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https://www.readbyqxmd.com/read/28208654/a-protein-isolate-from-moringa-oleifera-leaves-has-hypoglycemic-and-antioxidant-effects-in-alloxan-induced-diabetic-mice
#1
Paulo C Paula, Daniele O B Sousa, Jose T A Oliveira, Ana F U Carvalho, Bella G T Alves, Mirella L Pereira, Davi F Farias, Martonio P Viana, Flavia A Santos, Talita C Morais, Ilka M Vasconcelos
Moringa oleifera has been used in traditional medicine to treat diabetes. However, few studies have been conducted to relate its antidiabetic properties to proteins. In this study, a leaf protein isolate was obtained from M. oleifera leaves, named Mo-LPI, and the hypoglycemic and antioxidant effects on alloxan-induced diabetic mice were assessed. Mo-LPI was obtained by aqueous extraction, ammonium sulphate precipitation and dialysis. The electrophoresis profile and proteolytic hydrolysis confirmed its protein nature...
February 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28174261/identification-of-unique-antigenic-determinants-in-the-amino-terminus-of-ia-2-ica512-in-childhood-and-adult-autoimmune-diabetes-new-biomarker-development
#2
Maria Acevedo-Calado, Eddie A James, Michael P Morran, Susan L Pietropaolo, Qin Ouyang, David Arribas-Layton, Marco Songini, Marco Liguori, Anna Casu, Richard J Auchus, Shuai Huang, Liping Yu, Aaron Michels, Roberto Gianani, Massimo Pietropaolo
OBJECTIVE: The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new antigenic determinants in the neuroendocrine autoantigen IA-2 (ICA512) and assess whether circulating autoantibodies directed to new IA-2 epitopes identify autoimmune diabetes in young and adult populations with diabetes. RESEARCH DESIGN AND METHODS: Clinically diagnosed patients with type 2 diabetes (n = 258; diabetes duration: 0...
February 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28159227/alterations-of-serum-trace-elements-in-patients-with-type-2-diabetes
#3
Hongmei Zhang, Chonghuai Yan, Zhen Yang, Weiwei Zhang, Yixin Niu, Xiaoyong Li, Li Qin, Qing Su
OBJECTIVE: The aim of the present study is to investigate the association of trace elements and the risk of type 2 diabetes mellitus. DESIGN AND METHODS: The 1837 participants (637 men and 1200 women) aged 40-70 were from a cross-sectional community-based study performed in downtown Shanghai. All the participants without diabetes mellitus history underwent a 75-g OGTT. The participants with diabetes mellitus took 100g steamed bread as the substitute. The fasting and OGTT 2h or postprandial 2h venous blood samples were collected...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28159221/trace-elements-in-early-phase-type-2-diabetes-mellitus-a-population-based-study-the-hunt-study-in-norway
#4
Ailin Falkmo Hansen, Anica Simić, Bjørn Olav Åsvold, Pål Richard Romundstad, Kristian Midthjell, Tore Syversen, Trond Peder Flaten
Differences in trace elements levels between individuals with type 2 diabetes and controls have been reported in several studies in various body fluids and tissues, but results have been inconsistent. In order to examine trace element levels in the early phase of type 2 diabetes, we investigated the association between whole blood levels of 26 trace elements and the prevalence of previously undiagnosed, screening-detected type 2 diabetes. The study was conducted as a case-control study nested within the third survey of the population-based Nord-Trøndelag Health Study (HUNT3 Survey)...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28155628/matrix-gelatinases-in-atherosclerosis-and-diabetic-nephropathy-progress-and-challenges
#5
Grigorios G Dimas, Triantafyllos P Didangelos, Dimitrios M Grekas
Matrix metalloproteinases (MMPs) are zinc-dependent proteases that degrade components of the extracellular matrix (ECM). In glomerular disease, MMPs are major regulators of ECM degradation as well as structural and functional integrity in the glomerulus. In altered matrix composition diseases, glomerular damage is due to increased degradation of kidney and vessel basement membranes (BMs) by MMPs. MMP -2 and -9 are both considered as the main enzymes that degrade collagen type-IV (coll-IV), which represents the key collagenous component of ECM and constitutes the architectural structure of vessels and glomerular BM...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28138861/zinc-s-role-in-the-glycemic-control-of-patients-with-type-2-diabetes-a-systematic-review
#6
REVIEW
Gabrielli Barbosa de Carvalho, Paula Nascimento Brandão-Lima, Carla Soraya Costa Maia, Kiriaque Barra Ferreira Barbosa, Liliane Viana Pires
Past research has shown the importance of zinc in several metabolic processes, such as the glucidic metabolism. The present systematic review aims to discuss zinc's participation in the glycemic control of type 2 diabetes mellitus (DM2) patients. In order to accomplish that, a systematic search was performed in the Pubmed database using the following indexed and theme-related descriptors: "zinc" AND "type 2 diabetes mellitus", AND MeSH terms related to glycemic control combined with the boolean operator OR...
