keyword
https://read.qxmd.com/read/38535801/hortensins-type-1-ribosome-inactivating-proteins-from-seeds-of-red-mountain-spinach-isolation-characterization-and-their-effect-on-glioblastoma-cells
#1
JOURNAL ARTICLE
Sara Ragucci, Veronica Russo, Angela Clemente, Maria Giuseppina Campanile, Maria Antonietta Oliva, Nicola Landi, Paolo Vincenzo Pedone, Antonietta Arcella, Antimo Di Maro
Ribosome inactivating proteins (RIPs) are specific N-β-glycosylases that are well-characterized in plants. Their enzymatic action is to damage ribosomes, thereby blocking protein translation. Recently, several research groups have been working on the screening for these toxins in edible plants to facilitate the use of RIPs as biotechnological tools and biopesticides and to overcome public prejudice. Here, four novel monomeric (type 1) RIPs have been isolated from the seeds of Atriplex hortensis L. var...
March 4, 2024: Toxins
https://read.qxmd.com/read/38530761/probiotics-supplementation-in-the-treatment-of-male-infertility-a-systematic-review
#2
REVIEW
Licia Cristina Silva de Lima Oliveira, Elton Carvalho Costa, Fernanda Domingues Gomes Martins, Alcenir Sales da Rocha, Girlandia Alexandre Brasil
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents...
March 26, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38525521/beneficial-effects-of-oral-antioxidant-supplementation-on-semen-quality-parameters-reproductive-hormones-and-sperm-dna-integrity-in-men-with-idiopathic-oligoasthenoteratozoospermia
#3
JOURNAL ARTICLE
Chaymae Rochdi, Meriem Ouadrhiri, Larbi Allai, Ibtissam Bellajdel, Samira Mamri, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri
OBJECTIVE: Recently, oral antioxidants in combined forms have been used to treat men with idiopathic infertility. This study aimed to evaluate the effects of treatment with vitamin C, vitamin E, selenium, zinc, arginine, L-carnitine, and coenzyme Q10 on sperm quality parameters, DNA integrity, reproductive hormones, and pregnancy rates in men with infertility and idiopathic oligoasthenoteratozoospermia (OAT). METHODS: A prospective study was conducted on 420 men with infertility and idiopathic OAT who took an oral supplement of antioxidant SP-Power tablets twice daily for 6 months...
March 25, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38524634/unravelling-the-role-of-has2-grem1-and-ptgs2-gene-expression-in-cumulus-cells-implications-for-human-oocyte-development-competency-a-systematic-review-and-integrated-bioinformatic-analysis
#4
REVIEW
Ahmad Mohd Faizal, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in assessing these qualities - DNA fragmentation in sperm and oocyte development capacity (ODC) via evaluation of microenvironments involving its maturation process. Regarding oocytes, most evidence reveals the role of cumulus cells as non-invasive methods in assessing their development competency, mainly via gene expression evaluation...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38496096/the-influence-of-abstinence-interval-on-semen-quality-and-its-effect-on-an-assisted-reproductive-technology-art-pregnancy-a-case-report
#5
Rokaiya Shaikh, Akash More, Shilpa Dutta, Namrata Choudhary, Shivani Khemani
This case report focuses on a couple facing primary infertility, where the male partner exhibited asthenoteratozoospermia and high DNA fragmentation. The treatment approach involved three cycles of intracytoplasmic sperm injection (ICSI), an assisted reproductive technology (ART), to indicate and address the specific challenges posed by male factor infertility. The initial two attempts failed as DNA fragmentation was high, which was observed on days 4 and 3 of abstinence, respectively. In the third cycle, DNA fragmentation was low on day 2 of the abstinence period, resulting in the successful formation and cryopreservation of embryos...
February 2024: Curēus
https://read.qxmd.com/read/38489002/effects-of-calorie-restriction-on-preserving-male-fertility-particularly-in-a-state-of-obesity
#6
REVIEW
Mohammad Ishraq Zafar, Xiao Chen
PURPOSE OF REVIEW: Highlight the importance of exploring nutritional interventions that could be applied as alternative or supplementary therapeutic strategies to enhance men's fertility. RECENT FINDINGS: Lifestyle choices have prompted extensive discussions regarding its implications and applications as a complementary therapy. The growing concern over the decline in sperm quality underscores the urgency of investigating these alternative interventions. Calorie restriction (CR) has emerged as a promising strategy to improve male fertility...
