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https://www.readbyqxmd.com/read/28161756/safety-profile-of-finasteride-distribution-of-adverse-effects-according-to-structural-and-informational-dichotomies-of-the-mind-brain
#1
Ion G Motofei, David L Rowland, Mirela Manea, Simona R Georgescu, Ioana Păunică, Ioanel Sinescu
Finasteride is currently used extensively for male androgenic alopecia and benign prostatic hyperplasia; however, some adverse effects are severe and even persistent after treatment cessation, the so-called 'post-finasteride syndrome'. The following most severe adverse effects-sexual dysfunction and depression-often occur together and may potentiate one other, a fact that could explain (at least in part) the magnitude and persistence of finasteride adverse effects. This paper presents the pharmacological action of finasteride and the corresponding adverse effects, the biological base explaining the occurrence, persistence and distribution of these adverse effects, and a possible therapeutic solution for post-finasteride syndrome...
February 4, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28117051/update-on-frontal-fibrosing-alopecia
#2
L Esteban-Lucía, A M Molina-Ruiz, L Requena
Frontal fibrosing alopecia (FFA) is an increasingly common acquired primary scarring alopecia, first described by Kossard in 1994. Clinically it is characterized by frontotemporal hairline recession, frequently accompanied by eyebrow loss. FFA was initially thought to have a hormonal origin as it was first described in postmenopausal women and premenopausal women with a history of hysterectomy or early menopause. This origin, however, has been questioned in recent years due to the publication of cases in men and premenopausal women...
January 20, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28024997/androgen-receptor-ar-gene-cag-n-and-ggn-n-length-polymorphisms-and-symptoms-in-young-males-with-long-lasting-adverse-effects-after-finasteride-use-against-androgenic-alopecia
#3
Sabina Cauci, Giovanni Chiriacò, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
INTRODUCTION: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS: AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). MAIN OUTCOME MEASURES: Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS)...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28008278/acne-keloidalis-nuchae-prevalence-impact-and-management-challenges
#4
REVIEW
Adebola Ogunbiyi
Acne keloidalis nuchae (AKN) also known as folliculitis keloidalis nuchae (FKN) is a chronic form of scarring folliculitis seen mostly in men of African descent. The term AKN is commonly used even though the condition is not a keloid, and the affected individuals do not have a tendency to develop keloids in other areas of the body. It is seen in post pubertal men and is rare after the age of 55 years. A few cases have been reported in females. which has been classified as a primary cicatricial alopecia since the exact cause of acne keloidalis (AK) remains unknown...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27987270/the-role-of-oxidative-stress-in-early-onset-androgenetic-alopecia
#5
Hilal Kaya Erdogan, Isıl Bulur, Evin Kocaturk, Bahadir Yildiz, Zeynep Nurhan Saracoglu, Ozkan Alatas
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of alopecia in men. In the literature, although there are in vitro studies investigating the relationship between oxidative stress and AGA, any in vivo study does not exist. AIM: Our aim was to evaluate the oxidative stress status in male patients with early-onset AGA by measuring total oxidant levels (TOS), total antioxidant levels (TAS), and oxidative stress index (OSI). METHODS: Our study included 33 male patients with early-onset AGA and 30 healthy men between ages of 18 and 30 years old...
December 16, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27942367/digit-length-ratios-2d-4d-as-a-phenotypic-indicator-of-in-utero-androgen-exposure-is-not-prognostic-for-androgenic-alopecia-a-descriptive-analytic-study-of-1200-iranian-men
#6
Amir Feily, Masoomeh Hosseinpoor, Ali Bakhti, Mohamad Nekuyi, Saeed Sobhanian, Zahra Fathinezhad, Reza Sahraei, Marigdalia K Ramirez-Fort
The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0...
