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https://www.readbyqxmd.com/read/29045972/-acetylsalicylic-acid-treatment-enhanced-immunomodulatory-function-of-mesenchymal-stem-cells-derived-from-gingiva
#1
R L Yang, T T Yu, Y H Zhou
OBJECTIVE: To analyze the role of acetylsalicylic acid (ASA) in immunomodulation of mesenchymal stem cells derived from gingiva (GMSCs), and to explore the role of ASA in enhancing the immumomodulation of GMSCs and the capacity of GMSCs to treat immune disorders and the underlying mechanism. METHODS: Flow cytometry analysis were used to analyze the role of ASA in the expression of stem cells surface markers CD146, CD105, CD90, CD34 and CD45 in GMSCs,and the GMSCs proliferation was analyzed by 5-bromo-2-deoxyuridine (BrdU) staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045803/chitosan-based-trilayer-scaffold-for-multitissue-periodontal-regeneration
#2
E M Varoni, S Vijayakumar, E Canciani, A Cochis, L De Nardo, G Lodi, L Rimondini, M Cerruti
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues-namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)-based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultaneous healing. We produced 2 porous compartments for bone and gingiva regeneration by cross-linking with genipin either medium molecular weight (MMW) or low molecular weight (LMW) CH and freeze-drying the resulting scaffolds...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29044530/gingival-tissue-an-extrasynovial-source-of-malondialdehyde-acetaldehyde-adducts-citrullinated-and-carbamylated-proteins
#3
R Bright, G M Thiele, J Manavis, T R Mikuls, J B Payne, P M Bartold
BACKGROUND AND OBJECTIVE: Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate that inflamed human gingival tissue provides an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins all of which are considered to be linked to the development of rheumatoid arthritis...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29040143/extragingival-pregnancy-pyogenic-granuloma-on-the-lip
#4
Maitena Canivell-Zabaleta, Guiomar Martin-Lozano, Erika Olmos-Juarez, Maria Fontillon-Alberdi, Pedro Infante-Cossio
Pregnancy pyogenic granuloma is considered a benign common growth that usually develops on the gingiva in the second and third trimester of gestation, in response to local irritation, trauma or hormonal factors. Here, the authors report a case of a primigravida who presented an extragingival pyogenic granuloma with a rapid progression in the post-partum. The occurrence on the lower lip in the first few days after delivery was a relatively rarity in the present case which provoked a meaningful state of anxiety and cancerophobia to the female...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29035723/raloxifene-reduces-the-risk-of-local-alveolar-bone-destruction-in-a-mouse-model-of-periodontitis-combined-with-systemic-postmenopausal-osteoporosis
#5
Ryota Ichimaru, Tsukasa Tominari, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Yukihiro Numabe, Gillian Murphy, Hideaki Nagase, Chisato Miyaura, Masaki Inada
OBJECTIVE: Periodontitis is characterized by local inflammation leading to tooth loss and severe destruction of alveolar bone. Raloxifene is a selective estrogen receptor modulator (SERM) that halts estrogen deficiency-induced systemic bone loss in postmenopausal osteoporosis without the side effects of cancer in breast and uterus. In this study, we examined the effects of raloxifene on alveolar bone mass in a mouse model with estrogen deficiency-induced periodontitis. METHODS: Periodontitis was induced by the injection of lipopolysaccharide (LPS) into the lower gingiva in ovariectomized (OVX) mice, and the alveolar bone and femur bone mineral density (BMD) were analyzed by dual-energy X-ray absorptiometry...
September 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29034279/rare-and-extensive-malignant-melanoma-of-the-oral-cavity-report-of-two-cases
#6
Parviz Deyhimi, Sayed Mohammad Razavi, Shirin Shahnaseri, Saeedeh Khalesi, Solmaz Homayoni, Payam Tavakoli
Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor. This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29033487/gingival-hyperplasia-should-drug-interaction-be-blamed-for
#7
Pramod Kumar Sharma, Arup Kumar Misra, Ankita Chugh, Vinay Kumar Chugh, Nitesh Gonnade, Surjit Singh
Gingival overgrowth (GO) is one of the common findings in clinical practice. There could be several causes including drugs associated with the GO. Carbamazepine (CBZ) and amlodipine are the drugs which are infrequently documented as a cause in inducing the gingival hyperplasia. Certain drugs in the body fluid might limit the population of plaque bacteria and alter their metabolism that in turn induce the inflammatory mediators and also activate the genetic and biochemical factors responsible for gingival fibroblast growth...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29028846/periodontal-indices-and-status-in-34-growing-patients-with-unilateral-cleft-lip-and-palate-a-split-mouth-study
#8
Paweł Plakwicz, Beata Wyrębek, Renata Górska, Dorota Cudziło
Periodontal examination in growing patients with unilateral cleft lip and palate was performed in a split-mouth study design. Higher plaque acumulation and bleeding indices were recorded for teeth on the cleft side. Pocket probing depth (PPD) and clinical attachment level (CAL) values were higher at lateral incisors and canines adjacent to the cleft. Keratinized gingiva and depth of the vestibule were lower adjacent to the cleft. This study shows that growing patients with clefts present differences regarding periodontal parameters between the cleft and the control side...
