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Alon, Uri

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https://www.readbyqxmd.com/read/27912791/possible-failure-of-novel-direct-acting-oral-anticoagulants-in-management-of-pulmonary-embolism-a-case-report
#1
James Rankin, Menachem Nagar, Jonathan Crosby, Nojan Toomari, Richard Pietras, Uri M Ben-Zur
BACKGROUND: The relative effectiveness of vitamin K antagonists compared with novel oral anticoagulants in treating pulmonary embolism remains unclear. Recent trials comparing the efficacy of vitamin K antagonists with factor Xa inhibitors for the treatment of pulmonary emboli have been non-inferiority studies based primarily on risk reduction (such as bleeding events), rather than resolution of specific diseases such as pulmonary embolism. Consequently, there is a lack of evidence indicating which of these agents are more effective...
December 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27907133/phosphorous-nutritional-level-carbohydrate-reserves-and-flower-quality-in-olives
#2
Ran Erel, Uri Yermiyahu, Hagai Yasuor, Dan Cohen Chamus, Amnon Schwartz, Alon Ben-Gal, Arnon Dag
The olive tree is generally characterized by relatively low final fruit set consequential to a significant rate of undeveloped pistils, pistil abortion, and flower and fruitlet abscission. These processes are acknowledged to be governed by competition for resources between the developing vegetative and reproductive organs. To study the role of phosphorus (P) nutritional level on reproductive development, trees were grown under four levels of P for three years in large containers. Phosphorus nutritional level was positively related to rate of reproductive bud break, inflorescence weight, rate of hermaphrodite flowers, pistil weight, fruitlet persistence, fruit set and the consequential total number of fruits...
2016: PloS One
https://www.readbyqxmd.com/read/27875241/dynamical-compensation-in-physiological-circuits
#3
Omer Karin, Avital Swisa, Benjamin Glaser, Yuval Dor, Uri Alon
Biological systems can maintain constant steady-state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. However, it is unclear how physiological circuits also keep their output dynamics precise-including the amplitude and response time to a changing input. Such robustness is crucial for endocrine and neuronal homeostatic circuits because they need to provide a precise dynamic response in the face of wide variation in the physiological parameters of their target tissues; how such circuits compensate their dynamics for unavoidable natural fluctuations in parameters is unknown...
November 8, 2016: Molecular Systems Biology
https://www.readbyqxmd.com/read/27783882/temporal-trends-in-transcatheter-aortic-valve-implantation-2008-2014-patient-characteristics-procedural-issues-and-clinical-outcome
#4
Uri Landes, Alon Barsheshet, Ariel Finkelstein, Victor Guetta, Abid Assali, Amir Halkin, Hanna Vaknin-Assa, Amit Segev, Tamir Bental, Jeremy Ben-Shoshan, Israel M Barbash, Ran Kornowski
BACKGROUND: About a decade past the first transcatheter aortic valve implantation (TAVI), data are limited regarding temporal trends accompanying its evolution from novel technology to mainstream therapy. We evaluated these trends in a large multicenter TAVI registry. HYPOTHESIS: TAVI is changing and improving with time. METHODS: Patients who underwent TAVI between January 2008 and December 2014 at 3 high-volume Israeli centers were divided into 5 time quintiles according to procedure date...
October 26, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27741268/static-posturography-and-falls-according-to-pyramidal-sensory-and-cerebellar-functional-systems-in-people-with-multiple-sclerosis
#5
Alon Kalron, Uri Givon, Lior Frid, Mark Dolev, Anat Achiron
Balance impairment is common in people with multiple sclerosis (PwMS) and frequently impacts quality of life by decreasing mobility and increasing the risk of falling. However, there are only scarce data examining the contribution of specific neurological functional systems on balance measures in MS. Therefore, the primary aim of our study was to examine the differences in posturography parameters and fall incidence according to the pyramidal, cerebellar and sensory systems functional systems in PwMS. The study included 342 PwMS, 211 women and mean disease duration of 8...
2016: PloS One
https://www.readbyqxmd.com/read/27711185/exit-from-synchrony-in-joint-improvised-motion
#6
Assi Dahan, Lior Noy, Yuval Hart, Avi Mayo, Uri Alon
Motion synchrony correlates with effective and well-rated human interaction. However, people do not remain locked in synchrony; Instead, they repeatedly enter and exit synchrony. In many important interactions, such as therapy, marriage and parent-infant communication, it is the ability to exit and then re-enter synchrony that is thought to build strong relationship. The phenomenon of entry into zero-phase synchrony is well-studied experimentally and in terms of mathematical modeling. In contrast, exit-from-synchrony is under-studied...
