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Keywords Kinase targeting and ovarian c...

Kinase targeting and ovarian clear cell carcinoma

https://read.qxmd.com/read/37876143/3-hydroxypterostilbene-potently-suppresses-tumor-growth-via-inhibiting-the-activation-of-the-jak2-stat3-pathway-in-ovarian-clear-cell-carcinoma
#1
JOURNAL ARTICLE
Yen-Chun Koh, Wei-Zhe Huang, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
SCOPE: Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin-6 (IL-6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this cancer. This study aims to compare the anti-cancer effect of pterostilbene (PSB) and 2'- and 3'-hydroxypterostilbene (2HPSB and 3HPSB, respectively) on the JAK2/STAT3 pathway. METHODS AND RESULTS: In vitro experiments with the OCCC cell line TOV21G and a xenograft nude mouse model are used to achieve the study aims...
October 24, 2023: Molecular Nutrition & Food Research
https://read.qxmd.com/read/37676270/her2-status-as-a-potential-predictive-biomarker-for-ovarian-clear-cell-carcinoma
#2
JOURNAL ARTICLE
Michaela Kendall Bártů, Kristýna Němejcová, Romana Michálková, Ivana Stružinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Jan Laco, Radoslav Matěj, Jana Drozenová, Gábor Méhes, Pavel Fabian, Jitka Hausnerová, Marián Švajdler, Petr Škapa, David Cibula, Tomáš Zima, Pavel Dundr
Ovarian clear cell carcinoma (OCCC) is a subtype of ovarian carcinoma characterized by unique biological features and highly malignant characteristics including low chemosensitivity. Therefore, new therapeutic targets are needed. These could include the downstream pathways of receptor tyrosine kinases, especially the human epidermal growth factor receptor 2 (HER2). Our main objective was to characterize the HER2 status using immunohistochemistry (IHC) and FISH on 118 OCCCs, also considering the novel paradigm of HER2-zero and HER2-low status...
October 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37627318/endometriosis-associated-ovarian-carcinomas-how-pi3k-akt-mtor-pathway-affects-their-pathogenesis
#3
REVIEW
Tatiana S Driva, Christoph Schatz, Johannes Haybaeck
Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under the umbrella term "endometriosis-associated ovarian cancer" (EAOC), since they frequently arise from ectopic endometrium settled in the ovaries. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is known to be aberrantly activated both in endometriosis and EAOC; however, its role in the progression of endometriosis to ovarian cancer remains unclear. In fact, cancer-associated alterations in the mTOR pathway may be found in normal uterine epithelium, likely acting as a first step towards ovarian cancer, through the intermediary stage of endometriosis...
August 16, 2023: Biomolecules
https://read.qxmd.com/read/37303048/a-comprehensive-molecular-analysis-of-113-primary-ovarian-clear-cell-carcinomas-reveals-common-therapeutically-significant-aberrations
#4
JOURNAL ARTICLE
Ivana Stružinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Romana Michálková, Jiří Dvořák, Kristýna Němejcová, Radoslav Matěj, Jan Laco, Jana Drozenová, Pavel Fabian, Jitka Hausnerová, Gábor Méhes, Petr Škapa, Marián Švajdler, David Cibula, Filip Frühauf, Michaela Kendall Bártů, Pavel Dundr
BACKGROUND: Molecular aberrations occurring in primary ovarian clear cell carcinoma (OCCC) can be of diagnostic, predictive, and prognostic significance. However, a complex molecular study including genomic and transcriptomic analysis of large number of OCCC has been lacking. METHODS: 113 pathologically confirmed primary OCCCs were analyzed using capture DNA NGS (100 cases; 727 solid cancer related genes) and RNA-Seq (105 cases; 147 genes) in order to describe spectra and frequency of genomic and transcriptomic alterations, as well as their prognostic and predictive significance...
June 12, 2023: Diagnostic Pathology
https://read.qxmd.com/read/37288485/clinical-perspectives-of-rare-ovarian-tumors-clear-cell-ovarian-cancer
#5
JOURNAL ARTICLE
Satoe Fujiwara
Ovarian clear cell carcinoma (OCCC) is a rare and distinct histological type of epithelial ovarian carcinoma in terms of its histopathological, clinical and genetic features. Patients with OCCC are younger and diagnosed at earlier stages than those with the most common histological type-high-grade serous carcinoma. Endometriosis is considered a direct precursor of OCCC. Based on preclinical data, the most frequent gene alternations in OCCC are mutations of AT-rich interaction domain 1A and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha...