June 15, 2016: Dermatology Reports
https://www.readbyqxmd.com/read/27904832/frontal-fibrosing-alopecia-treatment-options
#7
Raymond Fertig, Antonella Tosti
Frontal fibrosing alopecia (FFA) is a rare dermatologic disease that causes scarring and hair loss and is increasing in prevalence worldwide. FFA patients typically present with hair loss in the frontal scalp region and eyebrows which may be associated with sensations of itching or burning. FFA is a clinically distinct variant of lichen planopilaris (LPP) that affects predominantly postmenopausal women, although men and premenopausal women may also be affected. Early diagnosis and prompt treatment are necessary to prevent definitive scarring and permanent hair loss...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27853485/study-on-the-efficacy-of-platelet-rich-fibrin-matrix-in-hair-follicular-unit-transplantation-in-androgenetic-alopecia-patients
#8
Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27799439/systemic-lupus-erythematosus-in-spanish-males-a-study-of-the-spanish-rheumatology-society-lupus-registry-relesser-cohort
#9
A Riveros Frutos, I Casas, I Rúa-Figueroa, F J López-Longo, J Calvo-Alén, M Galindo, A Fernández-Nebro, J M Pego-Reigosa, A Olivé Marqués
OBJECTIVE: The objective of this study was to describe the demographic, clinical, and immunological manifestations of systemic lupus erythematosus (SLE) in male patients. METHODS: A cross-sectional, multicenter study was carried out of 3651 patients (353 men, 9.7%, and 3298 women, 90.2%) diagnosed with SLE, included in the Spanish Rheumatology Society SLE Registry (RELESSER). RESULTS: Mean ages (18-92 years) of symptom onset were 37 (SD 17) years (men) and 32 (SD 14) years (women)...
October 31, 2016: Lupus
https://www.readbyqxmd.com/read/27721910/diagnostic-clues-to-frontal-fibrosing-alopecia-in-patients-of-african-descent
#10
Valerie D Callender, Sophia D Reid, Olubusayo Obayan, Liza Mcclellan, Leonard Sperling
Importance: Frontal fibrosing alopecia has previously been reported as rare among patients of African descent. The authors present 18 cases of frontal fibrosing alopecia affecting African American patients and review all published cases of frontal fibrosing alopecia involving patients of African descent. Observations: Since 2010, there have been 66 published cases of frontal fibrosing alopecia among patients of African descent; 59 women, five men, and two cases of unknown gender. Frontal fibrosing alopecia is not uncommon among patients of African descent...
April 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27661430/a-new-subtype-of-lichen-planopilaris-affecting-vellus-hairs-and-clinically-mimicking-androgenetic-alopecia
#11
Ali Abbasi, Kambiz Kamyab-Hesari, Ramin Rabbani, Farzaneh Mollaee, Sheida Abbasi
BACKGROUND: Lichen planopilaris (LPP) is a follicular variant of lichen planus. A new subtype of LPP mimicking androgenetic alopecia (AGA) may be misdiagnosed. Inappropriate medical therapy or hair transplantation may exacerbate this subtype. OBJECTIVE: To introduce clinicopathologic findings of a new subtype of LPP that selectively affects vellus hair in the pattern of AGA. MATERIALS AND METHODS: In a cross-sectional study, 433 (66.6%) men and 217 (33...
October 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27659058/risk-of-erectile-dysfunction-associated-with-use-of-5-%C3%AE-reductase-inhibitors-for-benign-prostatic-hyperplasia-or-alopecia-population-based-studies-using-the-clinical-practice-research-datalink
#12
Katrina Wilcox Hagberg, Hozefa A Divan, Rebecca Persson, J Curtis Nickel, Susan S Jick
OBJECTIVE:  To estimate the risk of erectile dysfunction in men who used 5-α reductase inhibitors to treat benign prostatic hyperplasia or alopecia. DESIGN:  Cohort studies with nested case-control analyses. SETTING:  UK Clinical Practice Research Datalink. POPULATION:  Two populations of men free of risk factors for erectile dysfunction and other sexual dysfunction or its treatment: men aged 40 or more with benign prostatic hyperplasia who received a prescription for a 5-α reductase inhibitor (finasteride or dutasteride) or α blocker, or both, and men aged 18-59 with alopecia...
September 22, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27618394/a-critical-assessment-of-the-evidence-for-low-level-laser-therapy-in-the-treatment-of-hair-loss
#13
Aditya K Gupta, Kelly A Foley
BACKGROUND: Low-level laser therapy (LLLT) is currently in use to stimulate hair growth and is quickly gaining in popularity due to the ease of use and absence of side effects. In 2015 alone, the number of LLLT devices with the Food and Drug Administration clearance has doubled. OBJECTIVE: To consolidate evidence and establish which data are still required for the widespread acceptance of LLLT for hair loss therapy. METHODS AND MATERIALS: A thorough search of the PubMed database was conducted to obtain studies investigating LLLT for androgenetic alopecia in men and women...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27601858/an-observational-study-of-the-association-between-androgenetic-alopecia-and-size-of-the-prostate
#14
Kanagaraj Ramsamy, Radhakrishnan Subramaniyan, Anjan Kumar Patra
INTRODUCTION: Androgenetic alopecia (AGA) is characterized by miniaturization of the hair follicle, leading to vellus transformation of the terminal hair follicle. It is caused by interactions between androgens, several genes, and environmental factors with hair follicles. Benign prostatic hyperplasia (BPH) is highly prevalent among elderly men but infrequent in those younger than 40 years. Because both entities share a common pathogenesis and AGA manifests before the onset of BPH, there could be an association between AGA and BPH...
