Daniel Doro, Annie Liu, Jia Shang Lau, Arun Kumar Rajendran, Christopher Healy, Marko Krstic, Agamemnon E Grigoriadis, Sachiko Iseki, Karen J Liu
The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development, homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural crest. During cranial bone repair, neural crest cells have been proposed to be key players; however, neural crest contributions to adult sutures are not well defined, and the relative importance of suture proximity is unclear. Here, we use genetic approaches to re-examine the neural crest-mesoderm boundaries in the adult mouse skull...
February 1, 2024: Development