July 31, 2023: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/36388156/aberrant-mapk-signaling-offers-therapeutic-potential-for-treatment-of-ovarian-carcinoma
#6
REVIEW
Eva Colic, Preya U Patel, Oliver A Kent
Ovarian cancer remains the most lethal gynecological malignancy worldwide due to lack of effective screening, vague early symptoms, poor description of biomarkers, and absence of effective treatment regimes. Epithelial ovarian carcinoma (EOC) is categorized into five distinct disease subtypes which collectively account for ~90% of ovarian carcinomas. Most women present at advanced stages contributing to a poor overall 5-year survival rate. Standard treatment for EOC is cytoreductive surgery and platinum-based chemotherapy; however, most patients suffer from recurrence and platinum-resistant disease, which highlights an urgent need for targeted therapy...
2022: OncoTargets and Therapy
https://read.qxmd.com/read/35996244/the-functions-of-epha1-receptor-tyrosine-kinase-in-several-tumors
#7
JOURNAL ARTICLE
Yinxin Wu, Zhuoying Du, Jie Mou, Xinyan Qiu, Jinlan Chen, Sanjin Cai, Dongming Ren, Fangxiang Xiao, Gang Zhou, Chengfu Yuan
BACKGROUND: Eph receptors tyrosine kinase (RTK) were identified in 1987 from hepatocellular carcinoma cell lines and were the largest known subfamily of RTK. Eph receptors can be divided into two categories, EphA and EphB, based on their structure and receptor-ligand specificity. EphA can be divided into 10 species (EphA 1-10), and EphB into 6 species (EphB1-6). Similarly, the ligands of Eph receptors are Ephrins. Ephrins also can be divided into Ephrin A and Ephrin B, of which there are five species(Ephrin-A1-5) and three species(Ephrin-B1-3)...
August 20, 2022: Current Medicinal Chemistry
https://read.qxmd.com/read/34464482/pdk2-leads-to-cisplatin-resistance-through-suppression-of-mitochondrial-function-in-ovarian-clear-cell-carcinoma
#8
JOURNAL ARTICLE
Sachiko Kitamura, Ken Yamaguchi, Ryusuke Murakami, Yoko Furutake, Koichiro Higasa, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai
Ovarian clear cell carcinoma (CCC) exhibits an association with endometriosis, resistance to oxidative stress, and poor prognosis owing to its resistance to conventional platinum-based chemotherapy. A greater understanding of the molecular characteristics and pathogenesis of ovarian cancer subtypes may facilitate the development of targeted therapeutic strategies, although the mechanism of drug resistance in ovarian CCC has yet to be determined. In this study, we assessed exome sequencing data to identify new therapeutic targets of mitochondrial function in ovarian CCC because of the central role of mitochondria in redox homeostasis...
November 2021: Cancer Science
https://read.qxmd.com/read/34328090/kaempferia-parviflora-extract-inhibits-tnf-%C3%AE-induced-release-of-mcp-1-in-ovarian-cancer-cells-through-the-suppression-of-nf-%C3%AE%C2%BAb-signaling
#9
JOURNAL ARTICLE
Phatarawat Thaklaewphan, Jirapak Ruttanapattanakul, Sathit Monkaew, Montanee Buatoom, Siriwoot Sookkhee, Wutigri Nimlamool, Saranyapin Potikanond
Ovarian clear cell carcinoma (OCCC) is an uncommon subtype of epithelial cell ovarian cancers (EOCs) that has poor response to conventional platinum-based therapy. Therefore, finding new potential therapeutic agents is required. Since inflammatory cytokine, tumor necrosis factor alpha (TNF-α), is strongly expressed in EOCs and associated with the level of tumor grade, disruption of this inflammation pathway may provide another potential target for OCCC treatment. We previously reported that Kaempferia parviflora (KP) extract decreased cell proliferation and induced apoptosis...
September 2021: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/34247767/clear-cell-carcinoma-of-the-ovary-epidemiology-pathological-and-biological-features-treatment-options-and-clinical-outcomes
#10
REVIEW
Angiolo Gadducci, Francesco Multinu, Stefania Cosio, Silvestro Carinelli, Mariacristina Ghioni, Giovanni Damiano Aletti
Clear cell carcinoma of the ovary is a rare and distinct histotype of epithelial ovarian carcinomas. Women diagnosed with clear cell carcinomas are usually younger and diagnosed at earlier stages than those with the most common high-grade serous histology. Endometriosis is considered a main risk factor for the development of clear cell carcinoma of the ovary, and it can be considered a precursor of of this tumor, as it is identified in more than 50% of patients with clear cell carcinoma. Different molecular pathways and alterations heve been identified in ovarian clear cell carcinoma, including the most common mutations of AT-rich interaction domain 1A [ARID1A] and phosphatidylinositol-4,5-bisphosphate 3-kinase [PIK3] catalytic subunit alpha [PIK3CA]...
