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nosocomial pneumonia with suspected or proven methicillin

Jing Guan, Rong Fu, Er-Bao Ruan, Yong Liang, Wen Qu, Guo-Jin Wang, Xiao-Ming Wang, Hong Liu, Yu-Hong Wu, Jia Song, Hua-Quan Wang, Li-Min Xing, Zong-Hong Shao
OBJECTIVE: To observe the efficacy and safety of linezolid for the treatment of gram positive coccus infections in hematological disease patients. METHODS: One hundred and two hematological disease patients with suspected or proven gram positive coccus bacteria infection were enrolled in this study. Linezolid was given at a dosage of 600 mg, iv, q12h. The mean treatment period was (10.82 ± 5.12) days (1 to 51 days) with 74.5% over 7 d and 51.0% over 10 d. RESULTS: Among 102 patients, 57 were male, 45 female aged 11 to 81 years, with a mean of (45...
August 2010: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
George G Zhanel, Ashley Lam, Frank Schweizer, Kristjan Thomson, Andrew Walkty, Ethan Rubinstein, Alfred S Gin, Daryl J Hoban, Ayman M Noreddin, James A Karlowsky
Ceftobiprole, an investigational cephalosporin, is currently in phase III clinical development. Ceftobiprole is a broad-spectrum cephalosporin with demonstrated in vitro activity against Gram-positive cocci, including meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-resistant S. epidermidis, penicillin-resistant S. pneumoniae, Enterococcus faecalis, Gram-negative bacilli including AmpC-producing Escherichia coli and Pseudomonas aeruginosa, but excluding extended-spectrum beta-lactamase-producing strains...
2008: American Journal of Clinical Dermatology
(no author information available yet)
Ceftobiprole medocaril [BAL 5788, RO 65-5788, JNJ 30982081] is a prodrug in phase III clinical development with Basilea Pharmaceutica and Cilag AG (Johnson & Johnson) for the potential treatment of serious bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole medocaril is the water-soluble prodrug of the pyrrolidinone cephalosporin, ceftobiprole [BAL 9141, RO 63-9141]. Because of the low water solubility of ceftobiprole, its clinical application was limited and Basilea began its investigations into ceftobiprole medocaril for further development...
2006: Drugs in R&D
Greg L Plosker, David P Figgitt
Linezolid (Zyvox), the first available oxazolidinone antibacterial agent, has good activity against Gram-positive pathogens, including multidrug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium. Randomised multicentre trials in patients with various types of serious Gram-positive infections showed that clinical cure rates with linezolid were similar to those with vancomycin or teicoplanin. In some subgroup analyses, which must be interpreted with a degree of caution, clinical advantages were noted for linezolid (e...
2005: PharmacoEconomics
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