Trudy Caljé-van der Klei, Qianhui Sun, J Geoffrey Chase, Cong Zhou, Merryn H Tawhai, Jennifer L Knopp, Knut Möller, Serge J Heines, Dennis C Bergmans, Geoffrey M Shaw
BACKGROUND AND OBJECTIVE: Recruitment maneuvers with subsequent positive-end-expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing alveoli collapse. However, determining a safe, effective, and patient-specific PEEP is not standardized, and this more optimal PEEP level evolves with patient condition, requiring personalised monitoring and care approaches to maintain optimal ventilation settings. METHODS: This research examines 3 physiologically relevant basis function sets (exponential, parabolic, cumulative) to enable better prediction of elastance evolution for a virtual patient or digital twin model of MV lung mechanics, including novel elements to model and predict distension elastance...
December 19, 2023: Computer Methods and Programs in Biomedicine