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https://www.readbyqxmd.com/read/28938505/-treatment-targets-in-hypertension
#1
Rainer Düsing
The optimal target blood pressure (BP) in the treatment of hypertensive patients remains controversial. Recently, the systolic blood pressure trial (SPRINT) has proposed that a target systolic blood pressure of < 120 mmHg provides prognostic benefit in elderly hypertensive patients at high cardiovascular risk. The results of SPRINT contrast with several other intervention trials which have investigated the effect of intense BP lowering (Secondary Prevention of Small Subcortical Strokes [SPS3], Action to Control Cardiovascular Risk in Diabetes [ACCORD], Heart Outcomes Prevention Evaluation [HOPE]-3)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938338/mortality-implications-of-lower-dbp-with-lower-achieved-systolic-pressures-in-coronary-artery-disease-long-term-mortality-results-from-the-international-verapamil-trandolapril-study-us-cohort
#2
Anita Wokhlu, Steven M Smith, Yan Gong, Eileen M Handberg, Islam Y Elgendy, Anthony A Bavry, Rhonda M Cooper-DeHoff, Carl J Pepine
OBJECTIVES: A goal SBP 120 mmHg or less reduced mortality in high-risk Systolic Blood Pressure Intervention Trial patients; however, mortality implications of concomitant DBP lowering in coronary artery disease (CAD) are uncertain. We examined the relationship between DBP lowering and all-cause mortality with lower achieved SBPs in a large cohort. METHODS: We categorized 17 131 hypertensive patients from the INternational VErapamil-trandolapril STudy US cohort, aged at least 50 years with CAD, by mean achieved SBP (<120, 120 to <130, 130 to <140, and ≥140 mmHg) and DBP tertiles (low, middle, and high per SBP category) during active follow-up...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#3
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937494/high-pitch-coronary-computed-tomographic-angiography-using-the-third-generation-dual-source-computed-tomography-initial-experience-in-patients-with-high-heart-rate
#4
Ruiqi Feng, Jingsong Mao, Xiaofei Liu, Yu Zhao, Jiajie Tong, Liang Zhang
OBJECTIVE: This study aimed to evaluate the feasibility, image quality, and radiation dose of prospectively high-pitch coronary computed tomographic (CT) angiography in patients with high heart rates (HRs) using the third-generation dual-source CT. METHODS: One hundred consecutive patients with sinus rhythm and HR between 70 and 100 beats per minute were enrolled into this study. All patients were divided into 2 groups. Patients in group A (n = 46) were examined with prospectively high-pitch scan mode in which image acquisition was triggered at 30% of the R-R interval...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937287/the-prevalence-and-predictors-of-hypertension-in-a-national-survey-of-australian-children
#5
Nicholas G Larkins, Armando Teixeira-Pinto, Jonathan C Craig
PURPOSE: To determine the prevalence of hypertension and predictors of blood pressure (BP) in a population based survey of Australian children. SUBJECTS AND METHODS: We analysed cross-sectional data for 2071 children, aged 5-17 years, from the Australian Health Survey 2011-13. Hypertension and high-normal BP were defined by a systolic or diastolic BP greater than the 95th and 90th centiles respectively, using the National High Blood Pressure Education Program fourth report reference data...
September 22, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28937256/evaluation-of-left-and-right-ventricular-systolic-and-diastolic-electromechanical-synchrony-in-older-people-a-population-based-observational-study
#6
R Laszlo, H Konz, K Kunz, D Dallmeier, J Klenk, M Denkinger, W Koenig, D Rothenbacher, J M Steinacker
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Um study including a random sample of people >/= 65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937241/preejection-period-as-a-sympathetic-activity-index-a-role-of-confounding-factors
#7
J Krohova, B Czippelova, Z Turianikova, Z Lazarova, I Tonhajzerova, M Javorka
In previous studies, one of the systolic time intervals - preejection period (PEP) - was used as an index of sympathetic activity reflecting the cardiac contractility. However, PEP could be also influenced by several other cardiovascular variables including preload, afterload and diastolic blood pressure (DBP). The aim of this study was to assess the behavior of the PEP together with other potentially confounding cardiovascular system characteristics in healthy humans during mental and orthostatic stress (head-up tilt test - HUT)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937061/long-term-evaluation-of-kidney-function-in-live-related-kidney-donors
#8
Kalpana S Mehta, Rudramani Swami, Atim Pajai, Sandip Bhurke, Abhishek Shirkande, Sunil Jawle
The consequences of live kidney donation on the donor health with main emphasis on postdonation blood pressure (BP), proteinuria, kidney size, and glomerular filtration rate (GFR) were evaluated. Twenty-five donors with minimum of six months postdonation duration were included in the study. Donor age at nephrectomy, duration postnephrectomy, systolic and diastolic BP measurement pre-and post-donation, postdonation, blood urea nitrogen, serum creatinine and 24-h proteinuria, blood sugar, two-dimensional echocardiogram were recorded...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937038/factors-related-to-ventricular-size-and-valvular-regurgitation-in-healthy-tibetans-in-lhasa
