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https://www.readbyqxmd.com/read/28239979/beyond-sodium-phosphate-and-potassium-potential-dietary-interventions-in-kidney-disease
#1
EDITORIAL
Jaimon T Kelly, Megan Rossi, David W Johnson, Katrina L Campbell
People with kidney disease are advised to restrict individual nutrients, such as sodium, potassium, and phosphate, in line with current best practice guidelines. However, there is limited evidence to support the efficacy of single nutrient strategies, and compliance remains a challenge for clinicians to overcome. Many factors contribute to poor compliance with dietary prescriptions, including conflicting priorities for single nutrient restriction, the arduous self-monitoring required, and the health-related knock-on effects resulting from targeting these nutrients in isolation...
February 26, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28239918/what-is-a-nurse-the-francis-report-and-the-historic-voice-of-nursing
#2
Ann Bradshaw
Following the Francis report into shockingly deficient standards of care at an English hospital, this paper examines UK nurse education and revisits the premises on which the professional narrative of nursing was built. The UK government's response to the report is to introduce the "associate nurse" role, to be nationally trained to do fundamental care in place of the registered nurse, and a nursing apprenticeship scheme-on-the-job training for a nursing degree. UK nursing bodies do not address the report's recommendations in regard to registered nurse education; rather, they advocate a further perpetuation of the current system...
February 26, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28239841/the-structure-of-nursing-a-national-examination-of-titles-and-practice-profiles
#3
G Gardner, C Duffield, A Doubrovsky, U T Bui, M Adams
AIM: To identify the practice patterns of the Australian registered nurse workforce according to position title and to map these disparate titles across all jurisdictions of the country. INTRODUCTION: Effective nursing workforce planning can contribute to improved patient care and increased effectiveness and efficiency of healthcare systems. BACKGROUND: The prevailing approach to nursing workforce planning focuses on number of nursing staff needed in relation to the number of patients...
February 26, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28239485/protocol-for-the-evaluation-of-a-digital-storytelling-approach-to-address-stigma-and-improve-readiness-to-seek-services-among-veterans
#4
Brian E Bunnell, Tatiana M Davidson, Jessica L Hamblen, Danna L Cook, Anouk L Grubaugh, Brian E Lozano, Peter W Tuerk, Kenneth J Ruggiero
BACKGROUND: Research suggests that at least 10% of veterans returning from Iraq and Afghanistan meet criteria for posttraumatic stress disorder (PTSD) related to their military experiences. National dissemination initiatives have increased veterans' access to best-practice interventions. However, treatment-seeking remains low among veterans with PTSD, often due to perceived stigma and other associated barriers. The National Center for PTSD recently developed and launched AboutFace, a digital storytelling (DST) resource designed to help veterans recognize PTSD and motivate them to seek evidence-based treatment...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28238590/the-current-status-of-hormonal-therapies-for-heavy-menstrual-bleeding
#5
REVIEW
Oskari Heikinheimo, Ian Fraser
Hormonal treatment of abnormal uterine bleeding (AUB), especially bleeding related to endometrial causes (AUB-E), ovulatory dysfunction (AUB-O) and coagulopathy (AUB-C), and to some extent, uterine leiomyomas and adenomyosis, has become the first-line evidence-based management strategy during recent years. Hormonal treatment of heavy menstrual bleeding (HMB) is also endorsed as the first line of treatment in several international guidelines. In the present article, we review the efficacy of the commonly used and widely available hormonal treatments of AUB-O, AUB-E and AUB-C...
January 21, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28238451/public-reaction-to-the-uk-government-strategy-on-childhood-obesity-in-england-a-qualitative-and-quantitative-summary-of-online-reaction-to-media-reports
#6
Rebecca Gregg, Ajay Patel, Sumaiya Patel, Laura O'Connor
This work aimed to summarise public real-time reaction to the publication of the UK government childhood obesity strategy by applying a novel research design method. We used a netnographic technique to carry out thematic analysis of user-generated comments to online newspaper articles related to the strategy. We examined likes/dislikes associated with comments as a proxy of agreement of the wider community with identified themes. To examine media influence on the comments we carried out thematic analysis of online media headlines published about the strategy, and compared these themes with themes identified from comments...
February 20, 2017: Health Policy
https://www.readbyqxmd.com/read/28237785/multi-site-tumor-sampling-msts-a-new-tumor-selection-method-to-enhance-intratumor-heterogeneity-detection
#7
José I López, Jesús M Cortés
Intratumor heterogeneity (ITH) is increasingly being recognized as a highly complex process with high clinical impact that deserves special attention from practicing pathologists. The value of the ITH detection depends on the correctness of the pathologist's sampling. The goal of this review is twofold. On the one hand, we provide a basic scientific context for the practical pathologist's perspective. On the other, we encourage pathologists to adopt a more scientific and up-to-date approach to a key component of their daily work, namely, how to sample a tumor for reliable histological and molecular analysis...
