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Ovarian clear cell carcinoma

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https://www.readbyqxmd.com/read/29325268/-clinical-significance-of-targeting-drug-based-molecular-biomarkers-expression-in-ovarian-clear-cell-carcinoma
#1
M J Li, H R Li, X Cheng, R Bi, X Y Tu, F Liu, L H Chen
Objective: To assess the expression level of targeting drug-based molecular biomarkers in ovarian clear cell carcinoma (OCCC) tissues and its clinical significance. Methods: A total of 63 OCCC patients included 40 primary OCCC and 23 recurrent OCCC for secondary cytoreductive surgery (SCS), who had received primary surgeries at Fudan University Shanghai Cancer Center between January, 2008 and December, 2015 were enrolled, and immunohistochemistry SP method was used to test human epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), aurora kinase A (AURKA), breast cancer susceptibility gene 1 (BRCA1), BRCA2 and programmed death-ligand 1 (PD-L1)protein expression in paraffin-embedded tissues...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29296226/annexin-a4-fucosylation-enhances-its-interaction-with-the-nf-kb-p50-and-promotes-tumor-progression-of-ovarian-clear-cell-carcinoma
#2
Huimin Wang, Lu Deng, Mingbo Cai, Huiyu Zhuang, Liancheng Zhu, Yingying Hao, Jian Gao, Juanjuan Liu, Xiao Li, Bei Lin
Objective: To study the structural relationship between annexin A4 and the Lewis y antigen and compare their expression and significance in ovarian clear cell carcinoma, and to explore how annexin A4 fucose glycosylation effects the interaction between annexin A4 and NF-kB p50, and how it promotes tumour progression of ovarian clear cell carcinoma. Methods: Structural relationships between annexin A4 and Lewis y antigen were detected using immunoprecipitation. Annexin A4 and Lewis y antigen expression in various subtypes of ovarian cancer tissues was detected by immunohistochemistry, and the relation between their expression was examined...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290781/kpna2-promotes-migration-and-invasion-in-epithelial-ovarian-cancer-cells-by-inducing-epithelial-mesenchymal-transition-via-akt-gsk-3%C3%AE-snail-activation
#3
Long Huang, Yun Zhou, Xin-Ping Cao, Jia-Xin Lin, Lan Zhang, Shu-Ting Huang, Min Zheng
Background: Increased karyopherin alpha 2 (KPNA2) expression has been demonstrated in epithelial ovarian carcinoma (EOC) tissue. However, its role in the disease is not clear. Here, we investigate the mechanism of involvement of KPNA2 in EOC. Methods: Stable cell lines expressing KPNA2, or KPNA2 shRNAs, were constructed. The effects of KPNA2 overexpression and knockdown on EOC cell migration, invasion, and epithelial-to-mesenchymal transition (EMT) were evaluated using relevant assays and western blot analysis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29285368/role-of-endometriosis-as-a-prognostic-factor-for-post-progression-survival-in-ovarian-clear-cell-carcinoma
#4
Hiroki Ishibashi, Masashi Takano, Morikazu Miyamoto, Hiroaki Soyama, Hiroko Matsuura, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Hitoshi Tsuda, Kenichi Furuya
The clinical significance of coexistence of endometriosis (EM) in ovarian clear cell carcinoma (CCC) has not yet been determined. The aim of the present study was to analyze the correlation of endometriosis with clinicopathological factors in CCC. The cases with CCC that received primary debulking surgery at the present hospital between 1990 and 2013 were identified. Retrospective analysis was conducted to evaluate the association between complications with EM and clinicopathological features in CCC. Of the 105 cases enrolled in the study, 45 cases were complicated with EM, and 60 cases did not have EM (non-EM)...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29277787/phenoxodiol-increases-cisplatin-sensitivity-in-ovarian-clear-cancer-cells-through-xiap-down-regulation-and-autophagy-inhibition
#5
Morikazu Miyamoto, Masashi Takano, Tadashi Aoyama, Hiroaki Soyama, Hiroki Ishibashi, Kento Kato, Hideki Iwahashi, Kazuki Takasaki, Mika Kuwahara, Hiroko Matuura, Takahiro Sakamoto, Tomoyuki Yoshikawa, Kenichi Furuya
BACKGROUND/AIM: To investigate whether XIAP down-regulation and autophagy inhibition sensitize ovarian clear cell cancer cells to cisplatin. MATERIALS AND METHODS: The ovarian clear cancer cell line KK was used for in vitro analysis. Hydroxychloroquine (HCQ) and phenoxodiol (PXD) or embelin were used as autophagy and XIAP inhibitors, respectively. Non-specific and XIAP-specific siRNAs were transfected using Lipofectamine. Cytotoxicity was assessed by MTT assays...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277326/identification-of-the-functional-alteration-signatures-across-different-cancer-types-with-support-vector-machine-and-feature-analysis
#6
ShaoPeng Wang, YuDong Cai
Cancers are regarded as malignant proliferations of tumor cells present in many tissues and organs, which can severely curtail the quality of human life. The potential of using plasma DNA for cancer detection has been widely recognized, leading to the need of mapping the tissue-of-origin through the identification of somatic mutations. With cutting-edge technologies, such as next-generation sequencing, numerous somatic mutations have been identified, and the mutation signatures have been uncovered across different cancer types...
