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https://www.readbyqxmd.com/read/29351483/prenatal-exposure-to-diesel-exhaust-pm2-5-causes-offspring-%C3%AE-cell-dysfunction-in-adulthood
#1
Minjie Chen, Shuai Liang, Xiaobo Qin, Li Zhang, Lianglin Qiu, Sufang Chen, Ziying Hu, Yanyi Xu, Wanjun Wang, Yuhao Zhang, Qi Cao, Zhekang Ying
BACKGROUND: Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure to ambient fine particulate matter (PM2.5) is associated with various fetal abnormalities, suggesting that it may program offspring's susceptibility to diabetes. In the present study, we therefore examined whether maternal exposure to diesel exhaust PM2.5 (DEP), one of the major sources of ambient PM2...
December 26, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29350662/high-protein-intake-in-human-maternal-milk-fortification-for-%C3%A2-1250-gr-infants-intrahospital-growth-and-neurodevelopmental-outcome-at-two-years
#2
Augusto Biasini, Fiorella Monti, Maria Chiara Laguardia, Marcello Stella, Lucia Marvulli, Erica Neri
BACKGROUND AND AIM OF THE STUDY: Extrauterine growth restriction and failure to thrive remain a major problem in Extremely Low Birth Weight infants. Nutritional support in preterm babies has the objective to improve the achieve rate of growth similar to those of the fetus in utero at the equivalent gestational age. The aim of the study was to evaluate feeding tolerance, intrahospital growth, neurological outcome and anthropometric data until 24 months of corrected age (mca) from different protein intake assumed by preterm babies <1250 g during their stay in NICU...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29349860/effects-of-maternal-anthropometrics-on-pregnancy-outcomes-in-south-asian-women-a-systematic-review
#3
REVIEW
E Slack, J Rankin, D Jones, N Heslehurst
AIM: This systematic review investigates associations between maternal pre-pregnancy/early-pregnancy anthropometrics (e.g. weight and body fat), anthropometric change and pregnancy outcomes in South Asian and White women. METHODS: Twelve electronic literature databases, reference lists and citations of all included studies were searched. Observational studies published in the English language were included. Descriptive synthesis was used to summarize the evidence base...
January 19, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29349843/pregnancy-after-bariatric-surgery-maternal-and-fetal-outcomes-of-39-pregnancies-and-a-literature-review
#4
Maria Manuel Costa, Sandra Belo, Pedro Souteiro, João S Neves, Daniela Magalhães, Rita B Silva, Sofia C Oliveira, Paula Freitas, Ana Varela, Joana Queirós, Davide Carvalho
AIM: We aimed to evaluate the impact of bariatric surgery (BS) on maternal and fetal outcomes. METHODS: A retrospective, descriptive, observational study of 39 pregnant women who underwent BS in our institution between 2010 and 2014 was carried out. A sample of women who became pregnant after BS was evaluated, based on data concerning pregnancy, childbirth, and newborns. RESULTS: Of the 1182 patients who underwent BS at our institution during the study period, 1016 (85...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29345098/influence-of-maternal-obesity-on-fetal-growth-at-different-periods-of-pregnancies-with-normal-glucose-tolerance
#5
Kei Tanaka, Miho Matsushima, Tomoko Izawa, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
AIM: We aimed to examine the influence of maternal obesity on fetal growth in utero at different periods of pregnancies with normal glucose tolerance. METHODS: A retrospective cohort study on 356 pregnant women with normal glucose tolerance was conducted. The women were categorized by pre-pregnancy body mass index (BMI) as obese (OB; BMI ≥ 25.0 kg/m2 ) or non-obese (n-OB). Z-scores of the fetal abdominal circumference (AC) and the rate of fetal macrosomia (AC ≥ 90th percentile) at 19, 30, and 36 gestational weeks (GW) were compared between the two groups...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29344846/evaluation-of-psychosocial-and-biological-parameters-in-women-seeking-for-a-caesarean-section-and-women-who-are-aiming-for-vaginal-delivery-a-cross-sectional-study
#6
Benjamin Tuschy, Sebastian Berlit, Paul Stützer, Stefanie Lis, Christian Schmahl, Ulf Baumgärtner, Marc Sütterlin
PURPOSE: To investigate psychosocial and biological parameters that may influence decision-making concerning the mode of delivery in women with caesarean section on maternal request (CSMR). METHODS: Two hundred and two women were enrolled prospectively. The study sample (n = 93) consisted of women who aimed for CSMR, the control sample were women who seeked for vaginal delivery (n = 109). Parturients of both samples were enrolled during the pre-birth counselling at the delivery room at the University Medical Centre Mannheim, University Heidelberg, Germany...
