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Xianming Zhang

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https://www.readbyqxmd.com/read/29758523/glycosides-of-naphthohydroquinones-and-anthraquinones-isolated-from-the-aerial-parts-of-morinda-parvifolia-bartl-ex-dc-rubiaceae-increase-p53-mrna-expression-in-a2780-cells
#1
Xianming Su, Jian Zhang, Changkang Li, Fenghua Li, Hongqing Wang, Haifeng Gu, Baoming Li, Ruoyun Chen, Jie Kang
Eight previously undescribed naphthohydroquinone glycosides, namely morindaparvins H-O, together with four known anthraquinone glycosides were isolated from the n-BuOH extract of the aerial parts of Morinda parvifolia Bartl. ex DC (Rubiaceae). The structures of morindaparvins H-O were elucidated on the basis of spectroscopic analysis. To our knowledge, this is the first isolation of quinone glycosides from the plant M. parvifolia. The results showed that all 12 compounds at the concentration of 50 μM significantly increased p53 mRNA expression in A2780 cells compared with the blank control group...
May 11, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29747038/emerging-high-level-ciprofloxacin-resistance-and-molecular-basis-of-resistance-in-salmonella-enterica-from-humans-food-and-animals
#2
Dai Kuang, Jianmin Zhang, Xuebin Xu, Weimin Shi, Sheng Chen, Xiaowei Yang, Xudong Su, Xianming Shi, Jianghong Meng
Disease caused by nontyphoidal serotypes of Salmonella enterica is the leading cause of foodborne illness worldwide. Many serotypes have also developed resistance to antimicrobials commonly used for the treatment of salmonellosis. Here we analyze 179 ciprofloxacin-resistant isolates identified among 3680 Salmonella isolated from humans, food, animals, and water collected in Shanghai, China. They were assessed for antimicrobial susceptibility, plasmid-mediated quinolone resistance (PMQR) determinants, and mutations in quinolone resistance determination regions (QRDRs); genetic relatedness was examined using PFGE...
May 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29664678/endothelial-and-smooth-muscle-cell-interaction-via-foxm1-signaling-mediates-vascular-remodeling-and-pulmonary-hypertension
#3
Zhiyu Dai, Maggie M Zhu, Yi Peng, Hua Jin, Narsa Machireddy, Zhijian Qian, Xianming Zhang, You-Yang Zhao
RATIONALE: Angioproliferative vasculopathy is a hallmark of pulmonary arterial hypertension (PAH). However, little is known how endothelial cell (EC) and smooth muscle cell (SMC) crosstalk regulates the angioproliferative vascular remodeling. OBJECTIVES: We aimed to investigate the role of EC and SMC interaction and underlying signaling pathways in PH development. METHODS: SMC-specific Foxm1 or Cxcr4 knockout mice, EC-specific Foxm1 or Egln1 knockout mice, as well as EC-specific Egln1/Cxcl12 double knockout mice were used to assess the role of FoxM1 on SMC proliferation and PH...
April 17, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29593330/ck1%C3%AE-suppresses-lung-tumour-growth-by-stabilizing-pten-and-inducing-autophagy
#4
Junchao Cai, Rong Li, Xiaonan Xu, Le Zhang, Rong Lian, Lishan Fang, Yongbo Huang, Xianming Feng, Ximeng Liu, Xu Li, Xun Zhu, Heng Zhang, Jueheng Wu, Musheng Zeng, Erwei Song, Yukai He, Yuxin Yin, Jun Li, Mengfeng Li
The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning as an autophagy inducer to activate an autophagy-regulating, tumour-suppressive PTEN/AKT/FOXO3a/Atg7 axis. Specifically, CK1α bound the C-terminal tail of PTEN and enhanced both PTEN stability and activity by competitively antagonizing NEDD4-1-induced PTEN polyubiquitination and abrogating PTEN phosphorylation, thereby inhibiting AKT activity and activating FOXO3a-induced transcription of Atg7...