December 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29276164/examining-the-selection-criteria-of-neoadjuvant-chemotherapy-patients
#7
Julia Mayba, Pascal Lambert, Donna Turner, Robert Lotocki, Erin Dean, Shaundra Popowich, Alon D Altman, Mark W Nachtigal
OBJECTIVES: To identify predictors of neoadjuvant chemotherapy (NAC) and to examine toxicities, dose reduction, interruptions, and second-line chemotherapy MATERIALS AND METHODS: A retrospective chart review of 391 patients with late-stage ovarian cancer diagnosed between January 1, 2004 and December 31, 2010 was conducted. Logistic regression was used to predict chemotherapy type. Cumulative incidence of toxicities, dose reduction, and treatment interruption were calculated using the Kaplan-Meier method...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29247567/adam9-is-over-expressed-in-human-ovarian-clear-cell-carcinomas-and-suppresses-cisplatin-induced-cell-death
#8
Mari Ueno, Takayuki Shiomi, Satsuki Mochizuki, Miyuki Chijiiwa, Masayuki Shimoda, Yae Kanai, Fumio Kataoka, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki, Yasunori Okada
ADAMs (a disintegrin and metalloproteinases) are involved in various biological events such as cell adhesion, migration and invasion, membrane protein shedding and proteolysis. However, there have been no systematic studies on the expression of ADAMs in human ovarian carcinomas. We therefore examined the mRNA expression of all the proteolytic ADAM species including ADAM8, 9, 10, 12, 15, 17, 19, 20, 21, 28, 30, 33 and ADAMDEC1 in human ovarian carcinomas, and found that prototype membrane-anchored ADAM9m, but not secreted isoform ADAM9s, is significantly over-expressed in the carcinomas than in the control non-neoplastic ovarian tissue...
December 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29241974/endometriosis-associated-ovarian-neoplasia
#9
REVIEW
Xavier Matias-Guiu, Colin J R Stewart
This article reviews the most relevant pathological and molecular features of ovarian tumours that are associated with endometriosis. Endometriosis is a common condition, affecting 5-15% of all women, and it has been estimated that 0.5-1% of cases are complicated by neoplasia. The most common malignant tumours in this setting are endometrioid adenocarcinoma and clear cell adenocarcinoma, each accounting for approximately 10% of ovarian carcinomas in Western countries. A minority of cases are associated with Lynch syndrome...
December 11, 2017: Pathology
https://www.readbyqxmd.com/read/29235520/ubiquitin-conjugating-enzyme-e2t-ube2t-and-denticleless-protein-homolog-dtl-are-linked-to-poor-outcome-in-breast-and-lung-cancers
#10
Javier Perez-Peña, Verónica Corrales-Sánchez, Eitan Amir, Atanasio Pandiella, Alberto Ocana
Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and basal-like tumors. With this approach we identified 16 ubiquitin related genes overexpressed in basal-like breast cancers compared with normal breast. We then explored the association between these genes and outcomes using the KMPlotter online tool. Two genes, the ubiquitin-conjugating enzyme E2T (UBE2T) and the denticleless protein homolog (DTL) were overexpressed and linked with detrimental outcome in basal-like and luminal breast cancer patients...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233531/genomic-landscape-of-ovarian-clear-cell-carcinoma-via-whole-exome-sequencing
#11
Se Ik Kim, Ji Won Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo
OBJECTIVE: To analyze whole exome sequencing (WES) data on ovarian clear cell carcinoma (OCCC) in Korean patients via the technique of next generation sequencing (NGS). Genomic profiles were compared between endometriosis-associated OCCC (EMS-OCCC) and Non-EMS-OCCC. METHODS: We used serum samples and cancer tissues, stored at the Seoul National University Hospital Human Biobank, that were initially collected from women diagnosed with OCCC between 2012 and 2016. In total, 15 patients were enrolled: 5 with pathologically confirmed EMS-OCCC and 10 with Non-EMS-OCCC...
