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https://www.readbyqxmd.com/read/29782836/dancing-with-the-diva-hsp90-client-interactions
#1
REVIEW
Martina Radli, Stefan G D Rüdiger
The molecular chaperone Hsp90 is involved in the folding, maturation and degradation of a large number structurally and sequentially unrelated clients, often connected to serious diseases. Elucidating the principles of how Hsp90 recognises this large variety of substrates is essential for comprehending the mechanism of this chaperone machinery, as well as it is a prerequisite for the design of client specific drugs targeting Hsp90. Here, we discuss the recent progress in understanding the substrate recognition principles of Hsp90 and its implications for the role of Hsp90 in the lifecycle of (signalling) molecules...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29745418/setting-the-research-agenda-for-induced-abortion-in-africa-and-asia
#2
Rachel H Scott, Veronique Filippi, Ann M Moore, Rajib Acharya, Akinrinola Bankole, Clara Calvert, Kathryn Church, Jenny A Cresswell, Katharine Footman, Joanne Gleason, Kazuyo Machiyama, Cicely Marston, Mike Mbizvo, Maurice Musheke, Onikepe Owolabi, Jennifer Palmer, Christopher Smith, Katerini Storeng, Felicia Yeung
Provision of safe abortion is widely recognized as vital to addressing the health and wellbeing of populations. Research on abortion is essential to meet the UN Sustainable Development Goals. Researchers in population health from university, policy, and practitioner contexts working on two multidisciplinary projects on family planning and safe abortion in Africa and Asia were brought together for a workshop to discuss the future research agenda on induced abortion. Research on care-seeking behavior, supply of abortion care services, and the global and national policy context will help improve access to and experiences of safe abortion services...
May 10, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29745212/-applications-of-eco-environmental-big-data-progress-and-prospect
#3
Miao Miao Zhao, Shi Cheng Zhao, Li Yun Zhang, Fen Zhao, Rui Shao, Li Xiang Liu, Hai Feng Zhao, Ming Xu
With the advance of internet and wireless communication technology, the fields of ecology and environment have entered a new digital era with the amount of data growing explosively and big data technologies attracting more and more attention. The eco-environmental big data is based airborne and space-/land-based observations of ecological and environmental factors and its ultimate goal is to integrate multi-source and multi-scale data for information mining by taking advantages of cloud computation, artificial intelligence, and modeling technologies...
May 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29718213/the-scientific-filesystem-scif
#4
Vanessa Sochat
Background: Here we present the Scientific Filesystem (SCIF), an organizational format that supports exposure of executables and metadata for discoverability of scientific applications. The format includes a known filesystem structure, a definition for a set of environment variables describing it, and functions for generation of the variables and interaction with the libraries, metadata, and executables located within. SCIF makes it easy to expose metadata, multiple environments, installation steps, files, and entrypoints to render scientific applications consistent, modular, and discoverable...
March 13, 2018: GigaScience
https://www.readbyqxmd.com/read/29714611/medical-writing-competency-model-section-1-functions-tasks-and-activities
#5
David B Clemow, Bertil Wagner, Christopher Marshallsay, Dan Benau, Darryl L'Heureux, David H Brown, Devjani Ghosh Dasgupta, Eileen Girten, Frank Hubbard, Helle-Mai Gawrylewski, Hiroko Ebina, Janet Stoltenborg, J P York, Kim Green, Linda Fossati Wood, Lisa Toth, Michael Mihm, Nancy R Katz, Nina-Maria Vasconcelos, Norihisa Sakiyama, Robin Whitsell, Shobha Gopalakrishnan, Susan Bairnsfather, Tatyana Wanderer, Thomas M Schindler, Yeshi Mikyas, Yumiko Aoyama
This article provides Section 1 of the 2017 Edition 2 Medical Writing Competency Model that describes the core work functions and associated tasks and activities related to professional medical writing within the life sciences industry. The functions in the Model are scientific communication strategy; document preparation, development, and finalization; document project management; document template, standard, format, and style development and maintenance; outsourcing, alliance partner, and client management; knowledge, skill, ability, and behavior development and sharing; and process improvement...
January 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29689176/addressing-sex-in-occupational-therapy-a-coconstructed-autoethnography
#6
Natalie Rose, Claire Hughes
Occupational therapy practitioners generally agree that sex is a meaningful occupation and should be part of the rehabilitation process; however, there has been reluctance to include clients' sexual concerns in practice. To explore how occupational therapy is addressing clients' sexual concerns, we (one author with a professional background in occupational therapy and the other who is a consumer of occupational therapy services) used a coconstructed autoethnographic approach that involved shared reflection between us...
May 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29672357/refugee-children-s-participation-in-the-women-infants-and-children-supplemental-nutrition-wic-program-in-massachusetts-1998-2010
#7
Laura Smock, Thinh Nguyen, Elizabeth Metallinos-Katsaras, Hema Magge, Jennifer Cochran, Paul L Geltman
OBJECTIVES: To (1) describe prevalence of growth abnormalities and anemia in refugee children; (2) describe the proportion of age-eligible refugee children enrolled in Special Supplemental Nutrition Program for Women, Infants, and Children (WIC); and (3) identify risk factors for lack of enrollment in WIC. DESIGN: Data were collected from 1731 health screenings for refugee children younger than 5 years in Massachusetts in 1998-2010 and matched to WIC program records...
