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Xianming Zhang

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https://www.readbyqxmd.com/read/28513149/vertical-profiles-sources-and-transport-of-pfass-in-the-arctic-ocean
#1
Leo Wai-Yin Yeung, Clifton Dassuncao, Scott Andrew Mabury, Elsie M Sunderland, Xianming Zhang, Rainer Lohmann
The relative importance of atmospheric versus oceanic transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is not well understood. Vertical profiles from the Central Arctic Ocean and shelf water, snow and meltwater samples were collected in 2012; 13 PFASs (C6-C12 PFCAs; C6, 8, 10 PFSAs; MeFOSAA and EtFOSAA, and FOSA) were routinely detected (range: <5 - 343 pg/L). PFASs were only detectable above 150 m depth in the polar mixed layer (PML) and halocline. Enhanced concentrations were observed in snow and meltpond samples, implying atmospheric deposition as an important source of PFASs...
May 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28486106/hippo-signaling-suppresses-cell-ploidy-and-tumorigenesis-through-skp2
#2
Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Suyuan Ji, Chengyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I Nakayama, Xianming Deng, Randy L Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou
Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling. Acetylated Skp2 is exclusively localized to the cytosol, which causes hyper-accumulation of the cyclin-dependent kinase inhibitor p27, leading to mitotic arrest and subsequently cell polyploidy. In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by acetylated Skp2, resulting in polyploid cell division, genomic instability, and oncogenesis...
May 8, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28454544/attenuation-of-acute-lung-injury-in-a-rat-model-by-semen-cassiae
#3
Xiuqing Chen, Xianming Zhang, Jie Zhang, Yang Gao, Zhaohui Yang, Shanshan Li, Haiwen Dai
BACKGROUND: Acute lung injury (ALI) is an inflammatory disorder. Semen Cassiae has potent anti-inflammatory activities. The aim of our study was to investigate whether Semen Cassiae plays a protective effect on lipopolysaccharide (LPS)-induced ALI and, if so, to elucidate its potential mechanism. METHODS: Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. Rats were treated with Semen Cassiae or vehicle 3 h after LPS challenge. Samples were harvested 24 h post-LPS administration...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28429101/human-circulating-and-tissue-gastric-cancer-stem-cells-display-distinct-epithelial-mesenchymal-features-and-behaviors
#4
Shengliang Zhang, Yanna Shang, Tie Chen, Xin Zhou, Wengtong Meng, Chuanwen Fan, Ran Lu, Qiaorong Huang, Xue Li, Xu Hong, Zongguang Zhou, Jiankun Hu, Xianming Mo
INTRODUCTION: Metastasis is a leading cause of cancer-related-deaths worldwide. Recently, cancer stem cells (CSCs) have been believed to be responsible for tumor initiation and metastasis, but till now, difference of cellular features and behaviors between CSCs from tumor tissues (TCSCs) and circulation (CCSCs) remains largely unknown, which hinders the progression of targeted therapies for metastasis. METHODS AND RESULTS: Here, we provide the features of circulating gastric cancer stem cells (CGCSCs) isolated from human gastric adenocarcinoma...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28428307/draft-genome-sequences-of-three-listeria-monocytogenes-isolates-from-foods-in-china
#5
Xudong Su, Guojie Cao, Dai Kuang, Jianmin Zhang, Yi Chen, Marc Allard, Eric Brown, Xianming Shi, Jianghong Meng, Xuebin Xu
Listeria monocytogenes is a foodborne pathogen of global concern because of the high mortality rate among patients. The draft genome sequences of three L. monocytogenes strains isolated from foods are reported here. The availability of these genomes should provide useful information on the genomic diversity of L. monocytogenes isolated from foods in China.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28421697/endothelium-originated-from-colorectal-cancer-stem-cells-constitute-cancer-blood-vessels
#6
Wenqi Shangguan, Chuanwen Fan, Xiaolong Chen, Ran Lu, Yuan Liu, Yu Li, Yanna Shang, Dongqin Yin, Shengliang Zhang, Qiaorong Huang, Xue Li, Wentong Meng, Hong Xu, Zongguang Zhou, Jiankun Hu, Xianming Mo
Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells generated from glioblastoma stem cells are largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues...
