Maria Pia Falcone, Kathryn Pritchard-Jones, Jesper Brok, William Mifsud, Richard D Williams, Kayo Nakata, Suzanne Tugnait, Reem Al-Saadi, Lucy Side, John Anderson, Catriona Duncan, Stephen D Marks, Detlef Bockenhauer, Tanzina Chowdhury
BACKGROUND: Wilms tumour (WT) survivors, especially patients with associated syndromes or genitourinary anomalies due to constitutional WT1 pathogenic variant, have increased risk of kidney failure. We describe the long-term kidney function in children with WT and WT1 pathogenic variant to inform the surgical strategy and oncological management of such complex children. METHODS: Retrospective analysis of patients with WT and constitutional WT1 pathogenic variant treated at a single centre between 1993 and 2016, reviewing genotype, phenotype, tumour histology, laterality, treatment, patient survival, and kidney outcome...
April 2022: Pediatric Nephrology