March 15, 2024: Current Obesity Reports
https://read.qxmd.com/read/38486154/update-on-known-and-emergent-viruses-affecting-human-male-genital-tract-and-fertility
#7
REVIEW
Sara Dabizzi, Mario Maggi, Maria Gabriella Torcia
Many viruses infect the male genital tract with harmful consequences at individual and population levels. In fact, viral infections may induce damage to different organs of the male genital tract (MGT), therefore compromising male fertility. The oxidative stress, induced during viral-mediated local and systemic inflammation, is responsible for testicular damage, compromising germinal and endocrine cell functions. A reduction in sperm count, motility, number of normal sperm and an increase in DNA fragmentation are all common findings in the course of viral infections that, however, generally regress after infection clearance...
March 14, 2024: Basic and Clinical Andrology
https://read.qxmd.com/read/38480649/effect-of-advanced-glycation-end-products-ages-on-sperm-parameters-and-function-in-c57bl-6-mice
#8
JOURNAL ARTICLE
Zahra Darmishonnejad, Vahideh Hassan Zadeh, Marziyeh Tavalaee, Farzad Kobarfard, Mahsa Hassani, Parviz Gharagozloo, Joël R Drevet, Mohammad Hossein Nasr-Esfahani
This study investigated the deleterious impact of advanced glycation end products (AGEs), commonly present in metabolic disorders like diabetes, obesity, and infertility-related conditions, on sperm structure and function using a mouse model where AGE generation was heightened through dietary intervention. Five-week-old C57BL/6 mice were divided into two groups, one on a regular diet (control) and the other on an AGE-rich diet. After 13 weeks, various parameters were examined, including fasting blood glucose, body weight, food consumption, sperm parameters and function, testicular superoxide dismutase levels, malondialdehyde content, total antioxidant capacity, Johnson score, AGE receptor (RAGE) content, and carboxymethyl lysine (CML) content...
March 13, 2024: Reproductive Sciences
https://read.qxmd.com/read/38467105/congenital-zika-virus-infection-impacts-on-male-mice-offspring-s-reproductive-biology
#9
JOURNAL ARTICLE
Natália Teixeira Wnuk, André Felipe Almeida Figueiredo, Talita De Oliveira Farias, Marcos Rocha Gouvêa Brener, Samyra Maria Dos Santos Nassif Lacerda, Vidyleison Neves Camargos, Paulo Henrique Amaral, Lidia Maria Andrade, Maria Ivonete Nogueira Silva, Roberta Araujo Lopes, Raphael Escorsim Szawka, Juan Carlos González, Mauro Martins Teixeira, Danielle da Glória Souza, Vivian Vasconcelos Costa, Guilherme Mattos Jardim Costa
Infection with ZIKV during pregnancy is associated with fetal developmental problems. Although neurological issues are being explored more in experimental studies, limited research has focused on the reproductive health consequences for offspring born to infected mothers. In this context, this study aimed to assess the impact of ZIKV infection during pregnancy on the testes and sperm of adult male offspring. Female mice were intraperitoneally inoculated with a Brazil strain of ZIKV during the 5.5th day of embryonic gestation...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38465706/swimming-trapper-decreases-the-proportion-of-chromosomally-unbalanced-spermatozoa-in-human-robertsonian-translocation-carriers
#10
JOURNAL ARTICLE
Xiao-Nan Liu, Mei-Yi Li, Qing-Ling Ma, Juan Chen, Shuai Liu, Yang Yu, Ling Sun
BACKGROUND: Carriers of reciprocal translocations often have more unbalanced spermatozoa and higher DNA fragmentation rates, elevating reproductive risk. The simple swim-up method (SSUM) can decrease the amount of spermatozoa with abnormal chromatin structure and fragmented DNA, however, it has limited efficacy in eliminating chromosomally unbalanced sperm. METHODS: The spermatozoa of eight Robertsonian translocation (Rob) carriers were split into three groups: original raw semen group (control group); SSUM and swimming trapper method group (STM) processed semen samples...
March 11, 2024: Andrology
https://read.qxmd.com/read/38461455/microfluidic-sperm-sorting-selects-a-subpopulation-of-high-quality-sperm-with-a-higher-potential-for-fertilization
#11
JOURNAL ARTICLE
Nadia Sheibak, Fatemehsadat Amjadi, Amir Shamloo, Fatemeh Zarei, Zahra Zandieh
STUDY QUESTION: Is a microfluidic sperm sorter (MSS) able to select higher quality sperm compared to conventional methods? SUMMARY ANSWER: The MSS selects sperm with improved parameters, lower DNA fragmentation, and higher fertilizing potential. WHAT IS KNOWN ALREADY: To date, the few studies that have compared microfluidics sperm selection with conventional methods have used heterogeneous study population and have lacked molecular investigations...