January 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29344772/safety-and-efficacy-of-lamivudine-or-telbivudine-started-in-early-pregnancy-for-mothers-with-active-chronic-hepatitis-b
#7
Tianyu He, Yuqing Bai, Haodong Cai, Xiaojuan Ou, Min Liu, Wei Yi, Jidong Jia
BACKGROUND: Few data exist regarding use of nucleos(t)ide analogs started in early pregnancy for mothers with active chronic hepatitis B (CHB). We assessed the safety and efficacy of lamivudine/telbivudine initiated in the first trimester versus no treatment in mothers with active CHB. METHODS: We retrospectively enrolled 94 mothers newly diagnosed with active CHB in the first trimester of pregnancy. Patients with or without antiviral therapy were followed until postpartum week 28...
January 17, 2018: Hepatology International
https://www.readbyqxmd.com/read/29340106/a-maternal-high-fat-diet-during-pregnancy-and-lactation-in-addition-to-a-postnatal-high-fat-diet-leads-to-metabolic-syndrome-with-spatial-learning-and-memory-deficits-beneficial-effects-of-resveratrol
#8
Shih-Wen Li, Hong-Ren Yu, Jiunn-Ming Sheen, Mao-Meng Tiao, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Kow-Aung Chang, Ching-Chou Tsai, Li-Tung Huang
We tested the hypothesis that high-fat diet consumption during pregnancy, lactation, and/or post weaning, altered the expression of molecular mediators involved in hippocampal synaptic efficacy and impaired spatial learning and memory in adulthood. The beneficial effect of resveratrol was assessed. Dams were fed a rat chow diet or a high-fat diet before mating, during pregnancy, and throughout lactation. Offspring were weaned onto either a rat chow or a high-fat diet. Four experimental groups were generated, namely CC, HC, CH, and HH (maternal chow diet or high-fat diet; postnatal chow diet or high-fat diet)...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29337272/circulating-adipokines-and-mrna-expression-in-adipose-tissue-and-the-placenta-in-women-with-gestational-diabetes-mellitus
#9
Panayoula C Tsiotra, Panagiotis Halvatsiotis, Konstantinos Patsouras, Eirini Maratou, George Salamalekis, Sotirios A Raptis, George Dimitriadis, Eleni Boutati
Maternal adipose tissue and the placenta secrete various molecules commonly called adipokines such as chemerin, omentin-1, visfatin, adiponectin, and leptin that are important players in the pathogenesis of insulin resistance. Gestational diabetes mellitus (GDM) is defined as a state of glucose intolerance characterized by β-cell dysfunction and insulin resistance. To examine whether circulating adipokines and their mRNA expression in the adipose tissue and the placenta are altered in GDM pregnancy, we compared 15 GDM women [obese (BMI > 30) and non-obese (BMI < 30)] to 23 NGT (normal glucose tolerance) women [obese and non-obese], at the time of the Cesarean section...
January 11, 2018: Peptides
https://www.readbyqxmd.com/read/29335783/maternal-and-neonatal-omentin-1-levels-in-gestational-diabetes
#10
Marie Franz, Mariella Polterauer, Stephanie Springer, Lorenz Kuessel, Peter Haslinger, Christof Worda, Katharina Worda
PURPOSE: To evaluate the effect of gestational diabetes on omentin-1 in maternal and cord plasma. As a potent mediator of insulin resistance, Omentin-1, an adipokine derived from human adipose and placental tissue, may be an important player in the pathophysiology of gestational diabetes. METHODS: This was a prospective case-control study. The study included 96 women with gestational diabetes and 96 pregnant women without. Omentin-1 was measured at the time of the oral glucose tolerance test, at 32 weeks in maternal plasma and right after delivery in umbilical cord blood by ELISA assay...
