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Li Xiao, Hisashi Okamura, Yasuo Kumazawa
Periodontal diseases (such as gingivitis and periodontitis) are the leading causes of tooth loss in adults. Inflammation in gingiva is the fundamental physiopathology of periodontal diseases. Current experimental models of periodontal diseases have been established in various types of animals. However, the physiopathology of animal models is different from that of humans, making it difficult to analyze cellular and molecular mechanisms and evaluate new medicines for periodontal diseases. Here, we present a detailed protocol for reconstructing human inflammatory tissue equivalents of gingiva (iGTE) in vitro...
April 3, 2018: Journal of Visualized Experiments: JoVE
N Katsoulas, K Tosios, A Sklavounou-Andrikopoulou
BACKGROUND: Lichenoid lesions of the upper labial mucosa, without other oral or extraoral manifestations seem to be rare. The clinicopathologic features of 24 such cases are presented and the pertinent literature is reviewed. MATERIALS AND METHODS: 24 Caucasian patients that clinically presented lichenoid features on the upper labial mucosa, with or without lichenoid lesions on the adjacent gingiva, were included in the study. Clinical features were extracted from the patients records, while dental plaque/calculus accumulation and composite resin restorations of the adjacent teeth were recorded...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Husniah Batool, Ahmed Nadeem, Muhammad Kashif, Faheem Shahzad, Romeeza Tahir, Nadeem Afzal
Background/Purpose. Chronic periodontitis is an inflammatory disease of gums that causes loss of supporting structures of teeth, that is, gingiva, periodontal ligament, cementum, and alveolar bone. Levels of various cytokines in the serum, gingival tissues, and gingival crevicular fluid in patients with chronic periodontitis have been studied, but limited data are available on the level of cytokines in saliva. Therefore, a study was designed to determine levels of salivary IL-6 and IL-17 in patients with calculus associated chronic periodontitis...
2018: BioMed Research International
Iman M Aboushady, Zeinab A Salem, Dina Sabry, Abbas Mohamed
Background: Mesenchymal stem cells (MSCs) can regenerate missing tissues and treat diseases. Hence, the current work aimed to compare the proliferation rate and the osteogenic differentiation potential of bone marrow MSCs (BMSCs), gingival MSCs (GMSCs) and submandibular MSCs (SMSCs). Material and Methods: MSCs derived from bone marrow, gingiva and submandibular salivary gland were isolated and cultured from rats. The proliferation capacity was judged by MTT proliferation Assay...
January 2018: Journal of Clinical and Experimental Dentistry
Razvan Ghinea, Luis Javier Herrera, María M Pérez, Ana M Ionescu, Rade D Paravina
OBJECTIVE: To design colorimetric and spectral models of gingival shade guides that adequately represent the color of human gingiva. MATERIALS AND METHODS: A previously compiled database on the spectral reflectance of healthy keratinized gingiva was used for optimization. Coverage Error (CE) and Maximal Error (ME) were optimized using CIELAB and CIEDE2000 color difference formulas. A two-phase process included an FCM algorithm and a nonlinear optimization. A t test was used to compare the performance of the different numbers of clusters/tabs in gingival shade guide models (α = ...
March 2018: Journal of Esthetic and Restorative Dentistry
Anna-Maija Matela, Jaana Hagström, Hellevi Ruokonen
OBJECTIVES: Lichen sclerosus (LS) is a rare, chronic mucocutaneous disease that most frequently affects the female genital area. Oral manifestations are seldom detected; only 36 well-documented and histopathologically verified oral LS cases have been published. MATERIALS AND METHODS: Here we describe one patient affected by oral (LS) and review of the literature 1957-2017. RESULTS: Findings in our review suggest a female to male ratio of 1...
April 16, 2018: Acta Odontologica Scandinavica
Eser Elemek
The color of gingiva is determined by number and size of blood vessels, thickness of epithelium, keratinization degree, and melanin pigments present in epithelium. Melanocytes, located in basal and suprabasal layers of epithelium, are the cells that produce melanin pigments which play a main role for pigmentation of gingiva. In this case series, the use of 810 nm diode laser for depigmentation of gingiva is presented. Two female patients applied with a chief complaint of "darkened gums" due to heavy smoking...