#9
Ying Yang, Yun-Dai Chen, Bin Feng, Zha-Xi-Duo Ji, Wei Mao, Guang Zhi
BACKGROUND: Lhasa is the main residence of Tibetans and one of the highest cities in the world. Its unique geography and ethnic population provide the chance to investigate the interactions among high altitude, ethnicity, and cardiac adaptation. Meanwhile, echocardiographic data about healthy Tibetans on a large scale are not available. This study aimed to analyze physiological factors related to ventricular size and valvular function in healthy Tibetans in Lhasa. METHODS: A representative sample of residents in Tibet was recruited using a multistage cluster random sampling method...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936737/peripartum-cardiomyopathy-do-exosomes-play-a-role
#10
Huanyu Gu, Qiying Dai, Zhuyuan Liu, Hongbao Wang, Jianhua Yao, Lei Zhou
Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been climbing up. Because of its high mortality, it is crucial for physicians to have high suspicious for the disease. Studies have been done to search into specific lab test and treatment for PPCM. Therapies like anti-viral, anti-inflammatory and immunosuppression regimen have been explored...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936576/improvement-of-continuous-subcutaneous-insulin-infusion-on-patients-with-type-2-diabetes-mellitus-by-3-dimensional-speckle-tracking-echocardiography
#11
Hong-Xia Luo, Xiao-Ling Zhou, Hong-Ju Kou, Xian-Wei Ni, Qing Wu, Chun-Peng Zou, Dao-Zhu Wu, Yong-Fang Liu
Three-dimensional speckle tracking echocardiography (3D-STE) was used to evaluate the improvement of continuous subcutaneous insulin infusion on the left ventricular (LV) systolic function of patients with type 2 diabetes mellitu (T2DM). We recruited T2DM patients (38 cases, diabetic group) and healthy volunteers (35 cases, control group) to collect LV full volume imaging. TomTec software was used for calculating LV global longitudinal strain (LVGLS), global circumferential strain (LVGCS), peak twist (LVTW), peak apical rotation (LVPAR), ejection fraction (LVEF), and torsion (LVT)...
September 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28936268/mildly-elevated-serum-total-bilirubin-is-negatively-associated-with-hemoglobin-a1c-independently-of-confounding-factors-among-community-dwelling-middle-aged-and-elderly-persons
#12
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
Abnormally high glycated hemoglobin (Hb) (HbA1c) is significantly associated with oxidative stress and an increased risk of cardiovascular disease (CVD). Serum total bilirubin (T-B) may have a beneficial role in preventing oxidative changes and be a negative risk factor of CVD. Limited information is available on whether serum T-B is an independent confounding factor of HbA1c. The study subjects were 633 men aged 70 ± 9 (mean ± standard deviation (SD)) years and 878 women aged 70 ± 8 years who were enrolled consecutively from among patients aged ≥40 years through a community-based annual check-up process...
January 2017: J Circ Biomark
https://www.readbyqxmd.com/read/28935953/very-low-density-lipoprotein-of-metabolic-syndrome-modulates-gap-junctions-and-slows-cardiac-conduction
#13
Hsiang-Chun Lee, Chih-Chieh Chen, Wei-Chung Tsai, Hsin-Ting Lin, Yi-Lin Shiao, Sheng-Hsiung Sheu, Bin-Nan Wu, Chu-Huang Chen, Wen-Ter Lai
Very-low-density lipoproteins (VLDL) is a hallmark of metabolic syndrome (MetS) and each manifestation of MetS is related to atrial fibrillation (AF) risks. Slowed atrial conduction is a mechanism of AF in MetS. We hypothesized that VLDL can modulate and reduce atrial gap junctions. VLDLs were separated from normal (Normal-VLDL) and MetS (MetS-VLDL) individuals. VLDLs (15 µg/g) and equivalent volumes of saline (CTL) were injected respectively to C57BL/6 mice for 6 weeks. Electrocardiograms demonstrated that MetS-VLDL induced prolongation of P wave (P = 0...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#14
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28935634/assessment-of-left-ventricular-function-and-peripheral-vascular-arterial-stiffness-in-patients-with-dipper-and-non-dipper-hypertension
#15
Yan Chen, Ju-Hua Liu, Zhe Zhen, Yuan Zuo, Qingshan Lin, Mingya Liu, Chunting Zhao, Min Wu, Gaozhen Cao, Run Wang, Hung-Fat Tse, Kai-Hang Yiu
A non-dipper pattern of high blood pressure is associated with increased risk of organ damage and cardiovascular disease in patients with hypertension. The aim of the study was to evaluate the left ventricular (LV) remodeling and function and arterial stiffness in a dipper/non-dipper pattern of high blood pressure in patients with hypertension. A total of 183 hypertensive patients with no history of adverse cardiovascular events were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 66 patients with a dipper pattern and 117 patients with non-dipper pattern...
