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https://www.readbyqxmd.com/read/29783860/giant-juvenile-xanthogranuloma-case-report-literature-review-and-algorithm-for-classification
#1
Malika A Ladha, Richard M Haber
Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is referred to as giant; this term encompasses JXG lesions larger than 2.0 cm. In this article, we report a case of a congenital cutaneous giant JXG. In addition, we reviewed and analyzed all cases (n = 51) of giant JXG reported in the English literature...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29765943/juvenile-xanthogranuloma-in-a-pediatric-patient-with-langerhans-cell-histiocytosis
#2
Radha Ram, Marissa D Marolf, Patricia Chévez-Barrios, Honey H Herce
Purpose: To report a case of juvenile xanthogranuloma that simulated a chalazion and to discuss the association between juvenile xanthogranuloma and Langerhans cell histiocytosis. Method: Case report and review of literature. Results: A 13-year-old boy with a prior history of Langerhans cell histiocytosis was referred to our clinic for a possible chalazion. The patient had undergone treatment for Langerhans cell histiocytosis 10 years prior...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29755270/histiocytic-lesions-of-the-orbit-a-study-of-9-cases
#3
A Kaan Gündüz, Emine Temel
Purpose: To describe the clinical presentation, treatment, and outcome of patients with histiocytic lesions of the orbit. Methods: Retrospective study of 9 patients treated and followed up between October 2001 and January 2018. Results: Eight patients in our series were males and one patient was female. The mean age at presentation was 16.8 years (range, 1 to 42 years). All patients had unilateral disease. The most common presenting complaint was upper eyelid swelling in 8 of 9...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29743654/expression-of-the-transcription-factor-zbtb46-distinguishes-human-histiocytic-disorders-of-classical-dendritic-cell-origin
#4
Ansuman T Satpathy, Ryanne A Brown, Ellen Gomulia, Carlos G Briseño, Maxwell R Mumbach, Zenggang Pan, Kenneth M Murphy, Yasodha Natkunam, Howard Y Chang, Jinah Kim
Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations. In this study, we demonstrate that expression of ZBTB46 identifies human dendritic cell neoplasms. We examined ZBTB46 expression in a range of benign and malignant histiocytic disorders and found that ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes...
May 9, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29737419/langerhans-cell-histiocytosis-presenting-as-crohn-s-disease-a-case-report
#5
Amelie Therrien, Zaki El Haffaf, Claire Wartelle-Bladou, Justin Côté-Daigneault, Bich N Nguyen
PURPOSE: We describe an exceptional case of Langerhans cell histiocytosis (LCH) that presented as Crohn's disease and primary sclerosing cholangitis. METHODS: The patient's clinical, endoscopic, and histologic data from the Centre Hospitalier de l'Universite de Montreal were reviewed, as well as the literature on LCH involving the digestive tract and the liver, with a focus on the similarities with Crohn's disease and primary sclerosing cholangitis. RESULTS: A 39 years-old man first presented with anal fissures and deep punctiform colonic ulcers...
May 8, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29643785/periorbital-necrobiotic-xanthogranuloma-successfully-treated-with-intravenous-immunoglobulin
#6
Rose M Olson, Andrew R Harrison, Amanda Maltry, Ali Mokhtarzadeh
Background: Necrobiotic xanthogranuloma (NXG) is a rare non-Langerhans histiocytosis with cutaneous manifestations, most commonly of the periorbital skin, and is often associated with hematologic disorders such as monoclonal gammopathy. Treatment of NXG is notoriously difficult, and fraught with recurrence and progression. Case Presentation: The authors describe a case of NXG with periorbital involvement in a patient with a complex autoimmune and hematologic medical history...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29624716/oral-juvenile-xanthogranuloma-in-a-child-clinical-histological-and-immunohistochemical-profile-of-a-rare-entity
#7
Celeste Sánchez-Romero, Ana Isabel Cuenca Arriaga, Oslei Paes de Almeida, Evangelina Gutiérrez Cortés
Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis (non-LCH) affecting normolipemic infants and children most frequently in the first year of life, often showing spontaneous regression within 3 to 6 years. Classic JXG is characterized by a yellowish asymptomatic papule or nodule, often located in the skin of the head, neck and upper trunk. Oral JXG have been reported, but is rare. Histologically JXG is composed mainly by an infiltrate of macrophages with a variable degree of lipidization (foamy macrophages), and (most of the times) scattered Touton type giant cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29619997/necrobiotic-xanthogranuloma-a-paraneoplastic-skin-lesion-of-haematological-malignancies
#8
Loukman Omarjee, Anne Janin, Gabriel Etienne, Abdelouahab Bellou, Olivier Stivalet, Vincent Jaquinandi, Guillaume Mahe
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29615198/necrobiotic-xanthogranuloma-a-cutaneous-manifestation-of-monoclonal-gammopathy
#9
I Pérez-López, J D Herrera-García, A Martínez-López, E García-Durá
No abstract text is available yet for this article.
March 31, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29607757/cutaneous-hematolymphoid-and-histiocytic-proliferations-in-children
#10
Alejandro A Gru, Louis P Dehner
This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Because lymphoblastic leukemias and lymphomas are more frequent in the pediatric setting, cutaneous leukemic infiltrates are relatively common in this age-group...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29600694/juvenile-myelomonocytic-leukemia-in-a-patient-with-neurofibromatosis-type-1-and-xanthogranulomas
#11
Emanuele Miraglia, Pasquale Fino, Stefano Calvieri, Sandra Giustini
No abstract text is available yet for this article.
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29568990/necrobiotic-xanthogranuloma-a-30-year-single-center-experience
#12
Talal Hilal, David J DiCaudo, Suzanne M Connolly, Craig B Reeder
To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, associated disorders, therapy, and response to therapy were extracted. Nineteen patients were identified. Mean age was 54 years (range, 17-84) with equal gender distribution. Median follow-up was 5...