April 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29574061/identification-and-characterization-of-two-novel-superantigens-among-staphylococcus-aureus-complex
#5
Dao-Feng Zhang, Xin-Yi Yang, Jing Zhang, Xiaojie Qin, Xiaozhen Huang, Yan Cui, Min Zhou, Chunlei Shi, Nigel P French, Xianming Shi
Staphylococcal enterotoxins (SEs), also known as superantigens, play a very important role in infections and food poisoning caused by Staphylococcus aureus. Recently, S. argenteus and S. schweitzeri were recognized as novel species closely related to S. aureus. In this study of these three species, it was found that two putative SE genes were located upstream of some vSaβ pathogenicity islands and the deduced amino acid sequences showed < 65.3% identity with those of known SEs. The related proteins, designated staphylococcal enterotoxin-like toxin 26 (SEl26) and 27 (SEl27), were identified and characterized among the three species...
March 6, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29558001/characteristics-and-outcomes-of-non-hodgkin-s-lymphoma-patients-with-leptomeningeal-metastases
#6
Xiangrui Meng, Jingwei Yu, Qian Fan, Lanfang Li, Wei Li, Zheng Song, Xianming Liu, Yanyang Jiang, Ming Gao, Huilai Zhang
BACKGROUND: Leptomeningeal metastasis is an uncommon but devastating complication. The incidence of non-Hodgkin's lymphoma has been increasing in recent decades, due to the poor central nervous system penetration of drugs and the prolonged overall survival of patients, leptomeningeal metastases has gradually increased over time. Patients with leptomeningeal metastases have short survival durations and poor quality of life; there are few studies about non-Hodgkin's lymphoma with leptomeningeal metastases...
March 20, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29531021/tranilast-directly-targets-nlrp3-to-treat-inflammasome-driven-diseases
#7
Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou
The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases, but the medications targeting NLRP3 inflammasome are not available in clinic. Here, we show that tranilast (TR), an old anti-allergic clinical drug, is a direct NLRP3 inhibitor. TR inhibits NLRP3 inflammasome activation in macrophages, but has no effects on AIM2 or NLRC4 inflammasome activation. Mechanismly, TR directly binds to the NACHT domain of NLRP3 and suppresses the assembly of NLRP3 inflammasome by blocking NLRP3 oligomerization...
April 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29519418/tpgs-functionalized-mesoporous-silica-nanoparticles-for-anticancer-drug-delivery-to-overcome-multidrug-resistance
#8
Peiqi Zhao, Lanfang Li, Shiyong Zhou, Lihua Qiu, Zhengzi Qian, Xianming Liu, Xuchen Cao, Huilai Zhang
Multidrug resistance (MDR) has become a very serious problem in cancer therapy. To effectively reverse MDR in tumor treatments, a new pH-sensitive nano drug delivery system (NDDS) composed of mesoporous silica nanoparticles (MSNs) and d-a-tocopheryl poly-ethylene glycol 1000 succinate (TPGS) copolymers was synthesized to deliver doxorubicin (DOX) into drug-resistant breast cancer cell line (MCF-7/ADR). DOX@MSNs-TPGS were characterized to have a single peak size distribution, high DOX loading efficiency and a pH-dependent drug release profile...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29438101/a-depth-encoding-pet-detector-that-uses-light-sharing-and-single-ended-readout-with-silicon-photomultipliers
#9
Zhonghua Kuang, Qian Yang, Xiaohui Wang, Xin Fu, Ning Ren, Ziru Sang, San Wu, Yunfei Zheng, Xianming Zhang, Zhanli Hu, Junwei Du, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Detectors with depth-encoding capability and good timing resolution are required to develop high-performance whole-body or total-body PET scanners. In this work, depth-encoding PET detectors that use light sharing between two discrete crystals and single-ended readout with silicon photomultipliers (SiPMs) were manufactured and evaluated. The detectors consisted of two unpolished 3  ×  3  ×  20 mm3 LYSO crystals with different coupling materials between them and were read out by Hamamatsu 3  ×  3 mm2 SiPMs with one-to-one coupling...