January 30, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28132967/kidney-cadmium-toxicity-diabetes-and-high-blood-pressure-the-perfect-storm
#7
Soisungwan Satarug, David A Vesey, Glenda C Gobe
Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively reabsorb Cd along with zinc, glucose and amino acids in the glomerular filtrate. Severe kidney damage, glycosuria and proteinuria are known outcomes after high dietary Cd intake (> 200 µg/day)...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28130446/coupling-of-insulin-secretion-and-display-of-a-granule-resident-zinc-transporter-znt8-on-the-surface-of-pancreatic-beta-cells
#8
Qiong Huang, Chengfeng Merriman, Hao Zhang, Dax Fu
The islet-specific zinc transporter ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell. This granular zinc transporter is also a major self-antigen found in type-1 diabetes (T1D) patients. It is not clear whether ZnT8 can be displayed on the cell surface and how insulin secretion may regulate the level of ZnT8 exposure to extracellular immune surveillance. Here we report specific antibody binding to the extracellular surface of rat insulinoma INS-1E cells that stably expressed a tagged human zinc transporter ZnT8...
January 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28120719/zinc-and-gastrointestinal-disorders-a-role-for-the-zinc-transporters-zips-and-znts
#9
Stephen Myers, Madhur D Shastri, John Adulcikas, Sukhwinder Singh Sohal, Shaghayegh Norouzi
BACKGROUND: Zinc is a critical metal ion essential for life. The biological significance of zinc is highlighted by the enormous number of proteins (approximately 10% of the human proteome) that have zinc-binding capacity. Accordingly, zinc concentrations in cells are tightly regulated by two families of zinc transporter proteins: Slc30a (ZnT) and Slc39a (Zip). ZnT and Zip are known to decrease and increase cytosolic zinc concentrations respectively. Both zinc transporters are suggested to be implicated in a number of disorders and disease states through dysfunctional zinc transport including cancer, diabetes and gastrointestinal (GI) disease...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28106816/nutrient-patterns-associated-with-fasting-glucose-and-glycated-haemoglobin-levels-in-a-black-south-african-population
#10
Tinashe Chikowore, Pedro T Pisa, Tertia van Zyl, Edith J M Feskens, Edelweiss Wentzel-Viljoen, Karin R Conradie
Type 2 diabetes (T2D) burden is increasing globally. However, evidence regarding nutrient patterns associated with the biomarkers of T2D is limited. This study set out to determine the nutrient patterns associated with fasting glucose and glycated haemoglobin the biomarkers of T2D. Factor analysis was used to derive nutrient patterns of 2010 participants stratified by urban/rural status and gender. Principal Component Analysis (PCA) was applied to 25 nutrients, computed from the quantified food frequency questionnaires (QFFQ)...
January 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28071754/far-infrared-protects-vascular-endothelial-cells-from-advanced-glycation-end-products-induced-injury-via-plzf-mediated-autophagy-in-diabetic-mice
#11
Cheng-Hsien Chen, Tso-Hsiao Chen, Mei-Yi Wu, Tz-Chong Chou, Jia-Rung Chen, Meng-Jun Wei, San-Liang Lee, Li-Yu Hong, Cai-Mei Zheng, I-Jen Chiu, Yuh-Feng Lin, Ching-Min Hsu, Yung-Ho Hsu
The accumulation of advanced glycation end products (AGEs) in diabetic patients induces vascular endothelial injury. Promyelocytic leukemia zinc finger protein (PLZF) is a transcription factor that can be activated by low-temperature far-infrared (FIR) irradiation to exert beneficial effects on the vascular endothelium. In the present study, we investigated the influence of FIR-induced PLZF activation on AGE-induced endothelial injury both in vitro and in vivo. FIR irradiation inhibited AGE-induced apoptosis in human umbilical vein endothelial cells (HUVECs)...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070499/metabolic-relationship-between-diabetes-and-alzheimer-s-disease-affected-by-cyclo-his-pro-plus-zinc-treatment
#12
REVIEW
Moon K Song, David S Bischoff, Albert M Song, Koichi Uyemura, Dean T Yamaguchi
BACKGROUND: Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice. SCOPE OF REVIEW: Metabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aβ degradation in brain and plasma tissues...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28070325/comparative-study-on-proximate-functional-mineral-and-antinutrient-composition-of-fermented-defatted-and-protein-isolate-of-parkia-biglobosa-seed
#13
Bolajoko I Ogunyinka, Babatunji E Oyinloye, Foluso O Osunsanmi, Abidemi P Kappo, Andrew R Opoku
The use of plant-derived foods in the prevention, treatment, and management of metabolic diseases especially diabetes has gained prominence; this has been associated with their physicochemical properties. This study was conducted to compare the proximate, functional, mineral, and antinutrient composition of the fermented seeds, the defatted seeds, and the protein isolate from Parkia biglobosa seeds. The results showed that the fermented, defatted, and protein isolate varied in composition within the parameters studied...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28059470/levels-of-heavy-metals-and-their-binding-protein-metallothionein-in-type-2-diabetics-with-kidney-disease
#14
Martina Raudenska, Veronika Dvorakova, Lukas Pacal, Katarina Chalasova, Monika Kratochvilova, Jaromir Gumulec, Branislav Ruttkay-Nedecky, Ondrej Zitka, Katerina Kankova, Vojtech Adam, Michal Masarik
Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin...
