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Iota models

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https://www.readbyqxmd.com/read/27647726/ep26-03-use-of-iota-terms-definitions-and-models-to-describe-ovarian-mass-with-elevated-%C3%AE-hcg-in-35-years-old-patient-case-report
#1
N Abdalla, R Piorkowski, M Pazura, K Cendrowski, W Sawicki
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27516258/sulfated-polysaccharide-fraction-from-marine-algae-solieria-filiformis-structural-characterization-gastroprotective-and-antioxidant-effects
#2
Willer M Sousa, Renan O Silva, Francisco F Bezerra, Rudy D Bingana, Francisco Clark N Barros, Luís E C Costa, Venicios G Sombra, Pedro M G Soares, Judith P A Feitosa, Regina C M de Paula, Marcellus H L P Souza, André Luiz R Barbosa, Ana Lúcia P Freitas
A sulfated polysaccharide (SFP) fraction from the marine alga Solieria filiformis was extracted and submitted to microanalysis, molar mass estimation and spectroscopic analysis. We evaluated its gastroprotective potential in vivo in an ethanol-induced gastric damage model and its in vitro antioxidant properties (DPPH, chelating ferrous ability and total antioxidant capacity). Its chemical composition revealed to be essentially an iota-carrageenan with a molar mass of 210.9kDa and high degree of substitution for sulfate groups (1...
November 5, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27507231/refining-ovarian-cancer-test-accuracy-scores-rockets-protocol-for-a-prospective-longitudinal-test-accuracy-study-to-validate-new-risk-scores-in-women-with-symptoms-of-suspected-ovarian-cancer
#3
Sudha Sundar, Caroline Rick, Francis Dowling, Pui Au, Kym Snell, Nirmala Rai, Rita Champaneria, Hilary Stobart, Richard Neal, Clare Davenport, Susan Mallett, Andrew Sutton, Sean Kehoe, Dirk Timmerman, Tom Bourne, Ben Van Calster, Aleksandra Gentry-Maharaj, Usha Menon, Jon Deeks
INTRODUCTION: Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways...
2016: BMJ Open
https://www.readbyqxmd.com/read/27489270/inhibition-of-human-metapneumovirus-binding-to-heparan-sulfate-blocks-infection-in-human-lung-cells-and-airway-tissues
#4
Edita M Klimyte, Stacy E Smith, Pasqua Oreste, David Lembo, Rebecca Ellis Dutch
UNLABELLED: Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requires only the viral fusion (F) protein. To characterize the features of this interaction critical for HMPV binding and the role of this interaction in infection in relevant models, we utilized sulfated polysaccharides, heparan sulfate mimetics, and occluding compounds...
October 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27391068/loss-of-lsr-affects-epithelial-barrier-integrity-and-tumor-xenograft-growth-of-caco-2-cells
#5
Bernd A Czulkies, Justin Mastroianni, Lisa Lutz, Sarah Lang, Carsten Schwan, Gudula Schmidt, Silke Lassmann, Robert Zeiser, Klaus Aktories, Panagiotis Papatheodorou
The lipolysis-stimulated lipoprotein receptor (LSR) is a lipoprotein receptor, serves as host receptor for clostridial iota-like toxins and is involved in the formation of tricellular contacts. Of particular interest is the role of LSR in progression of various cancers. Here we aimed to study the tumor growth of LSR-deficient colon carcinoma-derived cell lines HCT116 and CaCo-2 in a mouse xenograft model. Whereas knockout of LSR had no effect on tumor growth of HCT116 cells, we observed that CaCo-2 LSR knockout tumors grew to a smaller size than their wild-type counterparts...
July 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27374142/external-validation-of-the-iota-adnex-model-performed-by-two-independent-gynecologic-centers
#6
Sebastian Szubert, Andrzej Wojtowicz, Rafal Moszynski, Patryk Zywica, Krzysztof Dyczkowski, Anna Stachowiak, Stefan Sajdak, Dariusz Szpurek, Juan Luis Alcazar
OBJECTIVES: The external, two-center validation of the IOTA ADNEX model for differential diagnosis of adnexal tumors. METHODS: A total of 204 patients with adnexal masses (134 benign and 70 malignant) treated at the Division of Gynecologic Surgery, Poznan University of Medical Sciences, Poland (Center I), and 123 patients (89 benign and 34 malignant) from the Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain (Center II), were enrolled into the study...
