keyword
Keywords craniofacial growth and develo...

craniofacial growth and development

https://read.qxmd.com/read/38533046/the-application-of-zebrafish-model-in-the-study-of-cleft-lip-and-palate-development-a-systematic-review
#1
JOURNAL ARTICLE
Nora Alhazmi, Khalid A Alamoud, Farraj Albalawi, Bassam Alalola, Fathima F Farook
OBJECTIVE: Craniofacial growth and development are more than a scientific curiosity; it is of tremendous interest to clinicians. Insights into the genetic etiology of cleft lip and palate development are essential for improving diagnosis and treatment planning. The purpose of this systematic review was to utilize a zebrafish model to highlight the role of the IRF6 gene in cleft lip and palate development in humans. DATA: This review adhered to the guidelines outlined in the PRISMA statement...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38518579/correlation-of-palatal-anatomic-characteristics-with-dermatoglyphic-heterogeneity-in-different-growth-patterns
#2
JOURNAL ARTICLE
P Rishi, P Sharma, S Jain, A Jain, P Kumar, D Shetty
AIM AND OBJECTIVE: The study aimed to explore the correlation between dermatoglyphic patterns and quantitative palatal anatomic variables in individuals with different growth patterns. MATERIALS AND METHOD: A cross-sectional study was conducted involving 126 healthy patients aged 17-25 years. Participants were divided into three groups based on growth patterns: average, vertical, and horizontal. Dermatoglyphic patterns were recorded using an optical fingerprint sensor, and palatal characteristics were measured using digital software...
March 21, 2024: Morphologie: Bulletin de L'Association des Anatomistes
https://read.qxmd.com/read/38512806/zebrafish-raptor-mutation-inhibits-the-activity-of-mtorc1-inducing-craniofacial-defects-due-to-autophagy-induced-neural-crest-cell-death
#3
JOURNAL ARTICLE
Scott K Tucker, Ritika Gosul, Mary E Swartz, Stephanie Zhang, Johann K Eberhart
The mechanistic target of rapamycin (mTOR) coordinates metabolism and cell growth with environmental inputs. mTOR forms two functional complexes: mTORC1 and mTORC2. Proper development requires both complexes but mTORC1 has unique roles in numerous cellular processes, including cell growth, survival and autophagy. Here, we investigate the function of mTORC1 in craniofacial development. We created a zebrafish raptor mutant via CRISPR/Cas9, to specifically disrupt mTORC1. The entire craniofacial skeleton and eyes were reduced in size in mutants; however, overall body length and developmental timing were not affected...
March 15, 2024: Development
https://read.qxmd.com/read/38506523/speech-and-language-development-hearing-and-feeding-in-patients-with-genetically-confirmed-crouzon-syndrome-with-acanthosis-nigricans-a-36-year-longitudinal-retrospective-review-of-patients-at-the-oxford-craniofacial-unit
#4
JOURNAL ARTICLE
Sarah Kilcoyne, Paula Scully, Sarah Overton, Sally Brockbank, Gregory P L Thomas, Rosanna C Ching, Jayaratnam Jayamohan, James D Ramsden, Jon Jones, Andrew O M Wilkie, David Johnson
OBJECTIVE: Crouzon syndrome with acanthosis nigricans (CAN) is caused by the specific mutation c.1172C>A (p.Ala391Glu) in the fibroblast growth factor receptor 3 gene, and has an estimated prevalence of 1:1,000,000 births. Most cases occur de novo; however, autosomal dominant inheritance may occur. The clinical presentation typically includes craniosynostosis, midface and maxillary hypoplasia, choanal atresia/stenosis, hydrocephalus, and intracranial hypertension. Patients develop acanthosis nigricans, a hyperkeratotic skin disorder...
March 20, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38506013/-not-available
#5
JOURNAL ARTICLE
Maria Winther Gunnes, Andreas Benneche, Anne Grete Bechensteen
BACKGROUND: Anemia in children is common and finding the underlying cause is often uncomplicated. However, in some cases, the underlying diagnosis is rare and difficult to diagnose. CASE PRESENTATION: A toddler presented with severe anemia with normal red cell indices and a low reticulocyte count. The remaining hematological parameters were normal, bar a slight thrombocytosis. At this point a diagnosis of transient erythroblastopenia of childhood (TEC) was made...