April 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/27593381/efficacy-of-platelet-rich-plasma-in-the-treatment-of-androgenetic-male-patterned-alopecia-a-pilot-randomized-controlled-trial
#15
Mohammad Ali Mapar, Sadegh Shahriari, Mohammad Hosein Haghighizadeh
BACKGROUND: Platelet-rich plasma (PRP) has been proposed as an effective treatment for different diseases. OBJECTIVE: The aim of this study is to evaluate the efficacy of PRP in the treatment of androgenetic alopecia (AGA). MATERIAL AND METHODS: In this study, 19 men with AGA were recruited among whom 17 men completed the trial. At the beginning, 2 square-shaped areas of 2.5 × 2.5 centimeters, at least 3 cm apart from each other were selected on the scalp of each patient as case and control sites...
December 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27560098/perception-of-hair-transplant-for-androgenetic-alopecia
#16
Kristin L Bater, Masaru Ishii, Andrew Joseph, Peiyi Su, Jason Nellis, Lisa E Ishii
Importance: Hair transplant is among the most common cosmetic services sought by men, with more than 11 000 procedures performed in 2014. Despite its growing popularity, the effect of hair transplant on societal perceptions of youth, attractiveness, or facets of workplace and social success is unknown. Objectives: To determine whether hair transplant improves observer ratings of age, attractiveness, successfulness, and approachability in men treated for androgenetic alopecia and to quantify the effect of hair transplant on each of these domains...
December 1, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27554257/androgenetic-alopecia-an-update-of-treatment-options
#17
REVIEW
Yanna Kelly, Aline Blanco, Antonella Tosti
Androgenetic alopecia (AGA) is characterized by a non-scarring progressive miniaturization of the hair follicle in predisposed men and women with a pattern distribution. Although AGA is a very prevalent condition, approved therapeutic options are limited. This article discusses the current treatment alternatives including their efficacy, safety profile, and quality of evidence. Finasteride and minoxidil for male androgenetic alopecia and minoxidil for female androgenetic alopecia still are the therapeutic options with the highest level evidence...
September 2016: Drugs
https://www.readbyqxmd.com/read/27549867/superiority-of-dutasteride-over-finasteride-in-hair-regrowth-and-reversal-of-miniaturization-in-men-with-androgenetic-alopecia-a-randomized-controlled-open-label-evaluator-blinded-study
#18
Sujit J S Shanshanwal, Rachita S Dhurat
BACKGROUND: Finasteride and dutasteride are inhibitors of the enzyme 5-alpha-reductase which inhibits the conversion of testosterone to dihydrotestosterone. Dutasteride inhibits both type I and type II 5-alpha-reductase while finasteride inhibits only the type II enzyme. As both isoenzymes are present in hair follicles, it is likely that dutasteride is more effective than finasteride. AIMS: To compare the efficacy, safety and tolerability of dutasteride and finasteride in men with androgenetic alopecia...
January 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27516698/the-most-frequent-herbs-proposed-by-iranian-traditional-medicine-for-alopecia-areata
#19
Maedeh Rezghi, Shirin Fahimi, Sara Zakerin
BACKGROUND: Alopecia areata (AA) is a common immune-mediated hair loss disorder. AA has a reported incidence of 0.1-0.2% with a lifetime risk of 1.7%. Histologically, AA is characterized by the accumulation of mononuclear cells around the bulb of the affected hair follicles. Corticosteroids are the most popular drugs for the treatment of this disease. Despite its high prevalence, currently available treatments are mostly unsatisfactory and inefficient for the more chronic and severe types of the AA...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27506633/a-6-month-randomized-double-blind-placebo-controlled-study-evaluating-the-ability-of-a-marine-complex-supplement-to-promote-hair-growth-in-men-with-thinning-hair
#20
Glynis Ablon
BACKGROUND: Male pattern baldness, or androgenetic alopecia, affects approximately 50% of the adult population and can cause poor self-image, low self-esteem and have a significant negative impact on the quality of life. An oral nutraceutical supplement based on a marine complex formulation has previously been reported to significantly increase the number of terminal hairs in women with thinning hair. AIMS: The objective of this double-blind, placebo-controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal(®) Man; Lifes2good, Inc...
December 2016: Journal of Cosmetic Dermatology
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