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https://www.readbyqxmd.com/read/29920955/nimotuzumab-combined-with-chemotherapy-as-first-line-treatment-for-advanced-lung-squamous-cell-carcinoma
#1
Xiaoyan Si, Shafei Wu, Hanping Wang, Xiaotong Zhang, Mengzhao Wang, Xuan Zeng, Li Zhang
BACKGROUND: This study was conducted to evaluate the efficacy and safety of nimotuzumab combined with chemotherapy as first-line therapy in advanced lung squamous cell carcinoma (LSCC), and to explore predictive biomarkers of the efficacy of nimotuzumab. METHODS: A retrospective study was conducted of patients with advanced LSCC administered nimotuzumab combined with chemotherapy as first-line therapy from June 2012 to December 2016 at the Department of Respiratory Medicine, Peking Union Medical College Hospital...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29872671/review-of-quality-of-life-studies-in-women-with-alopecia
#2
REVIEW
D S Davis, V D Callender
Alopecia is a dermatologic condition that affects the pilosebaceous unit in both men and women. In addition to a thorough medical history and physical examination, a host of diagnostic tools may be warranted to differentiate nonscarring and scarring alopecias. Female pattern hair loss represents the most common form of hair loss experienced by up to 40% of women by a certain age. Although alopecia is a benign disorder, even the most negligible amount of hair loss can be devastating to a patient's self-esteem, self-image, and overall quality of life...
March 2018: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29869472/-injection-of-prp-platelet-rich-plasma-as-a-treatment-for-androgenetic-alopecia-a-systematic-review-of-the-literature
#3
REVIEW
O Oth, J-J Stene, R Glineur, A Vujovic
INTRODUCTION: Androgenetic alopecia is the most frequent alopecia both in men and women. Despite it affects a large proportion of the population, they are few therapeutic options often restrictive. The injection of PRP in alopecic areas is a new and easy therapeutic option. The aim of this article is to systematically review the literature about this topic by analysing the articles describing the clinical results of this new technique in the treatment of androgenetic alopecia in men and / or women with a follow-up of minimum 6 months...
May 30, 2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29797431/efficacy-of-non-surgical-treatments-for-androgenetic-alopecia-a-systematic-review-and-network-meta-analysis
#4
REVIEW
Aditya K Gupta, Rachel R Mays, Michelle S Dotzert, Sarah G Versteeg, Neil H Shear, Vincent Piguet
Androgenetic alopecia, or male/female pattern baldness, is the most common type of progressive hair loss disorder. The aim of this paper is to review recent advances in non-surgical treatments for androgenetic alopecia and identify the most effective treatments. A network meta-analysis (NMA) was conducted of the available literature of the six most common non-surgical treatment options for treating androgenetic alopecia in both men and women; dutasteride 0.5mg, finasteride 1mg, low level laser therapy (LLLT), minoxidil 2%, minoxidil 5% and platelet rich plasma (PRP)...
May 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29765963/alopecic-and-aseptic-nodules-of-the-scalp-first-report-in-south-america-and-second-in-america
#5
Cristián Fischer-Levancini, Matías Gompertz, Antonio Guglielmetti, Héctor Opazo
Alopecic and aseptic nodules of the scalp, also named pseudocysts of the scalp, are a relatively new, little-known, and for sure underdiagnosed disease. It affects mostly young men and is characterized by a solitary or a few dome-shaped nodules accompanied by nonscarring alopecia, deep inflammatory infiltration in the skin biopsy specimen, and, in most cases, granulomas. It has a good response to doxycycline, intralesional corticosteroids, or drainage/aspiration of the lesion. We present a case report and a summary of the published cases...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29764513/cellular-therapy-with-human-autologous-adipose-derived-adult-cells-of-stromal-vascular-fraction-for-alopecia-areata
#6
Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk, Aline Hamade
BACKGROUND: Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. The potential use of stem cell-based therapies (SCBT) for the repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions, which can be applied to prevent hair loss...
May 15, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29755912/scrotal-rejuvenation
#7
REVIEW
Philip R Cohen
Genital rejuvenation is applicable not only to women (vaginal rejuvenation) but also to men (scrotal rejuvenation). There is an increased awareness, reflected by the number of published medical papers, of vaginal rejuvenation; however, rejuvenation of the scrotum has not received similar attention in the medical literature. Scrotal rejuvenation includes treatment of hair-associated scrotal changes (alopecia and hypertrichosis), morphology-associated scrotal changes (wrinkling and laxity), and vascular-associated scrotal changes (angiokeratomas)...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29667763/prospective-randomized-study-of-sexual-function-in-men-taking-dutasteride-for-the-treatment-of-androgenetic-alopecia
#8
Tsen-Fang Tsai, Gwang Seong Choi, Beom Joon Kim, Moon-Bum Kim, Chi Fai Ng, Puja Kochhar, Stacy Jasper, Betsy Brotherton, Barbara Orban, Zrinka Lulic
Treatment with 5α-reductase inhibitors has been associated with sexual adverse events such as impotence (erectile dysfunction) and decreased libido. The primary objective of this study was to evaluate adverse events related to sexual function, based on their frequency, duration, persistence and associated treatment discontinuations, in men treated with dutasteride for androgenetic alopecia. Participants were randomized to receive double-blind dutasteride 0.5 mg or placebo once daily for 24 weeks, followed by open-label dutasteride 0...
