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https://www.readbyqxmd.com/read/28438009/modulation-format-free-and-automatic-bias-control-for-optical-iq-modulators-based-on-dither-correlation-detection
#1
Xiaolei Li, Lei Deng, Xiaoman Chen, Mengfan Cheng, Songnian Fu, Ming Tang, Deming Liu
A novel automatic bias control (ABC) method for optical in-phase and quadrature (IQ) modulator is proposed and experimentally demonstrated. In the proposed method, two different low frequency sine wave dither signals are generated and added on to the I/Q bias signal respectively. Instead of power monitoring of the harmonics of the dither signal, dither-correlation detection is proposed and used to adjust the bias voltages of the optical IQ modulator. By this way, not only frequency spectral analysis isn't required but also the directional bias adjustment could be realized, resulting in the decrease of algorithm complexity and the growth of convergence rate of ABC algorithm...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437993/integrated-optical-force-sensors-using-focusing-photonic-crystal-arrays
#2
Jingkun Guo, Richard A Norte, S Gröblacher
Mechanical oscillators are at the heart of many sensor applications. Recently several groups have developed oscillators that are probed optically, fabricated from high-stress silicon nitride films. They exhibit outstanding force sensitivities of a few aN/Hz<sup>1/2</sup> and can also be made highly reflective, for efficient detection. The optical read-out usually requires complex experimental setups, including positioning stages and bulky cavities, making them impractical for real applications. In this paper we propose a novel way of building fully integrated all-optical force sensors based on low-loss silicon nitride mechanical resonators with a photonic crystal reflector...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437991/high-speed-triangular-pattern-phase-shifting-3d-measurement-based-on-the-motion-blur-method
#3
Huijie Zhao, Xiaochun Diao, Hongzhi Jiang, Xudong Li
Recent advancements in 3D measurement technologies have increased the urgency of requiring high-speed 3D measurement in many fields. This study presents a novel four-step triangular pattern phase-shifting 3D measurement using the motion blur method, which combines the advantages of phase-shifting methods. To comply with the high speed requirement, binary coded triangular patterns are projected and could dither vertically. Therefore, the image captured by the camera is blurred into grayscale-intensity triangular patterns, which can be used for phase unwrapping and 3D reconstruction...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437932/electrifying-catheters-with-light
#4
Martin Pekař, Jeannet van Rens, Martin B van der Mark
Smart minimally invasive devices face a connectivity challenge. An example is found in intracardiac echocardiography where the signal transmission and supply of power at the distal end require many thin and fragile wires in order to keep the catheter slim and flexible. We have built a fully functional bench-top prototype to demonstrate that electrical wires may be replaced by optical fibers. The prototype is immediately scalable to catheter dimensions. The absence of conductors will provide intrinsic galvanic isolation as well as radio frequency (RF) and magnetic resonance imaging (MRI) compatibility...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437930/si-traceable-measurement-of-an-optical-frequency-at-the-low-10-sup-16-sup-level-without-a-local-primary-standard
#5
Hidekazu Hachisu, Gérard Petit, Fumimaru Nakagawa, Yuko Hanado, Tetsuya Ido
SI-traceable measurements of optical frequencies using International Atomic Time (TAI) do not require a local primary frequency reference, but suffer from an uncertainty in tracing to the SI second. For the measurement of the <sup>87</sup>Sr lattice clock transition, we have reduced this uncertainty to the low 10<sup>-16</sup> level by averaging three sets of ten-day intermittent measurements, in which we operated the lattice clock for 10<sup>4</sup> s on each day. Moreover, a combined oscillator of two hydrogen masers was employed as a local flywheel oscillator (LFO) in order to mitigate the impact of sporadic excursion of LFO frequency...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437928/terahertz-optical-bistability-of-graphene-in-thin-layers-of-dielectrics
#6
Kwang Jun Ahn, Fabian Rotermund
We theoretically studied in terahertz frequency regime optical bistability of graphene placed at the interface between thin dielectric layers. We solved self-consistently the nonlinear wave equations containing the third-order optical conductivity of graphene in four-layer structures and obtained hysteresis response of the transmitted power as a function of the incident power. We numerically observed that the critical powers for the up and down transitions and the Fermi-energy of graphene required for terahertz optical bistability can be reduced by carefully choosing material properties and the thicknesses of dielectric layers...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437920/cmos-integrated-gan-led-array-for-discrete-power-level-stepping-in-visible-light-communications
#7
Alexander D Griffiths, Mohamed Sufyan Islim, Johannes Herrnsdorf, Jonathan J D McKendry, Robert Henderson, Harald Haas, Erdan Gu, Martin D Dawson
We report a CMOS integrated micro-LED array capable of generating discrete optical output power levels. A 16 × 16 array of individually addressable pixels are on-off controlled through parallel logic signals. With carefully selected groups of LEDs driven together, signals suitable for discrete transmission schemes are produced. The linearity of the device is assessed, and data transmission using pulse amplitude modulation (PAM) and orthogonal frequency division multiplexing (OFDM) is performed. Error-free transmission at a symbol rate of 100 MSamples/s is demonstrated with 4-PAM, yielding a data rate of 200 Mb/s...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437918/modeling-and-designing-multilayer-2d-perovskite-silicon-bifacial-tandem-photovoltaics-for-high-efficiencies-and-long-term-stability
#8
Haejun Chung, Xingshu Sun, Aditya D Mohite, Rahul Singh, Lokendra Kumar, Muhammad A Alam, Peter Bermel
A key challenge in photovoltaics today is to develop cell technologies with both higher efficiencies and lower fabrication costs than incumbent crystalline silicon (c-Si) single-junction cells. While tandem cells have higher efficiencies than c-Si alone, it is generally challenging to find a low-cost, high-performance material to pair with c-Si. However, the recent emergence of 22% efficient perovskite photovoltaics has created a tremendous opportunity for high-performance, low-cost perovskite / crystalline silicon tandem photovoltaic cells...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437909/editorial-optics-express-now-how-did-that-happen
#9
J H Eberly
Founding Editor-in-Chief Joseph Eberly tells how Optics Express was conceived as an entirely new kind of journal and the significant effort required to launch the first issue.
