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Mesoblastic nephroma

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https://www.readbyqxmd.com/read/28856451/recurrent-and-metastatic-congenital-mesoblastic-nephroma-where-does-the-evidence-stand
#1
Susan Jehangir, Jujju J Kurian, Dharshini Selvarajah, Reju J Thomas, Andrew J A Holland
PURPOSE: Fifty years ago, Bolande described Congenital Mesoblastic Nephroma (CMN) as a benign lesion. Unexpected aggressive clinical behaviors prompted a sub-classification based on histology. Recent molecular genetic evidence has identified the aggressive cellular variant to be the renal manifestation of congenital infantile fibrosarcoma. We submit a reappraisal and analysis of the available literature on recurrent and metastatic CMN. METHODS: An electronic search of PubMed, MEDLINE, EMBASE, and Scopus yielded 38 children with local recurrence and/or metastases...
August 30, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28770142/cellular-congenital-mesoblastic-nephroma-in-a-newborn
#2
Prasanta Kumar Tripathy, Susmita Behera, Hiranya K Mohanty
No abstract text is available yet for this article.
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28736178/neonatal-solid-tumors
#3
Aravindan Chandrasekaran
BACKGROUND: Neonatal tumors are different from tumors of the older children and knowledge gained from treating older children can not be extrapolated to neonates. Neonates have immature physiology and their haematopoietic and immune systems are not fully developed and the response to therapy is unpredictable. Hence it is imperative to study these tumors as separate entity. The aim of this study is to analyse this rare set of tumors in terms of their incidence, clinical features and management...
July 11, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28643124/-solid-pediatric-tumors-a-brief-survey-of-the-rarity-cabinet
#4
B Gürtl-Lackner, D Gisselsson-Nord, G Vujanic
Solid tumors in childhood are extremely rare entities, which are usually treated in specialized centers. Diagnosis and therapy are carried out according to a joint European protocol, whereby the pathological evaluation and therapy are carried out according to international guidelines. For the correct diagnosis and/or therapy of most tumors, analysis of specific genetic changes is mandatory; therefore, tumors have to be adequately sampled for parallel genetic analysis during the pathological work-up. A second opinion reference of the histopathological assessment is part of the international guidelines...
July 2017: Der Pathologe
https://www.readbyqxmd.com/read/28426529/diagnostic-utility-of-pax8-pax2-and-ngfr-immunohistochemical-expression-in-pediatric-renal-tumors
#5
Nicoleta C Arva, Jeffrey Bonadio, Elizabeth J Perlman, Mariana M Cajaiba
Pediatric renal tumors (PRT) with small round blue or spindle cell morphology can be diagnostically challenging and only a limited number of immunohistochemical markers have been documented to help in the diagnosis: paired box (Pax) 2 and nerve growth factor receptor (NGFR) positivity have been demonstrated in Wilms tumor (WT) and clear cell sarcoma of the kidney (CCSK), respectively. However, the immunohistochemical expression of these markers in other PRT remains unknown. This study investigated Pax8, Pax2, and NGFR immunophenotype in a large series of PRT...
April 19, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28303733/bi-parametric-magnetic-resonance-imaging-applied-to-obstetrics
#6
Lucia Manganaro, Valeria Vinci, Antonella Giancotti, Sandro Gerli, Denis A Cozzi, Teresa Pusiol, Michele Scialpi, Luca Roncati
Foetal magnetic resonance imaging (MRI) plays an increasingly important role in the diagnosis of foetal abnormalities. Over the years, we have successfully applied bi-parametric MRI (bp-MRI) to the following obstetric conditions: (1) neurologic vascular diseases; (2) assessment of lung parenchyma maturation; (3) renal pathologies, such as polycystic kidney, suspected renal infarction, unilateral or bilateral renal agenesis; (4) placental pathologies, as twin-twin transfusion syndrome or placenta accreta; (5) benignant and malignant congenital tumours or cysts of the liver, such as haemangioendothelioma, hepatoblastoma or metastatic neuroblastoma, of the kidney (e...
July 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28282819/management-of-mixed-type-congenital-mesoblastic-nephroma-case-series-and-review-of-the-literature
#7
J Daniel, A Ruzic, J Dalland, V Miller, M Hanna
Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. The first case followed a typical course, previously described in the literature, while the other deviated significantly...
March 4, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28137351/congenital-mesoblastic-nephroma-presenting-with-refractory-hypertension-in-a-premature-neonate-a-case-study
#8
Tracey Robertson-Bell, Desi M Newberry, Amy J Jnah, Stephen D DeMeo
The most common nonencapsulated solid renal tumor in the neonatal period is congenital mesoblastic nephroma. Mesoblastic nephroma is a solid lesion originating within or extending from the renal parenchyma. These tumors proliferate rapidly, typically within 3-6 months after birth. Mesoblastic nephromas are stratified by classification as either classical (benign) or atypical (malignant); masses composed of both benign and malignant cells are also reported. The hallmark clinical manifestation of mesoblastic nephroma is a palpable abdominal mass, which may be accompanied by hypertension, hypercalcemia, hematuria, and polyuria...