February 22, 2017: Human Pathology
https://www.readbyqxmd.com/read/28237483/phylogenetic-analysis-reveals-cryptic-species-diversity-within-minute-intestinal-fluke-stellantchasmus-falcatus-onji-and-nishio-1916-trematoda-heterophyidae
#8
Chalobol Wongsawad, Nattawadee Nantarat, Pheravut Wongsawad
OBJECTIVE: To examine the taxonomic boundaries in the Stellantchasmus populations in different hosts and reveal the cryptic speciation of the Stellantchasmus in Thailand based on both morphological and molecular approaches. METHODS: Stellantchasmus falcatus (S. falcatus) s.l. was collected from different hosts throughout Thailand. The worms were examined and measured. The nuclear ITS2 gene and the mitochondrial COI gene were used to investigate the S. falcatus s...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28237404/pharmacogenetics-in-cardiovascular-diseases-state-of-the-art-and-implementation-recommendations-of-the-french-national-network-of-pharmacogenetics-rnpgx
#9
Fabien Lamoureux, Thomas Duflot
The use of genomic markers to predict drug response and effectiveness has the potential to improve healthcare by increasing drug efficacy and minimizing adverse effects. Polymorphisms associated with inter-individual variability in drug metabolism, transport, or pharmacodynamics of major cardiovascular drugs have been identified. These include single nucleotide polymorphisms (SNP) affecting clinical outcomes in patients receiving antiplatelet agents, oral anticoagulants and statins. Based on clinical evidence supporting genetic testing in the management of cardiovascular diseases using these drug classes, this short review presents clinical guidance regarding current pharmacogenetics implementation in routine medical practice...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#10
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237075/rasch-analysis-indicates-that-the-simple-shoulder-test-is-robust-but-minor-item-modifications-and-attention-to-gender-differences-should-be-considered
#11
Jayaprakash Raman, Joy C MacDermid, David Walton, George S Athwal
STUDY DESIGN: Repeated cross-sectional study. INTRODUCTION: Multiple studies have evaluated the psychometric properties of the Simple Shoulder Test (SST) through traditional methods supporting it as valid and reliable. Since the evidentiary pool supporting the use of the SST has only partially addressed key measurement properties and the development of SST pre-dates the common use of Rasch model, validation of SST has become a necessity to establish as a reliable and valid PRO for shoulder conditions...
February 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28237071/exploring-the-needs-of-certified-hand-therapists-regarding-electronic-applications
#12
Nathan Short, James LaRowe, T'Neill Treherne, Olivia Francis, Christopher Garau, Michael Schutt, Chun Yu Wei
STUDY DESIGN: Survey. INTRODUCTION: App technology may provide a beneficial clinical resource for CHTs. PURPOSE OF STUDY: This descriptive study examined beneficial components for inclusion in a potential app for certified hand therapists to use as a clinical resource based on a nationwide survey. METHODS: Certified hand therapist members of the American Society of Hand Therapists were surveyed to evaluate preferences of content to be included in a potential clinical app...
February 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28236994/-electroconvulsive-therapy-and-level-of-evidence-from-causality-to-dose-effect-relationship
#13
J-A Micoulaud-Franchi, C Quilès, M Cermolacce, R Belzeaux, M Adida, E Fakra, J-M Azorin
OBJECTIVES: The first objective of this article is to summarize the history of electroconvulsive therapy (ECT) in psychiatry in order to highlight the transition from clinical level of evidence based on phenomenological descriptions to controlled trial establishing causal relationship. The second objective is to apply the criteria of causation for ECT, to focus on the dose-effect relationship criteria, and thus to analyze the conditions of application of these criteria for ECT. METHODS: A literature review exploring the use of electricity, ECT and electroencephalography (EEG) in psychiatry was conducted...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236962/the-effectiveness-and-cost-of-lifestyle-interventions-including-nutrition-education-for-diabetes-prevention-a-systematic-review-and-meta-analysis
#14
Yu Sun, Wen You, Fabio Almeida, Paul Estabrooks, Brenda Davy
BACKGROUND: Type 2 diabetes is a significant public health concern. With the completion of the Diabetes Prevention Program, there has been a proliferation of studies attempting to translate this evidence base into practice. However, the cost, effectiveness, and cost-effectiveness of these adapted interventions is unknown. OBJECTIVE: The purpose of this systematic review was to conduct a comprehensive meta-analysis to synthesize the effectiveness, cost, and cost-effectiveness of lifestyle diabetes prevention interventions and compare effects by intervention delivery agent (dietitian vs non-dietitian) and channel (in-person vs technology-delivered)...