December 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29208958/the-positivity-of-estrogen-receptor-and-progesterone-receptor-may-not-be-associated-with-metastasis-and-recurrence-in-epithelial-ovarian-cancer
#12
Shouzhen Chen, Xujing Dai, Yifei Gao, Fang Shen, Jingxin Ding, Qi Chen
The estrogen (ER) or progesterone receptors (PR) is positively associated with better clinical outcomes in ovarian cancer. Whether metastasis or recurrence of ovarian cancer is correlated with this association has not been investigated. Data on 894 women with epithelial ovarian cancer were collected and the association between ER or PR positivity and peritoneal or lymph node metastases or recurrence was analysed. ER or PR positivity was higher in high-grade, low-grade serous and endometrioid carcinoma, but lower in mucinous and clear-cell carcinoma...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207009/tat%C3%A2-fused-ip3r%C3%A2-derived-peptide-enhances-cisplatin-sensitivity-of-ovarian-cancer-cells-by-increasing-er-ca2-release
#13
Qi Xie, Ye Xu, Weinan Gao, Yong Zhang, Jing Su, Yanan Liu, Yuting Guo, Minghan Dou, Kebang Hu, Liankun Sun
Ovarian cancer is the most common gynecological malignancy. At present, cisplatin is used to treat ovarian cancer; however, the development of cisplatin resistance during therapy is a common obstacle to achieving favorable outcomes. Recently, the B‑cell lymphoma 2 (Bcl‑2) BH4 domain has been reported to mediate the prosurvival activity of Bcl‑2 in cancer; however, the involvement of the BH4 domain of Bcl‑2 in the cisplatin resistance of ovarian carcinoma cells is not entirely clear. In this study, we observed the cytoplasmic and mitochondrial levels of Ca2+ by confocal laser microscopy...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29196245/novel-potential-photodynamic-therapy-strategy-using-5-aminolevulinic-acid-for-ovarian-clear-cell-carcinoma
#14
Toshiya Teshigawara, Mika Mizuno, Takuya Ishii, Yuya Kitajima, Fumi Utsumi, Jun Sakata, Hiroaki Kajiyama, Kiyosumi Shibata, Masahiro Ishizuka, Fumitaka Kikkawa
BACKGROUND: Photodynamic therapy (PDT) is known as a minimally invasive treatment for cancer. 5-Aminolevulinic acid (ALA) is a precursor of the photosensitizing agent protoporphyrin IX (PpIX). Patients with ovarian clear-cell carcinoma (CCC) have poorer prognoses than those of patients with other histological CCC types. We evaluated the efficacy of ALA-PDT on CCC cells in vitro. METHODS: We used seven human CCC cell lines to measure the cytotoxicity of ALA-PDT. PpIX production in cancer cells was measured using a micro-plate reader...
November 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29194190/an-evaluation-of-frozen-section-and-lymph-node-dissection-results-for-mucinous-ovarian-tumors
#15
Marisa R Moroney, Miriam D Post, Amber A Berning, Jeanelle Sheeder, Bradley R Corr
OBJECTIVES: Intraoperative frozen section has greater than 90% accuracy for ovarian tumors; however, mucinous histology has been shown to be associated with increased frozen section inaccuracy. Recent data demonstrate that primary ovarian mucinous carcinomas have no lymph node involvement, even when extraovarian disease is present, and therefore may not require lymph node dissection. Our primary objective is to evaluate the accuracy of identifying mucinous histology on frozen section...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29189263/b7-h4-is-inversely-correlated-with-t-cell-infiltration-in-clear-cell-but-not-serous-or-endometrioid-ovarian-cancer
#16
Gabriel M Pagnotti, Richard M Atkinson, Jamie Romeiser, Ali Akalin, Mallory B Korman, Kenneth R Shroyer
B7-H4, a tumor-associated cell surface protein, is expressed in endometrioid (EM), serous (SE), and clear cell (CC) ovarian carcinomas. Prior in vitro studies from other groups indicated that elevated B7-H4 expression by tumor cells blocks T-cell activation; therefore, it had been postulated to play a role in shielding cancer cells from immune surveillance and averting apoptotic programs. To test the validity of these hypotheses, the present study was designed to compare the immunohistochemical staining intensity of B7-H4 in tumor cells of ovarian cancers with the number of tumor-infiltrating T cells and macrophages and with the levels of caspase-3 staining in apoptotic debris...
