclampsia
#4
Yinan Wang, Yanhou Liu, Chang Shu, Jiya Wan, Yanhong Shan, Xinyi Zhi, Liguang Sun, Huanfa Yi, Yong-Guang Yang, Jin He
Myeloid-derived suppressor cells (MDSCs) expand in maternal peripheral blood and cord blood during normal pregnancy to maintain maternal-fetal tolerance. Here we investigated the expansion and function of MDSCs in preeclampsia (PE) patients. Maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) were sampled from healthy pregnant women and PE patients, and analyzed for the frequencies and phenotypes of MDSCs and T cells. Serum levels of key human MDSC effector enzymes were measured using appropriate detection kits...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29760169/dysbiosis-of-maternal-and-neonatal-microbiota-associated-with-gestational-diabetes-mellitus
#5
Jinfeng Wang, Jiayong Zheng, Wenyu Shi, Nan Du, Xiaomin Xu, Yanming Zhang, Peifeng Ji, Fengyi Zhang, Zhen Jia, Yeping Wang, Zhi Zheng, Hongping Zhang, Fangqing Zhao
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected...
May 14, 2018: Gut
https://www.readbyqxmd.com/read/29756666/abnormal-lymphatic-vessel-development-is-associated-with-decreased-decidual-regulatory-t-cells-in-severe-preeclampsia
#6
Yun Ji Jung, Yejin Park, Hyun-Soo Kim, Hwa Jin Lee, Yoo-Na Kim, JoonHo Lee, Young-Han Kim, Yong-Sun Maeng, Ja-Young Kwon
PROBLEM: The lymphatic vasculature controls leukocytes trafficking and limits the adaptive immune response. In previous models of preeclampsia (PE), defective immune function caused by disruption of lymphangiogenesis was shown to be involved in the disease pathophysiology. Especially, the dysfunction of regulatory T cells (Treg) at the maternal-fetal interface may be one of the causes of severe PE. In particular, activation of Tregs to obtain immune tolerance requires adequate antigen presentation through the lymphatic system...
May 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29746846/o-linked-n-acetyl-glucosamine-deposition-in-placental-proteins-varies-according-to-maternal-glycemic-levels
#7
Vanessa Dela Justina, Rinaldo R Dos Passos Junior, Alecsander F Bressan, Rita C Tostes, Fernando S Carneiro, Thaigra S Soares, Gustavo T Volpato, Victor Vitorino Lima, Sebastian San Martin, Fernanda R Giachini
AIMS: Hyperglycemia increases glycosylation with O-linked N‑acetyl‑glucosamine (O-GlcNAc) contributing to placental dysfunction and fetal growth impairment. Our aim was to determine how O-GlcNAc levels are affected by hyperglycemia and the O-GlcNAc distribution in different placental regions. MAIN METHODS: Female Wistar rats were divided into the following groups: severe hyperglycemia (>300 mg/dL; n = 5); mild hyperglycemia (>140 mg/dL, at least than two time points during oral glucose tolerance test; n = 7) or normoglycemia (<120 mg/dL; n = 6)...
May 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29741731/expression-of-grim-19-in-unexplained-recurrent-spontaneous-abortion-and-possible-pathogenesis
#8
Yang Yang, Laiyang Cheng, Xiaohui Deng, Hongling Yu, Lan Chao
STUDY QUESTION: Is aberrant expression of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) associated with unexplained recurrent spontaneous abortion (URSA)? SUMMARY ANSWER: GRIM-19 deficiency may regulate regulatory T cell/ T helper 17 cell (Treg/Th17) balance partly through reactive oxygen species (ROS) - mammalian target of rapamycin (mTOR) signaling axis in URSA. WHAT IS KNOWN ALREADY: Immunological disorders may cause impaired maternal immune tolerance to the fetus and result in fetal rejection...
May 8, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29739812/risk-factors-for-hyperglycemia-in-pregnancy-in-the-dali-study-differ-by-period-of-pregnancy-and-ogtt-time-point
#9
Lilian C Mendoza, Jürgen Harreiter, David Simmons, Gernot Desoye, Juan María Adelantado, Fabiola Juarez, Ana Chico, Roland Devlieger, Andre Van Assche, Sander Galjaard, Peter Damm, Elisabeth Mathiesen, Dorte M Jensen, Lise Lotte Andersen, Mette Tanvig, Annunziata Lapolla, Maria G Dalfra, Alessandra Bertolotto, Urszula Mantaj, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Judith Jelsma, Fj Snoek, Mireille Van Poppel, Christof Worda, Dagmar Bancher-Todesca, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy
OBJECTIVE Risk factors are widely used to identify women at risk for gestational diabetes mellitus (GDM) without clear distinction by pregnancy period or oral glucose tolerance test (OGTT) time points. We aimed to assess clinical risk factors for HiP differentiating by these two aspects. DESIGN AND METHODS 971 overweight/obese pregnant women, enrolled in the DALI study for preventing GDM. OGTTs were performed at ≤19+6, 24-28 and 35-37 weeks (IADPSG/WHO2013 criteria). Women with GDM or overt diabetes at one time point did not proceed to further OGTTs...