January 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29329330/obesity-and-abnormal-glucose-tolerance-in-offspring-of-diabetic-mothers-a-systematic-review-and-meta-analysis
#11
Maki Kawasaki, Naoko Arata, Celine Miyazaki, Rintaro Mori, Toru Kikuchi, Yoshihiro Ogawa, Erika Ota
BACKGROUND: Rising prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) is an emerging public health issue. OBJECTIVES: To investigate the association of maternal hyperglycemia exposure during pregnancy with obesity and abnormal glucose tolerance in offspring, and the age at occurrence. METHODS: We searched MEDLINE and EMBASE for observational studies on obesity and diabetes in offspring of diabetic mothers (gestational diabetes mellitus (GDM), type 1 diabetes mellitus (T1DM) and T2DM), and those on non-diabetic mothers...
2018: PloS One
https://www.readbyqxmd.com/read/29325773/how-safe-is-metformin-when-initiated-in-early-pregnancy-a-retrospective-5-year-study-of-pregnant-women-with-gestational-diabetes-mellitus-from-india
#12
Vanlalhruaii, Riddhi Dasgupta, Roshna Ramachandran, Jiji E Mathews, Annie Regi, Niranjan Thomas, Vijay Gupta, P Visalakshi, H S Asha, Thomas Paul, Nihal Thomas
BACKGROUND: The initiation of metformin in early pregnancy in Gestational Diabetes mellitus(GDM) remains controversial. The aim of our study was to assess the influence of Metformin on maternal and fetal outcomes when initiated within the first trimester of pregnancy in GDM. METHODS AND MATERIALS: A retrospective analysis of 540 women with diabetes complicating pregnancy (IADPSG criteria) over five years(January 2011 to May 2016)was done. The study population comprised of patients initiated on a)metformin within the first trimester (Group A:n=186),b) metformin after the first trimester(Group B:n=203) and c)insulin at any time during their pregnancy(Group C:n=151)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29324584/maternal-serum-eye-drops-in-the-management-of-pediatric-persistent-corneal-epithelial-defects-a-case-series
#13
Ashton J Kalhorn, Kirstin L Tawse, Avni A Shah, Jennifer L Jung, Darren G Gregory, Emily A McCourt
PURPOSE: We report our experience with the use of maternally derived serum eye drops as adjunctive treatment in the management of pediatric persistent corneal epithelial defects. METHODS: Five eyes of 4 patients were identified in a retrospective review of pediatric patients with persistent corneal epithelial defects who received maternal serum drops. Diagnoses associated with the defects comprised pontine tegmental cap dysplasia with bilateral cranial nerve V1, V2, V3, and VII palsies; pontine tegmental cap dysplasia with left cranial nerve V1, VII, and VIII palsies; traumatic left cranial nerve II, V1, V2, and VI palsies due to a basilar skull fracture; and Stevens-Johnson syndrome with ocular involvement...