January 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28124468/congenital-mesoblastic-nephroma-50-years-after-its-recognition-a-narrative-review
#9
REVIEW
S L Gooskens, M E Houwing, G M Vujanic, J S Dome, T Diertens, A Coulomb-l'Herminé, J Godzinski, K Pritchard-Jones, N Graf, M M van den Heuvel-Eibrink
Congenital mesoblastic nephroma (CMN) is a rare pediatric renal tumor with low malignant potential that most commonly occurs early in infancy. Treatment strategies are based on the few published CMN series, while a significant number of CMN patients have been described in case reports. The aim of this narrative review was to create an up-to-date overview of the literature. Complete surgical removal is curative in most cases. The risk of treatment-related mortality (both surgery- and chemotherapy-related) is relatively high in the first weeks of life, indicating that these young patients deserve special attention with respect to timing and type of treatment...
July 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27820132/renal-tumors-in-children-younger-than-12-months-of-age-a-65-year-single-institution-review
#10
Margaret G Lamb, Jennifer H Aldrink, Sarah H O'Brien, Han Yin, Michael A Arnold, Mark A Ranalli
Wilms tumor (WT) is the most prevalent pediatric renal tumor and most commonly occurs between ages 1 and 5 years. Data are lacking on children younger than 12 months with renal tumors. The cancer registry at the authors' institution was queried to identify patients 12 months and younger with renal masses. Demographics, clinical presentation, histopathology, stage, and survival outcomes were reviewed. The most common presenting symptoms included an asymptomatic abdominal mass (73%) and hematuria (9%). Histopathology revealed WT in 73% of patients, mesoblastic nephroma in 20%...
March 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27769870/braf-exon-15-mutations-in-pediatric-renal-stromal-tumors-prevalence-in-metanephric-stromal-tumors
#11
Lily Marsden, Lawrence J Jennings, Samantha Gadd, Min Yu, Elizabeth J Perlman, Mariana M Cajaiba
Metanephric stromal tumors are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of metanephric adenofibroma prompted us to investigate the prevalence of these mutations in metanephric stromal tumors and in other pediatric renal stromal tumors. In this study, 17 metanephric stromal tumors, 22 congenital mesoblastic nephromas and 6 ossifying renal tumors of infancy were selected for BRAF exon 15 testing...
October 18, 2016: Human Pathology
https://www.readbyqxmd.com/read/27748279/diagnostic-utility-of-wilms-tumour-1-protein-wt-1-immunostaining-in-paediatric-renal-tumours
#12
Surbhi Goyal, Kiran Mishra, Urvee Sarkar, Satendra Sharma, Anita Kumari
BACKGROUND & OBJECTIVES: Renal tumours constitute about 7 per cent of all neoplasms in children. It is important to differentiate Wilms' tumour (commonest tumour) from non-Wilms' tumours. The aim of this study was to evaluate the immunoexpression and diagnostic role of Wilms' tumour-1 protein (WT1) in paediatric renal tumours. METHODS: A total of 53 cases of renal tumours in children (below 18 yr) who underwent total nephrectomy were included in this retrospective study...
May 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27646897/-congenital-mesoblastic-nephroma-a-clinicopathologic-analysis-of-17-cases
#13
H Wang, Y Y Ma, D W Zhang, B Y Wu, C Fang, L Chen
No abstract text is available yet for this article.
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27484189/the-value-of-mitotic-count-and-ki67-proliferation-index-in-congenital-mesoblastic-nephroma
#14
Evsen Apaydin, Yasemin Ozluk, Secil Yuksel, Basak Erginel, Deniz Tugcu, Alaaddin Celik, Isin Kilicaslan
OBJECTIVE: We aimed to define the histopathologic features and proliferative rate of congenital mesoblastic nephroma (CMN) as a risk factor for recurrence. METHODS: Fourteen cases of CMN among 138 registered pediatric renal tumors were retrospectively reviewed. The prognostic impact for mitotic rate and Ki67 index was investigated. RESULTS: There were four (28.6%) classic, six (42.9%) cellular, and four (28.6%) mixed type CMNs, with average Ki-67 counts of 16...
