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https://www.readbyqxmd.com/read/28027573/defects-in-myo5b-are-associated-with-a-spectrum-of-previously-undiagnosed-low-%C3%AE-glutamyltransferase-cholestasis
#1
Yi-Ling Qiu, Jing-Yu Gong, Jia-Yan Feng, Ren-Xue Wang, Jun Han, Teng Liu, Yi Lu, Li-Ting Li, Mei-Hong Zhang, Jonathan A Sheps, Neng-Li Wang, Yan-Yan Yan, Jia-Qi Li, Lian Chen, Christoph H Borchers, Bence Sipos, A S Knisely, Victor Ling, Qing-He Xing, Jian-She Wang
: Hereditary cholestasis in childhood and infancy with normal serum gamma-glutamyltransferase activity (GGT) is linked to several genes. Many patients, however, remain genetically undiagnosed. Defects in myosin 5B (MYO5B) cause microvillus inclusion disease (MVID, MIM251850) with recurrent watery diarrhea. Cholestasis reported as an atypical presentation in MVID has been considered a side effect of parenteral alimentation. Here, however, we report ten patients who experienced cholestasis associated with biallelic, or suspected biallelic, mutations in MYO5B and who neither had recurrent diarrhea nor received parenteral alimentation...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28002520/clinical-immunological-and-pathological-profile-of-infants-suffering-from-cow-s-milk-protein-allergy
#2
Elena Tătăranu, Smaranda Diaconescu, Camelia Geanina Ivănescu, Ioan Sârbu, Maria Stamatin
Cow's milk protein allergy (CMPA) is the most frequently encountered form of food allergy in pediatric patients and occurs secondary to cow's milk proteins (CMP) ingestion. The aim of this study is to define the profile of children suffering from CMPA and to describe the associated pathological findings. The authors performed a retrospective case-control study on 160 infants that presented with CMPA symptoms at "Sf. Maria" Emergency Clinical Hospital for Children, Iassy, Romania, between January 2013 and January 2015...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27981459/taste-enjoyment-and-desire-of-flavors-change-after-sleeve-gastrectomy-short-term-results
#3
Michele A Janse Van Vuuren, Esben Strodl, Katherine M White, Philip David Lockie
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) incidence continues to increase worldwide because of its efficacy and low surgical risks. This study aimed to investigate satisfaction with eating and the change in taste perception, desire, and enjoyment of flavor changes and associations with extent of percentage excess weight loss (%excess weight loss (EWL)) post-LSG. METHODS: One hundred six participants completed an online questionnaire 4 to 6 weeks as well as 6 to 8 months post-LSG bariatric surgery...
December 15, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27975019/usefulness-of-the-clavien-dindo-classification-in-understanding-the-limitations-and-indications-of-larynx-preserving-esophageal-reconstruction
#4
Hiroki Umezawa, Junichi Nakao, Takeshi Matsutani, Hiroaki Kuwahara, Marie Taga, Rei Ogawa
BACKGROUND: The Clavien-Dindo (CD) classification is used to evaluate the severity of surgical complications. However, its usefulness in esophageal reconstruction has not been reported. To address this, this case series study used the CD classification to evaluate the complications after cervical esophageal reconstruction with free jejunum transfer or supercharged pedicled intestinal transfer. METHODS: All consecutive patients who underwent esophageal cancer surgery with larynx-preserving free jejunum or pedicled ileocolic transfer in June 2012-December 2015 were identified...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27951464/compensatory-growth-in-crossbred-aberdeen-angus-and-belgian-blue-steers-effects-on-the-colour-shear-force-and-sensory-characteristics-of-longissimus-muscle
#5
S M Keady, S M Waters, R M Hamill, P G Dunne, M G Keane, R I Richardson, D A Kenny, A P Moloney
The effect of feed restriction (99days) followed by compensatory growth during a 200day re-alimentation period on the colour and sensory characteristics of meat from Aberdeen Angus×Holstein-Friesian (AN) and Belgian Blue×Holstein-Friesian (BB) steers was examined. Compensatory growth had no effect on muscle pH and temperature decline, chemical composition, drip loss, fat colour, or juiciness, but increased (P=0.009) Warner-Bratzler shear force and decreased tenderness (P=0.08) and overall liking (P=0.09)...
March 2017: Meat Science
https://www.readbyqxmd.com/read/27928446/gastrostomy-with-peritoneal-collar-versus-percutaneous-endoscopic-gastrostomy
#6
Tudor C, Branescu C, Savlovschi C, El-Khatib A, Pantu H, Nica A, Dascalu Am, Masoumeh B, Tudor As, Oprescu Sm, Serban D
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27785098/single-shot-lamina-thoracic-paravertebral-block-with-ketofol-for-modified-radical-mastectomy
#7
Ambrose Rukewe, Oludolapo O Afuwape, Austin Ugheoke, Akinola A Fatiregun
We describe the use of single-shot lamina thoracic paravertebral block (TPVB) with sedation for a 56-year-old female patient who had modified radical mastectomy with axillary clearance. Two years ago, she suffered vocal cord palsy post thyroidectomy, which was managed with tracheostomy. The tracheostomy tube was removed 8 months later, leaving the patient with persistent hoarseness of voice and left vocal cord palsy. She declined general anesthesia and consented for TPVB. The surgery lasted 95 minutes and was successfully completed with TPVB...