March 10, 2024: Human Reproduction
https://read.qxmd.com/read/38455827/resolving-secondary-infertility-a-case-report-of-the-successful-treatment-of-sperm-dna-fragmentation-through-the-physiological-intracytoplasmic-sperm-injection-method
#12
Priyal Tilak, Pranita A Bawaskar, Ankit Badge, Mangesh Kohale, Jagadish G Makade, Nancy Nair
This case report presents an illustrative account of a couple experiencing secondary infertility attributed to the fragmentation of DNA in sperm. Secondary infertility, the inability to conceive after having previously successfully conceived a child, can be due to various factors, including male infertility issues. Sperm DNA fragmentation (SDF) has emerged as a major factor influencing male fertility, resulting in poor embryo development and lower pregnancy rates. This case is about the use of advanced assisted reproductive technologies, specifically physiological intracytoplasmic sperm injection (PICSI) and intracytoplasmic sperm injection (ICSI), to treat secondary infertility caused by fragmentation of sperm DNA...
February 2024: Curēus
https://read.qxmd.com/read/38450853/quantifying-the-association-of-sperm-dna-fragmentation-with-assisted-reproductive-technology-outcomes-an-umbrella-review
#13
REVIEW
Hassan Maghraby, Mohamad AlaaEldein Elsuity, Nehal Adel, Yasmin Magdi, Amr S Abdelbadie, Mosab M Rashwan, Ola Youssef Ahmed, Mohamed Elmahdy, Khalid S Khan, Mohamed Fawzy
BACKGROUND: Systematic reviews and meta-analyses are instrumental in shaping clinical practice. However, their findings can sometimes be marred by discrepancies and potential biases, thereby diluting the strength of the evidence presented. Umbrella reviews serve to comprehensively assess and synthesise these reviews, offering a clearer insight into the quality of the evidence presented. In the context of the relationship between sperm DNA fragmentation (SDF) and assisted conception outcomes, there is a divergence in the literature...
March 7, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/38449455/the-importance-of-discordant-follicle-stimulating-hormone-and-inhibin-b-levels-in-primary-infertile-men-findings-from-a-cross-sectional-study
#14
JOURNAL ARTICLE
Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d'Arma, Francesco Montorsi, Andrea Salonia
PURPOSE: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB). MATERIALS AND METHODS: Data from 1,230 consecutive men presenting for primary couple's infertility were analyzed. Health-significant comorbidities were scored with Charlson comorbidity index. Quartiles of FSH and InhB were considered to determine threshold values. Descriptive statistics and logistic regression models tested association between FSH and InhB values...
February 29, 2024: World Journal of Men's Health
https://read.qxmd.com/read/38449451/impact-of-varicocele-on-testicular-oxidative-stress-and-sperm-parameters-in-experimental-animals-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Giorgio Ivan Russo, Ramadan Saleh, Federica Finocchi, Almas Ramadhani Juma, Damayanthi Durairajanayagam, Oguzhan Kahraman, Emrullah Söğütdelen, Ioannis Sokolakis, Ranjit B Vishwakarma, Fahmi Bahar, Ahmed M Harraz, Parviz Kavoussi, Widi Atmoko, Eric Chung, Naveen Kumar, Wael Zohdy, Amarnath Rambhatla, Mohamed Arafa, Nguyen Ho Vinh Phuoc, Gianmaria Salvio, Aldo E Calogero, Tuncay Toprak, Germar-Michael Pinggera, Rossella Cannarella, Giovanni Colpi, Taha Abo-Almagd Abdel-Meguid Hamoda, Rupin Shah, Ashok Agarwal
PURPOSE: Varicocele has been associated with high seminal oxidative stress (OS), impaired semen quality, and reduced male fertility potential. However, the exact mechanism(s) underlying the development of varicocele-mediated infertility and the cause-effect relationship between varicocele and testicular dysfunction are not fully understood. The aim of this systematic review and meta-analysis (SRMA) is to investigate the impact of varicocele on testicular OS markers and sperm parameters in experimental animals with varicocele as compared to animals without varicocele...