September 2021: Gynecologic Oncology
https://read.qxmd.com/read/34221859/the-role-of-aldh2-in-tumorigenesis-and-tumor-progression-targeting-aldh2-as-a-potential-cancer-treatment
#11
REVIEW
Hong Zhang, Liwu Fu
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported. Either low or high ALDH2 expression contributes to tumor progression and varies among different tumor types. Furthermore, the ALDH2∗2 polymorphism (rs671) is the most common single nucleotide polymorphism (SNP) in Asia. Epidemiological studies associate ALDH2∗2 with tumorigenesis and progression...
June 2021: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/33947352/genetic-alterations-and-their-therapeutic-implications-in-epithelial-ovarian-cancer
#12
JOURNAL ARTICLE
Nina Lapke, Chien-Hung Chen, Ting-Chang Chang, Angel Chao, Yen-Jung Lu, Chyong-Huey Lai, Kien Thiam Tan, Hua-Chien Chen, Hsiao-Yun Lu, Shu-Jen Chen
BACKGROUND: Genetic alterations for epithelial ovarian cancer are insufficiently characterized. Previous studies are limited regarding included histologies, gene numbers, copy number variant (CNV) detection, and interpretation of pathway alteration patterns of individual patients. METHODS: We sequenced 410 genes to analyze mutations and CNV of 82 ovarian carcinomas, including high-grade serous (n = 37), endometrioid (n = 22) and clear cell (n = 23) histologies...
May 4, 2021: BMC Cancer
https://read.qxmd.com/read/33490224/endometriosis-associated-ovarian-carcinomas-insights-into-pathogenesis-diagnostics-and-therapeutic-targets-a-narrative-review
#13
REVIEW
Eleftherios P Samartzis, S Intidhar Labidi-Galy, Michele Moschetta, Mario Uccello, Dimitrios R Kalaitzopoulos, J Alejandro Perez-Fidalgo, Stergios Boussios
Endometriosis is a benign gynecologic condition affecting up to one woman out of ten of reproductive age. It is defined by the presence of endometrial-like tissue in localizations outside of the uterine cavity. It often causes symptoms such as chronic pain, most frequently associated with the menstrual cycle, and infertility, but may also be oligo- or asymptomatic. There is evidence that some ovarian carcinoma (OC) histotypes, mainly the ovarian clear cell (OCCC) and endometrioid (EnOC) carcinoma, may arise from endometriosis...
December 2020: Annals of Translational Medicine
https://read.qxmd.com/read/33034056/identification-of-novel-alk-rearrangements-in-gynecologic-clear-cell-carcinoma
#14
JOURNAL ARTICLE
Chen Yang, Lingxin Zhang, Latisha Love-Gregory, Lulu Sun, Ian S Hagemann, Dengfeng Cao
Clear cell carcinomas (CCCs) of the gynecologic tract are aggressive tumors with high resistance rate to conventional platinum-based chemotherapies. Currently, the molecular features of these tumors remain largely unknown and there is no targeted therapy available. The aim of our study was to identify anaplastic lymphoma kinase (ALK) translocations, a potential molecular target for therapy. Ninety-seven patients with gynecologic CCC (62 ovarian, 27 uterine corpus and 8 uterine cervical) were screened for ALK rearrangement and ALK copy number gain using an ALK break-apart fluorescence in situ hybridization probe...
January 15, 2021: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/33017609/functional-targeting-of-the-tgf-%C3%AE-r1-kinase-domain-and-downstream-signaling-a-role-for-the-galloyl-moiety-of-green-tea-derived-catechins-in-es-2-ovarian-clear-cell-carcinoma
#15
JOURNAL ARTICLE
Audrey-Ann Sicard, Narjara Gonzalez Suarez, Laurent Cappadocia, Borhane Annabi
The galloyl moiety is a specific structural feature which dictates, in part, the chemopreventive properties of diet-derived catechins. In ovarian cancer cells, galloylated catechins were recently demonstrated to target the transforming growth factor (TGF)-β-mediated control of the epithelial-mesenchymal transition process. The specific impact of the galloyl moiety on such signaling, however, remains poorly understood. Here, we questioned whether the sole galloyl moiety interacted with TGF-β-receptors to alter signal transduction and chemotactic migratory response in an ES-2 serous carcinoma-derived ovarian cancer cell model...
