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https://www.readbyqxmd.com/read/28743168/calorie-restriction-reverses-age-related-alteration-of-cavernous-neurovascular-structure-in-the-rat
#1
A Limanjaya, K-M Song, M-J Choi, K Ghatak, N N Minh, D H Kang, J Ock, G N Yin, H Y Chung, J-K Ryu, J-K Suh
Calorie restriction (CR) refers to a reduction of calorie intake without compromising essential nutrients to avoid malnutrition. CR has been established as a non-genetic method of altering longevity and attenuating biological changes associated with aging. Aging is also an important risk factor for erectile dysfunction. The aim of this study was to examine whether CR diet can reverse the age-related alterations of erectile tissue in the aged rat. Four groups of rats were used: young rats (7 months) + ad libitum, aged rats (22 months) + ad libitum, young rats + CR diet, and aged rats + CR diet...
July 25, 2017: Andrology
https://www.readbyqxmd.com/read/28743167/preoperative-bevacizumab-and-volumetric-recovery-after-resection-of-colorectal-liver-metastases
#2
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Kazunari Sasaki, Manijeh Zargham Pour, Ammar Deshwar, Jane Wang, Mounes Aliyari Ghasebeh, Christos Damaskos, Neda Rezaee, Timothy M Pawlik, Christopher L Wolfgang, Ihab R Kamel, Matthew J Weiss
BACKGROUND AND OBJECTIVES: While preoperative treatment is frequently administered to CRLM patients, the impact of chemotherapy, with or without bevacizumab, on liver regeneration remains controversial. METHODS: The early and late regeneration indexes were defined as the relative increase in liver volume (RLV) within 2 and 9 months from surgery. Regeneration rates of the preoperative treatment groups were compared. RESULTS: Preoperative chemotherapy details and volumetric data were available for 185 patients; 78 (42...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743131/the-spatial-extent-of-epiretinal-electrical-stimulation-in-the-healthy-mouse-retina
#3
Zohreh Hosseinazdeh, Archana Jalligampala, Eberhart Zrenner, Daniel Lleweylln Rathbun
BACKGROUND/AIMS: Retinal prostheses use electrical stimulation to restore functional vision to patients blinded by retinitis pigmentosa. A key detail is the spatial pattern of ganglion cells activated by stimulation. Therefore, we characterized the spatial extent of network-mediated electrical activation of retinal ganglion cells (RGCs) in the epiretinal monopolar electrode configuration. METHODS: Healthy mouse RGC activities were recorded with a micro-electrode array (MEA)...
July 26, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/28743100/studies-on-secondary-metabolite-profiling-anti-inflammatory-potential-in-vitro-photoprotective-and-skin-aging-related-enzyme-inhibitory-activities-of-malaxis-acuminata-a-threatened-orchid-of-nutraceutical-importance
#4
Biswajit Bose, Hiranjit Choudhury, Pramod Tandon, Suman Kumaria
Malaxis acuminata D. Don., a small, terrestrial orchid, is endemic to tropical Himalayas at an altitude of 1200-2000m asl. The dried pseudobulbs are important ingredients of century old ayurvedic drug 'Ashtavarga' and a polyherbal immune-booster nutraceutical 'Chyavanprash', known to restore vigour, vitality and youthfulness. Considering tremendous medicinal importance of this threatened orchid species, a detailed study was undertaken for the first time to address its antioxidant potential, secondary metabolite contents and biological activities against skin-aging related enzymes (anti-collagenase, anti-elastase, anti-tyrosinase and xanthine oxidase) and anti-inflammatory activity (5-lipoxygenase and hyaluronidase) in different plant parts of wild and in vitro-derived plants of M...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28743082/characterization-and-evaluation-of-nanoencapsulated-diethylcarbamazine-in-model-of-acute-hepatic-inflammation
#5
Gabriel Barros Rodrigues, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonça Junior, Laise Aline Martins Dos Santos, Wilma Helena de Oliveira, Maria Eduarda Rocha de França, Deniele Bezerra Lós, Brennda Martins Gabínio, Fábia Cristiane Melo Leite de Lira, Christina Alves Peixoto
Previous studies from our laboratory have demonstrated that Diethylcarbamazine (DEC) is a potent anti-inflammatory drug. The aim of the present study was to characterize the nanoencapsulation of DEC and to evaluate its effectiveness in a model of inflammation for the first time. C57BL/6 mice were divided into six groups: 1) Control; 2) Carbon tetrachloride (CCl4); 3) DEC 25mg/kg+CCl4; 4) DEC 50mg/kg+CCl4; 5) DEC-NANO 05mg/kg+CCl4 and 6) DEC-NANO 12.5mg/kg+CCl4. Liver fragments were stained with hematoxylin-eosin, and processed for Western blot, ELISA and immunohistochemistry...
