Ivana Stružinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Romana Michálková, Jiří Dvořák, Kristýna Němejcová, Radoslav Matěj, Jan Laco, Jana Drozenová, Pavel Fabian, Jitka Hausnerová, Gábor Méhes, Petr Škapa, Marián Švajdler, David Cibula, Filip Frühauf, Michaela Kendall Bártů, Pavel Dundr
BACKGROUND: Molecular aberrations occurring in primary ovarian clear cell carcinoma (OCCC) can be of diagnostic, predictive, and prognostic significance. However, a complex molecular study including genomic and transcriptomic analysis of large number of OCCC has been lacking. METHODS: 113 pathologically confirmed primary OCCCs were analyzed using capture DNA NGS (100 cases; 727 solid cancer related genes) and RNA-Seq (105 cases; 147 genes) in order to describe spectra and frequency of genomic and transcriptomic alterations, as well as their prognostic and predictive significance...
June 12, 2023: Diagnostic Pathology