2016: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/27777548/crush-syndrome-chez-l%C3%A2-adulte-et-problematique-de-sa-prise-en-charge-a-la-phase-aigu%C3%A3
#8
P F Hemou, H D Sama, P Tchétikè, T Potkar
Le crush syndrome se définit comme l'ensemble des manifestations locales et générales secondaires à une rhabdomyolyse traumatique avec ischémie de grosses masses musculaires par compression prolongée, à l'origine d'un syndrome compartimental ou syndrome des loges. Rarement isolé, il peut passer inaperçu dans les 24 à 48 premières heures de la phase aiguë d'un traumatisme sévère quand les principales préoccupations médicales sont la sauvegarde des fonctions vitales. La souffrance musculaire liée au syndrome compartimental entraîne la libération de myoglobine dans la circulation générale...
December 31, 2015: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27699170/network-based-approach-in-the-establishment-of-the-relationship-between-type-2-diabetes-mellitus-and-its-complications-at-the-molecular-level-coupled-with-molecular-docking-mechanism
#9
Shailima Rampogu, Mary Rampogu Lemuel
Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking to identify the common drug for all the three diseases. We have adopted several software programs such as Phenopedia, VennViewer, and CDOCKER to accomplish the objective. Our results revealed six genes that commonly associated and are involved in the signalling pathway...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27599954/-alimentary-and-lifestyle-changes-as-a-strategy-in-the-prevention-of-metabolic-syndrome-and-diabetes-mellitus-type-2-milestones-and-perspectives
#10
M M Hernández Ruiz de Eguilaz, M A Batlle, B Martínez de Morentin, R San-Cristóbal, S Pérez-Díez, S Navas-Carretero, J A Martínez
A high caloric intake in today's nutrition and a sedentary lifestyle are the main causes of the notable increase in obesity in our society. In turn, this results in an increase in associated pathologies, such as metabolic syndrome and diabetes type 2. In the present work we review most recent studies and programs, which are significant due to their sample size and geographical diversity. It clearly shows that changes in alimentation and lifestyles are an effective instrument for combatting or delaying the onset of these diseases...
2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/27566729/effect-of-age-on-the-occurrence-of-muscle-fiber-degeneration-associated-with-myopathies-in-broiler-chickens-submitted-to-feed-restriction
#11
G Radaelli, A Piccirillo, M Birolo, D Bertotto, F Gratta, C Ballarin, M Vascellari, G Xiccato, A Trocino
To evaluate muscle fiber degeneration (MFD) associated with white striping and wooden breast, pectoralis major of 192 broilers differing for genotype (standard vs. high breast yield), gender, and feeding regime (ad libitum vs. restricted rate 80% from 13 to 21 d of age) were sampled at 14, 21, 28, 35, and 46 d of age for histological analyses by hematoxylin and eosin (H&E) staining to evaluate tissue morphology, Masson's trichrome to identify collagen presence, and Oil red and Nile blue for lipid presence. Microvessels (diameter ≤15 μm), nuclei positive to anti-cleaved lamin A and monoclonal proliferating cell nuclear antigen (PCNA) antisera were counted to assess apoptotic and regenerative processes, respectively...
August 26, 2016: Poultry Science
https://www.readbyqxmd.com/read/27549243/clinical-importance-of-cine-mri-assessment-of-small-bowel-motility-in-patients-with-chronic-intestinal-pseudo-obstruction-a-retrospective-study-of-33-patients
#12
Akiko Fuyuki, Hidenori Ohkubo, Takuma Higurashi, Hiroshi Iida, Yumi Inoh, Masahiko Inamori, Atsushi Nakajima
BACKGROUND: Although chronic intestinal pseudo-obstruction (CIPO) is a rare and extremely severe functional digestive disorder, its clinical course and severity show various patterns. We assessed small bowel peristalsis in CIPO patients using cine-MRI (video-motion MRI) and their clinical characteristics to evaluate the clinical importance of performing cine-MRI in patients with this intractable disease. METHODS: The medical records of 131 patients referred to our institution with a suspected diagnosis of CIPO between 2010 and 2015 were retrospectively evaluated...
