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https://www.readbyqxmd.com/read/28239302/parent-grief-1-13-months-after-death-in-neonatal-and-pediatric-intensive-care-units
#1
JoAnne M Youngblut, Dorothy Brooten, Joy Glaze, Teresita Promise, Changwon Yoo
OBJECTIVE: Describe changes in mothers' and fathers' grief from 1 to 13 months after infant/child neonatal/pediatric intensive care unit death and identify factors related to their grief. METHODS: Mothers (n = 130) and fathers (n = 52) of 140 children (newborn-18 years) completed the Hogan Grief Reaction Checklist at 1, 3, 6, and 13 months post-death. RESULTS: Grief decreased from 3 to 13 months for mothers and from 3 to 6 months for fathers...
2017: Journal of Loss & Trauma
https://www.readbyqxmd.com/read/28238825/association-between-obesity-related-biomarkers-and-cognitive-and-motor-development-in-infants
#2
Ana Cristina R Camargos, Vanessa A Mendonça, Katherine S C Oliveira, Camila Alves de Andrade, Hércules Ribeiro Leite, Sueli Ferreira da Fonseca, Erica Leandro Marciano Vieira, Antônio Lúcio Teixeira Júnior, Ana Cristina Rodrigues Lacerda
BACKGROUND: This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. METHODS: A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development...
February 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28238681/early-amplitude-integrated-electroencephalography-for-monitoring-neonates-at-high-risk-for-brain-injury
#3
Gabriel Fernando Todeschi Variane, Maurício Magalhães, Renato Gasperine, Heitor Castelo Branco Rodrigues Alves, Thiago Luiz Pereira Donoso Scoppetta, Rodrigo de Jesus Gonçalves Figueredo, Francisco Paulo Martins Rodrigues, Alexandre Netto, Marcelo Jenne Mimica, Clery Bernardi Gallacci
OBJECTIVE: This study aimed to correlate amplitude-integrated electroencephalography findings with early outcomes, measured by mortality and neuroimaging findings, in a prospective cohort of infants at high risk for brain injury in this center in Brazil. METHODS: This blinded prospective cohort study evaluated 23 preterm infants below 31 weeks of gestational age and 17 infants diagnosed with hypoxic-ischemic encephalopathy secondary to perinatal asphyxia, with gestational age greater than 36 weeks, monitored with amplitude-integrated electroencephalography in a public tertiary center from February 2014 to January 2015...
February 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28235686/the-effects-of-massage-therapy-in-hospitalized-preterm-neonates-a-systematic-review
#4
REVIEW
María José Álvarez, Daniel Fernández, Juan Gómez-Salgado, Dolores Rodríguez-González, María Rosón, Santiago Lapeña
OBJECTIVE: The aim of this study was to perform a systematic review to identify, evaluate and summarise studies on the administration of therapeutic massage to preterm neonates during their stay in the NICU, and to assess their methodological quality. DESIGN: systematic review following PRISMA statements guidelines. DATA SOURCES: A comprehensive search was performed including relevant articles between January 2004 and December 2013, using the following electronic databases: Medline, PEDro, Web of Science and Scopus...
February 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28230411/the-bilingual-adaptation-how-minds-accommodate-experience
#5
Ellen Bialystok
According to some estimates, more than half of the world's population is multilingual to some extent. Because of the centrality of language use to human experience and the deep connections between linguistic and nonlinguistic processing, it would not be surprising to find that there are interactions between bilingualism and cognitive and brain processes. The present review uses the framework of experience-dependent plasticity to evaluate the evidence for systematic modifications of brain and cognitive systems that can be attributed to bilingualism...