March 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28236852/the-promising-anticancer-drug-3-bromopyruvate-is-metabolized-through-glutathione-conjugation-which-affects-chemoresistance-and-clinical-practice-an-evidence-based-view
#15
Salah Mohamed El Sayed, Hussam Baghdadi, Mohammed Zolaly, Hamdi H Almaramhy, Mongi Ayat, Jagadish G Donki
3-Bromopyruvate (3BP) is a promising effective anticancer drug against many different tumors in children and adults. 3BP exhibited strong anticancer effects in both preclinical and human studies e.g. energy depletion, oxidative stress, anti-angiogenesis, anti-metastatic effects, targeting cancer stem cells and antagonizing the Warburg effect. There is no report about 3BP metabolism to guide researchers and oncologists to improve clinical practice and prevent drug resistance. In this article, we provide evidences that 3BP is metabolized through glutathione (GSH) conjugation as a novel report where 3BP was confirmed to be attached to GSH followed by permanent loss of pharmacological effects in a picture similar to cisplatin...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28236806/test-treatment-rcts-are-susceptible-to-bias-a-review-of-the-methodological-quality-of-randomized-trials-that-evaluate-diagnostic-tests
#16
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Alice J Sitch, Chris Hyde, Jonathan J Deeks
BACKGROUND: There is a growing recognition for the need to expand our evidence base for the clinical effectiveness of diagnostic tests. Many international bodies are calling for diagnostic randomized controlled trials to provide the most rigorous evidence of impact to patient health. Although these so-called test-treatment RCTs are very challenging to undertake due to their methodological complexity, they have not been subjected to a systematic appraisal of their methodological quality...
February 24, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28236538/understanding-variations-in-the-use-of-hypofractionated-radiotherapy-and-its-specific-indications-for-breast-cancer-a-mixed-methods-study
#17
Joan Prades, Manel Algara, Josep A Espinàs, Blanca Farrús, Meritxell Arenas, Victoria Reyes, Virginia García-Reglero, Maria Josep Cambra, Esther Rubio, Lluis Anglada, Arantxa Eraso, Agustí Pedro, Maria J Fuentes-Raspall, Victòria Tuset, Judit Solà, Josep M Borras
BACKGROUND AND PURPOSE: Radiation oncology guidelines favour hypofractionated whole-breast radiotherapy (HWBRT) over more conventional schemes in the conservative treatment of breast cancer, but its adoption still varies in clinical practice. This study assessed the patterns of HWBRT adoption in Catalonia (Spain). MATERIAL AND METHODS: We used a mixed-methods approach based on an explanatory sequential design, first collecting and analysing quantitative data on HWBRT use (>2...
February 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28236475/update-of-the-grupo-espa%C3%A3-ol-de-leucemia-linfoc%C3%A3-tica-cr%C3%A3-nica-clinical-guidelines-of-the-management-of-chronic-lymphocytic-leukemia
#18
José A García-Marco, Julio Delgado, José A Hernández-Rivas, Ángel Ramírez Payer, Javier Loscertales Pueyo, Isidro Jarque, Pau Abrisqueta, Pilar Giraldo, Rafael Martínez, Lucrecia Yáñez, Mª José Terol, Marcos González, Francesc Bosch
BACKGROUND AND OBJECTIVE: The broad therapeutic arsenal and the biological heterogeneity of patients with chronic lymphocytic leukemia (CLL) makes it difficult to standardize treatment for CLL patients with specific clinical settings in routine clinical practice. These considerations prompted us to elaborate the present consensus document, which constitutes an update of the previous version published in 2013, mainly focusing on novel treatment strategies that have been developed over last 5 years, namely B-cell receptor inhibitors (ibrutinib and idelalisib), anti-CD20 monoclonal antibodies (ofatumumab and obinutuzumab), and Bcl-2 inhibitors (venetoclax)...
February 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28236412/annual-review-of-selected-scientific-literature-report-of-the-committee-on-scientific-investigation-of-the-american-academy-of-restorative-dentistry
#19
REVIEW
Terence E Donovan, Riccardo Marzola, Kevin R Murphy, David R Cagna, Frederick Eichmiller, James R McKee, James E Metz, Jean-Pierre Albouy
STATEMENT OF PROBLEM: It is clear the contemporary dentist is confronted with a blizzard of information regarding materials and techniques from journal articles, advertisements, newsletters, the internet, and continuing education events. While some of that information is sound and helpful, much of it is misleading at best. PURPOSE: This review identifies and discusses the most important scientific findings regarding outcomes of dental treatment to assist the practitioner in making evidence-based choices...
November 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28236157/toward-creating-synergy-among-policy-procedures-and-implementation-of-evidence-based-models-in-child-welfare-systems-two-case-examples
#20
REVIEW
Patricia Chamberlain
Over the past four to five decades, multiple randomized controlled trials have verified that preventive interventions targeting key parenting skills can have far-reaching effects on improving a diverse array of child outcomes. Further, these studies have shown that parenting skills can be taught, and they are malleable. Given these advances, prevention scientists are in a position to make solid empirically based recommendations to public child service systems on using parent-mediated interventions to optimize positive outcomes for the children and families that they serve...
February 24, 2017: Clinical Child and Family Psychology Review
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