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https://www.readbyqxmd.com/read/28454119/anti-proliferative-and-anti-secretory-effects-of-everolimus-on-human-pancreatic-neuroendocrine-tumors-primary-cultures-is-there-any-benefit-from-combination-with-somatostatin-analogs
#1
Amira Mohamed, David Romano, Alexandru Saveanu, Catherine Roche, Manuela Albertelli, Federica Barbieri, Thierry Brue, Patricia Niccoli, Jean-Robert Delpero, Stephane Garcia, Diego Ferone, Tullio Florio, Vincent Moutardier, Flora Poizat, Anne Barlier, Corinne Gerard
Therapeutic management of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is challenging. The mammalian target of rapamycin (mTOR) inhibitor everolimus recently obtained approval from the Food and Drug Administration for the treatment of patients with advanced pancreatic neuroendocrine tumors (pNETs). Despite its promising antitumor efficacy observed in cell lines, clinical benefit for patients is unsatisfactory. The limited therapeutic potential of everolimus in cancer cells has been attributed to Akt activation due to feedback loops relief following mTOR inhibition...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454097/upregulation-of-calprotectin-in-mild-ige-mediated-ovalbumin-hypersensitivity
#2
Qingling Zhu, Feng Li, Junli Wang, Jingqiu Ma, Xiaoyang Sheng
Calprotectin, also known as S100A8/A9, has been linked to gut inflammation caused by IgE-mediated food hypersensitivities, but the pathophysiologic abnormalities it causes remain to be determined. We created a mild food hypersensitivity model through oral gavage of ovalbumin in Norway brown rats without using immune adjuvant. Changes in the levels of calprotectin and inflammation-associated cytokines were then observed over time. We found that fecal calprotectin as well as jejunal and liver TLR4, TNF-α, NF-κB, IL-1β, and IL-6 were upregulated in hypersensitive rats...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454004/growth-and-phycocyanin-synthesis-in-the-heterotrophic-microalga-galdieria-sulphuraria-on-substrates-made-of-food-waste-from-restaurants-and-bakeries
#3
Jenni Katrine Sloth, Henriette Casper Jensen, Daniel Pleissner, Niels Thomas Eriksen
Galdieria sulphuraria 074G (Rhodophyta) was grown heterotrophically in defined medium and on amylolytic and proteolytic hydrolysed food waste from restaurants and bakeries. Substrate uptake, growth, and phycocyanin content were quantified in the cultures. The alga utilised carbohydrates and amino acids from the waste but ammonium and other inorganic nutrients were needed to stimulate phycocyanin synthesis. Highest specific phycocyanin contents (20-22mgg(-1)) were observed in cells grown at 25°C or 34°C on the food wastes...
April 17, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28448460/assessing-greenhouse-gas-emissions-and-health-co-benefits-a-structured-review-of-lifestyle-related-climate-change-mitigation-strategies
#4
REVIEW
Vivian G M Quam, Joacim Rocklöv, Mikkel B M Quam, Rebekah A I Lucas
This is the first structured review to identify and summarize research on lifestyle choices that improve health and have the greatest potential to mitigate climate change. Two literature searches were conducted on: (1) active transport health co-benefits, and (2) dietary health co-benefits. Articles needed to quantify both greenhouse gas emissions and health or nutrition outcomes resulting from active transport or diet changes. A data extraction tool (PRISMA) was created for article selection and evaluation...
April 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28447463/screening-of-debaryomyces-hansenii-strains-for-flavor-production-under-reduced-concentration-of-nitrifying-preservatives-used-in-meat-products
#5
Monica Flores, Daniel Moncunill, Rebeca Montero, Jose Javier López-Díez, Carmela Belloch
Fifteen D. hansenii strains from different food origins were genetically characterised and tested on a culture medium resembling the composition of fermented sausages but different concentrations of nitrifying preservatives. Genetic typing of the D. hansenii strains revealed two levels of discrimination, isolation source or strain specific. Different ability to proliferate on culture media containing different concentrations of nitrate and nitrite, as sole nitrogen sources and in presence of amino acids, was observed within D...
