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Xianming Zhang

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https://www.readbyqxmd.com/read/28858853/performance-of-a-sipm-based-semi-monolithic-scintillator-pet-detector
#1
Xianming Zhang, Xiaohui Wang, Ning Ren, Zhonghua Kuang, Xinhan Deng, Xin Fu, San Wu, Ziru Sang, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
A depth encoding PET detector module using semi-monolithic scintillation crystal single-ended readout by a SiPM array was built and its performance was measured. The semi-monolithic scintillator detector consists of 11 polished LYSO slices measuring 1×11.6×10 mm3. The slices are glued together with enhanced specular reflector (ESR) in between and outside of the slices. The bottom surface of the slices is coupled to a 4×4 SiPM array with a 1 mm light guide and silicon grease between them. No reflector is used on the top surface and two sides of the slices to reduce the scintillation photon reflection...
August 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28845969/calcium-sulfate-hemihydrate-nanowires-one-robust-material-in-separation-of-water-from-water-in-oil-emulsion
#2
Guangming Jiang, Wenyang Fu, Yuzheng Wang, Xiaoying Liu, Yuxin Zhang, Fan Dong, Zhiyong Zhang, Xianming Zhang, Yuming Huang, Sen Zhang, Xiaoshu Lv
Here we report a facile and cost-effective wet-chemical approach to the synthesis of calcium sulfate hemihydrate nanowires (HH NWs, CaSO4·0.5H2O), and their robust performance in immobilizing water molecules to the crystal lattice of CaSO4 and then separating them from a surfactant-stabilized water-in-oil emulsion (mean droplet size of around 1.2 μm). Every gram of HH NWs are capable of treating 20 mL emulsion (water content: 10.00 mg mL(-1)) with a separation efficiency of 99.23% at room temperature, and this efficiency can be further improved by tuning the surface charge density of HH...
September 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28841476/novel-functional-mesoporous-silica-nanoparticles-loaded-with-vitamin-e-acetate-as-smart-platforms-for-ph-responsive-delivery-with-high-bioactivity
#3
Zhuoxian Mai, Jiali Chen, Yang Hu, Fang Liu, Bin Fu, Hongwu Zhang, Xianming Dong, Wenhua Huang, Wuyi Zhou
Vitamin E (VE) exerts promising antioxidant activities against free radicals. However, its therapeutic efficacy and practical application are greatly restricted as a result of poor solubility, instability and low bioavailability. In this work, novel amino functionalized mesoporous silica nanoparticles (MSNs) were employed as the smart carriers to encapsulate Vitamin E acetate by the combination of soft-template method and recrystallization approach. Typically, two different surfactants were used as organic templates to fabricate different MSNs with various pore size distributions (∼4nm and ∼25nm)...
July 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28775252/conflict-between-conservation-and-development-cash-forest-encroachment-in-asian-elephant-distributions
#4
Peng Liu, Hui Wen, Franziska K Harich, Changhuan He, Lanxin Wang, Xianming Guo, Jianwei Zhao, Aidong Luo, Hongpei Yang, Xiao Sun, Yang Yu, Shaobo Zheng, Jing Guo, Li Li, Li Zhang
Over the last 4 decades, China has undergone major economic development, resulting in considerable impacts on its wildlife populations and habitats. It is essential to quantify the conflict between development and conservation to assist with policy-making because forestry policies and market trends affected indirectly the distribution of Asian elephants. Here, we mapped the historical distribution of elephants versus human land use. Elephant distributions appear to occur in unbroken natural forests only. However, over the 40-year period, the distribution ranges have become smaller and fragmented, with natural forest area also declining by 16%...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747575/d-dimer-levels-are-correlated-with-disease-activity-in-crohn-s-patients
#5
Junwu Zhang, Zhen Guo, Wei Yang, Zhongliang Zhu, Wanzhong Kong, Sujie Zheng, Lei Jiang, Xianming Fei, Yanxia Chen, Jinlin Liu
Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743901/temperature-and-energy-effects-on-secondary-electron-emission-from-sic-ceramics-induced-by-xe-17-ions
#6
Lixia Zeng, Xianming Zhou, Rui Cheng, Xing Wang, Jieru Ren, Yu Lei, Lidong Ma, Yongtao Zhao, Xiaoan Zhang, Zhongfeng Xu
Secondary electron emission yield from the surface of SiC ceramics induced by Xe(17+) ions has been measured as a function of target temperature and incident energy. In the temperature range of 463-659 K, the total yield gradually decreases with increasing target temperature. The decrease is about 57% for 3.2 MeV Xe(17+) impact, and about 62% for 4.0 MeV Xe(17+) impact, which is much larger than the decrease observed previously for ion impact at low charged states. The yield dependence on the temperature is discussed in terms of work function, because both kinetic electron emission and potential electron emission are influenced by work function...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740174/plakophilin-2-is-required-for-transcription-of-genes-that-control-calcium-cycling-and-cardiac-rhythm
#7
Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J Alvarado, Igor Dolgalev, Thomas V Karathanos, Kabir Malkani, Chantal J M Van Opbergen, Joanne J A van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E Morley, William A Coetzee, Natalia A Trayanova, Michael J Ackerman, Toon A B van Veen, Hector H Valdivia, Mario Delmar
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of state-of-the-art methods and a cardiomyocyte-specific, tamoxifen-activated, PKP2 knockout mouse to demonstrate that in addition to its role in cell adhesion, PKP2 is necessary to maintain transcription of genes that control intracellular calcium cycling. Lack of PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacna1c (coding for CaV1...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28725946/validation-and-characterization-of-a-qtl-for-adult-plant-resistance-to-stripe-rust-on-wheat-chromosome-arm-6bs-yr78
#8
Zhenzhen Dong, Joshua M Hegarty, Junli Zhang, Wenjun Zhang, Shiaoman Chao, Xianming Chen, Yonghong Zhou, Jorge Dubcovsky
This study validated one QTL for adult plant resistance to stripe rust, identified donor lines of the resistance allele, and demonstrated that it is different from previously named Yr genes. The spread of more virulent and aggressive races of Puccinia striiformis f. sp. tritici (Pst, causal pathogen of stripe rust) after the year 2000 has caused substantial yield losses worldwide. To find new sources of resistance, we previously performed a genome-wide association study and identified a strong QTL for adult plant resistance on the short arm of chromosome 6B (QYr...