2016: PloS One
https://www.readbyqxmd.com/read/27649169/spider-silk-cbd-cellulose-nanocrystal-composites-mechanism-of-assembly
#7
Sigal Meirovitch, Zvi Shtein, Tal Ben-Shalom, Shaul Lapidot, Carmen Tamburu, Xiao Hu, Jonathan A Kluge, Uri Raviv, David L Kaplan, Oded Shoseyov
The fabrication of cellulose-spider silk bio-nanocomposites comprised of cellulose nanocrystals (CNCs) and recombinant spider silk protein fused to a cellulose binding domain (CBD) is described. Silk-CBD successfully binds cellulose, and unlike recombinant silk alone, silk-CBD self-assembles into microfibrils even in the absence of CNCs. Silk-CBD-CNC composite sponges and films show changes in internal structure and CNC alignment related to the addition of silk-CBD. The silk-CBD sponges exhibit improved thermal and structural characteristics in comparison to control recombinant spider silk sponges...
September 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27602002/automated-video-analysis-of-non-verbal-communication-in-a-medical-setting
#8
Yuval Hart, Efrat Czerniak, Orit Karnieli-Miller, Avraham E Mayo, Amitai Ziv, Anat Biegon, Atay Citron, Uri Alon
Non-verbal communication plays a significant role in establishing good rapport between physicians and patients and may influence aspects of patient health outcomes. It is therefore important to analyze non-verbal communication in medical settings. Current approaches to measure non-verbal interactions in medicine employ coding by human raters. Such tools are labor intensive and hence limit the scale of possible studies. Here, we present an automated video analysis tool for non-verbal interactions in a medical setting...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27573663/phase-ii-weekly-vinblastine-for-chemotherapy-na%C3%A3-ve-children-with-progressive-low-grade-glioma-a-canadian-pediatric-brain-tumor-consortium-study
#9
Alvaro Lassaletta, Katrin Scheinemann, Shayna M Zelcer, Juliette Hukin, Beverley A Wilson, Nada Jabado, Anne Sophie Carret, Lucie Lafay-Cousin, Valerie Larouche, Cynthia E Hawkins, Gregory Russell Pond, Ken Poskitt, Daniel Keene, Donna L Johnston, David D Eisenstat, Rahul Krishnatry, Matthew Mistry, Anthony Arnoldo, Vijay Ramaswamy, Annie Huang, Ute Bartels, Uri Tabori, Eric Bouffet
PURPOSE: Vinblastine monotherapy has shown promising activity and a low-toxicity profile in patients with pediatric low-grade glioma (PLGG) who experienced treatment failure after initial treatment with chemotherapy and/or radiation. The aim of this study was to assess the activity of vinblastine in therapy-naïve children. PATIENTS AND METHODS: Patients < 18 years old with unresectable and/or progressive therapy-naïve PLGG were eligible. Vinblastine was administered once per week at a dose of 6 mg/m(2) intravenously over a period of 70 weeks...
August 29, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27562164/prediction-of-multidimensional-drug-dose-responses-based-on-measurements-of-drug-pairs
#10
Anat Zimmer, Itay Katzir, Erez Dekel, Avraham E Mayo, Uri Alon
Finding potent multidrug combinations against cancer and infections is a pressing therapeutic challenge; however, screening all combinations is difficult because the number of experiments grows exponentially with the number of drugs and doses. To address this, we present a mathematical model that predicts the effects of three or more antibiotics or anticancer drugs at all doses based only on measurements of drug pairs at a few doses, without need for mechanistic information. The model provides accurate predictions on available data for antibiotic combinations, and on experiments presented here on the response matrix of three cancer drugs at eight doses per drug...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27545349/massively-parallel-interrogation-of-the-effects-of-gene-expression-levels-on-fitness
#11
Leeat Keren, Jean Hausser, Maya Lotan-Pompan, Ilya Vainberg Slutskin, Hadas Alisar, Sivan Kaminski, Adina Weinberger, Uri Alon, Ron Milo, Eran Segal
Data of gene expression levels across individuals, cell types, and disease states is expanding, yet our understanding of how expression levels impact phenotype is limited. Here, we present a massively parallel system for assaying the effect of gene expression levels on fitness in Saccharomyces cerevisiae by systematically altering the expression level of ∼100 genes at ∼100 distinct levels spanning a 500-fold range at high resolution. We show that the relationship between expression levels and growth is gene and environment specific and provides information on the function, stoichiometry, and interactions of genes...