2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27324404/cytological-diagnosis-of-mesoblastic-nephroma-a-report-of-three-cases-with-summary-of-prior-published-cases
#15
REVIEW
Goutam Bera, Ram Narayan Das, Janki Bisht, Prafulla Kumar Mishra, Mamata Guha Mallick, Chhanda Datta, Manoj Kumar Chaudhuri, Uttara Chatterjee
Congenital mesoblastic nephroma (CMN) is a rare pediatric renal neoplasm, occurring most commonly in the first few months of life, with a favourable clinical outcome. Accurate pre-operative cytological diagnosis of this entity is important as pre-operative chemotherapy is not recommended and surgery is the treatment of choice. Cytodiagnosis of this rare tumor is discussed in only a few case reports. Here two cases of CMN and one case of cellular congenital mesoblastic nephroma (CCMN) diagnosed on FNAC along with their morphological differential diagnoses has been reported...
October 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27046976/uncommon-renal-tumors-in-children-a-single-center-experience
#16
Kartik Chandra Mandal, Madhumita Mukhopadhyay, Shibsankar Barman, Pankaj Halder, Biswanath Mukhopadhyay, Rajarshi Kumar
AIMS: Scrutiny over the clinical behaviors, management, and the final outcome of some rare renal neoplasm in order to find out some hidden facts about these tumors which are playing an important role in the disease course and its management. MATERIALS AND METHODS: Retrospective evaluation of uncommon (non-Wilms') renal neoplasm in the pediatric population in a tertiary care center. Fifteen cases of uncommon renal tumors were treated in our institution over the last 5 years (January 2008 to December 2012)...
April 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27020209/congenital-mesoblastic-nephroma-a-study-of-19-cases-using-immunohistochemistry-and-etv6-ntrk3-fusion-gene-rearrangement
#17
Dina El Demellawy, Caitlin A Cundiff, Ahmed Nasr, John A Ozolek, Nancy Elawabdeh, Shelley A Caltharp, Pourya Masoudian, Katrina J Sullivan, Joseph de Nanassy, Bahig M Shehata
Mesoblastic nephroma (MN) is the most common renal tumour in the first 3 months of life and accounts for 3-5% of all paediatric renal neoplasms. To further understand the morphological variants of MN, we identified 19 cases of MN (five classic, eight cellular and six mixed) and examined each case for markers known to be important in urogenital embryological development (PAX8, WT1 and RCC), stem cell associated markers (Oct 4, CD34 and c-kit), muscle/myofibroblastic markers (muscle specific actin, calponin and h-caldesmon), aberrant transcription factors, cell cycle regulation and other oncogenic proteins (p16, cyclin D1 and beta-catenin)...
January 2016: Pathology
https://www.readbyqxmd.com/read/26811558/mixed-subtype-of-congenital-mesoblastic-nephroma-with-poor-evolution-a-case-report-and-literature-review
#18
Sydney Correia Leão, Diego Marques Fernandes, Bruno Garcia Dias, Wlisses Ramon Oliveira, Simone Maria de Oliveira, Margareth Rose Uchoa Rangel
A male child born at 27 weeks, weighting 1305 g and presenting with a right-sided abdominal tumor. Computed tomography scan demonstrated the presence of a solid mass compressing the right kidney. Puncture biopsy revealed congenital mesoblastic nephroma. The patient underwent total right nephroureterectomy, and died on the second day after surgery.
November 2015: Radiologia Brasileira
https://www.readbyqxmd.com/read/26793537/growing-renal-mass-lessons-learned-on-the-road-from-an-atypical-presentation-to-successful-therapy
#19
Eliza Lamin, Dana A Weiss, Kassa Darge, Fumiko Dekio, Douglas A Canning
A 25 4/7 week boy was born with a prenatal diagnosis of polyhydramnios and enlarged left kidney. Over the next 2 months serial ultrasounds demonstrated abnormal growth of the kidney, with 28.9% split function. At gestational age 39 4/7, he underwent a left radical nephrectomy. Pathology revealed congenital mesoblastic nephroma with mixed classic and cellular features. This case was puzzling due to prenatally diagnosed renal enlargement in a premature infant and inconclusive post-natal ultrasonographic imaging...
September 2015: Urology Case Reports
https://www.readbyqxmd.com/read/26620031/mesoblastic-nephroma-in-a-22-years-old-woman
#20
S A Islam, M S Rahman, S Habib, M A Salam
Mesoblastic nephroma is an uncommon renal tumor of infancy and rarely occurs in adults. We report a case of mesoblastic nephroma in adult. A 22-year-old woman, who presented with left flank pain, was found to have a left renal mass by abdominal ultrasonography. Computed tomography revealed a heterogeneous tumor. Left radical nephrectomy was performed. The tumor was a creamy white solid mass. Microscopically, the tumor was composed of spindle cell proliferation. Atypia and mitoses were not identified. Among the tumor cells, there were tubular arranged epithelial elements...
October 2015: Mymensingh Medical Journal: MMJ
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