February 13, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29407397/influence-of-ethanol-adaptation-on-salmonella-enterica-serovar-enteritidis-survival-in-acidic-environments-and-expression-of-acid-tolerance-related-genes
#10
Shoukui He, Yan Cui, Xiaojie Qin, Fen Zhang, Chunlei Shi, George C Paoli, Xianming Shi
Cross-protection to environmental stresses by ethanol adaptation in Salmonella poses a great threat to food safety because it can undermine food processing interventions. The ability of Salmonella enterica serovar Enteritidis (S. Enteritidis) to develop acid resistance following ethanol adaptation (5% ethanol for 1 h) was evaluated in this study. Ethanol-adapted S. Enteritidis mounted cross-tolerance to malic acid (a two-fold increase in minimum bactericidal concentration), but not to acetic, ascorbic, lactic, citric and hydrochloric acids...
June 2018: Food Microbiology
https://www.readbyqxmd.com/read/29391068/can-profiles-of-poly-and-perfluoroalkyl-substances-pfass-in-human-serum-provide-information-on-major-exposure-sources
#11
Xindi C Hu, Clifton Dassuncao, Xianming Zhang, Philippe Grandjean, Pál Weihe, Glenys M Webster, Flemming Nielsen, Elsie M Sunderland
BACKGROUND: Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination...
February 1, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29351087/a-depth-encoding-pet-detector-using-light-sharing-and-single-ended-readout-with-sipms
#12
Zhonghua Kuang, Qian Yang, Xiaohui Wang, Xin Fu, Ning Ren, Ziru Sang, San Wu, Yunfei Zheng, Xianming Zhang, Zhanli Hu, Junwei Du, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Detectors with depth encoding capability and good timing resolution are required to develop a high-performance whole-body or total-body PET scanner. In this work, depth-encoding PET detectors using light sharing between two discrete crystals and single-ended readout with SiPMs were manufactured and evaluated. The detectors consisted of two unpolished LYSO crystals of 3×3×20 mm3 with different coupling materials between them and were read out by Hamamatsu 3×3 mm2 SiPMs with one-to-one coupling. The ratio of the energy of one SiPM to the total energy of two SiPMs is used to measure the depth of interaction (DOI)...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29229110/effects-of-two-types-of-equal-intensity-inspiratory-muscle-training-in-stable-patients-with-chronic-obstructive-pulmonary-disease-a-randomised-controlled-trial
#13
Weiliang Wu, Lili Guan, Xianming Zhang, Xiaoying Li, Yuqiong Yang, Bingpeng Guo, Yonger Ou, Lin Lin, Luqian Zhou, Rongchang Chen
PURPOSE: We conducted a randomised controlled trial to assess the effects of daily breathing pattern changes to stable patients with COPD excluding the confounding factors of inspiratory muscle mobilization, by ensuring the load intensities of two inspiratory training devices were equal. PATIENTS AND METHODS: Sixty patients with COPD were randomised to three groups: resistive-IMT group (T-IMT, 21 patients), threshold-IMT (R-IMT, 19 patients), and a control group (20 patients)...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29222959/development-of-depth-encoding-small-animal-pet-detectors-using-dual-ended-readout-of-pixelated-scintillator-arrays-with-sipms
#14
Zhonghua Kuang, Ziru Sang, Xiaohui Wang, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Qian Yang, Zhanli Hu, Junwei Du, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
PURPOSE: The performance of current small animal PET scanners is mainly limited by the detector performance and depth encoding detectors are required to develop PET scanner to simultaneously achieve high spatial resolution and high sensitivity. Among all depth encoding PET detector approaches, dual-ended readout detector has the advantage to achieve the highest depth of interaction (DOI) resolution and spatial resolution. Silicon photomultiplier (SiPM) is believed to be the photodetector of the future for PET detector due to its excellent properties as compared to the traditional photodetectors such as photomultiplier tube (PMT) and avalanche photodiode (APD)...