January 2018: European Journal of Dentistry
Noala Vicensoto Moreira Milhan, Letícia Cavassini Torquato, Victor Costa, Andrea Carvalho De Marco, Yasmin Rodarte Carvalho, Ana Lia Anbinde
Intravascular papillary endothelial hyperplasia (IPEH) is an unusual benign, non-neoplastic vascular lesion that usually occurs in skin, but is uncommon in the oral cavity. Herein, we review the pertinent literature of oraiiPEH and report a new mixed form. A 61-year- old man presented with an ulcerated nodule in the lingual portion of the gingiva related to the left mandibular canine. An excisional biopsy was performed presuming the clinical diagnosis of pyogenic granuloma. Histopathological analysis showed areas of granulation tissue consistent with pyogenic  granuloma...
February 15, 2018: Dermatology Online Journal
Nadir Kaci, Karima Hakem, Safia Laraba, Nasser Benrekaa, Michel Le Gall
INTRODUCTION: The aim of this study was to identify the fracture resistance of grade 23 Titanium mini-implants recycled for orthodontic purposes and having stayed in the mouth during different periods of time. MATERIALS AND METHODS: A total of 52 hybrid-designed titanium mini-implants, threaded length L=8mm, self-drilling and self-taping were used in 32 patients presenting orthodontic anomalies which required the use of mini-implants. Two types of tests were performed: polarizing optical imagery to assess the surface characteristics of the mini-implants (polarizing optical microscopy) and (mechanical) torsional strength tests, more quantitative, in order to establish the breaking point of the mini-implants during their re-use...
April 5, 2018: International Orthodontics
Sidharth Sonthalia, Sangeeta Varma, Abhijeet Kumar Jha, Deepak Jakhar, Feroze Kaliyadan
Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. However, the dermoscopic features of oral lichen planus with hand-held or videodermoscopy remain to be elucidated...
2018: F1000Research
Jungwon Lee, Dueun Park, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee
OBJECTIVE: This review aimed to investigate the feasibility of immediate implant placement in infected extraction sockets. MATERIAL AND METHODS: We performed electronic and manual searches up to March 2017 to obtain data from randomized controlled trials (RCTs) and nonrandomized controlled clinical trials (CCTs). Using a fixed-effects model to assess the difference in survival rate (primary outcome), we evaluated the risk difference for immediate implant placement in infected and non-infected sites...
April 3, 2018: Acta Odontologica Scandinavica
Basma Mostafa, Ibrahim El-Refai
AIM: The aim of this cross-sectional study is recording the prevalence and evaluation of the severity of plaque-induced gingival inflammation among a sample of the adult Egyptian population. PATIENTS AND METHODS: Four hundred and twenty-five subjects in this contemplate were seen from patients visiting the diagnostic clinic at the Faculty of Dentistry, Cairo University. The gingival and plaque indices for each patient diagnosed as having plaque-induced gingivitis were recorded...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
Woong Heo, Hee Chang Ahn
Bony anomaly caused by lip tie is not many reported yet. There was a case of upper lip tie wrapping into the anterior premaxilla. We represent a case of severe upper lip tie of limited lip motion, upper lips curling inside, and alveolar hypoplasia. Male patient was born on June 3, 2016. He had a deep philtral sulcus, low vermilion border and deep cupid's bow of upper lip due to tension of short, stout and very tight frenulum. His upper lip motion was severely restricted in particular lip eversion. There was anterior alveolar hypoplasia with deep sulcus in anterior maxilla...