May 8, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29735482/cd71-erythroid-suppressor-cells-promote-fetomaternal-tolerance-through-arginase-2-and-pdl-1
#10
Cole Delyea, Najmeh Bozorgmehr, Petya Koleva, Garett Dunsmore, Shima Shahbaz, Vivian Huang, Shokrollah Elahi
Survival of the allogeneic pregnancy depends on the maintenance of immune tolerance to paternal alloantigens at the fetomaternal interface. Multiple localized mechanisms contribute to the fetal evasion from the mother's immune rejection as the fetus is exposed to a wide range of stimulatory substances such as maternal alloantigens, microbes and amniotic fluids. In this article, we demonstrate that CD71+ erythroid cells are expanded at the fetomaternal interface and in the periphery during pregnancy in both humans and mice...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29735430/delivery-of-an-lga-infant-and-the-maternal-risk-of-diabetes-a-prospective-cohort-study
#11
Heidi Hakkarainen, Hanna Huopio, Henna Cederberg, Raimo Voutilainen, Seppo Heinonen
AIMS: Was to determine whether the birth weight of the infant predicts prediabetes (impaired fasting glucose, impaired glucose tolerance, or both) and type 2 diabetes (T2DM) during long-term follow-up of women with or without gestational diabetes mellitus (GDM). METHODS: The women with or without GDM during their pregnancies in Kuopio University Hospital in 1989-2009 (n=876) were contacted and invited for an evaluation. They were stratified into two groups according to the newborn's birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n=662) and >90th percentile (large-for-gestational-age; LGA) (n=116)...
May 4, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29730664/fetal-biometry-and-doppler-study-for-the-assessment-of-perinatal-outcome-in-stage-i-late-onset-fetal-growth-restriction
#12
Cecilia Villalaín, Ignacio Herraiz, María Soledad Quezada, Paula Isabel Gómez-Arriaga, Enery Gómez-Montes, Alberto Galindo
OBJECTIVE: To compare perinatal outcomes on fetuses classified as stage I late-onset fetal growth restriction (FGR) depending on the estimated fetal weight (EFW) centile category and the fetal and maternal Doppler study. MATERIAL AND METHODS: Retrospective cohort study on 131 cases of stage I late-onset FGR (diagnosis ≥32+0 weeks), defined as: EFW < 3rd centile and normal Doppler (G1) or EFW < 10th centile and mean uterine artery pulsatility index (PI) > 95th centile (G2) or EFW < 10th centile and mild fetal Doppler alteration: umbilical artery PI > 95th centile, middle cerebral artery PI < 5th centile, or cerebroplacental ratio < 5th centile (G3)...
May 4, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29729842/human-amniotic-epithelial-cells-inhibit-activation-and-pro-inflammatory-cytokines-production-of-naive-cd4-t-cells-from-women-with-unexplained-recurrent-spontaneous-abortion
#13
Hossein Motedayyen, Abbas Rezaei, Amir-Hassan Zarnani, Nader Tajik
Unexplained recurrent spontaneous abortion (URSA) has been assumed to be caused by a defect in maternal immunological tolerance to the fetus. Human amniotic epithelial cells (hAECs) have stem cell-like features and the ability to modulate the innate and adoptive immune responses. This study aimed to investigate whether hAECs have immunomodulatory effects on naive CD4+ T cells from URSA patients. hAECs were obtained from 15 healthy pregnant women and phenotypic profile of hAECs was determined by flow cytometry...
May 2, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29724483/immune-suppression-of-food-allergy-by-maternal-igg-in-murine-models
#14
Hirotaka Yamashita, Tadamasa Hayashi, Kenichi Saneyasu, Hiroki Matsuhara, Teruaki Matsui, Hiroyuki Tanaka, Naoki Inagaki
BACKGROUND: Most of the patients develop food allergy early in life. The factors related to parental immune condition might be one of the conceivable causes. METHODS: We reported murine models of food allergy and oral OVA tolerance. To investigate the influence of parental immune condition on infant food allergy, female and male mice with food allergy or oral tolerance were mated with each other. RESULTS: Food allergy was suppressed by decreased IgE production in the offspring of mice with food allergy...