March 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29543205/-juvenile-xanthogranuloma-of-the-eye
#13
A A Yarovoy, O V Golubeva, S S Kleyankina, T V Yanchenko
Juvenile xanthogranuloma (JX) is a benign growth of fibrohistiocytoma range that mainly affects children. The most frequent localization of the tumor is skin integument. Non-cutaneous forms of JX are found in 5-10% of cases; they are manifested as deep lesions of soft tissues, involvement of various organs (oropharynx, lungs, liver, spleen, pericardium, gastrointestinal tract, central nervous system, bone marrow) including the organ of vision. JX can develop in any part of the eye and its appendages. Taking into consideration how rare this pathology is, its diagnosis and treatment are complicated...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29524707/pediatric-case-of-xanthogranuloma-in-sellar-region-presenting-visual-disturbance-successfully-treated-by-endoscopic-endonasal-surgery
#14
Fumihiko Nishimura, Young-Su Park, Yasushi Motoyama, Ichiro Nakagawa, Shuichi Yamada, Hiroyuki Nakase
BACKGROUND: Xanthomatous pituitary diseases rarely occur in childhood. We report a rare pediatric case of a xanthogranuloma that developed in the sellar region resulting in visual disturbance that was successfully treated by endoscopic endonasal surgery. CASE DESCRIPTIONS: A 13-year-old boy came to us with a headache and visual disturbance that had occurred 1 month prior. Clinical examination findings showed that he was alert with signs of bitemporal hemianopsia, an endocrinological examination showed partial hypopituitarism, and brain magnetic resonance imaging (MRI) revealed a cystic mass in the sellar turcica compressing the optic apparatus...
March 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29503951/intraocular-juvenile-xanthogranuloma-of-the-iris-in-an-adult-patient
#15
Elias Flockerzi, Tobias Hager, Berthold Seitz
Purpose: Juvenile xanthogranuloma (JXG) is a rare histiocytic skin disease primarily of young children, which may also affect ocular structures and in particular the iris. Observations: This is a case report of a fifty-year-old patient without skin lesions showing a progressive decrease of visual acuity, iris vascularization and a yellowish iris tumor in the iridocorneal angle of his right eye. Treatment with topical and systemic prednisolone led to full recovery of visual acuity, tumor regression and restitutio ad integrum ...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29492155/solitary-intraspinal-juvenile-xanthogranuloma-in-an-infant
#16
Asha Shenoy, Shruti Shribhagwan Singhal, Sweety Shinde
Juvenile xanthogranuloma (JXG) is a benign, non-Langerhans cell histiocytic proliferative disorder. We report a case of solitary JXG in an infant presenting as an intraspinal mass. Awareness of this mode of presentation is very important as subsequent prognosis differs from other tumors at the same location. JXG is a self-limiting dermatologic disorder usually occurring in first two decades of life. On rare occasion, it has been reported at extra-cutaneous sites such as central nervous system (CNS), eyes, liver, spleen, lungs and kidneys, and in other age groups...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29488239/risk-of-intraocular-and-other-extracutaneous-involvement-in-patients-with-cutaneous-juvenile-xanthogranuloma
#17
Liat Samuelov, Michael Kinori, Sarah L Chamlin, Annette Wagner, Brandi M Kenner-Bell, Amy S Paller, Lacey L Kruse, Anthony J Mancini
BACKGROUND/OBJECTIVES: Cutaneous juvenile xanthogranuloma is an uncommon, usually benign disease affecting infants and young children. Ocular and other systemic involvement have been reported, but their incidence is unclear, and the utility of routine screening is not well established. Our aim was to characterize the risk of ocular and systemic complications in children with cutaneous juvenile xanthogranuloma. METHODS: In this retrospective study, we reviewed the medical charts of children with cutaneous juvenile xanthogranuloma seen at Ann and Robert H...
May 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29485184/necrobiotic-xanthogranuloma-associated-with-chronic-lymphocytic-leukemia
#18
Christine Fink, Roland Schneiderbauer, Wolfgang Hartschuh, Alexander Enk, Ferdinand Toberer
No abstract text is available yet for this article.
June 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29469704/congenital-juvenile-xanthogranuloma-with-ulceration-a-pediatric-case-report
#19
Mary E Logue, Hillary Elwood, Aimee Smidt
Congenital juvenile xanthogranuloma (JXG) is an uncommon diagnosis and even more rarely presents with ulceration. We report such a case in a two-week-old girl. Biopsy was performed to rule out any concerning entities. Adequate treatment was provided with topical petrolatum and occasional miconozole or zinc oxide; the mass spontaneously regressed. Because congenital JXG has an excellent prognosis, insight into unique presentations such as this may provide useful information and avoid unnecessary surgical interventions...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468209/juvenile-xanthogranuloma-involving-concurrent-iris-and-skin-clinical-pathological-and-molecular-pathological-evaluations
#20
Peter Meyer, Elisabeth Graeff, Corina Kohler, Francis Munier, Elisabeth Bruder
Purpose: To report a case of juvenile xanthogranuloma involving the iris and skin that clincally was diagnosed with an obvious cutaneous lesion. Observations: A four month-old girl with hyphema and increased intraocular pressure of the left eye persisting for 2 weeks. A suspicious yellow-brown mass with nodular surface and traversed by irregular vascularization was noted on the inferior iris surface. Ultrasound biomicroscopy (UBM; 35 MHz) of the mass revealed multiple nodular irregular hyperreflective lesions in the peripheral iris...
March 2018: American Journal of Ophthalmology Case Reports
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