February 7, 2024: World Journal of Men's Health
https://read.qxmd.com/read/38448740/effect-of-conditioned-medium-from-human-adipose-derived-mesenchymal-stem-cells-on-human-sperm-quality-during-cryopreservation
#16
JOURNAL ARTICLE
Hanieh Ghasemian Nafchi, Yaser Azizi, Iman Halvaei
The cryopreservation procedure decreases sperm quality, causing certain changes at structural and molecular levels affecting fertilizing ability. We aimed to investigate the impacts of human adipose-derived mesenchymal stem cells (HAd-MSCs) conditioned medium (CM) on the protection of human sperm from cryoinjury. Thirty normal semen specimens were evaluated in this study. Each specimen was separated into six groups and enhanced with varying concentrations of human Ad-MSCs-CM (0, 10, 30, 50, 70, and 100%). Sperm motility, viability, morphology, apoptosis, mitochondrial potential, and lipid peroxidation, and DNA fragmentation were evaluated before freezing and after thawing...
March 6, 2024: Reproductive Sciences
https://read.qxmd.com/read/38441570/thiacloprid-impairs-reproductive-functions-of-male-wistar-rats
#17
JOURNAL ARTICLE
Aya Abdel Nasser Mahmoud, Ebtehal Altohamy Ahmed, Amel Ramadan Omar
Global male infertility correlated to the rise of endocrine-disrupting chemicals, including insecticides, has grown into a pressing problem. Thiacloprid is one of the most commonly used neonicotinoids that accounts for more than 25% of the global pesticide industry. However, its impact on the reproductive system and male fertility has not been fully elucidated. The object of this study was to explore the adverse effects of thiacloprid on male Wistar rats' reproductive system. Thirty healthy male rats were separated into one of three groups: control group, and two groups that were orally administered with low (22...
March 5, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38427283/strengths-and-limitations-of-reduced-representation-bisulfite-sequencing-rrbs-in-the-perspective-of-dna-methylation-analysis-in-fish-a-case-study-on-rainbow-trout-spermatozoa
#18
JOURNAL ARTICLE
Marina El Kamouh, Aurélien Brionne, Amin Sayyari, Delphine Lallias, Catherine Labbé, Audrey Laurent
DNA methylation in CpG dinucleotides is an important epigenetic mark in fish spermatozoa since it has been shown that some sperm methylome features are transmitted to the offspring. Reduced representation bisulfite sequencing (RRBS) is one genome-scale methods developed to assess DNA methylation at CpG sites. It allows the sequencing of a reduced fraction of the genome expected to be enriched in CpGs. The aim of this study is to characterize the extent of the CpG sites that can be identified in the RRBS-reduced sequenced fraction of rainbow trout spermatozoa, in order to evaluate the potential of RRBS for sperm DNA methylation studies...
March 1, 2024: Fish Physiology and Biochemistry
https://read.qxmd.com/read/38420052/management-of-primary-infertility-a-comprehensive-approach-with-magnetic-activated-cell-sorting-in-an-asthenozoospermic-patient
#19
Princee Tyagi, Akash More, Namrata Chaudhary, Shivani Khemani, Prerana Dagwar
This report presents the cases of a 34-year-old male and a 29-year-old female who visited a fertility clinic and were experiencing primary infertility for the past three years. No previous medical history was identified in the couple. After a failed attempt of intrauterine insemination, the male partner was diagnosed with asthenozoospermia. A second attempt of intracytoplasmic sperm injection (ICSI) was performed which failed again. Subsequently, magnetic-activated cell sorting (MACS) technique was used as the sperm selection technique...
January 2024: Curēus
https://read.qxmd.com/read/38410342/application-of-physiological-sperm-selection-in-assisted-reproductive-technology-art-for-patients-with-diabetes-mellitus-a-case-report
#20
Krushnali S Kadu, Akash More, Namrata Choudhary, Shilpa Dutta, Jarul Shrivastava, Gauri Gajabe
This case report revolves around a 35-year-old woman and her 39-year-old husband, who have been married for 10 years and were seeking treatment for their secondary infertility. The husband had been diagnosed with diabetes mellitus (DM) for the past seven years and had been on continued medication. Both partners underwent medical evaluations, and the husband was found to have normozoospermia. The wife had a normal ovarian reserve but was still facing difficulties in conception. Previous medical history showed that the husband's DM had been treated with metformin, and the woman had a history of unsuccessful in vitro fertilization (IVF) cycles and one miscarriage upon investigation...
January 2024: Curēus
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