March 19, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/38495954/effects-of-lactalbumin-enzymatic-hydrolysate-on-human-squamous-cell-carcinoma-cells-an-in-vitro-study
#6
JOURNAL ARTICLE
Agustina Putri Kintan Arini, Worachat Namangkalakul, Phoonsuk Limraksasin, Thanaphum Osathanon
OBJECTIVES: Alpha-lactalbumin, the protein from human and bovine milk has been found to be promising as an alternative of anticancer agent . This study was aimed to investigate the effects of lactalbumin enzymatic hydrolysate (LAH) on cell proliferation, migration, and mRNA expression of matrix metalloproteinase ( MMP ) on human squamous cell carcinoma (hSCC) cell lines, in vitro . METHODS: Tongue (HSC-4 and 7) and pharyngeal (HN-30 and 31) hSCC cell lines were treated with a two-fold dilution of LAH (0...
2024: Journal of Oral Biology and Craniofacial Research
https://read.qxmd.com/read/38489820/neurocognitive-outcomes-and-associated-clinical-factors-5-years-after-surgery-in-children-with-craniosynostosis
#7
JOURNAL ARTICLE
Joo Whan Kim, Kyung Hyun Kim, Ji Hoon Phi, Ji Yeoun Lee, Eun Jung Koh, Byung Jun Kim, Jee Hyeok Chung, Min-Sup Shin, Seung-Ki Kim
OBJECTIVE: Craniosynostosis involves early closure of one or more sutures, which is known to limit normal cranium growth and interfere with normal brain development. Various surgical methods are used, ranging from minimally invasive strip craniectomy to more extensive whole-vault cranioplasty. This study aimed to evaluate neurocognitive outcomes 5 years after surgical treatment in children with craniosynostosis and to evaluate relevant clinical factors. METHODS: After exclusion of genetically confirmed syndromic craniosynostosis patients, a retrospective review was conducted on 112 nonsyndromic craniosynostosis patients who underwent surgical treatment and follow-up neurocognitive assessment...
March 15, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38456701/dynamic-morphological-growth-trajectory-of-crouzon-population-a-geometric-morphometric-analysis
#8
JOURNAL ARTICLE
Yehong Zhong, Zhewei Chen, Binghang Li, Hengyuan Ma, Bin Yang
This study is to visualize the morphological growth trajectory of the Crouzon population and provide a more comprehensive and perceptual understanding of pathologic aggregation in terms of maxillofacial and soft tissue surfaces. Twenty-two patients with Crouzon syndrome were included in this retrospective surgery. Preoperative computed tomography was segmented into maxillofacial and soft tissue surface morphologies. Fifty-two anatomical landmarks and a standardized template were used to extract the morphological phenotypes and transform them into spatial coordinates...
March 8, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38430973/calcification-patterns-and-morphology-of-sella-turcica-are-related-to-anteroposterior-skeletal-malocclusions-a-cross-sectional-study
#9
JOURNAL ARTICLE
João Armando Brancher, Larissa Alves Maciel da Silva, Caio Luiz Bitencourt Reis, Mírian Aiko Nakane Matsumoto, Leo de Carvalho, Leonardo Santos Antunes, Lívia Azeredo Alves Antunes, Maria Bernadete Sasso Stuani, Maria Fernanda Torres, Eva Paddenberg-Schubert, Christian Kirschneck, Erika Calvano Küchler
BACKGROUND: The sphenoid bone is an irregular, unpaired, symmetrical bone located in the middle of the anterior skull and is involved in craniofacial growth and development. Since the morphology of Sella turcica (ST) is associated with different craniofacial patterns, this study aimed to investigate if there is a correlation between ST morphology on the one hand and sagittal craniofacial patterns on the other hand. METHODS: This study was conducted with a convenience sample that included Brazilian individuals undergoing orthodontic treatment...
February 29, 2024: Annals of Anatomy
https://read.qxmd.com/read/38421207/clinical-research-fellowship-fosters-mentorship-teamwork-and-productivity-our-11-year-experience-with-a-craniofacial-research-fellowship
#10
JOURNAL ARTICLE
Dominic J Romeo, Steven Du, Benjamin B Massenburg, Jinggang J Ng, Meagan Wu, Dillan F Villavisanis, John P Fischer, Jordan W Swanson, Scott P Bartlett, Jesse A Taylor
INTRODUCTION: This study describes the development and explores the academic impact of a cleft and craniofacial research fellowship. MATERIALS AND METHODS: Research and career outcomes from 3 cleft and craniofacial surgeons, 14 clinical fellows, and 25 research fellows between 2010 and 2023 were examined. Academic productivity was measured by the number of peer-reviewed publications indexed in PubMed and podium presentations at national/international meetings. Residency match statistics were recorded for eligible research fellows...