July 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28743056/apigenin-attenuates-isoflurane-induced-cognitive-dysfunction-via-epigenetic-regulation-and-neuroinflammation-in-aged-rats
#6
Lin Chen, Wenji Xie, Wenqin Xie, Weiqiang Zhuang, Changcheng Jiang, Naizhen Liu
PURPOSE OF THE RESEARCH: Post operational cognitive dysfunction (POCD) occurs in patients after anesthesia and surgery. Abnormal histone acetylation and neuroinflammation are key factors in the pathogenesis of cognitive impairment. Apigenin not only has an anti-inflammatory activity but also modifies histone acetylation. We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling. MATERIALS AND METHODS: Spatial learning and memory were assessed by Morris water maze test...
July 6, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28743006/restoring-low-input-high-diversity-grasslands-as-a-potential-global-resource-for-biofuels
#7
Brian Machovina, Kenneth J Feeley
Reducing meat consumption by humans and shifting to more efficient plant and animal protein sources could potentially free up large areas of pasture and feedcrop agricultural land for restoration or conversion to low-input high-diversity (LIHD) grasslands. LIHD grasslands improve biodiversity, carbon sequestration, erosion control, water storage, while also providing opportunities to produce biofuels. We examined the potential of converting pastures globally, and animal feedstock agricultural lands in the USA and Brazil, to LIHD biomass sources and the capacity of these systems to meet national energy demands via (1) cellulosic ethanol and (2) integrated gasification and combined cycle technology with Fischer-Tropsch hydrocarbon synthesis (IGCC-FT) processing...
July 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28742984/single-versus-combined-immunoregulatory-approach-using-pd-1-and-ctla-4-modulators-in-controlling-sepsis
#8
Courtney P Rudick, David L Cornell, Devendra K Agrawal
Sepsis is a disease process characterized by an extreme inflammatory response followed by a period of severe immunosuppression. In recent years, there has been improved survival in the initial immune response during systemic inflammatory response syndrome, and compensatory anti-inflammatory response, yet is mostly unchanged with 18-30% mortality during the later stage of sepsis despite numerous Phase 3 clinical trials. Areas covered: This review article presents a critical evaluation of the most promising newer studies aimed at improving the immunosuppressive stage of sepsis...
July 25, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28742833/translational-approaches-to-coagulopathy-after-trauma-towards-targeted-treatment
#9
Mitchell Jay Cohen
Mitchell J. Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742696/transanal-versus-transabdominal-minimally-invasive-completion-proctectomy-with-ileal-pouch-anal-anastomosis-in-ulcerative-colitis-a-comparative-study
#10
Anthony de Buck van Overstraeten, Anders Mark-Christensen, Karin A Wasmann, Vivian P Bastiaenen, Christianne J Buskens, Albert M Wolthuis, Koen Vanbrabant, André D'hoore, Willem A Bemelman, Anders Tottrup, Pieter J Tanis
OBJECTIVE: This study aims to compare surgical outcome of transanal ileal pouch-anal anastomosis (ta-IPAA) with transabdominal minimal invasive approach in ulcerative colitis (UC), using the comprehensive complication index (CCI). BACKGROUND: Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a better exposure of the distal rectum and presumed better outcome. The same approach was introduced for patients with UC, resulting in decreased invasiveness...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742687/the-allosteric-hemoglobin-effector-itpp-inhibits-metastatic-colon-cancer-in-mice
#11
Perparim Limani, Michael Linecker, Marcel A Schneider, Philipp Kron, Christoph Tschuor, Ekaterina Kachaylo, Udo Ungethuem, Claude Nicolau, Jean-Marie Lehn, Rolf Graf, Bostjan Humar, Pierre-Alain Clavien
OBJECTIVE: To test the effects of enhanced intracellular oxygen contents on the metastatic potential of colon cancer. BACKGROUND: Colorectal cancer is the commonest gastrointestinal carcinoma. Distant metastases occur in half of patients and are responsible for most cancer-related deaths. Tumor hypoxia is central to the pathogenesis of metastases. Myo-Inositoltrispyrophosphate (ITPP), a nontoxic, antihypoxic compound, has recently shown significant benefits in experimental cancer, particularly when combined with standard chemotherapy...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742283/reliability-of-visual-and-instrumental-color-matching