November 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29028424/unique-tailoring-of-th17-at-the-gingival-oral-mucosal-barrier
#9
J E Konkel, N M Moutsopoulos
Our recent work highlights unique requirements for the induction of Th17 cells at the oral/gingival mucosal barrier. Unlike other barrier sites, such as the skin and gastrointestinal tract, we found that Th17 cells can develop at the gingiva independently of commensal microbiota colonization. Instead, we identified that damage, which occurs physiologically due to mastication, promotes induction of Th17 cells and tones homeostatic immunity at the gingiva.
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29026519/squamous-cell-carcinoma-arising-in-familial-gingival-fibromatosis-a-rare-case-report
#10
Dilasma Ghartimagar, Ujjwal Koirala, Arnab Ghosh, Manish Kiran Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
Familial gingival fibromatosis is a rare hereditary condition due to chromosomal abnormality which can occur as an isolated disease or as part of a syndrome and has an incidence of 1:350 000. This condition leads to esthetic, functional, psychological and masticatory disturbance of the oral cavity. Here, we present a case of 21-year-old female with severe enlargement of gums in maxilla and mandible. Deciduous teeth were erupted at normal age but the permanent teeth in the oral cavity were not erupted. Her grandmother, father and younger sister were also affected with the same condition...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29023624/two-year-clinical-evaluation-of-pedicled-buccal-fat-pad-alone-and-with-emdogain-for-root-coverage-of-severe-gingival-recession-defects-a-case-series
#11
Sally Abd-ElMeniem El-Haddad, Mohammad Abd-ElHakeem El-Shall
Gingival recession is defined as an apical displacement of the gingival margin beyond the cementoenamel junction leading to serious consequences, including exposure of the root surface, loss of periodontal attachment, root sensitivity to hot and cold air, and esthetic problems. The aim of this study was to evaluate the long-term effect of pedicled buccal fat pad (PBFP) alone and with Emdogain in covering severe gingival recession defects and restoring tooth function. A total of 10 severe buccal recession defects in maxillary first molars were selected to be treated with PBFP, with Emdogain (group I; n = 5) or alone (group II; n = 5)...
2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29021479/a-japanese-case-of-esophageal-lichen-planus-that-was-successfully-treated-with-systemic-corticosteroids
#12
Yuki Sato, Ryuta Takenaka, Akihiro Matsumi, Kensuke Takei, Shotaro Okanoue, Eriko Yasutomi, Daisuke Kawai, Koji Takemoto, Hirofumi Tsugeno, Takayoshi Miyake, Shigeatsu Fujiki
Esophageal lichen planus (ELP) is rare and only about 80 cases have been reported in the literature. An 85-year-old woman presented with dysphagia and odynophagia. Endoscopy revealed a severe stricture in the proximal esophagus. Oral examinations at two years after the first endoscopy revealed erosions around the gingiva, and an examination of biopsy specimens taken from the site of erosion led to a diagnosis of oral LP. Esophageal endoscopy was performed again, and biopsy specimens showed spongiosis and necrotic keratinocytes in the epithelium (civatte bodies)...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28989141/melanotic-macule-in-conjunction-with-a-giant-cell-fibroma
#13
Samantha D Seitz, Thanhphuong N Dinh, Thomas Yh Yoon
INTRODUCTION: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28989119/effects-of-protein-coated-nanofibers-on-conformation-of-gingival-fibroblast-spheroids-potential-utility-for-connective-tissues-regeneration
#14
Gili Kaufman, Ryan Whitescarver, Laiz Nunes, Xavier-Lewis Palmer, Drago Skrtic, Wojtek Tutak
Deep wounds in the gingiva caused by trauma or surgery require a rapid and robust healing of connective tissues. We propose utilizing gas-brushed nanofibers coated with collagen and fibrin for that purpose. Our hypotheses are that protein-coated nanofibers will: (i) attract and mobilize cells in various spatial orientations, and (ii) regulate the expression levels of specific extracellular matrix (ECM)-associated proteins, determining the initial conformational nature of dense and soft connective tissues. Gingival fibroblast monolayers and 3D spheroids were cultured on ECM substrate and covered with gas-blown poly-(DL-lactide-co-glycolide) (PLGA) nanofibers (uncoated/coated with collagen and fibrin)...