April 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28446905/okara-a-nutritionally-valuable-by-product-able-to-stabilize-lactobacillus-plantarum-during-freeze-drying-spray-drying-and-storage
#6
Gabriel Quintana, Esteban Gerbino, Andrea Gómez-Zavaglia
Okara is a nutritionally valuable by-product produced in large quantities as result of soymilk elaboration. This work proposes its use as both culture and dehydration medium during freeze-drying, spray-drying, and storage of Lactobacillus plantarum CIDCA 83114. Whole and defatted okara were employed as culture media for L. plantarum CIDCA 83114. The growth kinetics were followed by plate counting and compared with those of bacteria grown in MRS broth (control). No significant differences in plate counting were observed in the three media...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28446903/simulating-intestinal-growth-conditions-enhances-toxin-production-of-enteropathogenic-bacillus-cereus
#7
Nadja Jeßberger, Corinna Rademacher, Viktoria M Krey, Richard Dietrich, Ann-Katrin Mohr, Maria-Elisabeth Böhm, Siegfried Scherer, Monika Ehling-Schulz, Erwin Märtlbauer
Bacillus cereus is a ubiquitous bacterial pathogen increasingly reported to be the causative agent of foodborne infections and intoxications. Since the enterotoxins linked to the diarrheal form of food poising are foremost produced in the human intestine, the toxic potential of enteropathogenic B. cereus strains is difficult to predict from studies carried out under routine cultivation procedures. In this study, toxigenic properties of a panel of strains (n = 19) of diverse origin were compared using cell culture medium pre-incubated with CaCo-2 cells to mimic intestinal growth conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28446888/money-food-and-daily-life-objects-are-similarly-shared-in-the-dictator-game-a-study-among-poles-and-tsimane
#8
Piotr Sorokowski, Anna Oleszkiewicz, Agnieszka Niemczyk, Michalina Marczak, Tomas Huanca, Esther C Velasco, Agnieszka Sorokowska
The dictator game (DG) is one of the most popular methods for measuring sharing behaviors. However, the matter of goods used in the game has rarely been examined and discussed. We conducted a study in which all participants played standard version of DG in one of the three versions - "money," "food," or "daily life objects" sharing. Further, we wanted to expand the generalizability of our findings by investigating whether patterns in sharing various goods are independent of culture and the level of market integration...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28444234/inferring-allele-frequency-trajectories-from-ancient-dna-indicates-that-selection-on-a-chicken-gene-coincided-with-changes-in-medieval-husbandry-practices
#9
Liisa Loog, Mark G Thomas, Ross Barnett, Richard Allen, Naomi Sykes, Ptolemaios D Paxinos, Ophelie Lebrasseur, Keith Dobney, Joris Peters, Andrea Manica, Greger Larson, Anders Eriksson
Ancient DNA provides an opportunity to infer the drivers of natural selection by linking allele frequency changes to temporal shifts in environment or cultural practices. However, analyses have often been hampered by uneven sampling and uncertainties in sample dating, as well as being confounded by demographic processes. Here we present a Bayesian statistical framework for quantifying the timing and strength of selection using ancient DNA that explicitly addresses these challenges. We applied this method to time series data for two loci: TSHR and BCDO2, both argued to have undergone strong and recent selection in domestic chickens...
April 21, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28443289/frequency-and-duration-of-fecal-shedding-of-salmonella-enteritidis-by-experimentally-infected-laying-hens-housed-in-enriched-colony-cages-at-different-stocking-densities
#10
Richard K Gast, Rupa Guraya, Deana R Jones, Kenneth E Anderson, Darrin M Karcher
Human infections with Salmonella Enteritidis are often attributed to the consumption of contaminated eggs, so the prevalence of this pathogen in egg-laying poultry is an important public health risk factor. Numerous and complex environmental influences on Salmonella persistence and transmission are exerted by management practices and housing facilities used in commercial egg production. In recent years, the animal welfare implications of poultry housing systems have guided the development of alternatives to traditional cage-based housing, but their food safety consequences are not yet fully understood...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28440783/social-vulnerability-and-hypoglycemia-among-patients-with-diabetes
#11
Jorge Waitman, Gabriela Caeiro, Silvana A Romero Gonzalez, Danila P Ré, Andrea Daghero, Claudio D Gonzalez, Guillermo E Umpierrez
Lower-income populations are hit harder by the diabetes epidemic as regards both prevalence and the risk of complications. Food Insecurity is one of the mechanisms through which poverty may predispose people with low socio-economic status to poorer control and higher complication rates. The United Nations Food and Agriculture Organization defined food security as "the right to have access to sufficient nutritional and culturally acceptable food choices." Adults suffering from diabetes with limited income have a 40% greater chance of having food insecurity and an inadequate blood glucose control...
February 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28440549/feel-american-watch-american-eat-american-remote-acculturation-tv-and-nutrition-among-adolescent-mother-dyads-in-jamaica
#12
Gail M Ferguson, Henna Muzaffar, Maria I Iturbide, Hui Chu, Julie Meeks Gardner
Globalization prompts remote acculturation toward U.S. culture in Jamaica; this study used a bioecological systems approach to examine its proximal impact on nutrition through U.S. cable TV consumption, and maternal influences in the home. Overall, 330 randomly selected adolescent-mother dyads from schools in Kingston, Jamaica (Madolescent_age  = 13.8 years, SDadolescent_age  = 1.8) completed questionnaires reporting American identity and behavioral preferences, daily time spent watching U.S.-produced TV programs, and frequency of eating unhealthy foods...