April 18, 2017: Cancer Science
https://www.readbyqxmd.com/read/28366764/in%C3%A2-vivo-excision-of-hiv-1-provirus-by-sacas9-and-multiplex-single-guide-rnas-in-animal-models
#7
Chaoran Yin, Ting Zhang, Xiying Qu, Yonggang Zhang, Raj Putatunda, Xiao Xiao, Fang Li, Weidong Xiao, Huaqing Zhao, Shen Dai, Xuebin Qin, Xianming Mo, Won-Bin Young, Kamel Khalili, Wenhui Hu
CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome. Here, we demonstrate the feasibility and efficiency of excising the HIV-1 provirus in three different animal models using an all-in-one adeno-associated virus (AAV) vector to deliver multiplex single-guide RNAs (sgRNAs) plus Staphylococcus aureus Cas9 (saCas9). The quadruplex sgRNAs/saCas9 vector outperformed the duplex vector in excising the integrated HIV-1 genome in cultured neural stem/progenitor cells from HIV-1 Tg26 transgenic mice...
May 3, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28350446/temporal-shifts-in-poly-and-perfluoroalkyl-substances-pfass-in-north-atlantic-pilot-whales-indicate-large-contribution-of-atmospheric-precursors
#8
Clifton Dassuncao, Xindi C Hu, Xianming Zhang, Rossana Bossi, Maria Dam, Bjarni Mikkelsen, Elsie M Sunderland
Poly- and perfluoroalkyl substances (PFASs) are persistent, bioaccumulative anthropogenic compounds associated with adverse health impacts on humans and wildlife. PFAS production changed in North America and Europe around the year 2000, but impacts on wildlife appear to vary across species and location. Unlike other mammal species, cetaceans lack the enzyme for transforming an important intermediate precursor (perfluorooctane sulfonamide: FOSA), into a prevalent compound in most wildlife (perfluorooctanesulfonate: PFOS)...
March 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28333981/lipopolysaccharide-induced-endotoxemia-in-corn-oil-preloaded-mice-causes-an-extended-course-of-lung-injury-and-repair-and-pulmonary-fibrosis-a-translational-mouse-model-of-acute-respiratory-distress-syndrome
#9
Chaomin Wu, Colin E Evans, Zhiyu Dai, Xiaojia Huang, Xianming Zhang, Hua Jin, Guochang Hu, Yuanlin Song, You-Yang Zhao
Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia respiratory failure, bilateral pulmonary infiltrates, and pulmonary edema of non-cardiac origin. Effective treatments for ARDS patients may arise from experimental studies with translational mouse models of this disease that aim to delineate the mechanisms underlying the disease pathogenesis. Mouse models of ARDS, however, can be limited by their rapid progression from injured to recovery state, which is in contrast to the course of ARDS in humans...
2017: PloS One
https://www.readbyqxmd.com/read/28294998/economic-burden-for-lung-cancer-survivors-in-urban-china
#10
Xin Zhang, Shuai Liu, Yang Liu, Jian Du, Wenqi Fu, Xiaowen Zhao, Weidong Huang, Xianming Zhao, Guoxiang Liu, Zhengzhong Mao, Teh-Wei Hu
BACKGROUND: With the rapid increase in the incidence and mortality of lung cancer, a growing number of lung cancer patients and their families are faced with a tremendous economic burden because of the high cost of treatment in China. This study was conducted to estimate the economic burden and patient responsibility of lung cancer patients and the impact of this burden on family income. METHODS: This study uses data from a retrospective questionnaire survey conducted in 10 communities in urban China and includes 195 surviving lung cancer patients diagnosed over the previous five years...