October 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28985543/evaluation-of-interleukin-10-producing-cd19-b-cells-in-human-gingival-tissue
#15
Jiayin Dai, Liangjia Bi, Jiang Lin, Feng Qi
OBJECTIVE: This study aimed to evaluate IL-10 producing CD19(+) B cells and to examine the correlation between these cells and the expression levels of IL-1β, TNF-α, RANKL, and IL-10 cytokines in the gingival tissues of individuals with and without chronic periodontitis. DESIGN: Data were obtained from 20 patients with chronic periodontitis and 10 healthy controls. The gingival samples were analyzed by immunofluorescence, while real-time PCR and enzyme-linked immunosorbent assays were performed to determine cytokine levels...
September 18, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28985086/gingival-melanin-depigmentation-by-er-yag-laser-a-literature-review
#16
Verica Pavlic, Zlata Brkic, Sasa Marin, Smiljka Cicmil, Mirjana Gojkov-Vukelic, Akira Aoki
Laser ablation is recently suggested as a most effective and reliable technique for depigmentation of melanin hyperpigmented gingiva. To date, different lasers have been used for gingival depigmentation (CO2, diode, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers). The use of Er:YAG laser for depigmentation of melanin hyperpigmented gingiva has gained increasing importance in recent years. The purpose of this study was to report removal of gingival melanin pigmentation using an Er:YAG laser in a literature review. The main outcomes, such as improvement of signs (clinical parameters of bleeding, erythema, swelling and wound healing), symptoms (pain) and melanin recurrence/repigmentation were measured...
October 6, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28976348/-renal-cell-carcinoma-metastases-in-the-maxillofacial-area-case-series
#17
Sara Ruiz-Oslé, Carlos Prol, Rosa Lardies, Ayman Gaafar, Luis Barbier, Antón Arruza
Renal cell carcinoma is an unpredictable malignancy. Sometimes, metastases are the disease debut. On the other hand, metastases could present years after treatment of the primary tumor. Four clinical cases of atypical metastases in the head and neck location are presented: parotid gland, mandibular bone, attached molar gingiva and masticator space. Physiopathology, clinics, histology and management of metastatic renal cell carcinoma at those anatomical regions are reviewed.
October 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28971271/association-between-high-risk-for-preterm-birth-and-changes-in-gingiva-parameters-during-pregnancy-a-prospective-cohort-study
#18
Anne Brigitte Kruse, Anja C Kuerschner, Mirjam Kunze, Johan P Woelber, Ali Al-Ahmad, Annette Wittmer, Kirstin Vach, Petra Ratka-Krueger
OBJECTIVES: The objective of this study was to investigate clinical and microbiological gingival changes during pregnancy in women without periodontal disease. Additionally, these parameters were to be compared in women with high risk for preterm birth and women with a normal course of pregnancy. METHOD AND MATERIALS: Group I consisted of 40 subjects at high risk for preterm birth, while group II involved 49 subjects with a normal course of pregnancy. The control group (III) was made up of 50 non-pregnant women...
October 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28969915/accuracy-of-digitally-fabricated-trial-dentures
#19
Timea Wimmer, Marlis Eichberger, Nina Lümkemann, Bogna Stawarczyk
STATEMENT OF PROBLEM: Information about the accuracy of digital computer-aided design and computer-aided manufacturing (CAD-CAM) complete dentures is scarce. PURPOSE: The purpose of this in vitro study was to assess the reproducibility of the occlusion of wax dentures fabricated with digital steps and the contraction behavior of wax trial dentures processed with combined conventional-digital steps. These were compared with those fabricated completely conventionally in terms of storage duration...
September 29, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28969268/comparative-evaluation-of-platelet-rich-fibrin-and-dehydrated-amniotic-membrane-for-the-treatment-of-gingival-recession-a-clinical-study
#20
Ankita Jain, Gagan Rajesh Jaiswal, Kanteshwari Kumathalli, Rajesh Kumar, Alisha Singh, Aakrti Sarwan
INTRODUCTION: The main objective of any therapeutic intervention aimed at root coverage is to restore the tissue margin to the cemento-enamel junction and to regenerate the lost periodontium. AIM: To compare the effectiveness of Platelet Rich Fibrin (PRF) and Amniotic Membrane (AM) in the treatment of gingival recession by Coronally Advanced Flap (CAF) Technique. MATERIALS AND METHODS: Thirty systemically healthy patients who met inclusion-exclusion criteria were selected...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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