September 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27299852/targeting-atypical-protein-kinase-c-iota-reduces-viability-in-glioblastoma-stem-like-cells-via-a-notch-signaling-mechanism
#7
Emma Phillips, Verena Lang, Jonathan Bohlen, Frederic Bethke, Laura Puccio, Diana Tichy, Christel Herold-Mende, Thomas Hielscher, Peter Lichter, Violaine Goidts
In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem-like cell (GSC) survival. Here, we show that PKCι is overexpressed and activated in patient derived GSCs compared with normal neural stem cells and normal brain lysate, and that silencing of PRKCI in GSCs causes apoptosis, along with loss of clonogenicity and reduced proliferation. Notably, PRKCI silencing reduces tumor growth in vivo in a xenograft mouse model. PKCι has been intensively studied as a therapeutic target in non-small cell lung cancer, resulting in the identification of an inhibitor, aurothiomalate (ATM), which disrupts the PKCι/ERK signaling axis...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27194129/performance-of-the-iota-adnex-model-in-the-preoperative-discrimination-of-adnexal-masses-in-a-gynecologic-oncology-center
#8
Karla Galvão Araujo, Rodrigo Menezes Jales, Patrick Nunes Pereira, Adriana Yoshida, Liliana de Angelo Andrade, Luis Otávio Sarian, Sophie Derchain
OBJECTIVE: To evaluate the performance of the IOTA ADNEX model in the preoperative discrimination between benign ovarian (including tubal and para-ovarian) tumor, borderline ovarian tumor (BOT), stage I ovarian cancer (OC), stages II-IV OC and ovarian metastasis in a Brazilian gynecologic oncology center. METHODS: This was a diagnostic accuracy study including 131 women with adnexal masses. Ultrasonography was performed and serum CA 125 level was measured before surgery for all women...
May 19, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27057634/dna-polymerase-iota-pol-%C3%AE-promotes-invasion-and-metastasis-of-esophageal-squamous-cell-carcinoma
#9
Shitao Zou, Zeng-Fu Shang, Biao Liu, Shuyu Zhang, Jinchang Wu, Min Huang, Wei-Qun Ding, Jundong Zhou
DNA polymerase iota (Pol ι) is an error-prone DNA polymerase involved in translesion DNA synthesis (TLS) that contributes to the accumulation of DNA mutations. We recently showed that Pol ι is overexpressed in human esophageal squamous cell cancer (ESCC) tissues which promotes ESCC' progression. The present study was aimed at investigating the molecular mechanisms by which Pol ι enhances the invasiveness and metastasis of ESCC cells. We found that the expression of Pol ι is significantly higher in ESCCs with lymph node metastasis compared to those without lymph node metastasis...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/26922169/subjective-assessment-versus-ultrasound-models-to-diagnose-ovarian-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
E M J Meys, J Kaijser, R F P M Kruitwagen, B F M Slangen, B Van Calster, B Aertgeerts, J Y Verbakel, D Timmerman, T Van Gorp
INTRODUCTION: Many national guidelines concerning the management of ovarian cancer currently advocate the risk of malignancy index (RMI) to characterise ovarian pathology. However, other methods, such as subjective assessment, International Ovarian Tumour Analysis (IOTA) simple ultrasound-based rules (simple rules) and IOTA logistic regression model 2 (LR2) seem to be superior to the RMI. Our objective was to compare the diagnostic accuracy of subjective assessment, simple rules, LR2 and RMI for differentiating benign from malignant adnexal masses prior to surgery...
May 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/26800772/predicting-the-risk-of-malignancy-in-adnexal-masses-based-on-the-simple-rules-from-the-international-ovarian-tumor-analysis-group
#11
MULTICENTER STUDY
Dirk Timmerman, Ben Van Calster, Antonia Testa, Luca Savelli, Daniela Fischerova, Wouter Froyman, Laure Wynants, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Jeroen Kaijser, Artur Czekierdowski, Stefano Guerriero, Robert Fruscio, Francesco P G Leone, Alberto Rossi, Chiara Landolfo, Ignace Vergote, Tom Bourne, Lil Valentin
BACKGROUND: Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent metaanalysis concluded that the International Ovarian Tumor Analysis algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. OBJECTIVE: We sought to develop and validate a model to predict the risk of malignancy in adnexal masses using the ultrasound features in the Simple Rules...
April 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26547069/repair-of-clustered-damage-and-dna-polymerase-iota
#12
E A Belousova, O I Lavrik
Multiple DNA lesions occurring within one or two turns of the DNA helix known as clustered damage are a source of double-stranded DNA breaks, which represent a serious threat to the cells. Repair of clustered lesions is accomplished in several steps. If a clustered lesion contains oxidized bases, an individual DNA lesion is repaired by the base excision repair (BER) mechanism involving a specialized DNA polymerase after excising DNA damage. Here, we investigated DNA synthesis catalyzed by DNA polymerase iota using damaged DNA templates...
August 2015: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/26475383/association-of-polymorphisms-in-prkci-gene-and-risk-of-prostate-cancer-in-a-sample-of-iranian-population
#13
M Hashemi, G Shahkar, N Simforoosh, A Basiri, S A M Ziaee, B Narouie, M Taheri
The atypical protein kinase C iota (aPKCι) is an oncoprotein encoded by the PRKCI gene. It has been reported to play multifunctional roles in cellular maintenance, cell proliferation, survival, differentiation and apoptosis. In the present study we aimed to assess the impact of PRKCI rs546950 C>T and rs4955720 C>A polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH)...
