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https://www.readbyqxmd.com/read/29932633/intracellular-ros-induction-by-ag-zno-core-shell-nanoparticles-frontiers-of-permanent-optically-active-holes-in-breast-cancer-theranostic
#1
Behnaz Ghaemi, Elnaz Shaabani, Roqya Najafi Taher, Saeedeh Jafari Nodooshan, Amin Sadeghpour, Sharmin Kharrazi, Amir Amani
In this study, we investigated whether ZnO coating on Ag nanoparticles tunes electron flux and hole figuration at Metal-semiconductor interface under UV radiation. This effect triggers photo activity and generation of reactive oxygen species (ROS) from Ag@ZnO nanoparticles which results in enhanced cytotoxic effects and apoptotic cell death in human breast cancer cells (MDA-MB231). In this context, up-regulation of apoptotic cascade proteins (i.e. Bax/Bcl2 association, p53, Cytochrome C and caspase-3) along with activation of oxidative stress proteins suggested occurrence of apoptosis by Ag@ZnO NPs in cancer cells through mitochondrial pathway...
June 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29931560/comparison-of-synthetic-and-digital-mammography-with-digital-breast-tomosynthesis-or-alone-for-the-detection-and-classification-of-microcalcifications
#2
Ji Soo Choi, Boo-Kyung Han, Eun Young Ko, Ga Ram Kim, Eun Sook Ko, Ko Woon Park
OBJECTIVE: To compare the performance of synthetic mammography (SM) and digital mammography (DM) with digital breast tomosynthesis (DBT) or alone for the evaluation of microcalcifications. METHODS: This retrospective study includes 198 mammography cases, all with DM, SM, and DBT images, from January to October 2013. Three radiologists interpreted images and recorded the presence of microcalcifications and their conspicuity scores and final BI-RADS categories (1, 2, 3, 4a, 4b, 4c, 5)...
June 21, 2018: European Radiology
https://www.readbyqxmd.com/read/29931432/detection-of-sentinel-lymph-nodes-with-near-infrared-imaging-in-malignancies
#3
REVIEW
Huan-Cheng Zeng, Jia-Lin Hu, Jing-Wen Bai, Guo-Jun Zhang
Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the detection rate and accuracy. ICG has the advantages of low scattering in tissue absorbance, low auto-fluorescence, and high signal-to-background ratio...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29931431/imaging-cobalamin-uptake-within-malignant-breast-tumors-in-vivo
#4
Douglas A Collins
PURPOSE: To image the uptake of cobalamin (Cbl) within malignant breast tumors in vivo. PROCEDURES: Prior to surgery 20 female patients with clinically suspected breast tumors were intravenously administered 0.25 μg of an In-111 labeled 5-deoxyadenosylcobalamin (AC) analog ([111 In]AC) and sequentially imaged with whole-body planar (WBP) and single-photon emission computed tomography (SPECT) between 2-5 h and 20-24 h post-injection (P.I.). The tumor to background (T/B) ratio for [111 In]AC in breast tumors at 2-5 h was correlated to its expression of estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) receptors...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29930214/-a-case-of-primary-extradural-meningioma-located-at-the-high-convexity-a-case-report-and-review-of-the-literature
#5
Yohtaro Sakakibara, Yoshio Taguchi, Homare Nakamura, Hidetaka Onodera, Daisuke Wakui, Tetsuya Ikeda, Yoshio Aida
OBJECTIVES: Primary meningiomas arising outside the intracranial component are rather rare and have been termed primary extradural meningiomas(PEMs). We present a case of an intraosseous-type PEM occurring at a high convexity location and discuss the clinical characteristics of PEMs. CASE: An 80-year-old woman presented with a soft and painless subcutaneous mass of approximately 10 cm in diameter in the right parietal region, which had appeared 1 year previously...
June 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29930202/a-ca-2-stimulated-exosome-release-pathway-in-cancer-cells-is-regulated-by-munc13-4
#6
Scott W Messenger, Sang Su Woo, Zhongze Sun, Thomas F J Martin
Cancer cells secrete copious amounts of exosomes, and elevated intracellular Ca2+ is critical for tumor progression and metastasis, but the underlying cellular mechanisms are unknown. Munc13-4 is a Ca2+ -dependent SNAP receptor- and Rab-binding protein required for Ca2+ -dependent membrane fusion. Here we show that acute elevation of Ca2+ in cancer cells stimulated a fivefold increase in CD63+ , CD9+ , and ALIX+ exosome release that was eliminated by Munc13-4 knockdown and not restored by Ca2+ binding-deficient Munc13-4 mutants...