July 19, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28723123/a-both-end-blocked-peroxidase-mimicking-dnazyme-for-low-background-chemiluminescent-sensing-of-mirna
#9
Xianming Li, Houchun Zhang, Yurong Tang, Peng Wu, Shuxia Xu, Xinfeng Zhang
G-quadruplex DNAzymes that exhibited peroxidase-like activity have been shown to be appealing reporters for amplified readout of biosensing events simply by their formation or dissociation in the presence of analytes. For low background signaling, the efficient preblock of DNAzymes is critically important. Herein, we report a both-end blocked DNAzyme beacon strategy for chemiluminescent biosensing. The catalytic activity of peroxidase-mimicking DNAzyme can be inactivated fully by fixing both ends of the DNAzyme sequence, and easily recovered via a strand displace reaction between the miRNA and the block DNA...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720501/numb-positively-regulates-autophagic-flux-via-regulating-lysosomal-function
#10
Haiyan Sun, Yi Liu, Lei Zhang, Ximing Shao, Ke Liu, Zhihao Ding, Xianming Liu, Changan Jiang, Huashun Li, Hongchang Li
Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles. Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging, myopathies and neurodegenerative disorders. Here, using genetic knockdown, we uncover the role of Numb, an endocytic adaptor protein, in regulating the late steps of autophagy. We found that Numb depletion led to the accumulation of autophagic vacuole, as verified by RFP-LC3 staining combined with transmission electron microscopy...
September 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28682792/performance-of-a-high-resolution-depth-encoding-pet-detector-using-barium-sulfate-reflector
#11
Zhonghua Kuang, Xiaohui Wang, Cheng Li, Xinhan Deng, Kai Feng, Zhanli Hu, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Small animal positron emission tomography (PET) is a well-established imaging modality in preclinical biomedical research. The performance of current small animal PET scanners is mainly limited by the detector performance and depth-encoding detectors are required to simultaneously achieve high spatial resolution and high sensitivity. In this work, the performance of a high-resolution dual-ended readout lutetium-yttrium oxyorthosilicate (LYSO) array using barium sulfate powder (BaSO4) as the inter-crystal reflector was measured for the first time and compared to that of a LYSO array using the most commonly used enhanced specular reflector (ESR)...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28629007/upconverting-and-persistent-luminescent-nanocarriers-for-accurately-imaging-guided-photothermal-therapy
#12
Peiqi Zhao, Wei Ji, Shiyong Zhou, Lihua Qiu, Lanfang Li, Zhengzi Qian, Xianming Liu, Huilai Zhang, Xuchen Cao
The fluorescence-guided photothermal therapy (FPTT) has great potential in cancer treatment. However, the conventional FPTT has to be stimulated by external light, which tends to increase background noise and leads to the inaccurate infrared light irradiation for PTT. In this study, upconverting and persistent luminescent nanocarriers (UPLNs) loaded mesoporous silica nanoparticles (UPLNs@mSiO2) were first designed to solve the problem mentioned above. The UPLNs cores can effectively reduce the short-lived autofluorescence interference by exerting the delay time between signal acquisition and pulsed excitation light...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28614959/the-effects-of-triptolide-on-the-pharmacokinetics-of-sorafenib-in-rats-and-its-potential-mechanism
#13
Xianming Wang, Xin Zhang, Fei Liu, Minghai Wang, Shiyong Qin
CONTEXT: Combining sorafenib with triptolide could inhibit tumour growth with greater efficacy than single-agent treatment. However, their herb-drug interaction remains unknown. OBJECTIVE: This study investigates the herb-drug interaction between triptolide and sorafenib. MATERIALS AND METHODS: The effects of triptolide (10 mg/kg) on the pharmacokinetics of different doses of sorafenib (20, 50 and 100 mg/kg) in rats, and blood samples were collected within 48 h and evaluated using LC-MS/MS...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28591489/association-of-microalbuminuria-with-diabetes-is-stronger-in-people-with-prehypertension-compared-to-those-with-ideal-blood-pressure
#14
Qing Wang, Jingjing Huang, Yuemin Sun, Wenjuan Zhang, Yuxia Gao, Wei Yao, Bo Bian, Yongle Li, Xianming Wu, Kaijun Niu
AIM: Microalbuminuria (MA) has been demonstrated as a biomarker for microvascular dysfunction. This study is aimed to evaluate the association of glycemic status with MA in prehypertensive and ideal BP subjects and to evaluate the interaction between glycemic and blood pressure status as risk factors for MA prevalence. METHODS: 1059 subjects aged 40-70 with non-hypertension who were recruited from 6 districts of Tianjin were divided into prehypertensive group (622 cases) and ideal blood BP (437 cases)...