2015: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/26461961/simple-descriptors-and-simple-rules-of-the-international-ovarian-tumor-analysis-iota-group-a-prospective-study-of-combined-use-for-the-description-of-adnexal-masses
#14
Almudena Peces Rama, María Carmen Llanos Llanos, María Luisa Sánchez Ferrer, Juan Luis Alcázar Zambrano, Antonio Martínez Mendoza, Aníbal Nieto Díaz
OBJECTIVE: External validation of the IOTA group's three-step diagnostic model (Strategy 1) and comparison with assessment by an expert sonographer (Strategy 2). STUDY DESIGN: Prospective study in patients with persistent adnexal masses, in which an inexperienced sonographer performed transvaginal ultrasound applying simple descriptors (SD) and rules (SR) for classifying as benign or malignant. Any non-classifiable mass was then submitted to an expert examiner for subjective assessment (SA)...
December 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26344274/antimicrosporidian-activity-of-sulphated-polysaccharides-from-algae-and-their-potential-to-control-honeybee-nosemosis
#15
M Roussel, A Villay, F Delbac, P Michaud, C Laroche, D Roriz, H El Alaoui, M Diogon
Nosemosis is one of the most common and widespread diseases of adult honeybees. The causative agents, Nosema apis and Nosema ceranae, belong to microsporidia some obligate intracellular eukaryotic parasites. In this study, 10 sulphated polysaccharides from algae were evaluated for their antimicrosporidian activity. They were first shown to inhibit the in vitro growth of the mammal microsporidian model, Encephalitozoon cuniculi. The most efficient polysaccharides were then tested for their ability to inhibit the growth of Nosema ceranae in experimentally-infected adult honeybees...
November 20, 2015: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26126150/the-prospective-external-validation-of-international-ovarian-tumor-analysis-iota-simple-rules-in-the-hands-of-level-i-and-ii-examiners
#16
A Knafel, T Banas, A Nocun, M Wiechec, R Jach, A Ludwin, M Kabzinska-Turek, M Pietrus, K Pitynski
Objective: To externally validate the International Ovarian Tumor Analysis (IOTA) Simple Rules (SR) by examiners with different levels of sonographic experience defined by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) and to assess the morphological ultrasound features of the adnexal tumors classified as inconclusive based on IOTA SR. Materials and Methods: In the two-year prospective study adnexal tumors were assessed preoperatively with transvaginal ultrasound by examiners with different levels of experience (level 1- IOTA SR1, level 2-IOTA SR2)...
June 30, 2015: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/25897371/towards-an-evidence-based-approach-for-diagnosis-and-management-of-adnexal-masses-findings-of-the-international-ovarian-tumour-analysis-iota-studies
#17
J Kaijser
Whilst the outcomes for patients with ovarian cancer clearly benefit from centralised, comprehensive care in dedicated cancer centres, unfortunately the majority of patients still do not receive appropriate specialist treatment. Any improvement in the accuracy of current triaging and referral pathways whether using new imaging tests or biomarkers would therefore be of value in order to optimise the appropriate selection of patients for such care. An analysis of current evidence shows that such tests are now available, but still await recognition, acceptance and widespread adoption...
2015: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/25897370/practical-guidance-for-applying-the-adnex-model-from-the-iota-group-to-discriminate-between-different-subtypes-of-adnexal-tumors
#18
REVIEW
B Van Calster, K Van Hoorde, W Froyman, J Kaijser, L Wynants, C Landolfo, C Anthoulakis, I Vergote, T Bourne, D Timmerman
All gynecologists are faced with ovarian tumors on a regular basis, and the accurate preoperative diagnosis of these masses is important because appropriate management depends on the type of tumor. Recently, the International Ovarian Tumor Analysis (IOTA) consortium published the Assessment of Different NEoplasias in the adneXa (ADNEX) model, the first risk model that differentiates between benign and four types of malignant ovarian tumors: borderline, stage I cancer, stage II-IV cancer, and secondary metastatic cancer...
2015: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/25799452/clostridium-perfringens-type-e-virulence-traits-involved-in-gut-colonization
#19
Leandro M Redondo, Juan M Díaz Carrasco, Enzo A Redondo, Fernando Delgado, Mariano E Fernández Miyakawa
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells...
2015: PloS One
https://www.readbyqxmd.com/read/25687096/synthesis-and-characterization-of-modified-carrageenan-microparticles-for-the-removal-of-pharmaceuticals-from-aqueous-solutions
#20
Stavroula G Nanaki, George Z Kyzas, Areti Tzereme, M Papageorgiou, Margaritis Kostoglou, Dimitrios N Bikiaris, Dimitra A Lambropoulou
In the present study, carrageenan microparticles were synthesized using spray-drying method and used as biosorbents for the removal of pharmaceutical compounds. The cross-linking reaction of iota-carrageenan (iCAR) and kappa-carrageenan (kCAR) with glutaraldehyde (GLA) at different concentrations (2.5% or 5% (w/w), mass of GLA per mass of CAR) was studied (iCAR/GLA2.5, iCAR/GLA5, kCAR/GLA2.5, kCAR/GLA5). The physicochemical properties of the novel cross-linked polymers were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR)...
March 1, 2015: Colloids and Surfaces. B, Biointerfaces
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