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Xianming Zhang

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https://www.readbyqxmd.com/read/29125562/a-new-nortriterpenoid-a-sesquiterpene-and-hepatoprotective-lignans-isolated-from-the-fruit-of-schisandra-chinensis
#1
Fenghua Li, Ting Zhang, Hua Sun, Haifeng Gu, Hongqing Wang, Xianming Su, Changkang Li, Baoming Li, Ruoyun Chen, Jie Kang
A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M₂ (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4-6 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111356/effects-of-antibiotics-on-biological-activity-of-cry1ac-in-bt-susceptible-and-bt-resistant-helicoverpa-armigera-strains
#2
Myint Myint Khaing, Xianming Yang, Man Zhao, Wanna Zhang, Bingjie Wang, Jizhen Wei, Gemei Liang
In this study, the results showed that the population of midgut bacteria and larval mortality due to Cry1Ac are significantly reduced in antibiotic-treated larvae from Bt-susceptible, -resistant and field-collected strains (96S, BtR, FS respectively) of Helicoverpa armigera. The percentage reduction of larval mortality with increasing concentrations of antibiotics was significantly different among strains with the smallest effect observed in FS. It has been suggested that antibiotics could influence the toxicity of Cry1Ac, possibly by eliminating gut bacteria, hence gut bacteria might be playing essential roles in Bt-induced killing of H...
October 27, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29097199/trpv4-is-involved-in-irisin-induced-endothelium-dependent-vasodilation
#3
Li Ye, Mengnan Xu, Min Hu, Hai Zhang, Xianming Tan, Qing Li, Bing Shen, Junhao Huang
Irisin, an exercise-induced myokine, induces conversion of white into brown adipocytes, promoting mitochondrial biogenesis and energy expenditure. Irisin has a vascular protective effect on endothelial function in animals, including humans. Defects in irisin signaling pathways result in endothelial dysfunction in obesity and diabetes. However, the mechanisms underlying the effects of irisin on endothelial function have not been elucidated. Transient receptor potential vanilloid subtype 4 (TRPV4) channels are one of the most important Ca(2+)-permeable cation channels in vascular endothelial cells...
October 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29058585/preliminary-comparative-genomics-revealed-pathogenic-potential-and-international-spread-of-staphylococcus-argenteus
#4
Dao-Feng Zhang, Xiao-Yang Zhi, Jing Zhang, George C Paoli, Yan Cui, Chunlei Shi, Xianming Shi
BACKGROUND: Staphylococcus argenteus and S. schweitzeri, were recently proposed as novel species within S. aureus complex (SAC). S. argenteus has been reported in many countries and can threaten human health. S. schweitzeri has not been associated with human infections, but has been isolated from non-human primates. Questions regarding the evolution of pathogenicity of these two species will remain elusive until an exploratory evolutionary framework is established. RESULTS: We present genomic comparison analysis among members of SAC based on a pan-genome definition, which included 15 S...
October 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29045475/association-between-rna-binding-protein-ptbp2-and-germ-cell-injury-in-an-experimentally-induced-unilateral-cryptorchidism-murine-model
#5
Xianming Dou, Jingjing Gao, Pan Gao, Dongdong Tang, Dangwei Peng, Jun Mao, Zhenyu Huang, Peng Chen, He Chen, Shengwei Ke, Chaozhao Liang, Xiansheng Zhang
RNA binding protein polypyrimidine tract binding protein 2 (Ptbp2) as a key alternative splicing regulator for male germ cell development is well established. However, its expression levels and role in cryptorchidism testes tissues has not been explored. Additionally, the molecular mechanism of heat stress impacts the correct proliferation and differentiation of germ cells is unclear. To investigate whether changes in Ptbp2 expression are correlated with heat stress-induced germ cell injury in testicular tissue, we used a murine model of intraperitoneal cryptorchidism with surgical operation...
2017: PloS One
https://www.readbyqxmd.com/read/29042443/mammalian-numb-protein-antagonizes-notch-by-controlling-postendocytic-trafficking-of-the-notch-ligand-delta-like-4
#6
Ximing Shao, Zhihao Ding, Ming Zhao, Ke Liu, Haiyan Sun, Juntao Chen, Xianming Liu, Yuzhen Zhang, Yang Hong, Huashun Li, Hongchang Li
The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce Notch protein levels at the cell surface. However, some aspects of how Numb antagonizes Notch remain unclear. Here, we report a novel mechanism in which Numb acts as a Notch antagonist by controlling the intracellular destination and stability of the Notch ligand Delta-like 4 (Dll4) through a postendocytic-sorting process...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29024054/multifunctional-nanohybrid-based-on-porous-silicon-nanoparticles-gold-nanoparticles-and-acetalated-dextran-for-liver-regeneration-and-acute-liver-failure-theranostics
#7
Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T Hirvonen, Hongbo Zhang, Dawang Zhou, Xianming Deng, Hélder A Santos
Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application...
