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https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of-chronic-viral-illness
#1
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C desire to achieve pregnancy. Patients with chronic viral illnesses desire children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, Hepatitis B, and Hepatitis C so that reproductive goals can be addressed and optimized...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28194463/improved-bovine-embryo-production-in-an-oviduct-on-a-chip-system-prevention-of-poly-spermic-fertilization-and-parthenogenic-activation
#2
Marcia A M M Ferraz, Heiko H W Henning, Pedro F Costa, Jos Malda, Ferry P Melchels, R Wubbolts, Tom A E Stout, Peter L A M Vos, Bart M Gadella
The oviduct provides the natural micro-environment for gamete interaction, fertilization and early embryo development in mammals, such as the cow. In conventional culture systems, bovine oviduct epithelial cells (BOEC) undergo a rapid loss of essential differentiated cell properties; we aimed to develop a more physiological in vitro oviduct culture system capable of supporting fertilization. U-shaped chambers were produced using stereo-lithography and mounted with polycarbonate membranes, which were used as culture inserts for primary BOECs...
February 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28193084/value-of-endometrial-echopattern-at-hcg-administration-day-in-predicting-ivf-outcome
#3
Firoozeh Ahmadi, Farnaz Akhbari, Mina Zamani, Fariba Ramezanali, Rezvaneh Cheraghi
BACKGROUND: Assisted reproductive  treatment  (ART)  cycle  is an  expensive  procedure with low implantation and pregnancy rate; therefore, it is necessary to evaluate the predictors of success in these patients. OBJECTIVE: The relationship between endometrial echopattern and pregnancy rate was evaluated. METHODS: The endometrial  echopattern  was  analyzed  prospectively  on  the  day  of  human chorionic  gonadotropin  (HCG) administration  in  280  in  vitro  fertilization/intracytoplasmic  sperm  injection (IVF/ICSI) cycles with 8-14 mm endometrial thickness at Royan institute in 2013-2014...
February 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28191261/global-dna-methylation-levels-are-altered-by-modifiable-clinical-manipulations-in-assisted-reproductive-technologies
#4
Jayashri Ghosh, Christos Coutifaris, Carmen Sapienza, Monica Mainigi
BACKGROUND: We analyzed placental DNA methylation levels at repeated sequences (LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fertilization. We included four potential modifiable factors: oxygen tension during embryo culture, fresh embryo transfer vs frozen embryo transfer, intracytoplasmic sperm injection (ICSI) vs conventional insemination or day 3 embryo transfer vs day 5 embryo transfer...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28185120/-one-for-sorrow-two-for-joy-american-embryo-transfer-guideline-recommendations-practices-and-outcomes-for-gestational-surrogate-patients
#5
REVIEW
Pamela M White
In January 2016, Melissa Cook, a California gestational surrogate experiencing a multiple-birth pregnancy following the in vitro fertilization (IVF) transfer of three embryos comprised of donor eggs and sperm provided by the intended father, went to the media when the intended father requested that she undergo a fetal reduction because twins were less expensive to raise than triplets. Much of the legal interest in this case to date has centered on the enforceability of surrogacy contracts. However, the Cook case also raises troubling issues about fertility treatment practices involving gestational surrogates, twin preference, and third-party reproduction medical decision-making...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28178360/melatonin-protects-oocyte-quality-from-bisphenol-a-induced-deterioration-in-the-mouse
#6
Mianqun Zhang, Xiaoxin Dai, Yajuan Lu, Yilong Miao, Changyin Zhou, Zhaokang Cui, Honglin Liu, Bo Xiong
BPA (Bisphenol A) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% VS 57.0%, p < 0...
February 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28169188/clinical-outcomes-after-ivf-or-icsi-using-human-blastocysts-derived-from-oocytes-containing-aggregates-of-smooth-endoplasmic-reticulum
#7
Fumiaki Itoi, Yukiko Asano, Masashi Shimizu, Rika Nagai, Kanako Saitou, Hiroyuki Honnma, Yasutaka Murata
In this study the clinical and neo-natal outcomes after transfer of blastocysts derived from oocytes containing aggregates of smooth endoplasmic reticulum (SER) were compared between IVF and intracytoplasmic sperm injection (ICSI) cycles. Clinical and neo-natal outcomes of blastocysts in cycles with at least one SER metaphase II oocyte (SER + MII; SER + cycles) did not significantly differ between the two insemination methods. When SER + MII were cultured to day 5/6, fertilization, embryo cleavage and blastocyst rates were not significantly different between IVF and ICSI cycles...
January 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28168654/worldwide-prevalence-of-adverse-pregnancy-outcomes-associated-with-in-vitro-fertilization-intracytoplasmic-sperm-injection-among-multiple-births-a-systematic-review-and-meta-analysis-based-on-cohort-studies
#8
REVIEW
Jia-Bi Qin, Xiao-Qi Sheng, Hua Wang, Guo-Chong Chen, Jing Yang, Hong Yu, Tu-Bao Yang
PURPOSE: To perform a systematic review and meta-analysis of reported estimates of adverse pregnancy outcomes among multiple births conceived with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). METHODS: PubMed, Google Scholar, Cochrane Libraries and Chinese databases were searched through May 2016 for cohort studies assessing adverse pregnancy outcomes associated with IVF/ICSI multiple births. Random-effects meta-analyses were used to calculate pooled estimates of adverse pregnancy outcomes and, where appropriate, heterogeneity was explored in group-specific analyses...