August 25, 2016: Cell
https://www.readbyqxmd.com/read/27445878/manipulating-the-placebo-response-in-experimental-pain-by-altering-doctor-s-performance-style
#12
Efrat Czerniak, Anat Biegon, Amitai Ziv, Orit Karnieli-Miller, Mark Weiser, Uri Alon, Atay Citron
BACKGROUND: Performance is paramount in traditional healing rituals. From a Western perspective, such performative behavior can be understood principally as inducing patients' faith in the performer's supernatural healing powers and effecting positive changes through the same mechanisms attributed to the placebo response, which is defined as improvement of clinical outcome in individuals receiving inactive treatment. Here we examined the possibility of using theatrical performance tools, including stage directions and scripting, to reproducibly manipulate the style and content of a simulated doctor-patient encounter and influence the placebo response in experimental pain...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27325869/interventions-to-reduce-childhood-antibiotic-prescribing-for-upper-respiratory-infections-systematic-review-and-meta-analysis
#13
Yanhong Hu, John Walley, Roger Chou, Joseph D Tucker, Joseph I Harwell, Xinyin Wu, Jia Yin, Guanyang Zou, Xiaolin Wei
BACKGROUND: Antibiotics are overprescribed for children with upper respiratory infections (URIs), leading to unnecessary expenditures, adverse events and antibiotic resistance. This study assesses whether interventions antibiotic prescription rates (APR) for childhood URIs can be reduced and what factors impact intervention effectiveness. METHODS: MEDLINE, Embase, Google Scholar, Web of Science, Global Health, WHO website, United States CDC website and The Cochrane Central Register of Controlled Trials (CENTRAL) were searched by December 2015...
June 20, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27317850/discontinuation-of-infliximab-in-patients-with-ulcerative-colitis-is-associated-with-increased-risk-of-relapse-a-multinational-retrospective-cohort-study
#14
Gionata Fiorino, Pablo Navarro Cortes, Pierre Ellul, Carla Felice, Pantelis Karatzas, Marco Silva, Peter L Lakatos, Fabrizio Bossa, Bella Ungar, Shaji Sebastian, Federica Furfaro, Konstantinos Karmiris, Konstantinos H Katsanos, Martina Muscat, Dimitrios K Christodoulou, Giovanni Maconi, Uri Kopylov, Fernando Magro, Gerassimos J Mantzaris, Alessandro Armuzzi, Marta Maia Boscà-Watts, Shomron Ben-Horin, Stefanos Bonovas, Silvio Danese
BACKGROUND & AIMS: Infliximab is a safe and effective therapy for ulcerative colitis (UC). We conducted a multicenter retrospective cohort study that included 7 European countries and Israel to examine whether infliximab discontinuation can be considered for patients who achieve sustained remission. METHODS: We performed a retrospective cohort study, collecting medical records from 13 tertiary care referral inflammatory bowel disease centers of all patients with UC treated with infliximab (n = 193)...
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27314963/gait-characteristics-according-to-pyramidal-sensory-and-cerebellar-edss-subcategories-in-people-with-multiple-sclerosis
#15
Alon Kalron, Uri Givon
Walking deterioration is a common problem in people with multiple sclerosis (PwMS). However, there are only scarce data examining the contribution of specific neurological functional systems on gait performance in multiple sclerosis (MS). Therefore, the objective of the current study was to examine the differences in spatio-temporal parameters of gait according to the pyramidal, cerebellar and sensory functional systems. The cross-sectional study included 289 PwMS with mean disease duration of 8.0 (SD = 8...
September 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27269943/therapeutic-impact-of-cytoreductive-surgery-and-irradiation-of-posterior-fossa-ependymoma-in-the-molecular-era-a-retrospective-multicohort-analysis
#16
Vijay Ramaswamy, Thomas Hielscher, Stephen C Mack, Alvaro Lassaletta, Tong Lin, Kristian W Pajtler, David T W Jones, Betty Luu, Florence M G Cavalli, Kenneth Aldape, Marc Remke, Martin Mynarek, Stefan Rutkowski, Sridharan Gururangan, Roger E McLendon, Eric S Lipp, Christopher Dunham, Juliette Hukin, David D Eisenstat, Dorcas Fulton, Frank K H van Landeghem, Mariarita Santi, Marie-Lise C van Veelen, Erwin G Van Meir, Satoru Osuka, Xing Fan, Karin M Muraszko, Daniela P C Tirapelli, Sueli M Oba-Shinjo, Suely K N Marie, Carlos G Carlotti, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Claudia C Faria, Sofia Nunes, Jaume Mora, Ronald L Hamilton, Peter Hauser, Nada Jabado, Kevin Petrecca, Shin Jung, Luca Massimi, Massimo Zollo, Giuseppe Cinalli, László Bognár, Almos Klekner, Tibor Hortobágyi, Sarah Leary, Ralph P Ermoian, James M Olson, Jeffrey R Leonard, Corrine Gardner, Wieslawa A Grajkowska, Lola B Chambless, Jason Cain, Charles G Eberhart, Sama Ahsan, Maura Massimino, Felice Giangaspero, Francesca R Buttarelli, Roger J Packer, Lyndsey Emery, William H Yong, Horacio Soto, Linda M Liau, Richard Everson, Andrew Grossbach, Tarek Shalaby, Michael Grotzer, Matthias A Karajannis, David Zagzag, Helen Wheeler, Katja von Hoff, Marta M Alonso, Teresa Tuñon, Ulrich Schüller, Karel Zitterbart, Jaroslav Sterba, Jennifer A Chan, Miguel Guzman, Samer K Elbabaa, Howard Colman, Girish Dhall, Paul G Fisher, Maryam Fouladi, Amar Gajjar, Stewart Goldman, Eugene Hwang, Marcel Kool, Harshad Ladha, Elizabeth Vera-Bolanos, Khalida Wani, Frank Lieberman, Tom Mikkelsen, Antonio M Omuro, Ian F Pollack, Michael Prados, H Ian Robins, Riccardo Soffietti, Jing Wu, Phillipe Metellus, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E Hawkins, James T Rutka, Peter Dirks, Stefan M Pfister, Thomas E Merchant, Mark R Gilbert, Terri S Armstrong, Andrey Korshunov, David W Ellison, Michael D Taylor
PURPOSE: Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known. METHODS: Four independent nonoverlapping retrospective cohorts of posterior fossa ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models were designed based on known clinical and newly described molecular biomarkers identified by multivariable Cox proportional hazards analyses...