February 29, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38420002/photometric-analysis-of-the-relationship-between-craniovertebral-angle-and-facial-profile-in-children-aged-10-12-years
#11
JOURNAL ARTICLE
Maya Rosita, Sarworini B Budiardjo, Mochamad Fahlevi Rizal
BACKGROUND: Head posture deviation is seen in 52.5 % of children aged 6-15 years. Studies have shown that poor posture habits can impair muscle function during craniofacial growth and development. A muscle imbalance causes abnormal positioning of dental and skeletal structures, a condition that exerts negative impacts, such as changes in facial morphology. OBJECTIVE: To determine through photometric analysis the relationship between craniovertebral angle as a function of head posture and glabella-subnasale-pogonion (G-Sn-Pg) angle as a function of facial profile in 10-12-year-old children, and the results will help to avoid facial development issues...
February 2024: Saudi Dental Journal
https://read.qxmd.com/read/38409951/feasibility-of-spheno-occipital-synchondrosis-fusion-stages-as-an-indicator-for-the-assessment-of-maxillomandibular-growth-a-mixed-longitudinal-study
#12
JOURNAL ARTICLE
Jing Geng, Guangpu Zhao, Yan Gu
OBJECTIVES: This study aimed to assess the relative growth rates (RGRs) of the maxilla and mandible at varying fusion stages of the spheno-occipital synchondrosis (SOS), thereby elucidating the potential of SOS stages in predicting maxillomandibular growth. MATERIALS AND METHODS: A total of 320 subjects (171 boys and 149 girls), aged 6 to 18 years, were retrospectively included. Each subject had a minimum of two longitudinal cone-beam computed tomography (CBCT) images, with no more than one interval of SOS fusion stage change between the two scans...
February 26, 2024: Orthodontics & Craniofacial Research
https://read.qxmd.com/read/38407232/modeling-fetal-alcohol-spectrum-disorders-in-zebrafish-to-characterize-the-impact-of-an-adverse-embryonic-environment-on-adult-social-behavior
#13
JOURNAL ARTICLE
Mindy Rampersad, Yohaan Fernandes
Fetal alcohol spectrum disorders (FASD) describe all alcohol-induced birth defects. Birth defects such as growth deficiencies, craniofacial, behavioral, and cognitive abnormalities are associated with FASD. Social difficulties are common behavioral abnormalities associated with FASD and often result in serious health issues. Animal models are critical to understanding the mechanisms responsible for ethanol-induced social defects. Zebrafish are social vertebrates that produce externally fertilized transparent eggs; these characteristics provide researchers with a precise yet simple procedure for creating the FASD phenotype and an innate behavior that can be leveraged to model the social deficits associated with FASD...
February 9, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38397313/relationship-between-nutrition-and-development-of-the-jaws-in-children-a-pilot-study
#14
JOURNAL ARTICLE
Paula Boo Gordillo, Laura Marqués Martínez, Carla Borrell García, Esther García Miralles
Craniofacial growth and development have been shown to be influenced by various environmental factors that impact child development. This study aims to analyze the different patterns of feeding during early childhood, starting from birth, and assess the variability of nutrition during the first stage of childhood, along with the habits developed, to study their impact on jaw development. The study was conducted on a sample of twenty-five patients aged 3 to 5, following approval from the ethics committee of the Catholic University of Valencia...
February 5, 2024: Children
https://read.qxmd.com/read/38396475/isolated-sagittal-craniosynostosis-a-comprehensive-review
#15
REVIEW
Peter Spazzapan, Tomaz Velnar
Sagittal craniosynostosis, a rare but fascinating craniofacial anomaly, presents a unique challenge for both diagnosis and treatment. This condition involves premature fusion of the sagittal suture, which alters the normal growth pattern of the skull and can affect neurological development. Sagittal craniosynostosis is characterised by a pronounced head shape, often referred to as scaphocephaly. Asymmetry of the face and head, protrusion of the fontanel, and increased intracranial pressure are common clinical manifestations...