October 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28976741/semivolatile-organic-contaminants-in-the-hawaiian-atmosphere
#8
Xianming Zhang, John Barnes, Ying D Lei, Frank Wania
An air sampling campaign on the Island of Hawaii aimed to assess background concentrations of semivolatile organic compounds (SVOCs) over the Central Northern Pacific and to explore their distribution along an altitudinal transect. XAD-resin-based passive air samplers were deployed from May to September 2011 at six sites along a transect from the northeastern coast to the Mauna Loa Observatory and at three other island sites. By crossing the trade wind inversion, the transect comprised the marine boundary layer and free troposphere...
October 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28969045/d-dimer-levels-are-correlated-with-disease-activity-in-crohn-s-patients
#9
Junwu Zhang, Zhen Guo, Wei Yang, Zhongliang Zhu, Wanzhong Kong, Sujie Zheng, Lei Jiang, Xianming Fei, Yanxia Chen, Jinlin Liu
Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951605/new-12-8-eudesmanolides-from-eutypella-sp-1-15
#10
Yuezhou Wang, Yue Wang, An-An Wu, Lei Zhang, Zhiyu Hu, Huiying Huang, Qingyan Xu, Xianming Deng
Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC50 values of 8.4 and 28.5 μM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity...
October 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28858853/performance-of-a-sipm-based-semi-monolithic-scintillator-pet-detector
#11
Xianming Zhang, Xiaohui Wang, Ning Ren, Zhonghua Kuang, Xinhan Deng, Xin Fu, San Wu, Ziru Sang, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
A depth encoding PET detector module using semi-monolithic scintillation crystal single-ended readout by a SiPM array was built and its performance was measured. The semi-monolithic scintillator detector consists of 11 polished LYSO slices measuring 1×11.6×10 mm3. The slices are glued together with enhanced specular reflector (ESR) in between and outside of the slices. The bottom surface of the slices is coupled to a 4×4 SiPM array with a 1 mm light guide and silicon grease between them. No reflector is used on the top surface and two sides of the slices to reduce the scintillation photon reflection...
August 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28845969/calcium-sulfate-hemihydrate-nanowires-one-robust-material-in-separation-of-water-from-water-in-oil-emulsion
#12
Guangming Jiang, Wenyang Fu, Yuzheng Wang, Xiaoying Liu, Yuxin Zhang, Fan Dong, Zhiyong Zhang, Xianming Zhang, Yuming Huang, Sen Zhang, Xiaoshu Lv
Here we report a facile and cost-effective wet-chemical approach to the synthesis of calcium sulfate hemihydrate nanowires (HH NWs, CaSO4·0.5H2O), and their robust performance in immobilizing water molecules to the crystal lattice of CaSO4 and then separating them from a surfactant-stabilized water-in-oil emulsion (mean droplet size of around 1.2 μm). Every gram of HH NWs are capable of treating 20 mL emulsion (water content: 10.00 mg mL(-1)) with a separation efficiency of 99.23% at room temperature, and this efficiency can be further improved by tuning the surface charge density of HH...
September 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28841476/novel-functional-mesoporous-silica-nanoparticles-loaded-with-vitamin-e-acetate-as-smart-platforms-for-ph-responsive-delivery-with-high-bioactivity
#13
Zhuoxian Mai, Jiali Chen, Yang Hu, Fang Liu, Bin Fu, Hongwu Zhang, Xianming Dong, Wenhua Huang, Wuyi Zhou
Vitamin E (VE) exerts promising antioxidant activities against free radicals. However, its therapeutic efficacy and practical application are greatly restricted as a result of poor solubility, instability and low bioavailability. In this work, novel amino functionalized mesoporous silica nanoparticles (MSNs) were employed as the smart carriers to encapsulate Vitamin E acetate by the combination of soft-template method and recrystallization approach. Typically, two different surfactants were used as organic templates to fabricate different MSNs with various pore size distributions (∼4nm and ∼25nm)...