March 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28166993/resveratrol-and-epigallocatechin-3-gallate-addition-to-thawed-boar-sperm-improves-in%C3%A2-vitro-fertilization
#9
B Gadani, D Bucci, M Spinaci, C Tamanini, G Galeati
Thawing is one of the most delicate process after semen cryopreservation as spermatozoa pass from a dormant metabolic stage to a sudden awakening in cellular metabolism. The rapid oxygen utilization leads to an overproduction of reactive oxygen species that can damage sperm cells, thus causing a significant decrease of fertilizing potential of frozen-thawed spermatozoa. Resveratrol (Res) is a natural grape-derived phytoalexin and Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea (Camellia sinensis); both molecules are known to possess high levels of antioxidant activity...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28166693/revitalizing-genetically-modified-mouse-strains-using-frozen-thawed-sperm-after-up-to-192%C3%A2-h-of-refrigerated-epididymis-transportation
#10
Gonzalo Moreno-Del Val, Patricia Muñoz-Robledano
In the scientific interchange of genetically-modified mouse strains the transportation of refrigerated epididymis has several advantages over the transportation of live animals, especially with regard to the 3R (replacement, reduction and refinement) principles. The major limiting factor is the duration of the transportation. Previous reports have shown that sperm collected from transported epididymis maintained their fertility for around 72 h, but there are no published data with longer transportation times, and this window of time may be too short, especially for international shipments and where locations are not well connected...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28163265/significant-heparin-effect-on-bovine-embryo-development-during-sexed-in-vitro-fertilization
#11
Li-You An, Sanjeev A Chaubal, Yanhong Liu, Yexiang Chen, Tshimangadzo L Nedambale, Jie Xu, Fei Xue, Juan F Moreno, Shenghong Tao, Giorgio Antonio Presicce, Fuliang DU
The aim of this study was to investigate the effect of different heparin concentrations in the course of sexed in vitro fertilization (IVF), on bovine embryonic development and development to term following embryo transfer (ET). With a total of 9156 oocytes for IVF, sorted as well as unsorted sperm from four bulls had different heparin requirements for achieving the highest rate of development in vitro. However, when optimal heparin concentrations were used (40 to 80 µg/ml), the performance of X-sorted sperm (0...
February 5, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28162936/obstetric-and-neo-natal-outcomes-of-icsi-cycles-using-pentoxifylline-to-identify-viable-spermatozoa-in-patients-with-immotile-spermatozoa
#12
Purificación Navas, Alessio Paffoni, Giulia Intra, Antonio González-Utor, Ana Clavero, Maria Carmen Gonzalvo, Rocío Díaz, Rocío Peña, Liliana Restelli, Edgardo Somigliana, Enrico Papaleo, Jose A Castilla, Paola Viganò
Pentoxifylline (PF) represents an effective tool in stimulating motility and identifying viable spermatozoa in intracytoplasmic sperm injection (ICSI) patients presenting exclusively with immotile spermatozoa. However, its use is not universally accepted for its possible detrimental effects on oocytes, embryos or newborns. To evaluate whether PF use may affect obstetrical/neo-natal outcomes, 102 patients achieving a clinical pregnancy after a PF-ICSI in four IVF units in Spain and Italy were followed up after delivery...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28160506/evaluation-of-the-effect-of-indomethacin-and-piroxicam-administration-before-embryo-transfer-on-pregnancy-rate
#13
Serkan Kumbasar, Özer Gül, Aytek Şık
AIM: The aim of this study was to evaluate the effect of non-steroidal anti-inflammatory drug (NSAID) administration before embryo transfer (ET) on pregnancy rates in women undergoing in vitro fertilization/intracytoplasmic sperm injection ET. METHODS: Our study included 255 patients diagnosed with primary or secondary infertility caused by a male or tubal-related factor, endometriosis or unexplained factors. The patients were divided randomly into three groups...
February 4, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28160207/impact-of-prolonged-oocyte-incubation-time-before-vitrification-on-oocyte-survival-embryo-formation-and-embryo-quality-in-mice
#14
Azade Karami, Mitra Bakhtiari, Mehri Azadbakht, Rostam Ghorbani, Mozafar Khazaei, Mansour Rezaei
Oocyte incubation time before freezing is one of the factors affecting oocyte vitrification. In the assisted reproductive technology (ART) clinics, it is sometimes decided to perform oocyte vitrification after a long period of incubation time due to various conditions, such as inability to collect semen samples, unsuccessful urological interventions (PESA, TESE, etc.), or unexpected conditions. A time factor of up to 6 h has been studied in the available reports. Therefore, this study was designed to evaluate oocyte incubation time before freezing at 0, 6, 12, 18, and 24 h after retrieval...