April 18, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29659116/efficacy-and-safety-of-a-new-5-minoxidil-formulation-in-male-androgenetic-alopecia-a-randomized-placebo-controlled-double-blind-noninferiority-study
#9
Ulrike Blume-Peytavi, Zahida Issiakhem, Stephanie Gautier, Jan Kottner, Walter Wigger-Alberti, Tobias Fischer, Rolf Hoffmann, Françoise Tonner, Athmane Bouroubi, Jean-Jacques Voisard
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of hair loss in men. Topical minoxidil solutions can help to treat AGA but have to be applied continuously to be effective. OBJECTIVES: A new minoxidil formulation with improved cosmetic characteristics (DC0120, Pierre-Fabre Dermatologie) was tested for noninferiority vs a comparator minoxidil product (ALOSTIL® , Johnson & Johnson) in stimulating hair growth in men with AGA. METHODS: Two 10 cm2 areas on the scalp of each subject were randomized to receive DC0120, the comparator, or one of their corresponding vehicles, applied twice per day for 16 weeks...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29601622/a-systematic-review-of-topical-finasteride-in-the-treatment-of-androgenetic-alopecia-in-men-and-women
#10
Sung Won Lee, Margit Juhasz, Pezhman Mobasher, Chloe Ekelem, Natasha Atanaskova Mesinkovska
INTRODUCTION: Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia. Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising. METHODS: A search was conducted to identify studies regarding human in vivo topical FNS treatment efficacy including clinically relevant case reports, randomized controlled trials (RCTs), and prospective studies...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29569785/sex-and-age-adjusted-prevalence-estimates-of-five-chronic-inflammatory-skin-diseases-in-france-results-of-the-%C3%A2-objectifs-peau-%C3%A2-study
#11
Marie-Aleth Richard, Florence Corgibet, Marie Beylot-Barry, Annick Barbaud, Christine Bodemer, Véronique Chaussade, Michel D'Incan, Pascal Joly, Marie Thérèse Leccia, Jean Marie Meurant, Antoine Petit, Brigitte Roy Geffroy, Jean François Sei, Charles Taieb, Laurent Misery, Khaled Ezzedine
BACKGROUND: There are few population-based studies assessing the prevalence of skin diseases. OBJECTIVES: To estimate the prevalence of five chronic skin inflammatory diseases, i.e. atopic dermatitis (AD), psoriasis, alopecia areata (AA), vitiligo and hidradenitis suppurativa (HS) in France, using validated self-diagnostic questionnaires. METHODS: Population-based study using a representative sample of the French general population aged more than 15 years and sampling-with-replacement design...
March 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29490767/association-of-alopecia-areata-with-atopic-dermatitis-and-chronic-spontaneous-urticaria
#12
Eli Magen, Tinatin Chikovani, Dan-Andrei Waitman, Natan R Kahan
BACKGROUND: Epidemiologic studies report that alopecia areata (AA) is related to various atopic and autoimmune diseases. The purpose of this study was to identify clinical characteristics and the prevalence of comorbid conditions in Israeli patients with AA. METHODS: This retrospective, matched, case-control study was based on data from an electronic patient record data base. The patients with an electronically documented diagnosis of AA were included in the AA group...
