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Alon, Uri

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https://www.readbyqxmd.com/read/28892513/placebo-can-enhance-creativity
#1
Liron Rozenkrantz, Avraham E Mayo, Tomer Ilan, Yuval Hart, Lior Noy, Uri Alon
BACKGROUND: The placebo effect is usually studied in clinical settings for decreasing negative symptoms such as pain, depression and anxiety. There is interest in exploring the placebo effect also outside the clinic, for enhancing positive aspects of performance or cognition. Several studies indicate that placebo can enhance cognitive abilities including memory, implicit learning and general knowledge. Here, we ask whether placebo can enhance creativity, an important aspect of human cognition...
2017: PloS One
https://www.readbyqxmd.com/read/28879535/hypercalcemia-a-consultant-s-approach
#2
Ari Auron, Uri S Alon
Due to their daily involvement in mineral metabolism, nephrologists are often asked to consult on children with hypercalcemia. This might become even more pertinent when the hypercalcemia is associated with acute kidney injury and/or hypercalciuria and renal calcifications. The best way to assess the severity of hypercalcemia is by measurement of plasma ionized calcium, and if not available by adjusting serum total calcium to albumin concentration. The differential diagnosis of the possible etiologies of the disturbance in the mineral homeostasis starts with the assessment of serum parathyroid hormone concentration, followed by that of vitamin D metabolites in search of both genetic and acquired etiologies...
September 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28877882/mechanotransduction-signaling-in-podocytes-from-fluid-flow-shear-stress
#3
Tarak Srivastava, Hongying Dai, Daniel P Heruth, Uri S Alon, Robert E Garola, Jianping Zhou, R Scott Duncan, Ashraf El-Meanawy, Ellen T McCarthy, Ram Sharma, Mark L Johnson, Virginia J Savin, Mukut Sharma
Recently we and others have found that hyperfiltration-associated increase in biomechanical forces, namely tensile stress and fluid flow shear stress (FFSS) can directly and distinctly alter podocyte structure and function. The ultrafiltrate flow over the major processes and cell body generates FFSS to podocyte. Our previous work suggests that COX2-PGE2-EP2 axis plays an important role in mechanoperception of FFSS in podocyte (Srivastava et al. Am J Physiol Renal Physiol 307: F1323-F1333, 2014). To address mechanotransduction of the perceived mechanical stimulus through EP2 receptor, cultured podocytes were exposed to FFSS (2 dynes/cm2) for 2hrs...
September 6, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28769825/a-pilot-study-of-possible-easy-to-use-electrophysiological-index-for-early-detection-of-antidepressive-treatment-non-response
#4
Goded Shahaf, Shahak Yariv, Boaz Bloch, Uri Nitzan, Aviv Segev, Alon Reshef, Yuval Bloch
INTRODUCTION: The evaluation of response to pharmacological treatment in MDD requires 4-8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of prime significance. Many studies have demonstrated significant results regarding the ability to use EEG and ERP markers, including attention-associated markers such as P300, for early prediction of response to treatment. But these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28767668/creative-foraging-an-experimental-paradigm-for-studying-exploration-and-discovery
#5
Yuval Hart, Avraham E Mayo, Ruth Mayo, Liron Rozenkrantz, Avichai Tendler, Uri Alon, Lior Noy
Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution automated paradigms. To address this, we present such an automated paradigm, the creative foraging game, in which people search for novel and valuable solutions in a large and well-defined space made of all possible shapes made of ten connected squares. Players discovered shape categories such as digits, letters, and airplanes as well as more abstract categories...
2017: PloS One
https://www.readbyqxmd.com/read/28700387/treatment-of-recurrent-lumbar-disc-herniation-with-or-without-fusion-in-workers-compensation-subjects
#6
Jeffrey A O'Donnell, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To determine outcomes after reoperation discectomy with or without fusion surgery for recurrent lumbar disc herniation (RLDH) in the workers' compensation (WC) population. SUMMARY OF BACKGROUND DATA: RLDH is estimated to occur in 7% to 24% of patients after discectomy. There are two main surgical options after reherniation: a revision discectomy (RD), or an RD combined with fusion (RDF)...
July 15, 2017: Spine
https://www.readbyqxmd.com/read/28685172/erratum-to-phosphate-homeostasis-and-its-role-in-bone-health
#7
Maria Goretti Pinedo, Uri S Alon
No abstract text is available yet for this article.
July 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28672730/analytical-and-clinical-performance-of-thyroglobulin-autoantibody-assays-in-thyroid-cancer-follow-up
#8
Waddah Katrangi, Stephan K G Grebe, Alicia Algeciras-Schimnich
BACKGROUND: While thyroglobulin autoantibodies (TgAb) can result in false low serum thyroglobulin (Tg) immunoassay (IA) measurements, they might also be indicators of disease persistence/recurrence. Hence, accurate TgAb measurement, in addition to Tg quantification, is crucial for thyroid cancer monitoring. We compared the analytical and clinical performance of four commonly used TgAb IAs. METHODS: We measured Tg by mass spectrometry (Tg-MS) and by four pairs of Tg and TgAb IAs (Beckman, Roche, Siemens, Thermo) in 576 samples...