February 16, 2024: Diagnostics
https://read.qxmd.com/read/38396323/pterion-variation-in-the-skulls-of-rhesus-macaques-from-cayo-santiago-inheritance-development-and-pathology
#16
JOURNAL ARTICLE
George Francis, Qian Wang
The pterion is the sutural juncture of the frontal, parietal, sphenoidal, temporal, and zygomatic bones on the lateral aspect of the cranium. As a craniometric landmark, the pterion has a taxonomic valence, in addition to a common neurosurgical entry point in medicine. Variation in the articulation patterns at the pterion have been documented between primate species yet have a high degree of uniformity within species, suggesting a genetic control for this complex region of the skull. In this study, pterion pattern variation was investigated in 1627 Rhesus macaque crania of the Cayo Santiago colony...
February 23, 2024: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://read.qxmd.com/read/38385025/transforming-growth-factor-beta-signaling-and-craniofacial-development-modeling-human-diseases-in-zebrafish
#17
REVIEW
Sabrina C Fox, Andrew J Waskiewicz
Humans and other jawed vertebrates rely heavily on their craniofacial skeleton for eating, breathing, and communicating. As such, it is vital that the elements of the craniofacial skeleton develop properly during embryogenesis to ensure a high quality of life and evolutionary fitness. Indeed, craniofacial abnormalities, including cleft palate and craniosynostosis, represent some of the most common congenital abnormalities in newborns. Like many other organ systems, the development of the craniofacial skeleton is complex, relying on specification and migration of the neural crest, patterning of the pharyngeal arches, and morphogenesis of each skeletal element into its final form...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38366756/cephalometric-changes-of-pushing-splints-3-compared-to-rapid-maxillary-expansion-and-facemask-therapy-on-the-airway-space-in-class-iii-growing-patients-a-randomized-clinical-trial
#18
JOURNAL ARTICLE
Angela Galeotti, Valeria Viarani, Lorenzo Franchi, Stefano Martina, Roberto Rongo, Vincenzo D'Antò, Roberto Uomo, Francesco Aristei, Paola Festa
BACKGROUND: Early orthopaedic treatment with rapid maxillary expansion (RME) associated with facemask (FM) has been shown to be effective in correcting Class III malocclusions in children. Treatment with pushing splints 3 (PS3) has shown to correct skeletal discrepancies in Class III growing patients. However, the effects of orthopaedic treatment on the upper airways in children with Class III malocclusion is controversial. OBJECTIVES: The aim of this study was to evaluate the cephalometric changes in the airways of PS3 compared to the RME/FM protocol...
February 17, 2024: Orthodontics & Craniofacial Research
https://read.qxmd.com/read/38364324/unilateral-nasal-obstruction-mediates-reversible-morphological-and-phenotypic-changes-in-masticatory-muscles-of-growing-rats
#19
JOURNAL ARTICLE
Shuntaro Iwaki, Ikuo Yonemitsu, Makoto Tabata, Mirei Keitoku, Guan Hao, Takashi Ono
OBJECTIVE: Mouth breathing as a result of nasal obstruction affects craniofacial growth and development. This study aimed to investigate the effects of unilateral nasal obstruction and its recovery, along with the role of nitric oxide (NO) in masticatory muscle physiology. MATERIALS AND METHODS: Forty-eight 4-week-old male rats were divided into control and experimental groups. The five experimental groups were subjected to left-sided nasal obstruction by suturing the external nostril, and the sutures were removed after 1, 3, 5, 7, or 9 weeks to allow for varying recovery periods...
April 1, 2024: European Journal of Orthodontics
https://read.qxmd.com/read/38345329/cranial-suture-lineage-and-contributions-to-repair-of-the-mouse-skull
#20
JOURNAL ARTICLE
Daniel Doro, Annie Liu, Jia Shang Lau, Arun Kumar Rajendran, Christopher Healy, Marko Krstic, Agamemnon E Grigoriadis, Sachiko Iseki, Karen J Liu
The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development, homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural crest. During cranial bone repair, neural crest cells have been proposed to be key players; however, neural crest contributions to adult sutures are not well defined, and the relative importance of suture proximity is unclear. Here, we use genetic approaches to re-examine the neural crest-mesoderm boundaries in the adult mouse skull...
February 1, 2024: Development
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