June 21, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29929997/hereditary-lobular-breast-cancer-with-an-emphasis-on-e-cadherin-genetic-defect
#7
Giovanni Corso, Joana Figueiredo, Carlo La Vecchia, Paolo Veronesi, Gabriella Pravettoni, Debora Macis, Rachid Karam, Roberto Lo Gullo, Elena Provenzano, Antonio Toesca, Ketti Mazzocco, Fátima Carneiro, Raquel Seruca, Soraia Melo, Fernando Schmitt, Franco Roviello, Alessandra Margherita De Scalzi, Mattia Intra, Irene Feroce, Elisa De Camilli, Maria Grazia Villardita, Chiara Trentin, Francesca De Lorenzi, Bernardo Bonanni, Viviana Galimberti
Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer (LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A multidisciplinary workgroup discussed genetic susceptibility, pathophysiology and clinical management of hereditary LBC (HLBC). The team has established the clinical criteria for CDH1 screening and results' interpretation, and created consensus guidelines regarding genetic counselling, breast surveillance and imaging techniques, clinicopathological findings, psychological and decisional support, as well as prophylactic surgery and plastic reconstruction...
June 21, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29927832/comparison-of-immediate-versus-delayed-deep-inferior-epigastric-artery-perforator-diep-flap-reconstruction-in-women-who-require-post-mastectomy-radiotherapy
#8
Rachel L O'Connell, Rosa Di Micco, Komel Khabra, Anna M Kirby, Paul A Harris, Stuart E James, Kieran Power, Kelvin Wd Ramsey, Jennifer E Rusby
INTRODUCTION: The aim of this study was to investigate aesthetic outcome and patient satisfaction in women who have undergone DIEP reconstruction in the setting of PMRT. Patients who underwent DIEP reconstruction without PMRT were the control group. METHODS: Participants who had undergone DIEP between 9/1/2009-9/1/2014 were recruited, answered the BREAST-Q and underwent 3D surface-imaging. A panel assessed the aesthetic outcome by reviewing these images. RESULTS: 167 women participated...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927636/breast-compression-across-consecutive-examinations-among-women-participating-in-breast-screen-norway
#9
Gunvor G Waade, Sofie Sebuødegård, Peter Hogg, Solveig Hofvind
OBJECTIVE: Breast compression is used in mammography to improve image quality and reduce radiation dose. However, optimal values for compression force are not known, and studies has found large variation in use of compression forces between breast centres and radiographers. We investigated breast compression, including compression force, compression pressure and compressed breast thickness across four consecutive full field digital mammography (FFDM) screening examinations for 25,143 subsequently screened women aged 50-69 years...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29927337/systematic-review-of-agreement-between-tomosynthesis-and-pathologic-tumor-size-for-newly-diagnosed-breast-cancer-and-comparison-with-other-imaging-tests
#10
M Luke Marinovich, Petra Macaskill, Daniela Bernardi, Nehmat Houssami
Introduction Tomosynthesis is proposed to improve breast cancer assessment and staging as a complementary role to its detection capability. We examine the accuracy of tomosynthesis in measuring tumor size relative to pathology and compared with other tests. Areas covered A systematic literature search identified studies of tomosynthesis in estimating the size of newly-diagnosed breast cancers. Descriptive analyses were performed due to heterogeneity in patients, technology and methods between studies. Eight studies were eligible (678 patients)...
June 21, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29926793/recommendations-on-prevention-and-screening-for-breast-cancer-in-hong-kong
#11
T H Lam, K H Wong, K Kl Chan, M Cm Chan, D Vk Chao, A Ny Cheung, C Ym Fan, J Ho, E P Hui, K O Lam, C K Law, W L Law, H Hf Loong, R Kc Ngan, T Hf Tsang, M Cs Wong, R Mw Yeung, A Ch Ying, R Ching
In Hong Kong, breast cancer is the most common cancer among women and poses a significant health care burden. The Cancer Expert Working Group on Cancer Prevention and Screening (CEWG) was set up in 2002 by the Cancer Coordinating Committee to review and assess local and international scientific evidence, and to formulate recommendations for cancer prevention and screening. After considering the local epidemiology, emerging scientific evidence, and local and overseas screening practices, the CEWG concluded that it was unclear whether population-based breast cancer screening did more harm than good in local asymptomatic women at average risk...
June 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29926160/the-clinical-usefulness-of-optical-coherence-tomography-during-cancer-interventions
#12
REVIEW
Labrinus van Manen, Jouke Dijkstra, Claude Boccara, Emilie Benoit, Alexander L Vahrmeijer, Michalina J Gora, J Sven D Mieog
INTRODUCTION: Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features, quantitative features and the diagnostic value of OCT...
June 20, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29926133/the-originating-pattern-of-deep-inferior-epigastric-artery-anatomical-study-and-surgical-considerations
#13
Yujin Myung, Bomi Choi, Sang Jun Yim, Bo La Yun, Heeyeon Kwon, Chang Sik Pak, Chanyeong Heo, Jae Hoon Jeong
PURPOSE: Studies focusing on the originating patterns of the deep inferior epigastric artery (DIEA) have not been conducted. Here, we analyzed the vascular anatomy of the DIEA with computed tomographic angiography (CTA) to provide assistance during proximal pedicle dissection of a DIEA-based flap. METHODS: We conducted a retrospective study on patients who had undergone breast reconstruction with the transverse rectus abdominis musculocutaneous flap and the deep inferior epigastric perforator flap from March 2006 to October 2016...