June 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28652282/biphasic-response-as-a-mechanism-against-mutant-takeover-in-tissue-homeostasis-circuits
#9
Omer Karin, Uri Alon
Tissues use feedback circuits in which cells send signals to each other to control their growth and survival. We show that such feedback circuits are inherently unstable to mutants that misread the signal level: Mutants have a growth advantage to take over the tissue, and cannot be eliminated by known cell-intrinsic mechanisms. To resolve this, we propose that tissues have biphasic responses in and the signal is toxic at both high and low levels, such as glucotoxicity of beta cells, excitotoxicity in neurons, and toxicity of growth factors to T cells...
June 26, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28590343/impact-of-infliximab-and-cyclosporine-on-the-risk-of-colectomy-in-hospitalized-patients-with-ulcerative-colitis-complicated-by-cytomegalovirus-a-multicenter-retrospective-study
#10
Uri Kopylov, Konstantinos Papamichael, Konstantinos Katsanos, Matti Waterman, Ariella Bar-Gil Shitrit, Trine Boysen, Francisco Portela, Armando Peixoto, Andrew Szilagyi, Marco Silva, Giovanni Maconi, Ofir Har-Noy, Peter Bossuyt, Gerassimos Mantzaris, Manuel Barreiro de Acosta, Maria Chaparro, Dimitrios K Christodoulou, Rami Eliakim, Jean-Francois Rahier, Fernando Magro, David Drobne, Marc Ferrante, Elena Sonnenberg, Britte Siegmund, Vinciane Muls, Tamara Thurm, Henit Yanai, Iris Dotan, Tim Raine, Avi Levin, Eran Israeli, Fahd Ghalim, Franck Carbonnel, Severine Vermeire, Shomron Ben-Horin, Xavier Roblin
BACKGROUND: Cytomegalovirus (CMV) is frequently detected in patients with ulcerative colitis (UC). The impact of CMV infection on the outcome of UC exacerbation remains unclear. The benefit of combining antiviral with anti-inflammatory treatment has not been evaluated yet. The aim of this study was to compare the outcome of CMV-positive hospitalized patients with UC treated with antiviral therapy either alone or combined with salvage anti-inflammatory therapy (infliximab [IFX] or cyclosporine A [CsA])...
September 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28516132/life-threatening-hypercalcemia-during-prodrome-of-pneumocystis-jiroveci-pneumonia-in-an-immunocompetent-infant
#11
Judith Sebestyen VanSickle, Tarak Srivastava, Uri S Alon
Severe hypercalcemia in infants is usually attributed to genetic etiologies and less commonly to acquired ones. An 8-week-old girl presented with failure to thrive, mild respiratory distress, and life-threatening hypercalcemia (23.5 mg/dL). Serum 1,25(OH)2-vitamin D (1,25(OH)2-D) level was elevated and parathyroid hormone undetectable. Evaluation for genetic mutations and malignant etiologies of hypercalcemia was negative. Treatment with intravenous hydration, loop diuretic, and calcitonin failed to correct the hypercalcemia, which was subsequently controlled with bisphosphonate therapy...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28455844/open-probe-fast-gc-ms-combining-ambient-sampling-ultra-fast-separation-and-in-vacuum-ionization-for-real-time-analysis
#12
Uri Keshet, Tal Alon, Alexander B Fialkov, Aviv Amirav
An Open Probe inlet was combined with a low thermal mass ultra-fast gas chromatograph (GC), in-vacuum electron eonization (EI) ion source and a mass spectrometer (MS) of GC-MS for obtaining real time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air and the ultra-fast GC provides ~30 s separation while if no separation is required it can act as a transfer line with 2-3 s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the open probe oven and getting the results in 30 s...
April 28, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28452299/new-insights-into-treatment-of-children-with-exercise-induced-asthma-symptoms
#13
Iwona Stelmach, Anna Sztafińska, Joanna Jerzyńska, Daniela Podlecka, Paweł Majak, Włodzimierz Stelmach
BACKGROUND: Exercise is one of the most common triggers of bronchoconstriction and affects up to 80% of children with asthma. OBJECTIVE: The purpose of this randomized, double-blind, placebo-controlled study was to assess the effectiveness of treatment with ciclesonide 160 microgram, either alone, with a higher dose, with a leukotriene receptor antagonist (LTRA), or with a long-acting beta-agonist (LABA) in children with asthma with postexercise-induced symptoms...