April 30, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29723118/protective-effects-of-interferon-tau-against-lipopolysaccharide-induced-embryo-implantation-failure-in-pregnant-mice
#15
Kangfeng Jiang, Jing Yang, Yu Chen, Shuai Guo, Gan Zhao, Haichong Wu, Ganzhen Deng
Interferon-tau (IFN-τ), a novel type I interferon, is produced by trophoblast cells in ruminants. Previous studies have confirmed that IFN-τ could induce immunological tolerance in humans and other species. However, there are few reports on whether IFN-τ has a protective effect on embryo implantation failure caused by excessive inflammation at the maternal-fetal interface. In our study, a mouse model of lipopolysaccharide (LPS)-induced implantation failure was successfully established, and we investigated the protective effects of IFN-τ...
May 3, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29720646/hyperosmotic-tolerance-of-adult-fish-and-early-embryos-are-determined-by-discrete-single-loci-in-the-genus-oryzias
#16
Taijun Myosho, Hideya Takahashi, Kento Yoshida, Tadashi Sato, Satoshi Hamaguchi, Tatsuya Sakamoto, Mitsuru Sakaizumi
The acquisition of environmental osmolality tolerance traits in individuals and gametes is an important event in the evolution and diversification of organisms. Although teleost fish exhibit considerable intra- and interspecific variation in salinity tolerance, the genetic mechanisms underlying this trait remain unclear. Oryzias celebensis survives in sea and fresh water during both the embryonic and adult stages, whereas its close relative Oryzias woworae cannot survive in sea water at either stage. A linkage analysis using backcross progeny identified a single locus responsible for adult hyperosmotic tolerance on a fused chromosome that corresponds to O...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29713810/the-role-of-interleukin-10-in-the-pathophysiology-of-preeclampsia
#17
REVIEW
Hajrunisa Cubro, Sonu Kashyap, Meryl C Nath, Allan W Ackerman, Vesna D Garovic
PURPOSE OF REVIEW: The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface...
April 30, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29712482/does-pregnancy-interval-after-laparoscopic-sleeve-gastrectomy-affect-maternal-and-perinatal-outcomes
#18
Alper Basbug, Aşkı Ellibeş Kaya, Sami Dogan, Mevlut Pehlivan, Gokhan Goynumer
BACKGROUND: Obesity is a global health epidemic and is associated with many maternal and neonatal complications. Laparoscopic sleeve gastrectomy (LSG) is among the surgical treatments for obesity. The appropriate timing of pregnancy following LSG remains controversial and few studies have evaluated this public health issue. OBJECTIVE: To evaluate the effect of pregnancy timing after LSG on maternal and perinatal outcomes. STUDY DESIGN: We performed a retrospective observational study of 23 pregnant women who underwent LSG at a tertiary hospital in Turkey...
April 30, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29704909/gut-immunity-its-development-and-reasons-and-opportunities-for-modulation-in-monogastric-production-animals
#19
Leon J Broom, Michael H Kogut
The intestine performs the critical roles of nutrient acquisition, tolerance of innocuous and beneficial microorganisms, while retaining the ability to respond appropriately to undesirable microbes or microbial products and preventing their translocation to more sterile body compartments. Various components contribute to antimicrobial defenses in the intestine. The mucus layer(s), antimicrobial peptides and IgA provide the first line of defense, and seek to trap and facilitate the removal of invading microbes...
April 29, 2018: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29704840/body-lipid-composition-modulates-acute-cadmium-toxicity-in-daphnia-magna-adults-and-juveniles
#20
Aline Ferain, Nancy De Saeyer, Yvan Larondelle, Jean-François Rees, Cathy Debier, Karel A C De Schamphelaere
Long chain polyunsaturated fatty acids (LC-PUFAs) such as eicosapentaenoic acid (EPA, 20:5n-3) affect zooplankton fitness and ability to cope with environmental stressors. However, the impact of LC-PUFAs on zooplankton sensitivity to chemical stressors is unknown. Here, we aimed to document the interaction between EPA and cadmium (Cd), as model chemical stressor, in Daphnia magna. A life-history experiment was performed in which daphnid neonates were raised into adulthood on three diets of different lipid composition: (i) algae mix; (ii) algae mix supplemented with control liposomes; (iii) algae mix supplemented with liposomes containing EPA...
April 17, 2018: Chemosphere
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