February 2018: Medical Physics
https://www.readbyqxmd.com/read/29222390/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes
#15
Mathilde R Rivaud, Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, Mingliang Zhang, Eli Rothenberg, Connie R Bezzina, Mario Delmar, Carol Ann Remme
BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herein investigated sodium channel remodeling within distinct cardiomyocyte microdomains during heart failure. METHODS AND RESULTS: Mice were subjected to 6 weeks of transverse aortic constriction (TAC; n=32) to induce heart failure...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29125562/a-new-nortriterpenoid-a-sesquiterpene-and-hepatoprotective-lignans-isolated-from-the-fruit-of-schisandra-chinensis
#16
Fenghua Li, Ting Zhang, Hua Sun, Haifeng Gu, Hongqing Wang, Xianming Su, Changkang Li, Baoming Li, Ruoyun Chen, Jie Kang
A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M₂ (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4-6 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111356/effects-of-antibiotics-on-biological-activity-of-cry1ac-in-bt-susceptible-and-bt-resistant-helicoverpa-armigera-strains
#17
Myint Myint Khaing, Xianming Yang, Man Zhao, Wanna Zhang, Bingjie Wang, Jizhen Wei, Gemei Liang
In this study, the results showed that the population of midgut bacteria and larval mortality due to Cry1Ac are significantly reduced in antibiotic-treated larvae from Bt-susceptible, -resistant and field-collected strains (96S, BtR, FS respectively) of Helicoverpa armigera. The percentage reduction of larval mortality with increasing concentrations of antibiotics was significantly different among strains with the smallest effect observed in FS. It has been suggested that antibiotics could influence the toxicity of Cry1Ac, possibly by eliminating gut bacteria, hence gut bacteria might be playing essential roles in Bt-induced killing of H...
January 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29097199/trpv4-is-involved-in-irisin-induced-endothelium-dependent-vasodilation
#18
Li Ye, Mengnan Xu, Min Hu, Hai Zhang, Xianming Tan, Qing Li, Bing Shen, Junhao Huang
Irisin, an exercise-induced myokine, induces conversion of white into brown adipocytes, promoting mitochondrial biogenesis and energy expenditure. Irisin has a vascular protective effect on endothelial function in animals, including humans. Defects in irisin signaling pathways result in endothelial dysfunction in obesity and diabetes. However, the mechanisms underlying the effects of irisin on endothelial function have not been elucidated. Transient receptor potential vanilloid subtype 4 (TRPV4) channels are one of the most important Ca2+ -permeable cation channels in vascular endothelial cells...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29058585/preliminary-comparative-genomics-revealed-pathogenic-potential-and-international-spread-of-staphylococcus-argenteus
#19
Dao-Feng Zhang, Xiao-Yang Zhi, Jing Zhang, George C Paoli, Yan Cui, Chunlei Shi, Xianming Shi
BACKGROUND: Staphylococcus argenteus and S. schweitzeri, were recently proposed as novel species within S. aureus complex (SAC). S. argenteus has been reported in many countries and can threaten human health. S. schweitzeri has not been associated with human infections, but has been isolated from non-human primates. Questions regarding the evolution of pathogenicity of these two species will remain elusive until an exploratory evolutionary framework is established. RESULTS: We present genomic comparison analysis among members of SAC based on a pan-genome definition, which included 15 S...
October 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29045475/association-between-rna-binding-protein-ptbp2-and-germ-cell-injury-in-an-experimentally-induced-unilateral-cryptorchidism-murine-model
#20
Xianming Dou, Jingjing Gao, Pan Gao, Dongdong Tang, Dangwei Peng, Jun Mao, Zhenyu Huang, Peng Chen, He Chen, Shengwei Ke, Chaozhao Liang, Xiansheng Zhang
RNA binding protein polypyrimidine tract binding protein 2 (Ptbp2) as a key alternative splicing regulator for male germ cell development is well established. However, its expression levels and role in cryptorchidism testes tissues has not been explored. Additionally, the molecular mechanism of heat stress impacts the correct proliferation and differentiation of germ cells is unclear. To investigate whether changes in Ptbp2 expression are correlated with heat stress-induced germ cell injury in testicular tissue, we used a murine model of intraperitoneal cryptorchidism with surgical operation...
2017: PloS One
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