November 1, 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28426947/structural-neuroplasticity-of-the-superior-temporal-plane-in-early-and-late-blindness
#14
Hicret Atilgan, Olivier Collignon, Uri Hasson
Blindness is associated with well-documented changes to the morphometry and function of the occipital cortex. By comparison, its impact on the perisylvian regions in the superior temporal plane (STP) is poorly understood, with many studies reporting null findings on this issue. Here we re-approach this question using a morphometric analysis that relied on fine-scale, manual annotation of 13 sub-regions within the STP and that quantified both univariate and multivariate differences in morphometry. We applied these analyses to both cortical thickness (CT) and surface area (SA) data from congenitally and late blind, as compared to two matched sighted control groups...
July 2017: Brain and Language
https://www.readbyqxmd.com/read/28382624/cinacalcet-as-an-alternative-to-phosphate-therapy-in-x-linked-hypophosphataemic-rickets
#15
LETTER
Uri S Alon, Dale Jarka, Penny J Monachino, Judith Sebestyen VanSickle, Tarak Srivastava
No abstract text is available yet for this article.
April 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28339567/role-of-biomechanical-forces-in-hyperfiltration-mediated-glomerular-injury-in-congenital-anomalies-of-the-kidney-and-urinary-tract
#16
Tarak Srivastava, Ganesh Thiagarajan, Uri S Alon, Ram Sharma, Ashraf El-Meanawy, Ellen T McCarthy, Virginia J Savin, Mukut Sharma
Congenital anomalies of the kidney and urinary tract (CAKUT) including solitary kidney constitute the main cause of progressive chronic kidney disease (CKD) in children. Children born with CAKUT develop signs of CKD only during adolescence and do not respond to renin-angiotensin-aldosterone system blockers. Early cellular changes underlying CKD progression to end-stage renal disease by early adulthood are not well understood. The mechanism of maladaptive hyperfiltration that occurs from loss of functional nephrons, including solitary kidney, is not clear...
May 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28290192/further-construct-validity-of-the-timed-up-and-go-test-as-a-measure-of-ambulation-in-persons-with-multiple-sclerosis
#17
Alon Kalron, Mark Dolev, Uri Givon
BACKGROUND: The importance of mobility impairments in people with multiple sclerosis (PwMS) denotes a need for valid, reliable, sensitive and feasible clinical measuring tools. The Timed Up and Go (TUG) test is a unique mobility measure as it captures other functions apart from walking, ie, rising out of a chair or turning around an object. AIM: To expand the construct validity of the TUG test in PwMS and determine the ability of the TUG score to discriminate between four levels of disability between fallers, recurrent fallers and non-fallers...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28282010/complications-and-mortality-associated-with-temporary-abdominal-closure-techniques-a-systematic-review-and-meta-analysis
#18
REVIEW
Adam Cristaudo, Scott Jennings, Ronny Gunnarsson, Alan DeCosta
Temporary abdominal closure (TAC) techniques are routinely used in the open abdomen. Ideally, they should prevent evisceration, aid in removal of unwanted fluid from the peritoneal cavity, facilitate in achieving safe definitive fascial closure, as well as prevent the development of intra-abdominal complications. TAC techniques used in the open abdomen were compared with negative pressure wound therapy (NPWT) to identify which was superior. A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines involving Medline, Excerpta Medica, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, and <ext-link ext-link-type="uri" xlink:href="http://Clinicaltrials...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28270142/dynamic-proteomics-reveals-bimodal-protein-dynamics-of-cancer-cells-in-response-to-hsp90-inhibitor
#19
Anat Zimmer, Shlomit Amar-Farkash, Tamar Danon, Uri Alon
BACKGROUND: Drugs often kill some cancer cells while others survive. This stochastic outcome is seen even in clonal cells grown under the same conditions. Understanding the molecular reasons for this stochastic outcome is a current challenge, which requires studying the proteome at the single cell level over time. In a previous study we used dynamic proteomics to study the response of cancer cells to a DNA damaging drug, camptothecin. Several proteins showed bimodal dynamics: they rose in some cells and decreased in others, in a way that correlated with eventual cell fate: death or survival...
March 7, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28253312/monumental-megalithic-burial-and-rock-art-tell-a-new-story-about-the-levant-intermediate-bronze-dark-ages
#20
Gonen Sharon, Alon Barash, Davida Eisenberg-Degen, Leore Grosman, Maya Oron, Uri Berger
The Intermediate Bronze Age (IB) in the Southern Levant (ca. 2350-2000 BCE) is known as the "Dark Ages," following the collapse of Early Bronze urban society and predating the establishment of the Middle Bronze cities. The absence of significant settlements and monumental building has led to the reconstruction of IB social organization as that of nomadic, tribal society inhabiting rural villages with no central governmental system. Excavation in the Shamir Dolmen Field (comprising over 400 dolmens) on the western foothills of the Golan Heights was carried out following the discovery of rock art engravings on the ceiling of the central chamber inside one of the largest dolmens ever recorded in the Levant...
2017: PloS One
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