March 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29483947/metabolic-syndrome-and-the-skin-a-more-than-superficial-association-reviewing-the-association-between-skin-diseases-and-metabolic-syndrome-and-a-clinical-decision-algorithm-for-high-risk-patients
#13
REVIEW
Ellie C Stefanadi, Georgios Dimitrakakis, Christos-Konstantinos Antoniou, Dimitrios Challoumas, Nikita Punjabi, Inetzi Aggeliki Dimitrakaki, Sangeeta Punjabi, Christodoulos I Stefanadis
There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS comprises a combination of parameters that predispose individuals to the development of type 2 diabetes and cardiovascular disease (CVD). Three or more of the following criteria are necessary: fasting glucose > 110 mg/dl (5.6 mmol/l), hypertriglyceridemia > 150 mg/dl (1.7 mmol/l), HDL levels < 40 mg/dl (men)/< 50 mg/dl (women), blood pressure > 130/85 mmHg, waist circumference (values for Mediterranean populations > 94 cm (men)/> 89 cm (women)...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29457012/impact-of-folliculitis-decalvans-on-quality-of-life-and-subjective-perception-of-disease
#14
Cristina Pindado-Ortega, David Saceda-Corralo, Laura Miguel-Gómez, Diego Buendía-Castaño, Pablo Fernández-González, Oscar M Moreno-Arrones, Pablo Fonda-Pascual, Adrian Alegre-Sánchez, Rita Rodrigues-Barata, Sergio Vañó-Galván
Folliculitis decalvans (FD) is a primary neutrophilic scarring alopecia characterized by perifollicular papules, crusts, and pustules frequently located on the vertex. FD may affect young men and women. Since it may lead to hair loss, it can have a negative impact on patients' quality of life. Nevertheless, studies have focused on clinical, prognostic, and therapeutic aspects without considering the psychological impact of FD. In our study, we found that FD patients experienced a considerable impact on their quality of life...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29457005/effectiveness-of-platelet-rich-plasma-for-androgenetic-alopecia-a-review-of-the-literature
#15
REVIEW
Jessica Cervantes, Marina Perper, Lulu L Wong, Ariel E Eber, Alexandra C Villasante Fricke, Tongyu Cao Wikramanayake, Joaquin J Jimenez
Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Platelet-rich plasma (PRP), a treatment modality shown to promote wound healing, has also been explored as a treatment for AGA. This literature review was conducted to assess the effectiveness of PRP treatment for AGA. Twelve studies conducted from 2011 to 2017 were evaluated and summarized by study characteristics, mode of preparation, and treatment protocols...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29407002/a-hypothetical-pathogenesis-model-for-androgenic-alopecia-clarifying-the-dihydrotestosterone-paradox-and-rate-limiting-recovery-factors
#16
Robert S English
Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence and extensive study, a coherent pathology model describing androgenic alopecia's precursors, biological step-processes, and physiological responses does not yet exist. While consensus is that androgenic alopecia is genetic and androgen-mediated by dihydrotestosterone, questions remain regarding dihydrotestosterone's exact role in androgenic alopecia onset...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29403185/standardization-of-smp-procedure-and-its-impact-on-outcome
#17
Rachita S Dhurat, Sujit J S Shanshanwal, Ameet L Dandale
Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Scalp micropigmentation (SMP) is one of the concealers recently gaining popularity. Objectives: SMP is a novel technique wherein microdot tattoos are placed in a stippling pattern to mimic hair follicles that are cut close to the scalp and various variables affecting its outcome were evaluated...
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29376219/selenium-for-preventing-cancer
#18
REVIEW
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29363345/androgenetic-alopecia-drug-safety-and-therapeutic-strategies
#19
REVIEW
Ion G Motofei, David L Rowland, Daniela L Baconi, Mircea Tampa, Maria-Isabela Sârbu, Stana Păunică, Vlad D Constantin, Cristian Bălălău, Ioana Păunică, Simona Roxana Georgescu
Androgenetic alopecia (AGA) is a benign condition with variable psychosocial impact, with some individuals adapting well while others needing therapeutic support. Although 5α-reductase inhibitors like finasteride and dutasteride have proven effective in ameliorating AGA, their use/selection is currently a subject of debate. Areas covered: Treatment of AGA with 5α-reductase inhibitors lead to variable adverse effects and relatively unstable results (therapeutic efficacy ending with treatment cessation), so the choice of optimal therapy is not straightforward...
April 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29362834/-postmenopausal-lichen-planopilaris-also-known-as-fibrosing-frontotemporal-alopecia-kossard-an-evidence-oriented-practical-guide-to-treatment-from-the-university-of-the-saarland-hair-research-center-of-the-dr-rolf-m-schwiete-foundation
#20
REVIEW
T Vogt, C Thomas, J Reichrath, L Schilling, D Mawlood, R Christmann, B Loretz, U Schäfer, C-M Lehr, C Müller
Postmenopausal lichen planopilaris (PLPP), also known as fibrosing frontotemporal alopecia Kossard (FFAK), is a not uncommon inflammatory scalp disease affecting approximately 5% of patients at specialized hair centers. The overall incidence of sporadic occurrence is believed to be just under 1% in the older, predominantly female, general population. Since the disease is often undiagnosed, it is statistically likely to be underrepresented. It especially occurs in postmenopausal women who are in the 6th and 7th decade of life (90%), but also in about 10% of premenopausal women, and in men it is documented only in isolated cases...
February 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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