July 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28775252/conflict-between-conservation-and-development-cash-forest-encroachment-in-asian-elephant-distributions
#14
Peng Liu, Hui Wen, Franziska K Harich, Changhuan He, Lanxin Wang, Xianming Guo, Jianwei Zhao, Aidong Luo, Hongpei Yang, Xiao Sun, Yang Yu, Shaobo Zheng, Jing Guo, Li Li, Li Zhang
Over the last 4 decades, China has undergone major economic development, resulting in considerable impacts on its wildlife populations and habitats. It is essential to quantify the conflict between development and conservation to assist with policy-making because forestry policies and market trends affected indirectly the distribution of Asian elephants. Here, we mapped the historical distribution of elephants versus human land use. Elephant distributions appear to occur in unbroken natural forests only. However, over the 40-year period, the distribution ranges have become smaller and fragmented, with natural forest area also declining by 16%...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747575/d-dimer-levels-are-correlated-with-disease-activity-in-crohn-s-patients
#15
Junwu Zhang, Zhen Guo, Wei Yang, Zhongliang Zhu, Wanzhong Kong, Sujie Zheng, Lei Jiang, Xianming Fei, Yanxia Chen, Jinlin Liu
Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743901/temperature-and-energy-effects-on-secondary-electron-emission-from-sic-ceramics-induced-by-xe-17-ions
#16
Lixia Zeng, Xianming Zhou, Rui Cheng, Xing Wang, Jieru Ren, Yu Lei, Lidong Ma, Yongtao Zhao, Xiaoan Zhang, Zhongfeng Xu
Secondary electron emission yield from the surface of SiC ceramics induced by Xe(17+) ions has been measured as a function of target temperature and incident energy. In the temperature range of 463-659 K, the total yield gradually decreases with increasing target temperature. The decrease is about 57% for 3.2 MeV Xe(17+) impact, and about 62% for 4.0 MeV Xe(17+) impact, which is much larger than the decrease observed previously for ion impact at low charged states. The yield dependence on the temperature is discussed in terms of work function, because both kinetic electron emission and potential electron emission are influenced by work function...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740174/plakophilin-2-is-required-for-transcription-of-genes-that-control-calcium-cycling-and-cardiac-rhythm
#17
Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J Alvarado, Igor Dolgalev, Thomas V Karathanos, Kabir Malkani, Chantal J M Van Opbergen, Joanne J A van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E Morley, William A Coetzee, Natalia A Trayanova, Michael J Ackerman, Toon A B van Veen, Hector H Valdivia, Mario Delmar
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of state-of-the-art methods and a cardiomyocyte-specific, tamoxifen-activated, PKP2 knockout mouse to demonstrate that in addition to its role in cell adhesion, PKP2 is necessary to maintain transcription of genes that control intracellular calcium cycling. Lack of PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacna1c (coding for CaV1...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28725946/validation-and-characterization-of-a-qtl-for-adult-plant-resistance-to-stripe-rust-on-wheat-chromosome-arm-6bs-yr78
#18
Zhenzhen Dong, Joshua M Hegarty, Junli Zhang, Wenjun Zhang, Shiaoman Chao, Xianming Chen, Yonghong Zhou, Jorge Dubcovsky
This study validated one QTL for adult plant resistance to stripe rust, identified donor lines of the resistance allele, and demonstrated that it is different from previously named Yr genes. The spread of more virulent and aggressive races of Puccinia striiformis f. sp. tritici (Pst, causal pathogen of stripe rust) after the year 2000 has caused substantial yield losses worldwide. To find new sources of resistance, we previously performed a genome-wide association study and identified a strong QTL for adult plant resistance on the short arm of chromosome 6B (QYr...
October 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28723123/a-both-end-blocked-peroxidase-mimicking-dnazyme-for-low-background-chemiluminescent-sensing-of-mirna
#19
Xianming Li, Houchun Zhang, Yurong Tang, Peng Wu, Shuxia Xu, Xinfeng Zhang
G-quadruplex DNAzymes that exhibited peroxidase-like activity have been shown to be appealing reporters for amplified readout of biosensing events simply by their formation or dissociation in the presence of analytes. For low background signaling, the efficient preblock of DNAzymes is critically important. Herein, we report a both-end blocked DNAzyme beacon strategy for chemiluminescent biosensing. The catalytic activity of peroxidase-mimicking DNAzyme can be inactivated fully by fixing both ends of the DNAzyme sequence, and easily recovered via a strand displace reaction between the miRNA and the block DNA...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720501/numb-positively-regulates-autophagic-flux-via-regulating-lysosomal-function
#20
Haiyan Sun, Yi Liu, Lei Zhang, Ximing Shao, Ke Liu, Zhihao Ding, Xianming Liu, Changan Jiang, Huashun Li, Hongchang Li
Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles. Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging, myopathies and neurodegenerative disorders. Here, using genetic knockdown, we uncover the role of Numb, an endocytic adaptor protein, in regulating the late steps of autophagy. We found that Numb depletion led to the accumulation of autophagic vacuole, as verified by RFP-LC3 staining combined with transmission electron microscopy...
September 23, 2017: Biochemical and Biophysical Research Communications
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