June 20, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29924486/monitoring-the-effects-of-pharmacological-reagents-on-mitochondrial-morphology
#14
Dong Fu, Jennifer Lippincott-Schwartz
This protocol describes how to apply appropriate pharmacological controls to induce mitochondrial fusion or fission in studies of mitochondria morphology for four different mammalian cell types, HepG2 human liver hepatocellular carcinoma cells, MCF7 human breast adenocarcinoma cells, HEK293 human embryonic kidney cells, and collagen sandwich culture of primary rat hepatocytes. The protocol provides methods of treating cells with these pharmacological controls, staining mitochondria with commercially available MitoTracker Green and TMRE dyes, and imaging the mitochondrial morphology in live cells using a confocal fluorescent microscope...
June 2018: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/29923998/clinical-study-on-postoperative-triple-negative-breast-cancer-with-chinese-medicine-study-protocol-for-an-observational-cohort-trial
#15
Jiajing Chen, Yuenong Qin, Chenping Sun, Wei Hao, Shuai Zhang, Yi Wang, Juan Chen, Lixin Chen, Yiying Ruan, Sheng Liu
BACKGROUND: Breast cancer (BC) poses a tremendous threat to the health of women worldwide, especially triple-negative breast cancers (TNBCs). Currently, the curative effect of traditional Chinese medicine (TCM) has been recognized in more and more people worldwide; however, the specific effect has not been systematically evaluated. The purpose of this cohort study is to evaluate the clinical effects of TCM syndrome differentiation on recurrence and metastasis rate, survival rate, and the quality of life in patients with TNBC...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923634/radioimmunoimaging-and-targeting-treatment-in-an-immunocompetent-murine-model-of-triple-negative-breast-cancer-using-radiolabeled-anti-pd-l1-monoclonal-antibody
#16
Xiaoxi Pang, Meng Liu, Rongfu Wang, Xuhe Liao, Ping Yan, Chunli Zhang
The overall aim of this study was to evaluate whether iodine-131 radiolabeled monoclonal antibody (mAb) targeting PD-L1 can be used for imaging of PD-L1 expression noninvasively in vivo, and playing synergistic effect combined with immunotherapy. Anti-PD-L1 mAb was radiolabeled with iodine-131 (131 I-PD-L1 mAb), and was characterized in vitro. Biodistribution and imaging in vivo were performed periodically. Therapy study was conducted in triple-negative breast cancer bearing BALB/c mice. As results, the labeling efficiencies of 131 I-PD-L1 mAb reached 80 % ± 3 %, with radiochemical purity was 97 % ± 1 %...
June 20, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29923514/whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-18-f-fdg-pet-ct-for-staging-locally-advanced-breast-cancer-a-prospective-study-from-a-tertiary-cancer-centre-in-south-india
#17
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29922090/extramedullary-hematopoiesis-secondary-to-malignant-solid-tumors-a-case-report-and-literature-review
#18
Youting Bao, Zhichao Liu, Meiying Guo, Butuo Li, Xindong Sun, Linlin Wang
Extramedullary hematopoiesis (EMH) usually occurs in hematological disease, but more rarely develops in cases of malignant solid tumors. Due to its features on computed tomography (CT) and magnetic resonance imaging (MRI) that are atypical, EMH in tumor patients might easily be misdiagnosed as metastasis leading to the improper TNM staging and inappropriate therapy. Here, we reported the first case of pleural EMH occurring in a patient with esophageal carcinoma whose pleural lesion was first diagnosed as metastasis and confirmed EMH after the needle biopsy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29921960/plasmonic-optical-imaging-of-gold-nanorods-localization-in-small-animals
#19
Keying Xu, Junwei Shi, Ali Pourmand, Thirupandiyur S Udayakumar, Nesrin Dogan, Weizhao Zhao, Alan Pollack, Yidong Yang
Gold nanoparticles (GNP) have been intensively investigated for applications in cancer imaging and therapy. Most imaging studies focused on microscopic imaging. Their potential as optical imaging probes for whole body small animal imaging has rarely been explored. Taking advantage of their surface plasmon resonance (SPR) properties, we aim to develop a noninvasive diffuse optical imaging method to map the distribution of a special type of GNP, gold nanorods (GNR), in small animals. We developed an integrated dual-modality imaging system capable of both x-ray computed tomography (XCT) and diffuse optical tomography (DOT)...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921747/diagnostic-performance-of-contrast-enhanced-ultrasound-and-enhanced-magnetic-resonance-for-breast-nodules
#20
Cui-Ying Li, Hai-Yan Gong, Li-Jun Ling, Li-Wen Du, Tong Su, Shui Wang, Jie Wang
In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve...
June 1, 2018: Journal of Biomedical Research
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