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https://www.readbyqxmd.com/read/28819322/nampt-enzyme-activity-regulates-catabolic-gene-expression-in-gingival-fibroblasts-during-periodontitis
#1
Ka Hyon Park, Duck-Kyu Kim, Yun Hyun Huh, Gyuseok Lee, Su-Hyeon Lee, Yunkyung Hong, Sun-Hun Kim, Min-Suk Kook, Jeong-Tae Koh, Jang-Soo Chun, Shee Eun Lee, Je-Hwang Ryu
Periodontal disease is one of the most prevalent chronic disorders worldwide. It is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss. Here, we focused on the role of adipokines, which are locally expressed by periodontal tissues, in the regulation of catabolic gene expression leading to periodontal inflammation. The expression of the nicotinamide phosphoribosyltransferase (NAMPT) adipokine was dramatically increased in inflamed human and mouse gingival tissues...
August 18, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28817741/reconstruction-of-a-severely-atrophied-alveolar-ridge-by-computer-aided-gingival-simulation-and-3d-printed-surgical-guide-a-case-report
#2
In-Seok Song, Mi-Ran Lee, Jae-Jun Ryu, Ui-Lyong Lee
Dental implants positioned in severely atrophied anterior maxillae require esthetic or functional compromises. This case report describes the rehabilitation of a severely atrophied alveolar ridge with a three-dimensional (3D) computer-aided design/computer-aided manufacture (CAD/CAM) surgical guide. A 50-year-old woman had a severely atrophied anterior maxilla with unfavorably positioned dental implants. Functional and esthetic prosthodontic restoration was difficult to achieve. An anterior segmental osteotomy was planned to reposition the dental implants...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817140/relationship-between-clinical-and-histologic-periodontal-biotypes-in-humans
#3
Sergio Henrique Gonçalves Motta, Marcos Paulo Ferreira Camacho, Danielle Carvalho Quintela, Ronaldo B Santana
Histologic and histomorphometric evaluations of gingival biopsy samples of patients presenting either a thick or a thin gingival biotype were performed. Full-thickness gingival biopsy samples were obtained and processed for histologic and histometric evaluations. Thickness of the keratinized mucosa or gingiva was found to be increased in the thick biotype. Specifically, the connective tissue layer was thicker with no change in epithelial thickness. In conclusion, gingival transparency appears to be an adequate, clinically useful method to classify the gingival biotype...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28816295/-three-dimensional-data-fusion-method-for-tooth-crown-and-root-based-on-curvature-continuity-algorithm
#4
Y J Zhao, Y Liu, Y C Sun, Y Wang
OBJECTIVE: To explore a three-dimensional (3D) data fusion and integration method of optical scanning tooth crowns and cone beam CT (CBCT) reconstructing tooth roots for their natural transition in the 3D profile. METHODS: One mild dental crowding case was chosen from orthodontics clinics with full denture. The CBCT data were acquired to reconstruct the dental model with tooth roots by Mimics 17.0 medical imaging software, and the optical impression was taken to obtain the dentition model with high precision physiological contour of crowns by Smart Optics dental scanner...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28815185/saliva-derived-host-defense-peptides-histatin1-and-ll-37-increase-secretion-of-antimicrobial-skin-and-oral-mucosa-chemokine-ccl20-in-an-il-1%C3%AE-independent-manner
#5
Mireille A Boink, Sanne Roffel, Kamran Nazmi, Jan G M Bolscher, Enno C I Veerman, Susan Gibbs
Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and uninflamed. Host defense peptides (HDPs) make up the body's first line of defense against many invading pathogens and are involved in the orchestration of innate immunity and the inflammatory response. In this study, we investigated the effect of two salivary HDPs, LL-37 and Hst1, on the inflammatory and antimicrobial response by skin and oral mucosa (gingiva) keratinocytes and fibroblasts...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28809375/clinical-parameters-of-implants-placed-in-healed-sites-using-flapped-and-flapless-techniques-a-systematic-review
#6
O Llamas-Monteagudo, P Girbés-Ballester, J Viña-Almunia, D Peñarrocha-Oltra, M Peñarrocha-Diago
BACKGROUND: Dental implant placement using flapless surgery is a minimally invasive technique that improves blood supply compared with flapped surgery. However, the flapless technique does not provide access to allow bone regeneration. OBJECTIVE: The aim of this systematic review was to evaluate the clinical parameters following implant surgery in healed sites, using two procedures: flapped vs. flapless surgery. MATERIALS AND METHODS: A detailed electronic search was carried out in the PubMed/Medline, Embase and Cochrane Library databases...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809373/scoring-systems-for-oral-lichen-planus-used-by-differently-experienced-raters
#7
M Gobbo, K Rupel, V Zoi, G Perinetti, G Ottaviani, R Di Lenarda, L Bevilacqua, S-B Woo, M Biasotto
BACKGROUND: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. MATERIALS AND METHODS: Consecutive patients with OLP were assessed for pain using the Visual Analogue Scale and examined at 10 intraoral sites before starting (T0) and three weeks after (T1) steroid therapy (Clobetasol)...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28805207/periodontal-diseases
#8
REVIEW
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease...