February 3, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28152037/reassessing-the-feasibility-of-the-zygote-score-for-predicting-embryo-viability-in-ivf-icsi-using-the-gnrh-antagonist-protocol-compared-to-the-long-protocol
#15
Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yi-Chi Lin, Hsin-Ju Chiang, Yu-Ju Lin, Kuo-Chung Lan
BACKGROUND: Many factors from the oocyte/sperm or the process of fertilization may affect the zygote formation. The zygote score (Z-score) describes the quality of a human zygote based on its pronuclear morphology, nucleolar precursor bodies, and alignment of polar bodies, and it can be used in the selection process at the zygote stage for embryo transfer or cryopreservation. OBJECTIVE: The aim of this retrospective cohort study was to investigate the relationship between different controlled ovarian stimulation (COS) protocols and the zygote score (Z-score) and to assess the feasibility of the Z-score for predicting embryo survival in the GnRH-antagonist (GnRH-ant) protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28140471/use-of-intracytoplasmic-sperm-injection-and-birth-outcomes-in-women-conceiving-through-in-vitro-fertilization
#16
Xu Xiong, Richard P Dickey, Pierre Buekens, Jeffrey G Shaffer, Gabriella Pridjian
BACKGROUND: Despite questionable evidence of benefits over conventional in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) use has markedly increased in recent decades among couples without male factor infertility. We assessed the frequency of ICSI use and its effect on birth outcomes. METHODS: A retrospective cohort study was conducted in 141 030 women conceiving through IVF using 2006-2010 data from the Society for Assisted Reproductive Technology (SART)...
January 31, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28137755/melatonin-improves-the-fertilization-ability-of-post-ovulatory-aged-mouse-oocytes-by-stabilizing-ovastacin-and-juno-to-promote-sperm-binding-and-fusion
#17
Xiaoxin Dai, Yajuan Lu, Mianqun Zhang, Yilong Miao, Changyin Zhou, Zhaokang Cui, Bo Xiong
STUDY QUESTION: What are the underlying mechanisms of the decline in the fertilization ability of post-ovulatory aged oocytes? SUMMARY ANSWER: Melatonin improves the fertilization ability of post-ovulatory aged oocytes by reducing aging-induced reactive oxygen species (ROS) levels and inhibiting apoptosis and by maintaining the levels and localization of the fertilization proteins, ovastacin and Juno. WHAT IS KNOWN ALREADY: Following ovulation, the quality of mammalian metaphase II oocytes irreversibly deteriorates over time with a concomitant loss of fertilization ability...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28127436/sperm-quality-and-paternal-age-effect-on-blastocyst-formation-and-pregnancy-rates
#18
Aurélie Chapuis, Anna Gala, Alice Ferrières-Hoa, Tiffany Mullet, Sophie Bringer-Deutsch, Emmanuelle Vintejoux, Antoine Torre, Samir Hamamah
BACKGROUND: Several studies suggest a decrease in sperm quality in men in the last decades. Therefore, the aim of this work was to assess the influence of male factors (sperm quality and paternal age) on the outcomes of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). METHODS: This retrospective study included all couples who underwent IVF or ICSI at Montpellier University Hospital, France, between 1 January 2010 and 31 December 2015...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28122315/intrauterine-insemination-no-more-mr-n-i-c-e-guy
#19
Minna E Geisler, Mark Ledwidge, Margaret Bermingham, Mary McAuliffe, Moya B McMenamin, John J Waterstone
OBJECTIVE: To determine the per cycle chance of a live birth and to identify factors that may support a more individualised application of IUI in view of National Institute for Health and Care Excellence (NICE) updated guideline on fertility 2013. STUDY DESIGN: A retrospective, cohort study of 851 couples (1688 cycles) with unexplained, mild endometriosis, one patent Fallopian tube (with ovulation occurring in the corresponding ovary), mild male factor or ovulatory dysfunction, who initiated their first cycle of IUI/COH during the study period 2009-2013 and completed up to 3 cycles...
January 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28122284/periodic-elevation-of-regulatory-t-cells-on-the-day-of-embryo-transfer-is-associated-with-better-in-vitro-fertilization-outcome
#20
Wen-Juan Wang, Fu-Jun Liu, Xia Zhang, Xue-Mei Liu, Qing-Lan Qu, Feng-Hua Li, Li-Li Zhuang, Xiao-Xiao Li, Cui-Fang Hao
Treg cells have been shown to be important in maintaining maternofetal tolerance, but the expression of Tregs in assisted reproductive technology (ART) in women on the day of embryo transfer (D0), 5days (D5) and 14days after ET (D14); the related factors influencing the expression levels of Tregs; the proliferation ability and the relevant cytokine epression by Tregs on D14 have not been investigated. In this study, 124 women undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF/ICSI) were enrolled...
January 19, 2017: Journal of Reproductive Immunology
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