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437888/protective-effects-of-tranilast-on-experimental-colitis-in-rats
#10
Yoshiki Seto, Kouki Kato, Ryota Tsukada, Hiroki Suzuki, Yuuki Kaneko, Yoshiki Kojo, Hideyuki Sato, Satomi Onoue
The present study aimed to verify the efficacy of tranilast (TL) for treating inflammatory bowel disease (IBD) with the use of an experimental colitis model. The experimental colitis model was prepared by intrarectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 40mg/kg) dissolved in water containing 25% ethanol. The pharmacological effects of TL after repeated oral administration were evaluated by biomarker and histological analyses, and the pharmacokinetic behavior of TL was also examined after single oral administration...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437869/risk-modeling-of-interdependent-complex-systems-of-systems-theory-and-practice
#11
Yacov Y Haimes
The emergence of the complexity characterizing our systems of systems (SoS) requires a reevaluation of the way we model, assess, manage, communicate, and analyze the risk thereto. Current models for risk analysis of emergent complex SoS are insufficient because too often they rely on the same risk functions and models used for single systems. These models commonly fail to incorporate the complexity derived from the networks of interdependencies and interconnectedness (I-I) characterizing SoS. There is a need to reevaluate currently practiced risk analysis to respond to this reality by examining, and thus comprehending, what makes emergent SoS complex...
April 24, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28437859/multiple-sclerosis-broke-my-heart
#12
Géraldine Androdias, Emilien Bernard, Damien Biotti, Nicolas Collongues, Françoise Durand-Dubief, Julie Pique, Ingrid Sanchez, Clément Delmas, Jacques Ninet, Romain Marignier, Sandra Vukusic
We report 5 cases of acute heart failure (AHF) related to multiple sclerosis (MS) relapses. AHF was inaugural in 3 patients, always preceded or accompanied by signs of brainstem dysfunction; it was severe, requiring intensive care management. Echocardiography showed left ventricular hypokinesis. No other cause of AHF has been found. All patients showed a new medullary lesion on brain MRI. All had rapid and complete recovery of ventricular function after intravenous corticosteroids. We concluded to a takotsubo phenomenon...
April 24, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28437852/a-diagnostic-microdosing-approach-to-investigate-platinum-sensitivity-in-non-small-cell-lung-cancer
#13
Si-Si Wang, Maike Zimmermann, Hongyong Zhang, Tzu-Yin Lin, Michael Malfatti, Kurt Haack, Kenneth W Turteltaub, George D Cimino, Ralph de Vere White, Chong-Xian Pan, Paul T Henderson
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are often used for chemotherapy, but drug resistance is common. The prediction of resistance to these drugs via genomics is a challenging problem since hundreds of genes are involved. A possible alternative is to use mass spectrometry to determine the propensity for cells to form drug-DNA adducts-the pharmacodynamic drug-target complex for this class of drugs. The feasibility of predictive diagnostic microdosing was assessed in non-small cell lung cancer (NSCLC) cell culture and a pilot clinical trial...
April 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28437843/a-bayesian-belief-network-model-assessing-the-risk-to-wastewater-workers-of-contracting-ebola-virus-disease-during-an-outbreak
#14
Joseph W Zabinski, Kelsey J Pieper, Jacqueline MacDonald Gibson
During an outbreak of Ebola virus disease (EVD), hospitals' connections to municipal wastewater systems may provide a path for patient waste bearing infectious viral particles to pass from the hospital into the wastewater treatment system, potentially posing risks to sewer and wastewater workers. To quantify these risks, we developed a Bayesian belief network model incorporating data on virus behavior and survival along with structural characteristics of hospitals and wastewater treatment systems. We applied the model to assess risks under several different scenarios of workers' exposure to wastewater for a wastewater system typical of a mid-sized U...