August 22, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27535186/the-nutritional-intake-of-elderly-patients-with-dysphagia-admitted-to-the-internal-medical-department-of-the-emergency-hospital-was-analyzed-the-fujishima-dysphagia-scale-after-care-and-treatment-by-the-nutrition-support-team-was-assessed
#13
Mototaka Niwano
AIM: The Nutrition Support Team (NST) assessed the severity of dysphagia in elderly patients admitted to the internal medical department, and the appropriate nutritional treatment was determined. Patients were treated with either oral nutrition (enteral nutrition, EN) or artificial alimentation (parenteral nutrition, PN). The goal of this study was to analyze whether or not the route of nutrition affected the patient discharge rates. METHODS: We divided 290 elderly inpatients with dysphagia into 2 groups, the pneumonia group (200 patients) and the non-pneumonia group (90 patients)...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27521402/-les-z%C3%A3-bres-m%C3%A3-laniques-leurs-soins-et-alimentation
#14
James A Dickinson
No abstract text is available yet for this article.
August 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27477384/microvillus-inclusion-disease-a-subtotal-enterectomy-as-a-bridge-to-transplantation
#15
Karen van Hoeve, Ilse Hoffman, Fabio Fusaro, Jacques Pirenne, Ann Vander Auwera, Anne-Marie Dieltjens, Gert De Hertogh, Diethard Monbaliu, Marc Miserez
BACKGROUND: Microvillus inclusion disease (MVID) is a known congenital cause of intractable diarrhea resulting in permanent intestinal failure. There is need for a lifelong total parenteral nutrition (TPN) from diagnosis and the prognosis is poor. Most patients die by the second decade of life as a result of complications of parenteral alimentation including liver failure or sepsis. The only available treatment at this moment is a small bowel transplantation. But before that moment, the patients often suffer from a persistent failure to thrive and electrolyte disturbances despite continuous TPN...
December 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27471505/nutritional-and-nanotechnological-modulators-of-microglia
#16
REVIEW
Dusica Maysinger, Issan Zhang
Microglia are the essential responders to alimentary, pharmacological, and nanotechnological immunomodulators. These neural cells play multiple roles as surveyors, sculptors, and guardians of essential parts of complex neural circuitries. Microglia can play dual roles in the central nervous system; they can be deleterious and/or protective. The immunomodulatory effects of alimentary components, gut microbiota, and nanotechnological products have been investigated in microglia at the single-cell level and in vivo using intravital imaging approaches, and different biochemical assays...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27456604/gastro-splenic-fistula-as-a-complication-of-chemotherapy-for-large-b-cell-lymphoma
#17
Sergio Gentilli, Alberto Oldani, Manuela Zanni, Erika Ferreri, Alfonso Terrone, Guido Valente, Pietro Occhipinti
AIM: Gastro-splenic fistula is a rare entity in which malignant tumors are the primary cause, followed by perforated peptic ulcers and Crohn's disease. CASE REPORT: A 66 years old patient undergoing chemotherapy for gastric large cells B lymphoma presented fever, fatigue and worsening of general conditions. A CT scan showed the presence of an abdominal abscess resulting from a pathological communication between stomach and spleen. RESULTS: En - bloc splenectomy and gastric wedge resection was performed; gastric wall was sutured with a linear stapler...
July 26, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27441902/quality-of-life-and-recommendations-for-further-care
#18
Michael S Putman, Hyo Jung Tak, Farr A Curlin, John D Yoon
OBJECTIVES: Physician recommendations for further medical treatment or palliative treatment only at the end of life may influence patient decisions. Little is known about the patient characteristics that affect physician-assessed quality of life or how such assessments are related to subsequent recommendations. DESIGN, SETTING, AND SUBJECTS: A 2010 mailed survey of practicing U.S. physicians (1,156/1,878 or 62% of eligible physicians responded). MEASUREMENTS AND MAIN RESULTS: Measures included an end of life vignette with five experimentally varied patient characteristics: setting, alimentation, pain, cognition, and communication...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27428564/a-retrospective-observational-study-of-enteral-nutrition-in-patients-with-enteroatmospheric-fistulas
#19
Alexander Reinisch, Juliane Liese, Guido Woeste, Wolf Bechstein, Nils Habbe
Enteroatmospheric fistulas (EAFs) represent a challenging problem in patients with an open abdomen (OA). A retrospective, descriptive study was conducted to evaluate the effects of enteral alimentation on wound status and management and nutrition. All patients with an EAF in an OA treated between October 2012 and December 2014 at a university hospital in Germany were included without criteria for exclusions. Demographic and morbidity-related data collected included age, gender, surgeries, OA grading, body mass index (BMI), serum albumin, and serum creatinin...
July 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27384436/an-epidemiologic-study-on-ageing-and-dysphagia-in-the-acute-care-geriatric-hospitalized-population-a-replication-and-continuation-study
#20
Steven B Leder, Debra M Suiter, George O Agogo, Leo M Cooney
United States census data project dramatic increases in the geriatric population ageing demographics by 2060 with concomitant health-care consequences. The purpose of this replication and continuation study was to collect new 2014 demographic data relative to ageing, swallow evaluation referral rates, and oral feeding status in geriatric-hospitalized patients for comparison with published data from 2000 to 2007. This was a planned data acquisition study of consecutive hospitalized patients referred for swallow assessments...
October 2016: Dysphagia
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