#12
Christopher Igiel, Karl Martin Lehmann, Razvan Ghinea, Michael Weyhrauch, Ysbrand Hangx, Herbert Scheller, Rade D Paravina
OBJECTIVE: The aim of this investigation was to evaluate intrarater and inter-rater reliability of visual and instrumental shade matching. MATERIALS AND METHODS: Forty individuals with normal color perception participated in this study. The right maxillary central incisor of a teaching model was prepared and restored with 10 feldspathic all-ceramic crowns of different shades. A shade matching session consisted of the observer (rater) visually selecting the best match by using VITA classical A1-D4 (VC) and VITA Toothguide 3D Master (3D) shade guides and the VITA Easyshade Advance intraoral spectrophotometer (ES) to obtain both VC and 3D matches...
July 25, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28742204/mir-144-functions-as-tumor-suppressor-by-targeting-pim1-in-gastric-cancer
#13
K Ren, Q-Q Liu, Z-F An, D-P Zhang, X-H Chen
OBJECTIVE: Gastric cancer (GC) is one of the most prevalent types of malignant disease Worldwide. Mounting evidence has demonstrated the involvement of miRNAs in the development of GC. One of these miRNAs, miR-144 has been found aberrantly expressed in a variety of human malignancies. PATIENTS AND METHODS: GC tissues were collected from patients, and the level of miR-144 was determined by qRT-PCR. GC cell lines SGC7901 and AGS were used as model cell lines and the anti-tumor effect of miR-144 in both cells were examined...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28742140/short-16-mer-locked-nucleic-acid-splice-switching-oligonucleotides-restore-dystrophin-production-in-duchenne-muscular-dystrophy-myotubes
#14
Vanessa Borges Pires, Ricardo Simões, Kamel Mamchaoui, Célia Carvalho, Maria Carmo-Fonseca
Splice-switching antisense oligonucleotides (SSOs) offer great potential for RNA-targeting therapies, and two SSO drugs have been recently approved for treating Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA). Despite promising results, new developments are still needed for more efficient chemistries and delivery systems. Locked nucleic acid (LNA) is a chemically modified nucleic acid that presents several attractive properties, such as high melting temperature when bound to RNA, potent biological activity, high stability and low toxicity in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28742067/long-term-microdystrophin-gene-therapy-is-effective-in-a-canine-model-of-duchenne-muscular-dystrophy
#15
Caroline Le Guiner, Laurent Servais, Marie Montus, Thibaut Larcher, Bodvaël Fraysse, Sophie Moullec, Marine Allais, Virginie François, Maeva Dutilleul, Alberto Malerba, Taeyoung Koo, Jean-Laurent Thibaut, Béatrice Matot, Marie Devaux, Johanne Le Duff, Jack-Yves Deschamps, Inès Barthelemy, Stéphane Blot, Isabelle Testault, Karim Wahbi, Stéphane Ederhy, Samia Martin, Philippe Veron, Christophe Georger, Takis Athanasopoulos, Carole Masurier, Federico Mingozzi, Pierre Carlier, Bernard Gjata, Jean-Yves Hogrel, Oumeya Adjali, Fulvio Mavilio, Thomas Voit, Philippe Moullier, George Dickson
Duchenne muscular dystrophy (DMD) is an incurable X-linked muscle-wasting disease caused by mutations in the dystrophin gene. Gene therapy using highly functional microdystrophin genes and recombinant adeno-associated virus (rAAV) vectors is an attractive strategy to treat DMD. Here we show that locoregional and systemic delivery of a rAAV2/8 vector expressing a canine microdystrophin (cMD1) is effective in restoring dystrophin expression and stabilizing clinical symptoms in studies performed on a total of 12 treated golden retriever muscular dystrophy (GRMD) dogs...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28742043/mixed-modality-stimulation-to-evoke-two-modalities-simultaneously-in-one-channel-for-electrocutaneous-sensory-feedback
#16
Kyunghwan Choi, Pyungkang Kim, Kyung-Soo Kim, Soohyun Kim
One of the long-standing challenges in upper limb prosthetics is restoring the sensory feedback that is missing due to amputation. Two approaches have previously been presented to provide various types of sensory information to users, namely, multi-modality sensory feedback and using an array of singlemodality stimulators. However, the feedback systems used in these approaches were too bulky to be embedded in prosthesis sockets. In this paper, we propose an electrocutaneous sensory feedback method that is capable of conveying two modalities simultaneously with only one electrode...