January 10, 2018: Cornea
https://www.readbyqxmd.com/read/29321878/asymmetric-reproductive-interference-the-consequences-of-cross-pollination-on-reproductive-success-in-sexual-apomictic-populations-of-potentilla-puberula-rosaceae
#14
Christoph Dobeš, Susanne Scheffknecht, Yulia Fenko, Dagmar Prohaska, Christina Sykora, Karl Hülber
Apomixis evolves from a sexual background and usually is linked to polyploidization. Pseudogamous gametophytic apomicts, which require a fertilization to initiate seed development, of various ploidy levels frequently co-occur with their lower-ploid sexual ancestors, but the stability of such mixed populations is affected by reproductive interferences mediated by cross-pollination. Thereby, reproductive success of crosses depends on the difference in ploidy levels of mating partners, that is, on tolerance of deviation from the balanced ratio of maternal versus paternal genomes...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321370/activation-induced-cytidine-deaminase-deficiency-accelerates-autoimmune-diabetes-in-nod-mice
#15
Qiyuan Tan, Ningwen Tai, Yangyang Li, James Pearson, Sean Pennetti, Zhiguang Zhou, F Susan Wong, Li Wen
B cells play an important role in type 1 diabetes (T1D) development. However, the role of B cell activation-induced cytidine deaminase (AID) in diabetes development is not clear. We hypothesized that AID is important in the immunopathogenesis of T1D. To test this hypothesis, we generated AID-deficient (AID-/-) NOD mice. We found that AID-/-NOD mice developed accelerated T1D, with worse insulitis and high levels of anti-insulin autoantibody in the circulation. Interestingly, neither maternal IgG transferred through placenta, nor IgA transferred through milk affected the accelerated diabetes development...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29315988/impaired-treg-and-nk-cells-profile-in-overweight-women-with-gestational-diabetes-mellitus
#16
Thalita Frutuoso Lobo, Camila de Moraes Borges, Rosiane Mattar, Caio Perez Gomes, Ana Geisa Santos de Angelo, Karen Priscilla Tezotto Pendeloski, Silvia Daher
PROBLEM: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. METHOD OF STUDY: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood...
January 5, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29310607/risk-factors-associated-with-the-development-of-postpartum-diabetes-in-japanese-women-with-gestational-diabetes
#17
Yukari Kugishima, Ichiro Yasuhi, Hiroshi Yamashita, So Sugimi, Yasushi Umezaki, Sachie Suga, Masashi Fukuda, Nobuko Kusuda
BACKGROUND: Although the onset of gestational diabetes (GDM) is known to be a significant risk factor for the future development of type 2 diabetes, this risk specifically in women with GDM diagnosed by the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria has not yet been thoroughly investigated. This study was performed to investigate the risk factors associated with the development of postpartum diabetes in Japanese women with a history of GDM, and the effects of the differences in the previous Japanese criteria and the IADPSG criteria...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29306610/hypoglycemia-during-oral-glucose-tolerance-test-among-post-bariatric-surgery-pregnant-patients-incidence-and-perinatal-significance
#18
Amihai Rottenstreich, Ram Elazary, Yossef Ezra, Geffen Kleinstern, Nahum Beglaibter, Uriel Elchalal
BACKGROUND: While hypoglycemia during an oral glucose tolerance test (OGTT) has been shown to occur in a considerable portion of nonpregnant post-bariatric surgery (BS) patients, its incidence among pregnant post-BS patients evaluated for gestational diabetes has only been sparsely studied. OBJECTIVES: We investigated OGTT results and pregnancy outcomes in pregnant women who underwent 3 types of bariatric procedures before pregnancy. SETTING: A university hospital...
December 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29300005/food-allergy
#19
REVIEW
Harald Renz, Katrina J Allen, Scott H Sicherer, Hugh A Sampson, Gideon Lack, Kirsten Beyer, Hans C Oettgen
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic shock. Major progress has been made in basic, translational and clinical research, leading to a better understanding of the underlying immunological mechanisms that lead to the breakdown of clinical and immunological tolerance against food antigens, which can result in either immunoglobulin E (IgE)-mediated reactions or non-IgE-mediated reactions...
January 4, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29290627/trim28-regulated-transposon-repression-is-required-for-human-germline-competency-and-not-primed-or-naive-human-pluripotency
#20
Yu Tao, Ming-Ren Yen, Tsotne Chitiashvili, Haruko Nakano, Rachel Kim, Linzi Hosohama, Yao Chang Tan, Atsushi Nakano, Pao-Yang Chen, Amander T Clark
Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs). In mouse, ICR methylation and TE expression are each regulated by TRIM28; however, the role of TRIM28 in humans is less clear. Here, we show that a null mutation in TRIM28 causes significant alterations in TE expression in both the naive and primed states of human pluripotency, and phenotypically this has limited effects on self-renewal, instead causing a loss of germline competency...
December 26, 2017: Stem Cell Reports
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