April 25, 2017: Child Development
https://www.readbyqxmd.com/read/28437594/a-mesoamerican-origin-of-cherimoya-annona-cherimola-mill-implications-for-the-conservation-of-plant-genetic-resources
#13
N Larranaga, F J Albertazzi, G Fontecha, M Palmieri, H Rainer, M van Zonneveld, J I Hormaza
Knowledge on the structure and distribution of genetic diversity is a key aspect in order to plan and execute an efficient conservation and utilization of the genetic resources of any crop as well as for determining historical demographic inferences. In this work, a large data set of 1765 accessions of cherimoya (Annona cherimola Mill, Annonaceae), an underutilized fruit tree crop native to the neotropics and used as a food source by pre-Columbian cultures, was collected from 6 different countries across the American continent and amplified with 9 highly informative microsatellite markers...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28436102/nutrition-in-adolescents-physiology-metabolism-and-nutritional-needs
#14
REVIEW
Jai K Das, Rehana A Salam, Kent L Thornburg, Andrew M Prentice, Susan Campisi, Zohra S Lassi, Berthold Koletzko, Zulfiqar A Bhutta
Adolescence is the period of development that begins at puberty and ends in early adulthood. Most commonly, adolescence is divided into three developmental periods: early adolescence (10-14 years of age), late adolescence (15-19 years of age), and young adulthood (20-24 years of age). Adolescence is marked by physical and sexual maturation, social and economic independence, development of identity, acquisition of skills needed to carry out adult relationships and roles, and the capacity for abstract reasoning...
April 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28435352/development-of-high-cordycepin-producing-cordyceps-militaris-strains
#15
Naru Kang, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among Cordyceps species and can be cultured artificially. For these reasons, C. militaris is widely used as herb or functional food in the East Asia. In this study, we developed a new strain of C. militaris that produces higher cordycepin content than parent strains through mating-based sexual reproduction. Twenty parent strains were collected and identified as C. militaris based on internal trasncrived spacer and rDNA sequences...
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28431310/characterization-of-bacterial-communities-of-donkey-milk-by-high-throughput-sequencing
#16
Maria de Los Dolores Soto Del Rio, Alessandra Dalmasso, Tiziana Civera, Maria Teresa Bottero
The interest in donkey milk (DM) is growing because of its functional properties and nutritional value, especially for children with allergies and food intolerances. However, most of the available reports of DM microbiota are based on culture-dependent methods to investigate food safety issues and the presence of lactic acid bacteria (LAB). The aim of this study was to determine the composition of DM bacterial communities using a high-throughput sequencing (HTS) approach. Bulk milk samples from Italian donkey dairy farms from two consecutive years were analysed using the MiSeq Illumina platform...
March 30, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28429168/bedaquiline-susceptibility-test-for-totally-drug-resistant-tuberculosis-mycobacterium-tuberculosis
#17
Ji-Chan Jang, Yong-Gyun Jung, Jungil Choi, Hyunju Jung, Sungweon Ryoo
This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M...
April 20, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28428778/evidence-for-nitric-oxide-synthase-activity-in-staphylococcus-xylosus-mediating-nitrosoheme-formation
#18
Geoffrey Ras, Véronique Zuliani, Patrick Derkx, Tim M Seibert, Sabine Leroy, Régine Talon
Staphylococcus xylosus is used as a starter culture in fermented meat products and contributes to color formation by the reduction of nitrate to nitrite. Nitrite is a food additive that is chemically turned to nitric oxide (NO) in meat but its safety has been questioned. The objective of this study was to determine the ability of NO synthase (NOS) of S. xylosus C2a to produce NO. For this purpose, a nos deletion mutant (Δnos) in S. xylosus was constructed and NO production was evaluated in a test based on its ability to form nitrosomyoglobin and nitrosoheme...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28427828/a-combined-clostridium-perfringens-trueperella-pyogenes-inactivated-vaccine-induces-complete-immunoprotection-in-a-mouse-model
#19
Wenlong Zhang, Pu Wang, Bing Wang, Bo Ma, Junwei Wang
Clostridium perfringens (C. perfringens) and Trueperella pyogenes (T. pyogenes) are two bacterial pathogens frequently associated with wound infections and following lethal complications in livestock. However, prudent use of antimicrobial agents is highly required given the emergence of multidrug-resistant strains of both bacteria and need for food safety. In the current study, a combined vaccine, composed of inactivated C. perfringens and T. pyogenes, was prepared. The amount of formaldehyde being used to inactivate two bacteria was optimized to retain the immunogenicity of antigens...
April 17, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28426751/the-role-of-microsporidian-polar-tube-protein-4-ptp4-in-host-cell-infection
#20
Bing Han, Valérie Polonais, Tatsuki Sugi, Rama Yakubu, Peter M Takvorian, Ann Cali, Keith Maier, Mengxian Long, Matthew Levy, Herbert B Tanowitz, Guoqing Pan, Frédéric Delbac, Zeyang Zhou, Louis M Weiss
Microsporidia have been identified as pathogens that have important effects on our health, food security and economy. A key to the success of these obligate intracellular pathogens is their unique invasion organelle, the polar tube, which delivers the nucleus containing sporoplasm into host cells during invasion. Due to the size of the polar tube, the rapidity of polar tube discharge and sporoplasm passage, and the absence of genetic techniques for the manipulation of microsporidia, study of this organelle has been difficult and there is relatively little known regarding polar tube formation and the function of the proteins making up this structure...
April 20, 2017: PLoS Pathogens
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