June 7, 2017: Nephrology
https://www.readbyqxmd.com/read/28513149/vertical-profiles-sources-and-transport-of-pfass-in-the-arctic-ocean
#15
Leo W Y Yeung, Clifton Dassuncao, Scott Mabury, Elsie M Sunderland, Xianming Zhang, Rainer Lohmann
The relative importance of atmospheric versus oceanic transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is not well understood. Vertical profiles from the Central Arctic Ocean and shelf water, snow and meltwater samples were collected in 2012; 13 PFASs (C6-C12 PFCAs; C6, 8, 10 PFSAs; MeFOSAA and EtFOSAA; and FOSA) were routinely detected (range: <5-343 pg/L). PFASs were only detectable above 150 m depth in the polar mixed layer (PML) and halocline. Enhanced concentrations were observed in snow and meltpond samples, implying atmospheric deposition as an important source of PFASs...
June 5, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28486106/hippo-signaling-suppresses-cell-ploidy-and-tumorigenesis-through-skp2
#16
Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Suyuan Ji, Chengyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I Nakayama, Xianming Deng, Randy L Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou
Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling. Acetylated Skp2 is exclusively localized to the cytosol, which causes hyper-accumulation of the cyclin-dependent kinase inhibitor p27, leading to mitotic arrest and subsequently cell polyploidy. In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by acetylated Skp2, resulting in polyploid cell division, genomic instability, and oncogenesis...
May 8, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28454544/attenuation-of-acute-lung-injury-in-a-rat-model-by-semen-cassiae
#17
Xiuqing Chen, Xianming Zhang, Jie Zhang, Yang Gao, Zhaohui Yang, Shanshan Li, Haiwen Dai
BACKGROUND: Acute lung injury (ALI) is an inflammatory disorder. Semen Cassiae has potent anti-inflammatory activities. The aim of our study was to investigate whether Semen Cassiae plays a protective effect on lipopolysaccharide (LPS)-induced ALI and, if so, to elucidate its potential mechanism. METHODS: Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. Rats were treated with Semen Cassiae or vehicle 3 h after LPS challenge. Samples were harvested 24 h post-LPS administration...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28429101/human-circulating-and-tissue-gastric-cancer-stem-cells-display-distinct-epithelial-mesenchymal-features-and-behaviors
#18
Shengliang Zhang, Yanna Shang, Tie Chen, Xin Zhou, Wengtong Meng, Chuanwen Fan, Ran Lu, Qiaorong Huang, Xue Li, Xu Hong, Zongguang Zhou, Jiankun Hu, Xianming Mo
INTRODUCTION: Metastasis is a leading cause of cancer-related-deaths worldwide. Recently, cancer stem cells (CSCs) have been believed to be responsible for tumor initiation and metastasis, but till now, difference of cellular features and behaviors between CSCs from tumor tissues (TCSCs) and circulation (CCSCs) remains largely unknown, which hinders the progression of targeted therapies for metastasis. METHODS AND RESULTS: Here, we provide the features of circulating gastric cancer stem cells (CGCSCs) isolated from human gastric adenocarcinoma...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28428307/draft-genome-sequences-of-three-listeria-monocytogenes-isolates-from-foods-in-china
#19
Xudong Su, Guojie Cao, Dai Kuang, Jianmin Zhang, Yi Chen, Marc Allard, Eric Brown, Xianming Shi, Jianghong Meng, Xuebin Xu
Listeria monocytogenes is a foodborne pathogen of global concern because of the high mortality rate among patients. The draft genome sequences of three L. monocytogenes strains isolated from foods are reported here. The availability of these genomes should provide useful information on the genomic diversity of L. monocytogenes isolated from foods in China.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28421697/endothelium-originated-from-colorectal-cancer-stem-cells-constitute-cancer-blood-vessels
#20
Wenqi Shangguan, Chuanwen Fan, Xiaolong Chen, Ran Lu, Yuan Liu, Yu Li, Yanna Shang, Dongqin Yin, Shengliang Zhang, Qiaorong Huang, Xue Li, Wentong Meng, Hong Xu, Zongguang Zhou, Jiankun Hu, Xianming Mo
Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are generated from glioblastoma stem cells is largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues...
July 2017: Cancer Science
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