July 24, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28742024/elastic-force-restricts-the-growth-of-the-murine-utricle
#17
Ksenia Gnedeva, Adrian Jacobo, Joshua D Salvi, Aleksandra A Petelski, A James Hudspeth
Dysfunctions of hearing and balance are often irreversible in mammals owing to the inability of cells in the inner ear to proliferate and replace lost sensory receptors. To determine the molecular basis of this deficiency we have investigated the dynamics of growth and cellular proliferation in a murine vestibular organ, the utricle. Based on this analysis, we have created a theoretical model that captures the key features of the organ's morphogenesis. Our experimental data and model demonstrate that an elastic force opposes growth of the utricular sensory epithelium during development, confines cellular proliferation to the organ's periphery, and eventually arrests its growth...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28741879/mir-376a-suppresses-the-proliferation-and-invasion-of-non-small-cell-lung-cancer-by-targeting-c-myc
#18
Youyu Wang, Wei Cong, Gang Wu, Xueming Ju, Zhixi Li, Xin Duan, Xueli Wang, Hong Gao
It has been reported that miR-376a is involved in the formation and progression of several types of cancer However, the expression and function of miR-376a is still unknown in non-small cell lung carcinomas (NSCLC). In this study, the expression of miR-376a in NSCLC tissues and cell lines were examined by real-time PCR, the effects of miR-376a on cell proliferation, apoptosis and invasion were evaluated in vitro. Luciferase reporter assay was performed to identify the targets of miR-376a. The results showed that miR-376a was significantly downregulated in NSCLC tissues and cell lines...
July 25, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28741855/in-vivo-rescue-of-the-hematopoietic-niche-by-pluripotent-stem-cell-complementation-of-defective-osteoblast-compartments
#19
Rhiannon Chubb, James Oh, Alyssa K Riley, Takaharu Kimura, Sean M Wu, Joy Y Wu
Bone-forming osteoblasts play critical roles in supporting bone marrow hematopoiesis. Pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are capable of differentiating into osteoblasts. To determine the capacity of stem cells needed to rescue aberrant skeletal development and bone marrow hematopoiesis in vivo, we employed a skeletal complementation model. Mice deficient in Runx2, a master transcription factor for osteoblastogenesis, fail to form a mineralized skeleton and bone marrow...
July 25, 2017: Stem Cells
https://www.readbyqxmd.com/read/28741841/pulmonary-valve-opening-with-two-rotary-left-ventricular-assist-devices-for-biventricular-support
#20
Eric L Wu, Frank Nestler, Matthias Kleinheyer, Michael C Stevens, Jo P Pauls, John F Fraser, Shaun D Gregory
Right ventricular failure is a common complication associated with rotary left ventricular assist device (LVAD) support. Currently, there is no clinically approved long-term rotary right ventricular assist device (RVAD). Instead, clinicians have implanted a second rotary LVAD as RVAD in biventricular support. To prevent pulmonary hypertension, the RVAD must be operated by either reducing pump speed or banding the outflow graft. These modes differ in hydraulic performance, which may affect the pulmonary valve opening (PVO) and subsequently cause fusion, valvular insufficiency, and thrombus formation...
July 25, 2017: Artificial Organs
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