January 6, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28057574/a-proteomic-approach-to-identify-metalloproteins-and-metal-binding-proteins-in-liver-from-diabetic-rats
#15
Camila Pereira Braga, José Cavalcante Souza Vieira, Ryan A Grove, Cory H T Boone, Aline de Lima Leite, Marília Afonso Rabelo Buzalaf, Ana Angélica Henrique Fernandes, Jiri Adamec, Pedro de Magalhaes Padilha
Proteins play crucial roles in biological systems, thus studies comparing the protein pattern present in a healthy sample with an affected sample have been widely used for disease biomarker discovery. Although proteins containing metal ions constitute only a small proportion of the proteome, they are essential in a multitude of structural and functional processes. The correct association between metal ions and proteins is essential because this binding can significantly interfere with normal protein function...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28045430/administration-of-zinc-plus-cyclo-his-pro-increases-hippocampal-neurogenesis-in-rats-during-the-early-phase-of-streptozotocin-induced-diabetes
#16
Bo Young Choi, In Yeol Kim, Jin Hee Kim, Bo Eun Lee, Song Hee Lee, A Ra Kho, Min Sohn, Sang Won Suh
The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administered by gavage once daily for one or six weeks from the third day after the STZ injection, and histological evaluation was performed at 10 (early phase) or 45 (late phase) days after STZ injection...
January 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28032423/comparison-of-the-impact-of-human-vs-analogue-insulins-on-glycosylated-haemoglobin-in-a-population-with-diabetes-mellitus
#17
Jorge Enrique Machado-Alba, Diego Alejandro Medina-Morales
AIMS: To compare the effect on metabolic control of treatment with conventional and analogue insulins for patients with diabetes mellitus. METHODS: Retrospective cohort study held in cities of Colombia (Pereira and Manizales). People insured by the paid healthcare system, who were diagnosed with diabetes mellitus type 1 and 2, and treated with conventional and analogue insulin for at least 6 months prior to the start of the study were sampled and followed up for 18 months...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27998308/semilobar-holoprosencephaly-in-a-12-month-old-baby-boy-born-to-a-primigravida-patient-with-type-1-diabetes-mellitus-a-case-report
#18
Pedro Pallangyo, Frederick Lyimo, Paulina Nicholaus, Hilda Makungu, Maria Mtolera, Isaac Mawenya
BACKGROUND: Holoprosencephaly is a rare spectrum of cephalic disorders resulting from a failure or incomplete division of the embryonic forebrain into distinct cerebral hemispheres. It is the most common brain malformation with an incidence of 1:250 during embryogenesis; however, owing to the associated high rates of spontaneous abortion the incidence is 1:16,000 among live deliveries. Pathogenesis of holoprosencephaly is complex and heterogeneous involving genetic abnormalities, teratogenic exposures, and syndromic associations...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27990559/prevention-of-hypoglycemia-induced-hippocampal-neuronal-death-by-n-acetyl-l-cysteine-nac
#19
A Ra Kho, Bo Young Choi, Jin Hee Kim, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Jeong Hyun Jeong, Min Sohn, Sang Won Suh
Type 1 and type 2 diabetic patients who are treated with insulin or other blood glucose reducing agents for tight control of blood glucose levels are frequently at risk of experiencing severe hypoglycemia which can lead to seizures, loss of consciousness and death. Hypoglycemic neuronal cell death is not a simple result of low glucose supply to the brain, but, instead, results from a cell death signaling pathway that is started by the re-administration of glucose after glucose deprivation. Zinc is a biologically important element for physiological function of central nervous system...
February 2017: Amino Acids
https://www.readbyqxmd.com/read/27984016/trace-elements-and-diabetes-assessment-of-levels-in-tears-and-serum
#20
A Cancarini, J Fostinelli, L Napoli, M E Gilberti, P Apostoli, F Semeraro
Tear film is critical for the well-being and homeostasis of the ocular surface. Although the composition of the tear film is well known, the composition of metallic elements have yet to be analysed. Despite trace elements metabolism has been reported to play a role in the pathogenesis of diabetes mellitus, a metabolic disease that affects several aspects of homeostasis, little is known in the literature regarding concentration and possible variation of metallic elements in tear film. We studied the concentrations of several essential and non-essential metallic elements in the tear fluid and serum of patients with type II diabetes mellitus and a group of non-diabetic controls...
October 29, 2016: Experimental Eye Research
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