September 20, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28935474/superselective-embolization-for-arterial-upper-gastrointestinal-bleeding-using-n-butyl-cyanoacrylate-a-single-center-experience-in-152-patients
#16
Saebeom Hur, Hwan Jun Jae, Hyukjoon Lee, Myungsu Lee, Hyo-Cheol Kim, Jin Wook Chung
PURPOSE: To evaluate 30-day safety and efficacy of superselective embolization for arterial upper gastrointestinal bleeding (UGIB) using N-butyl cyanoacrylate (NBCA). MATERIALS AND METHODS: This single-center retrospective 10-year study included 152 consecutive patients with UGIB (gastric, n = 74; duodenal, n = 78) who underwent embolization with NBCA for angiographically positive arterial bleeding. The primary endpoint was clinical success rate defined as achievement of hemostasis without rebleeding or UGIB-related mortality within 30 days after embolization...
September 19, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28935461/short-and-long-term-outcome-in-very-old-patients-with-st-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#17
Roberta Sappa, Maria Teresa Grillo, Martino Cinquetti, Giulio Prati, Leonardo Spedicato, Gaetano Nucifora, Andrea Perkan, Davide Zanuttini, Gianfranco Sinagra, Alessandro Proclemer
BACKGROUND: Although octogenarians constitute a fast-growing portion of cardiovascular patients, few data are available on the outcome of patients aged ≥85 years with ST-Elevation Myocardial Infarction (STEMI). METHODS AND RESULTS: We analyzed 126 consecutive patients aged ≥85 years (age 88±2 years) with STEMI, undergoing primary percutaneous coronary intervention (pPCI) within 12 hours from symptoms onset. Long-term follow-up (median 898 days) was obtained for the 102 patients surviving the index-hospitalization...
September 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935460/myocardial-fibrosis-detected-by-magnetic-resonance-in-systemic-sclerosis-patients-relationship-with-biochemical-and-echocardiography-parameters
#18
Milan Hromádka, Jitka Seidlerová, David Suchý, Daniel Rajdl, Jan Lhotský, Jaroslav Ludvík, Richard Rokyta, Jan Baxa
OBJECTIVES: Systemic scleroderma (SSc) is a rare connective tissue disease presenting with fibrosis affecting skin and internal organs. Cardiovascular magnetic resonance (CMR) with quantification of extracellular volume (ECV) and T1 mapping might help to detect heart involvement. We aimed to evaluate whether myocardial involvement correlates with functional and laboratory parameters. METHODS: Thirty-three asymptomatic SSc patients (29 women, aged 56.6±12.2years) and 20 controls (10 women, 53...
September 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935145/determinants-of-obstructive-sleep-apnea-syndrome-pro-inflammatory-state-and-dysfunction-of-high-density-lipoprotein
#19
Yusuf Karadeniz, Altan Onat, Tuğba Akbaş, Barış Şimşek, Hüsniye Yüksel, Günay Can
OBJECTIVE: The goal of this study was to determine variables preceding and predicting incident obstructive sleep apnea syndrome (OSAS) in the population at large. METHODS: Anthropometric, lipid, and non-lipid variables in participants with newly developing OSAS (n = 131) were compared with those of a cohort sample (n = 2615) of the Turkish Adult Risk Factor study. Available values preceding (by a median of 32 mo) the development of OSAS were used in multivariable Cox regression models...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28935038/bone-marrow-derived-tenascin-c-attenuates-cardiac-hypertrophy-by-controlling-inflammation
#20
Lei Song, Lai Wang, Fuqiang Li, Ada Yukht, Minghui Qin, Haley Ruther, Mingjie Yang, Aurelio Chaux, Prediman K Shah, Behrooz G Sharifi
BACKGROUND: Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern during development and disease. Remodeling of the left ventricle (LV) in response to pressure overload leads to the re-expression of the fetal gene program. OBJECTIVES: The aim of this study was to investigate the function of TNC in cardiac hypertrophy in response to pressure overload. METHODS: Pressure overload was induced in TNC knockout and wild-type mice by constricting their abdominal aorta or by infusion of angiotensin II...
September 26, 2017: Journal of the American College of Cardiology
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