March 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28280321/transdiaphragmatic-pressure-and-neural-respiratory-drive-measured-during-inspiratory-muscle-training-in-stable-patients-with-chronic-obstructive-pulmonary-disease
#11
Weiliang Wu, Xianming Zhang, Lin Lin, Yonger Ou, Xiaoying Li, Lili Guan, Bingpeng Guo, Luqian Zhou, Rongchang Chen
PURPOSE: Inspiratory muscle training (IMT) is a rehabilitation therapy for stable patients with COPD. However, its therapeutic effect remains undefined due to the unclear nature of diaphragmatic mobilization during IMT. Diaphragmatic mobilization, represented by transdiaphragmatic pressure (Pdi), and neural respiratory drive, expressed as the corrected root mean square (RMS) of the diaphragmatic electromyogram (EMGdi), both provide vital information to select the proper IMT device and loads in COPD, therefore contributing to the curative effect of IMT...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28230150/an-experimental-study-on-the-impacts-of-inspiratory-and-expiratory-muscles-activities-during-mechanical-ventilation-in-ards-animal-model
#12
Xianming Zhang, Juan Du, Weiliang Wu, Yongcheng Zhu, Ying Jiang, Rongchang Chen
In spite of intensive investigations, the role of spontaneous breathing (SB) activity in ARDS has not been well defined yet and little has been known about the different contribution of inspiratory or expiratory muscles activities during mechanical ventilation in patients with ARDS. In present study, oleic acid-induced beagle dogs' ARDS models were employed and ventilated with the same level of mean airway pressure. Respiratory mechanics, lung volume, gas exchange and inflammatory cytokines were measured during mechanical ventilation, and lung injury was determined histologically...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218703/phenolic-acid-profiling-antioxidant-and-anti-inflammatory-activities-and-mirna-regulation-in-the-polyphenols-of-16-blueberry-samples-from-china
#13
Xianming Su, Jian Zhang, Hongqing Wang, Jing Xu, Jiuming He, Liying Liu, Ting Zhang, Ruoyun Chen, Jie Kang
To investigate the anti-atherosclerosis related mechanism of blueberries, the phenolic acids (PAs) content, antioxidant and anti-inflammatory activities, as well as the microRNA (miRNA) regulation of polyphenol fractions in blueberry samples from China were studied. Sixteen batches of blueberries including 14 commercialized cultivars (Reka, Patriot, Brigitta, Bluecrop, Berkeley, Duke, Darrow, Northland, Northblue, Northcountry, Bluesource, Southgood, O'Neal, and Misty) were used in this study. Seven PAs in the polyphenol fractions from 16 blueberry samples in China were quantified by high performance liquid chromatography/tandem mass spectrometry (HPLC/MS²)...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28217711/source-attribution-of-poly-and-perfluoroalkyl-substances-pfass-in-surface-waters-from-rhode-island-and-the-new-york-metropolitan-area
#14
Xianming Zhang, Rainer Lohmann, Clifton Dassuncao, Xindi C Hu, Andrea K Weber, Chad D Vecitis, Elsie M Sunderland
Exposure to poly and perfluoroalkyl substances (PFASs) has been associated with adverse health effects in humans and wildlife. Understanding pollution sources is essential for environmental regulation but source attribution for PFASs has been confounded by limited information on industrial releases and rapid changes in chemical production. Here we use principal component analysis (PCA), hierarchical clustering, and geospatial analysis to understand source contributions to 14 PFASs measured across 37 sites in the Northeastern United States in 2014...
September 13, 2016: Environmental Science & Technology Letters
https://www.readbyqxmd.com/read/28123471/endovascular-treatment-of-irregular-and-complicated-intracranial-aneurysms-with-coils-using-double-microcatheter-technique
#15
Yang Zhang, Ge Gao, Yingjiu Chao, Yu Chen, Jian Yu, Daqun Gu, Jianjun Wei, Chaoshi Niu, Xianming Fu
Embolisation of irregular and complicated aneurysms is a great challenge for neuroradiologists. To overcome possible complications of endovascular treatment of these type of aneurysms, methods such as intracranial stents, balloon remodelling, and the double microcatheter technique have been developed. The aim of the study was to report our preliminary experience with endovascular treatment of irregular and complicated intracranial aneurysm with coils using double microcatheter technique, and evaluation of its feasibility and clinical advantages...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28106154/anisotropic-hydrogen-diffusion-in-%C3%AE-zr-and-zircaloy-predicted-by-accelerated-kinetic-monte-carlo-simulations
#16
Yongfeng Zhang, Chao Jiang, Xianming Bai
