Qinchao Hu, Bin Zhang, Yaobin Jing, Shuai Ma, Lei Hu, Jingyi Li, Yandong Zheng, Zijuan Xin, Jianmin Peng, Si Wang, Bin Cheng, Jing Qu, Weiqi Zhang, Guang-Hui Liu, Songlin Wang
Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis, a worldwide prevalent inflammatory disease. However, a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still lacking. Here, we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging, by which a panel of cell type-specific signatures were elucidated...
April 5, 2024: Protein & Cell