July 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27183180/deoxygenation-increases-photoluminescence-lifetime-of-protein-responsive-organic-probes-with-triplet-singlet-resonant-energy-transfer
#17
Kadri Ligi, Erki Enkvist, Asko Uri
Cells and bodily fluids possess strong nanosecond-lifetime autofluorescence, therefore photoluminescent probes with microsecond-scale luminescence decay time would be useful for analysis of biological samples, as they allow the performance of measurements in time-resolved (TR) format in a time gate (time window) where the nonspecific background fluorescence has ceased. We have previously disclosed binding-responsive luminescent probes for protein kinases (PKs), ARC-Lum(Fluo) probes. High brightness of the probes is achieved through intramolecular Förster-type resonant energy transfer (FRET) from excited triplet state of a thiophene- or selenophene-comprising phosphor ((3)D*) to singlet acceptor dye ((1)A) leading to amplified emission from the dye...
June 9, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27181182/construct-validity-of-the-four-square-step-test-in-multiple-sclerosis
#18
Alon Kalron, Uri Givon
OBJECTIVE: To expand the construct validity of the Four Square Step Test (FSST) in people with multiple sclerosis (PWMS). DESIGN: Cross-sectional study. SETTING: Multiple sclerosis center. PARTICIPANTS: PWMS (N=218; 133 women, 85 men; mean age, 43.2±13.5y; mean disease duration, 7.5±7.7y since diagnosis) were enrolled in the study. The Expanded Disability Status Scale score was 3.1±1.3, indicating minimal to moderate neurologic disability...
September 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27166013/a-new-paradigm-for-the-role-of-smooth-muscle-cells-in-the-human-cervix
#19
Joy Y Vink, Sisi Qin, Clifton O Brock, Noelia M Zork, Helen M Feltovich, Xiaowei Chen, Paul Urie, Kristin M Myers, Timothy J Hall, Ronald Wapner, Jan K Kitajewski, Carrie J Shawber, George Gallos
BACKGROUND: Premature cervical remodeling resulting in spontaneous preterm birth may begin with premature failure or relaxation at the internal os (termed "funneling"). To date, we do not understand why the internal os fails or why funneling occurs in some cases of premature cervical remodeling. Although the human cervix is thought to be mostly collagen with minimal cellular content, cervical smooth muscle cells are present in the cervix and can cause cervical tissue contractility. OBJECTIVE: To understand why the internal os relaxes or why funneling occurs in some cases of premature cervical remodeling, we sought to evaluate cervical smooth muscle cell content and distribution throughout human cervix and correlate if cervical smooth muscle organization influences regional cervical tissue contractility...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27143659/human-metapneumovirus-infections-following-hematopoietic-cell-transplantation-factors-associated-with-disease-progression
#20
Sachiko Seo, Ted A Gooley, Jane M Kuypers, Zachary Stednick, Keith R Jerome, Janet A Englund, Michael Boeckh
BACKGROUND: Human metapneumovirus (HMPV) is a newly identified pulmonary pathogen that can cause fatal lower respiratory tract disease (LRD) in hematopoietic cell transplantation (HCT) recipients. Little is known about progression rates from upper respiratory tract infection (URI) to LRD and risk factors associated with progression. METHODS: A total of 118 HCT recipients receiving transplantation between 2004 and 2014 who had HMPV detected in nasopharyngeal, bronchoalveolar lavage, or lung biopsy samples by real-time reverse transcription polymerase chain reaction were retrospectively analyzed...
July 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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