June 22, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28804534/mtor-inhibition-rejuvenates-the-aging-gingival-fibroblasts-through-alleviating-oxidative-stress
#9
Yiru Xia, Mengjun Sun, Yufeng Xie, Rong Shu
The aging periodontium may be vulnerable to periodontal pathogens and poor response to inflammation and susceptible to tumorigenesis. Human gingival fibroblasts (hGFs) through continuously replicative culture served as an in vitro surrogate for aging. To investigate the effects of the mechanistic target of rapamycin (mTOR) inhibition on the aging gingiva, we stimulated the high-passage hGFs with rapamycin (20 nmol/L) for 3 days and 30 days. The cellular and biological changes were examined by immunofluorescence, real-time PCR, ELISA, Western blotting, and flow cytometry...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28800146/the-relationship-between-open-versus-normal-contact-point-and-inter-proximal-papilla-dimensions-in-periodontally-healthy-young-adults-a-controlled-clinical-trial
#10
Ronaldo Barcellos de Santana, Jose Luis Carneiro de Miranda, Carolina Miller Mattos de Santana
AIM: The gingival architecture is determined by the spatial orientation of the gingival zenith (GZ) and the interdental papillae (IP). Among the factors commonly associated with the presence and morphology of the IP, the contact point (CP) and the interdental distance relationships have been considered the most important. The objective of the present controlled clinical trial was to evaluate the role of the CP in determining the clinical and morphometric parameters of the interdental papilla...
August 11, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28796987/evaluation-of-periodontal-tissues-in-growing-patients-with-bilateral-cleft-lip-and-palate-a-pilot-study
#11
Beata Wyrębek, Dorota Cudziło, Paweł Plakwicz
AIM: To evaluate the periodontal status, mucogingival parameters and oral hygiene in growing patients with bilateral cleft lip and palate. MATERIAL AND METHODS: Assessment was performed in 15 patients aged 6 to 18 years with a bilateral cleft. Records included probing pocket depth, clinical attachment level, keratinized gingiva, recession, vestibule depth, biotype, type of fraena, dental plaque and bleeding. RESULTS: The mean scores of pocket depth were: 1...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28789700/two-different-protein-expression-profiles-of-oral-squamous-cell-carcinoma-analyzed-by-immunoprecipitation-high-performance-liquid-chromatography
#12
Soung Min Kim, Dasul Jeong, Min Keun Kim, Sang Shin Lee, Suk Keun Lee
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most dangerous cancers in the body, producing serious complications with individual behaviors. Many different pathogenetic factors are involved in the carcinogenesis of OSCC. Cancer cells derived from oral keratinocytes can produce different carcinogenic signaling pathways through differences in protein expression, but their protein expression profiles cannot be easily explored with ordinary detection methods. METHODS: The present study compared the protein expression profiles between two different types of OSCCs, which were analyzed through immunoprecipitation high-performance liquid chromatography (IP-HPLC)...
August 8, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28776953/establishment-of-oral-bacterial-communities-in-germ-free-mice-and-the-influence-of-recipient-age
#13
Yingying Wu, Caroline Westwater, E Xiao, Jôice Dias Corrêa, Wenmei Xiao, Dana T Graves
The acquisition of the oral microbiome is a complex process. We examined how the timing of microbial exposure alters bacterial colonization of the tooth surface. Germ-free mice were conventionalized by exposure to specific pathogen free (SPF) mice to acquire a commensal microbiome over three distinct four week periods, 0-4 weeks of age (Conv0-4w), 4-8 weeks (Conv4-8w), or 8-12 weeks (Conv8-12w). Bacterial DNA was extracted from the tooth surface and analyzed by 16S rDNA sequencing. Total bacteria and inflammatory cytokine expression in gingiva were determined by quantitative real-time PCR...