January 2021: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/33005248/gsk-3%C3%AE-mediates-the-effects-of-hnf-1%C3%AE-overexpression-in-ovarian-clear-cell-carcinoma
#16
JOURNAL ARTICLE
Naoki Kawahara, Ayano Mizutani, Sho Matsubara, Yoshinori Takeda, Hiroshi Kobayashi
Deubiquitinase USP28 is a target gene of the transcription factor HNF1 homeobox β (HNF-1β), which promotes the survival of ovarian clear cell carcinoma (OCCC) cell lines. However, the pharmacological inhibition of HNF-1β can cause several adverse effects as it is abundantly expressed in numerous organ systems, including the kidney, liver, pancreas and digestive tract. Therefore, small interfering RNA (siRNA) screening was performed in the current study to identify other potential downstream targets of the HNF-1β-mediated pathway...
November 2020: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/32948640/clear-cell-carcinoma-of-the-ovary-a-clinical-and-molecular-perspective
#17
REVIEW
Yasushi Iida, Aikou Okamoto, Robert L Hollis, Charlie Gourley, C Simon Herrington
Clear cell carcinoma of the ovary has distinct biology and clinical behavior. There are significant geographical and racial differences in the incidence of clear cell carcinoma compared with other epithelial ovarian tumors. Patients with clear cell carcinoma are younger, tend to present at an early stage, and their tumors are commonly associated with endometriosis, which is widely accepted as a direct precursor of clear cell carcinoma and has been identified pathologically in approximately 50% of clear cell carcinoma cases...
April 2021: International Journal of Gynecological Cancer
https://read.qxmd.com/read/32927276/bet-src-and-bcl2-family-inhibitors-are-synergistic-drug-combinations-with-parp-inhibitors-in-ovarian-cancer
#18
JOURNAL ARTICLE
Goldie Y L Lui, Reid Shaw, Franz X Schaub, Isabella N Stork, Kay E Gurley, Caroline Bridgwater, Robert L Diaz, Rachele Rosati, Hallie A Swan, Tan A Ince, Thomas C Harding, Vijayakrishna K Gadi, Barbara A Goff, Christopher J Kemp, Elizabeth M Swisher, Carla Grandori
BACKGROUND: Homologous recombination deficiencies (HRD) are present in approximately half of epithelial ovarian cancers, for which PARP inhibitors (PARPi) are becoming a preferred treatment option. However, a considerable proportion of these carcinomas acquire resistance or harbour de novo resistance, posing a significant challenge to treatment. METHODS: To identify new combinatorial therapeutics to overcome resistance to PARPi, we employed high-throughput conditional RNAi and drug screening of patient-derived ovarian cancer cells...
October 2020: EBioMedicine
https://read.qxmd.com/read/32455595/wise-management-of-ovarian-cancer-on-the-cutting-edge
#19
REVIEW
Stergios Boussios, Christos Mikropoulos, Eleftherios Samartzis, Peeter Karihtala, Michele Moschetta, Matin Sheriff, Afroditi Karathanasi, Agne Sadauskaite, Elie Rassy, Nicholas Pavlidis
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality among women. Two-thirds of patients present at advanced stage at diagnosis, and the estimated 5 year survival rate is 20-40%. This heterogeneous group of malignancies has distinguishable etiology and molecular biology. Initially, single-gene sequencing was performed to identify germline DNA variations associated with EOC. However, hereditary EOC syndrome can be explained by germline pathogenic variants (gPVs) in several genes. In this regard, next-generation sequencing (NGS) changed clinical diagnostic testing, allowing assessment of multiple genes simultaneously in a faster and cheaper manner than sequential single gene analysis...
May 21, 2020: Journal of Personalized Medicine
https://read.qxmd.com/read/32366386/endometriosis-associated-extraovarian-malignancies-a-challenging-question-for-the-clinician-and-the-pathologist
#20
REVIEW
Angiolo Gadducci, Gian Franco Zannoni
Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2.5% of women, and, when it occurs, it involves ovarian and extraovarian sites in 75% and 25% of the cases, respectively. Endometriosis correlates with presentation of clear cell and endometrioid carcinoma of the ovary. Activation of phosphatidylinositol 3-kinase (PIK3) - protein kinase B (AKT) - mammalian target of rapamycin (mTOR) pathway, aberrant chromatin remodeling due to AT-rich interactive domain-containing protein 1A (ARID1A) mutation and inactivation of estrogen receptor-α signaling seem to play a major role in the carcinogenesis...
May 2020: Anticancer Research
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