March 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28227297/features-of-cerebral-oxygenation-detects-brain-injury-in-premature-infants
#6
John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, Daragh Finn, Eugene M Dempsey, Mmoloki Kenosi, John M Otoole, Geraldine B Boylan
Babies born prematurely can develop brain injury within days after birth. Early identification of high-risk infants enables appropriate clinical care to mitigate potential lifelong disabilities. Near infra-red spectroscopy is an established technology that can provide continuous measurements of cerebral oxygen saturation (rcSO2) over this critical period. We develop a feature set of the rcSO2 signal for the purpose of detecting brain injury. Our feature set contains amplitude, spectral, and fractal dimension features within 5 frequency bands...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226644/examining-the-effect-of-mgso4-on-sharp-wave-transient-activity-in-the-hypoxic-ischemic-fetal-sheep-model
#7
Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Laura Bennet, Hamid Abbasi, Alistair J Gunn, Meherzad J Lakadia, Charles P Unsworth
Hypoxic-ischemic encephalopathy (HIE) due to lack of oxygen is a debilitating disorder experienced by a significant number of preterm infants during birth. Studies show that the brain undergoes different phases of injury following hypoxic insult, but the first 6-8 hours (known as a latent phase) are the key to treatment efficacy. Cerebral hypothermia is one known treatment, and for it to be effective it must be started during the latent phase and continued for several days. In order to determine the effectiveness of treatment it is important to pinpoint the time of insult...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226452/high-resolution-eeg-source-imaging-of-one-year-old-children
#8
Zeynep Akalin Acar, Silvia Ortiz-Mantilla, April Benasich, Scott Makeig, Zeynep Akalin Acar, Silvia Ortiz-Mantilla, April Benasich, Scott Makeig, April Benasich, Scott Makeig, Zeynep Akalin Acar, Silvia Ortiz-Mantilla
Recently we described an iterative skull conductivity and source location estimation (SCALE) algorithm for simultaneously estimating head tissue conductivities and brain source locations. SCALE uses a realistic FEM forward problem head model and scalp maps of 10 or more near-dipolar sources identified by independent component analysis (ICA) decomposition of sufficient high-density EEG data. In this study, we applied SCALE to 20 minutes of 64-channel EEG data and magnetic resonance (MR) head images from four twelve-months-of-age infants...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226446/a-challenging-issue-detection-of-white-matter-hyperintensities-in-neonatal-brain-mri
#9
Baptiste Morel, Yongchao Xu, Alessio Virzi, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Baptiste Morel, Yongchao Xu, Alessio Virzi, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Alessio Virzi, Yongchao Xu, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Baptiste Morel
The progress of magnetic resonance imaging (MRI) allows for a precise exploration of the brain of premature infants at term equivalent age. The so-called DEHSI (diffuse excessive high signal intensity) of the white matter of premature brains remains a challenging issue in terms of definition, and thus of interpretation. We propose a semi-automatic detection and quantification method of white matter hyperintensities in MRI relying on morphological operators and max-tree representations, which constitutes a powerful tool to help radiologists to improve their interpretation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226317/neuroprotective-effects-of-acetyl-l-carnitine-on-neonatal-hypoxia-ischemia-induced-brain-injury-in-rats
#10
Shiyu Tang, Su Xu, Xin Lu, Rao P Gullapalli, Mary C McKenna, Jaylyn Waddell
Perinatal hypoxia ischemia (HI) is a significant cause of brain injury in surviving infants. Although hypothermia improves outcomes in some infants, additional therapies are needed since about 40% of infants still have a poor outcome. Acetyl-L-carnitine (ALCAR), an acetylated derivative of L-carnitine, protected against early changes in brain metabolites and mitochondrial function after HI on postnatal day (PND) 7 in a rat pup model of near-term HI injury. However, its efficacy in long-term structural and functional outcomes remains unexplored...
February 23, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28219764/gabaa-receptor-expression-and-white-matter-disruption-in-intrauterine-growth-restricted-piglets
#11
Viskasari P Kalanjati, Julie A Wixey, Stephanie M Miller, Paul B Colditz, Stella T Bjorkman
Intrauterine growth restriction (IUGR) is one of the most common causes of perinatal mortality and morbidity. White matter and neuronal injury are major pathophysiological features of the IUGR neonatal brain. GABAA (γ-aminobutyric acid type A) receptors have been shown to play a role in oligodendrocyte differentiation and proliferation in the neonatal brain and may be a key factor in white matter injury and myelination in IUGR neonates. Whether there are impairments to the GABAergic system and neuronal cytoskeleton in IUGR brain has yet to be elucidated...
February 17, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28217829/vitamin-d-and-autism-what-s-new
#12
REVIEW
John Jacob Cannell
An increasing amount of evidence points to the possibility that gestational and early childhood vitamin D deficiency [25(OH)D < 40 ng/ml] cause some cases of autism. Vitamin D is metabolized into a seco-steroid hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development, having effects on cellular proliferation, differentiation, calcium signaling, neurotrophic and neuroprotective actions; it also appears to have an effect on neurotransmission and synaptic plasticity...
February 20, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28216147/differential-responses-of-human-fetal-brain-neural-stem-cells-to-zika-virus-infection
#13
Erica L McGrath, Shannan L Rossi, Junling Gao, Steven G Widen, Auston C Grant, Tiffany J Dunn, Sasha R Azar, Christopher M Roundy, Ying Xiong, Deborah J Prusak, Bradford D Loucas, Thomas G Wood, Yongjia Yu, Ildefonso Fernández-Salas, Scott C Weaver, Nikos Vasilakis, Ping Wu
Zika virus (ZIKV) infection causes microcephaly in a subset of infants born to infected pregnant mothers. It is unknown whether human individual differences contribute to differential susceptibility of ZIKV-related neuropathology. Here, we use an Asian-lineage ZIKV strain, isolated from the 2015 Mexican outbreak (Mex1-7), to infect primary human neural stem cells (hNSCs) originally derived from three individual fetal brains. All three strains of hNSCs exhibited similar rates of Mex1-7 infection and reduced proliferation...