This report presents an accelerated kinetic Monte Carlo (KMC) method to compute the diffusivity of hydrogen in hcp metals and alloys, considering both thermally activated hopping and quantum tunneling. The acceleration is achieved by replacing regular KMC jumps in trapping energy basins formed by neighboring tetrahedral interstitial sites, with analytical solutions for basin exiting time and probability. Parameterized by density functional theory (DFT) calculations, the accelerated KMC method is shown to be capable of efficiently calculating hydrogen diffusivity in α-Zr and Zircaloy, without altering the kinetics of long-range diffusion...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069705/multilevel-analyses-of-scn5a-mutations-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy-suggest-non-canonical-mechanisms-for-disease-pathogenesis
#17
Anneline S J M Te Riele, Esperanza Agullo-Pascual, Cynthia A James, Alejandra Leo-Macias, Marina Cerrone, Mingliang Zhang, Xianming Lin, Bin Lin, Nara L Sobreira, Nuria Amat-Alarcon, Roos F Marsman, Brittney Murray, Crystal Tichnell, Jeroen F van der Heijden, Dennis Dooijes, Toon A B van Veen, Harikrishna Tandri, Steven J Fowler, Richard N W Hauer, Gordon Tomaselli, Maarten P van den Berg, Matthew R G Taylor, Francesca Brun, Gianfranco Sinagra, Arthur A M Wilde, Luisa Mestroni, Connie R Bezzina, Hugh Calkins, J Peter van Tintelen, Lei Bu, Mario Delmar, Daniel P Judge
AIMS: Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) is often associated with desmosomal mutations. Recent studies suggest an interaction between the desmosome and sodium channel protein Nav1.5. We aimed to determine the prevalence and biophysical properties of mutations in SCN5A (the gene encoding Nav1.5) in ARVD/C. METHODS AND RESULTS: We performed whole-exome sequencing in six ARVD/C patients (33% male, 38.2 ± 12.1 years) without a desmosomal mutation...
January 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28041923/prevalence-and-associated-factors-of-premature-ejaculation-in-the-anhui-male-population-in-china-evidence-based-unified-definition-of-lifelong-and-acquired-premature-ejaculation
#18
Jingjing Gao, Dangwei Peng, Xiansheng Zhang, Zongyao Hao, Jun Zhou, Song Fan, Yao Zhang, Jun Mao, Xianming Dou, Chaozhao Liang
INTRODUCTION: In 2014, new evidence-based definitions of lifelong premature ejaculation (LPE) and acquired premature ejaculation (APE) were proposed by the International Society for Sexual Medicine. Based on the new PE definitions, the prevalence of and factors associated with LPE and APE have not been investigated in China. AIM: To evaluate the prevalence of and factors associated with LPE and APE in men with the complaint of PE in China. METHODS: From December 2011 to December 2015, a cross-sectional field survey was conducted in five cities in the Anhui province of China...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27997868/one-step-ethanolysis-of-lignin-into-small-molecular-aromatic-hydrocarbons-over-nano-sic-catalyst
#19
Yigang Chen, Fang Wang, Yingjie Jia, Nan Yang, Xianming Zhang
Catalytic depolymerization of lignin for preparation of aromatic hydrocarbons without external hydrogen was first carried out over nano-SiC catalyst in supercritical ethanol. Mixture of the catalyst and lignin was innovatively suspended in a closed reactor and small-molecular aromatic hydrocarbons were successfully achieved at 500°C. Results revealed that not only did conversion of lignin increase sharply under the nano-SiC catalyst, but also phenols were not detected. The increase of residence time under the Fe-SiC catalyst did not change distribution of the liquid products besides the yield improvement, suggesting that the catalyst was suitable and selective towards formation of small-molecular benzenes, especially C6-C8 benzenes...
February 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27989107/atomic-h-induced-mo2c-hybrid-as-an-active-and-stable-bifunctional-electrocatalyst
#20
Xiujun Fan, Yuanyue Liu, Zhiwei Peng, Zhenhua Zhang, Haiqing Zhou, Xianming Zhang, Boris I Yakobson, William A Goddard, Xia Guo, Robert H Hauge, James M Tour
Mo2C nanocrystals (NCs) anchored on vertically aligned graphene nanoribbons (VA-GNR) as hybrid nanoelectrocatalysts (Mo2C-GNR) are synthesized through the direct carbonization of metallic Mo with atomic H treatment. The growth mechanism of Mo2C NCs with atomic H treatment is discussed. The Mo2C-GNR hybrid exhibits highly active and durable electrocatalytic performance for the hydrogen-evolution reaction (HER) and oxygen-reduction reaction (ORR). For HER, in an acidic solution the Mo2C-GNR has an onset potential of 39 mV and a Tafel slope of 65 mV dec(-1), and in a basic solution Mo2C-GNR has an onset potential of 53 mV, and Tafel slope of 54 mV dec(-1)...
January 3, 2017: ACS Nano
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