March 2018: Archives of Craniofacial Surgery
A Soancă, M Lupse, M Moldovan, E Pall, M Cenariu, A Roman, O Tudoran, P Surlin, O Șorițău
BACKGROUND: Normal or inflamed gingival tissues are regarded as a source of mesenchymal stem cells (MSCs) abundant and easily accessible through minimally invasive dental procedures. Due to the proximity of dental resin composites to gingival tissues and to the possible local cytotoxic effect of the eluted components, gingiva-derived MSCs could be used to investigate the biocompatibility of dental biomaterials. PURPOSE: The present research aimed to isolate (MSCs) from inflamed and normal gingiva, to fully characterize them and to observe their behavior in relation with some commercial resin composite materials and one experimental material...
March 28, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
C A W Leung, J Poukens, B Vernooy-Slavenburg
A 7-year-old boy was referred to the paediatric clinic with a swollen cheek since one day. Intraoral examination revealed erythematous and swollen gingivae in the right upper quadrant. The consulted maxillofacial surgeon diagnosed him with a canine fossa abscess. The patient recovered quickly after incision and drainage, followed by antibiotic therapy.
2018: Nederlands Tijdschrift Voor Geneeskunde
Maha A Bahammam
Gingival depigmentation is a periodontal plastic surgery procedure for the removal of pigmented gingiva. A gingival depigmentation procedure can be accomplished with the use of a laser; however, as described in this case report, laser burns can be associated with such a procedure, and if one occurs it must be subsequently managed. In this case, the patient presented with a large elliptical ulceration at the right maxillary premolar region. The underlying alveolar bone was exposed and the surrounding gingival margins were inflamed...
April 2018: Compendium of Continuing Education in Dentistry
Ying-Sheng Lin, Wen-Chung Liu, Kuan-Ying Wang, Yaoh-Shiang Lin, Kuo-Chung Yang
OBJECTIVE: To reconstruct extensive head and neck defects usually necessitates double free flaps, which require a time-and-manpower-consuming surgical procedure. We present using a single fibula or peroneal flap with the novel design of obliquely-arranged double skin paddles to reconstruct an extensive head and neck defect. METHODS: From 1998 to 2016, eight patients with the age of 52.25 (35-71) years old had extensive head and neck defects after oral cancer ablation...
March 30, 2018: Microsurgery
Viviane Ankli, Francisco Ivison Rodrigues Limeira, Monica Yamauti, Tassiana Cançado Melo Sá
Implant therapy has become a common practice and esthetic demands have tremendously increased, especially in the replacement of anterior teeth in patients with a high lip line. This report presents a gingival veneer as a viable treatment modality to mask peri-implant marginal gingival defects. An impression of the upper arch was made and the gingival veneer was waxed, and clinical confirmation was obtained, followed by laboratory processing, finishing, and polishing. After installing, it adapted to the proximal niches and exhibited good stability...
January 2018: Contemporary Clinical Dentistry
Rana Tarzemany, Guoqiao Jiang, Jean X Jiang, Corrie Gallant-Behm, Colin Wiebe, David A Hart, Hannu Larjava, Lari Häkkinen
Fibroblasts are the most abundant connective tissue cells and play an important role in wound healing. It is possible that faster and scarless wound healing in oral mucosal gingiva relative to skin may relate to the distinct phenotype of the fibroblasts residing in these tissues. Connexin 43 (Cx43) is the most ubiquitous Cx in skin (SFBLs) and gingival fibroblasts (GFBLs), and Cx43 assembles into hemichannels (HCs) and gap junctions (GJs) on the cell membrane. We hypothesized that SFBLs and GFBLs display distinct expression or function of Cx43, and that this may partly underlie the different wound healing outcomes in skin and gingiva...
March 26, 2018: Experimental Cell Research
Rong Mingdeng, Huang Yanhong, Lu Haibin, Xu Gelin, Li Shaobing, Su Yuan, Chen Pei, Jiang Pan, Zhang Xueyang
OBJECTIVE: This study aimed to evaluate the clinical effect of periodontal microscopic surgery on the augmentation of attached gingiva and determined the clinical principle on how to use minimally invasive surgery to improve the surgery success rate. METHODS: Twenty patients with insufficient attached gingiva around implants were selected. Periodontal microscopic surgery for free gingival graft was performed to increase the width of the attached gingiva around the implants...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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