October 20, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29184869/skin-metastases-in-ovarian-clear-cell-adenocarcinoma-a-case-report-and-a-review-of-the-literature
#17
Gina Nam, Young-Mee Lim, Min Sun Cho, Junghye Lee, Yun Hwan Kim
Epithelial ovarian carcinoma is a high mortality neoplasm in gynecologic malignancy. It usually can metastasize to distant organs such as pleura, liver, lung, and lymph nodes. However, the skin metastases are not common and related to very poor prognosis. Here we report a 54-year-old patient with ovarian clear cell carcinoma with skin metastases on the anterior chest at 11 months after initial diagnosis. Although she received palliative chemotherapy, she expired due to disease progression 2 months later after the diagnosis of skin metastases...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29178260/origin-of-clear-cell-carcinoma-nature-or-nurture
#18
David L Kolin, Daniela M Dinulescu, Christopher P Crum
A rare but serious complication of endometriosis is the development of carcinoma, and clear cell and endometrioid carcinomas of the ovary are the two most common malignancies which arise from endometriosis. They are distinct diseases, characterized by unique morphologies, immunohistochemical profiles, and responses to treatment. However, both arise in endometriosis and can share common mutations. The overlapping mutational profiles of clear cell and endometrioid carcinoma suggests that their varied histologies may be due to a different cell of origin which gives rise to each type of cancer...
November 27, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29170871/the-diagnostic-role-of-pten-and-arid1a-in-serous-effusions
#19
Ben Davidson, Maurizio Pinamonti, Dolors Cuevas, Arild Holth, Pio Zeppa, Thomas Hager, Jeremias Wohlschlaeger, Martin Tötsch
The aim of this study was to analyze the diagnostic role of PTEN and ARID1A in effusion cytology. Effusions (n = 279), consisting of 226 carcinomas (70 ovarian, 64 breast, 36 lung, and 15 uterine corpus carcinomas; 41 carcinomas of other origin) and 53 malignant mesotheliomas, were analyzed for PTEN and ARID1A expression using immunohistochemistry. PTEN was preserved in 166 (59%) tumors, partially lost in 38 (14%), and absent in 75 (27%), with lower expression in malignant mesotheliomas compared to carcinomas, though not significantly (p = 0...
November 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29140878/clear-cell-renal-cell-carcinoma-metastatic-to-the-gynecologic-tract-a-clinicopathologic-analysis-of-17-cases
#20
Oluwole Fadare, Mohamed M Desouki, Katja Gwin, Krisztina Z Hanley, Elke A Jarboe, Sharon X Liang, Charles M Quick, Kojo R Rawish, Andres A Roma, Wenxin Zheng, Jonathan L Hecht, Vinita Parkash, Adeboye O Osunkoya
Clear cell renal cell carcinomas (CCRCC) rarely metastasizes to the gynecologic tract. In this study, we analyzed a multi-institutional data set to provide insights into the clinical, morphologic, and immunophenotypic features of this phenomenon. Seveteen metastatic CCRCC involving the gynecologic tract [ovary/fallopian tube (n=9), vulva (n=2), uterine corpus (n=3), cervix (n=2), uterine serosa (n=1)] were analyzed. Mean patient age was 62 yr (range: 45-79 yr). Most cases (15/17) presented as a recurrence 6 to 72 mo postnephrectomy, 1 case was concurrently diagnosed, and 1 case (a cervical metastasis) was diagnosed prenephrectomy...
November 14, 2017: International Journal of Gynecological Pathology
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