February 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28215317/docosahexaenoic-acid-supplementation-during-pregnancy-as-phospholipids-did-not-improve-the-incorporation-of-this-fatty-acid-into-rat-fetal-brain-compared-with-the-triglyceride-form
#14
Antonio Gázquez, Inmaculada Hernández-Albaladejo, Elvira Larqué
Prenatal docosahexaenoic acid (DHA) supply is important to ensure an adequate infant neurodevelopment. Several fat supplements with DHA under different chemical structures are available. There is an increased placental phospholipase activity at the end of pregnancy. The hypothesis of this study was to discern whether DHA consumption during pregnancy as phospholipids (PLs) could be more available for placental DHA uptake and fetal accretion than triglycerides (TGs) form. We aimed to evaluate maternofetal DHA status in pregnant rats fed with DHA as PL from egg yolk or TG from algae oil to determine which source might be most effective during pregnancy...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28215282/how-does-experience-shape-early-development-considering-the-role-of-top-down-mechanisms
#15
L L Emberson
Perceptual development requires infants to adapt their perceptual systems to the structures and statistical information of their environment. In this way, perceptual development is not only important in its own right, but is a case study for behavioral and neural plasticity-powerful mechanisms that have the potential to support developmental change in numerous domains starting early in life. While it is widely assumed that perceptual development is a bottom-up process, where simple exposure to sensory input modifies perceptual representations starting early in the perceptual system, there are several critical phenomena in this literature that cannot be explained with an exclusively bottom-up model...
2017: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/28214967/increased-atrial-%C3%AE-adrenergic-receptors-and-grk-2-gene-expression-can-play-a-fundamental-role-in-heart-failure-after-repair-of-congenital-heart-disease-with-cardiopulmonary-bypass
#16
Marcela Silva Oliveira, Fabio Carmona, Walter V A Vicente, Paulo H Manso, Karina M Mata, Mara Rúbia Celes, Erica C Campos, Simone G Ramos
Surgeries to correct congenital heart diseases are increasing in Brazil and worldwide. However, even with the advances in surgical techniques and perfusion, some cases, especially the more complex ones, can develop heart failure and death. A retrospective study of patients who underwent surgery for correction of congenital heart diseases with cardiopulmonary bypass (CPB) in a university tertiary-care hospital that died, showed infarction in different stages of evolution and scattered microcalcifications in the myocardium, even without coronary obstruction...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28214639/congenital-glioblastoma-with-distinct-clinical-and-molecular-characteristics-case-reports-and-a-literature-review
#17
Masahiro Kameda, Yoshihiro Otani, Tomotsugu Ichikawa, Akira Shimada, Koichi Ichimura, Isao Date
BACKGROUND: The molecular diagnosis of brain tumors is important in classifying tumors and determining appropriate treatment. Congenital glioblastoma multiforme (GBM) is a rare tumor that occurs in infants, and the prognosis is poor. Approximately 60 patients diagnosed as congenital GBM have been reported. However, few reports have conducted molecular analyses of congenital GBM. CASE DESCRIPTION: We describe two congenital GBM patients treated in our hospital, and report results of immunohistochemistry, fluorescent in situ hybridization (FISH), direct sequencing, and methylation analyses...
February 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28212403/cerebrospinal-fluid-biomarkers-of-infantile-congenital-hydrocephalus
#18
David D Limbrick, Brandon Baksh, Clinton D Morgan, Gakwaya Habiyaremye, James P McAllister, Terrie E Inder, Deanna Mercer, David M Holtzman, Jennifer Strahle, Michael J Wallendorf, Diego M Morales
INTRODUCTION: Hydrocephalus is a complex neurological disorder with a pervasive impact on the central nervous system. Previous work has demonstrated derangements in the biochemical profile of cerebrospinal fluid (CSF) in hydrocephalus, particularly in infants and children, in whom neurodevelopment is progressing in parallel with concomitant neurological injury. The objective of this study was to examine the CSF of children with congenital hydrocephalus (CHC) to gain insight into the pathophysiology of hydrocephalus and identify candidate biomarkers of CHC with potential diagnostic and therapeutic value...
2017: PloS One
https://www.readbyqxmd.com/read/28211647/clinical-characteristics-predicting-abnormal-brain-magnetic-resonance-image-findings-in-hypoxic-ischemic-encephalopathy-infants
#19
Sook K Yum, Cheong-Jun Moon, Young-Ah Youn, In K Sung
BACKGROUND: The aim of this study was to elucidate the specific clinical characteristics associated with abnormal brain magnetic resonance image(MRI) findings in hypoxic ischemic encephalopathy(HIE) infants in order to discern how to predict poorer outcomes more accurately. METHODS: A retrospective data analysis of HIE infants admitted to the neonatal intensive care unit of a tertiary hospital was performed. Baseline perinatal information and physical and neurological findings were compared in HIE infants according to the presence of abnormal brain MRI findings...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28211317/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#20
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
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