April 24, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28437835/pten-downregulation-promotes-%C3%AE-oxidation-to-fuel-hypertrophic-liver-growth-after-hepatectomy-in-mice
#15
Ekaterina Kachaylo, Christoph Tschuor, Nicolas Calo, Nathalie Borgeaud, Perparim Limani, Anne-Christine Piguet, Jean-Francois Dufour, Michelangelo Foti, Rolf Graf, Pierre A Clavien, Bostjan Humar
In regenerating liver, hepatocytes accumulate lipids before the major wave of parenchymal growth. This transient, regeneration-associated steatosis (TRAS) is required for liver recovery, but its purpose is unclear. The tumor suppressor PTEN is a key inhibitor of the AKT-mTOR axis that regulates growth and metabolic adaptations after hepatectomy. In quiescent liver, PTEN causes pathological steatosis when lost, while its role in regenerating liver remains unknown. Here, we show that PTEN downregulation promotes liver growth in a TRAS-dependent way...
April 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28437834/elucidation-of-factor-viii-activity-pharmacokinetics-a-pooled-population-analysis-in-hemophilia-a-patients-treated-with-moroctocog-alfa
#16
João A Abrantes, Elisabet I Nielsen, Joan Korth-Bradley, Lutz Harnisch, Siv Jönsson
This study investigated the disposition of coagulation factor VIII activity in 754 moderate to severe hemophilia A patients following the administration of moroctocog alfa, a B-domain deleted recombinant factor VIII. Data analyzed included patients aged 1 day to 73 years enrolled in 13 studies conducted over a period of 20 years in 25 countries. A two-compartment population pharmacokinetic model with a baseline model described the pooled data well. Body size, age, inhibitors, race and analytical assay were identified as significant predictors of factor VIII disposition...
April 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28437823/-medicolegal-assessment-of-psychic-sequelae-after-minor-traumatic-events
#17
Bernhard Widder
The majority of medicolegal assessments in claimed psychic sequelae after accidents concerns minor traumatic events. In this case, the focus is on three questions: Was the event appropriate to cause a traumatic disturbance according to current psychiatric classification systems (especially current DSM-5)? Which psychical or physical initial injury can be proven beyond reasonable doubt ("full proof") according to German law? What is the impact of personality characteristics and competing life events in the development and maintenance of the mental disorder? Causality between mental disorders and minor traumatic events is to be confirmed especially in the case of persistent physical accident sequelae, but attention has to be paid to the differences in the various legal requirements...
April 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28437818/-towards-a-rehabilitation-and-participation-oriented-psychotherapy
#18
Beate Muschalla, Jürgen Bengel, Matthias Morfeld, Ulrike Worringen
Mental disorders (such as recurrent mood disorders, personality disorders, or psychotic disorders) come along with enduring impairment in daily life activities. Therefore psychotherapeutic actions in inpatient or outpatient settings require a life-span and participation-oriented treatment perspective. Participation-oriented treatment aims at social and vocational integration in general life despite enduringly recurring or resting symptoms. According to the model of health problems offered by the International Classification of Functioning, Disability and Health, ICF (WHO, 2001), disability can be defined as context-dependent activity impairment due to illness...
April 24, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28437816/-subjective-level-of-information-and-information-needs-of-patients-with-an-approved-rehabilitation-application-and-patients-at-the-end-of-rehabilitation-results-of-a-written-survey
#19
Anna Lena Walther, Dora Schreiber, Johannes Falk, Ruth Deck
AimThe aim of the study was to identify the subjective level of information and information needs of patients with an approved rehabilitation application and patients at the end of rehabilitation with regard to preferred subjects and kind of information transfer. Method Written survey with N=283 patients with approved rehabilitation application and N=388 patients at the end of rehabilitation. ResultsBoth groups reported high information needs particularly regarding treatments during rehabilitation, rehabilitation aftercare and rehabilitation aims...
April 24, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28437794/hepatitis-b-virus-reactivation-associated-with-direct-acting-antiviral-therapy-for-chronic-hepatitis-c-virus-a-review-of-cases-reported-to-the-u-s-food-and-drug-administration-adverse-event-reporting-system
#20
Susan J Bersoff-Matcha, Kelly Cao, Mihaela Jason, Adebola Ajao, S Christopher Jones, Tamra Meyer, Allen Brinker
Background: Direct-acting antiviral agents (DAAs) are used increasingly to treat hepatitis C virus (HCV) infection. Reports were published recently on hepatitis B virus (HBV) reactivation (HBV-R) in patients with HBV-HCV co-infection. Hepatitis B virus reactivation, defined as an abrupt increase in HBV replication in patients with inactive or resolved HBV infection, may result in clinically significant hepatitis. Objective: To assess whether HBV-R is a safety concern in patients receiving HCV DAAs...
April 25, 2017: Annals of Internal Medicine
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