August 4, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28770188/early-childhood-caries-prevalence-risk-factors-and-prevention
#14
REVIEW
Sukumaran Anil, Pradeep S Anand
Early childhood caries (ECC) is major oral health problem, mainly in socially disadvantaged populations. ECC affects infants and preschool children worldwide. The prevalence of ECC differs according to the group examined, and a prevalence of up to 85% has been reported for disadvantaged groups. ECC is the presence of one or more decayed, missing, or filled primary teeth in children aged 71 months (5 years) or younger. It begins with white-spot lesions in the upper primary incisors along the margin of the gingiva...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28770159/peripheral-odontogenic-myxoma-in-a-12-year-old-girl-a-rare-entity
#15
Sampada Kanitkar, Mamata Kamat, Sridevi Tamagond, Aniruddha Varekar, Uma Datar
Peripheral odontogenic myxoma is a rare odontogenic tumor representing an extra osseous counterpart of central odontogenic myxoma. It is commonly seen in gingiva between the 3rd and 4th decades of life and appears predominantly in females. Compared to central odontogenic myxoma, it is a less aggressive, slow-growing lesion with a low recurrence rate. However, close postoperative follow-up is required because of the unlimited growth potential of incompletely removed lesions. It shares many features with other soft tissue myxoid proliferations occurring in the oral cavity and hence needs to be differentiated from them...
June 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28770157/is-elective-neck-dissection-needed-in-squamous-cell-carcinoma-of-maxilla
#16
Jung-Hyun Park, Woong Nam, Hyung Jun Kim, In-Ho Cha
OBJECTIVES: To define the risk of occult cervical metastasis of maxillary squamous cell carcinoma (SCC) and the therapeutic value of elective neck dissection (END) in survival of clinically negative neck node (cN0) patients. MATERIALS AND METHODS: Sixty-seven patients with maxillary SCC and cN0 neck were analyzed retrospectively, including 35 patients with maxillary gingiva and 32 patients with maxillary sinus. RESULTS: Of 67 patients, 10 patients (14...
June 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28764802/mesenchymal-stem-cells-derived-from-inflamed-dental-pulpal-and-gingival-tissue-a-potential-application-for-bone-formation
#17
Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti, Carla Giordano
BACKGROUND: Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution as autologous cells. In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth...
August 1, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28764790/successful-management-of-rare-gingival-metastasis-from-gastric-adenocarcinoma-a-case-report-and-literature-review
#18
Zhili Wu, Jun Tang, Yan Li, Husheng Lu, Jun Xu, Donglai Lv
BACKGROUND: Gastric cancer rarely metastasizes to the oral cavity, especially to gingiva. Only 18 cases have been reported worldwide to date. This paper herein presents the nineteenth case of gingival metastasis from gastric cancer. CASE PRESENTATION: A 75-year-old man who underwent a radical gastrectomy for gastric adenocarcinoma was admitted to clinical oncology center for gingival mass which was originally diagnosed as epulis. The subsequent positron emission tomography-computed tomography (PET-CT) and histopathological examination revealed a gingival metastatic adenocarcinoma originated from gastric carcinoma...
August 1, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28748521/clinical-outcome-of-alveolar-ridge-augmentation-with-individualized-cad-cam-produced-titanium-mesh
#19
K Sagheb, E Schiegnitz, M Moergel, C Walter, B Al-Nawas, W Wagner
BACKGROUND: The augmentation of the jaw has been and continues to be a sophisticated therapy in implantology. Modern CAD-CAM technologies lead to revival of old and established augmentation techniques such as the use of titanium mesh (TM) for bone augmentation. The aim of this retrospective study was to evaluate the clinical outcome of an individualized CAD-CAM-produced TM based on the CT/DVT-DICOM data of the patients for the first time. METHODS: In 17 patients, 21 different regions were augmented with an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28747595/nac-ameliorates-dental-composite-induced-dna-double-strand-breaks-and-chromatin-condensation
#20
Panorea Styllou, Marianthi Styllou, Reinhard Hickel, Christof Högg, Franz Xaver Reichl, Harry Scherthan
Released (co)monomers from dental composite components can induce DNA damage of which DNA double-strand breaks (DSBs) threaten genome integrity. Here, we tested whether the administration of the antioxidant N-acetylcysteine (NAC) is able to reduce the dental composite-induced DSBs in primary human gingiva fibroblasts. The dental composites Bis-GMA (bisphenol-A-glycerolate dimethacrylate), GMA (glycidyl methacrylate), HEMA (2-hydroxyethyl methacrylate) and TEGDMA (triethyleneglycol dimethacrylate) were found to induce co-localizing microscopic nuclear foci numbers of the DSB markers γ-H2AX and 53BP1 per cell in the order: GMA>Bis-GMA>TEGDMA>HEMA...
July 26, 2017: Dental Materials Journal
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