April 18, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29671662/goal-setting-dynamics-that-facilitate-or-impede-a-client-centered-approach
#8
Dorothy Kessler, Ian Walker, Katrine Sauvé-Schenk, Mary Egan
BACKGROUND: Client-centred goal setting is central to the process of enabling occupation. Yet, there are multiple barriers to incorporating client-centred goal setting in practice. We sought to determine what might facilitate or impede the formation of client-centred goals in a context highly supportive of client-centred goal setting Methods: We used conversational analysis to examine goal-setting conversations that took place during a pilot trial of Occupational Performance Coaching for stroke survivors...
April 19, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29659780/health-outcomes-for-clients-of-needle-and-syringe-programs-in-prisons
#9
Jeffrey V Lazarus, Kelly Safreed-Harmon, Kristina L Hetherington, Daniel J Bromberg, Denise Ocampo, Niels Graf, Anna Dichtl, Heino Stöver, Hans Wolff
High levels of drug dependence have been observed in the prison population globally, and the sharing of injecting drug equipment in prisons has contributed to higher prevalence of bloodborne diseases in prisoners than in the general population. Few prison needle and syringe programs (PNSPs) exist. We conducted a systematic review to assess evidence regarding health outcomes of PNSPs. We searched peer-reviewed databases for data relating to needle and syringe programs in prisons. The search methodology was conducted in accordance with accepted guidelines...
April 12, 2018: Epidemiologic Reviews
https://www.readbyqxmd.com/read/29659031/staff-perceptions-of-borderline-personality-disorder-and-recovery-a-q-sort-method-approach
#10
Rebecca Dean, Sara Siddiqui, Frank Beesley, John Fox, Katherine Berry
OBJECTIVES: This study was the first to explore how staff that work with people diagnosed with borderline personality disorder (BPD) perceive recovery in this client group. These views are important because of the crucial role that staff play in the care of people with BPD, and the challenges that staff experience with these clients. DESIGN: A Q methodology design was used, containing 58 statements about recovery. METHODS: Twenty-nine mental health staff sorted recovery statements according to perceived importance to recovery in BPD...
April 16, 2018: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29656858/a-recurrent-de-novo-pacs2-heterozygous-missense-variant-causes-neonatal-onset-developmental-epileptic-encephalopathy-facial-dysmorphism-and-cerebellar-dysgenesis
#11
Heather E Olson, Nolwenn Jean-Marçais, Edward Yang, Delphine Heron, Katrina Tatton-Brown, Paul A van der Zwaag, Emilia K Bijlsma, Bryan L Krock, E Backer, Erik-Jan Kamsteeg, Margje Sinnema, Margot R F Reijnders, David Bearden, Amber Begtrup, Aida Telegrafi, Roelineke J Lunsing, Lydie Burglen, Gaetan Lesca, Megan T Cho, Lacey A Smith, Beth R Sheidley, Christelle Moufawad El Achkar, Phillip L Pearl, Annapurna Poduri, Cara M Skraban, Jennifer Tarpinian, Addie I Nesbitt, Dietje E Fransen van de Putte, Claudia A L Ruivenkamp, Patrick Rump, Nicolas Chatron, Isabelle Sabatier, Julitta De Bellescize, Laurent Guibaud, David A Sweetser, Jessica L Waxler, Klaas J Wierenga, Jean Donadieu, Vinodh Narayanan, Keri M Ramsey, Caroline Nava, Jean-Baptiste Rivière, Antonio Vitobello, Frédéric Tran Mau-Them, Christophe Philippe, Ange-Line Bruel, Yannis Duffourd, Laurel Thomas, Stefan H Lelieveld, Janneke Schuurs-Hoeijmakers, Han G Brunner, Boris Keren, Julien Thevenon, Laurence Faivre, Gary Thomas, Christel Thauvin-Robinet
Developmental and epileptic encephalopathies (DEEs) represent a large clinical and genetic heterogeneous group of neurodevelopmental diseases. The identification of pathogenic genetic variants in DEEs remains crucial for deciphering this complex group and for accurately caring for affected individuals (clinical diagnosis, genetic counseling, impacting medical, precision therapy, clinical trials, etc.). Whole-exome sequencing and intensive data sharing identified a recurrent de novo PACS2 heterozygous missense variant in 14 unrelated individuals...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29622750/think-about-animal-welfare-this-national-pet-month
#12
(no author information available yet)
April is National Pet Month and the Animal Welfare Foundation has some informative guides for vets to share with clients, says AWF Manager Erika Singh .
April 7, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29613769/protein-protein-interactions-in-the-molecular-chaperone-network
#13
Rebecca Freilich, Taylor Arhar, Jennifer L Abrams, Jason E Gestwicki
Molecular chaperones play a central role in protein homeostasis (a.k.a. proteostasis) by balancing protein folding, quality control, and turnover. To perform these diverse tasks, chaperones need the malleability to bind nearly any "client" protein and the fidelity to detect when it is misfolded. Remarkably, these activities are carried out by only ∼180 dedicated chaperones in humans. How do a relatively small number of chaperones maintain cellular and organismal proteostasis for an entire proteome? Furthermore, once a chaperone binds a client, how does it "decide" what to do with it? One clue comes from observations that individual chaperones engage in protein-protein interactions (PPIs)-both with each other and with their clients...
April 3, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29604955/multivariate-analysis-of-covariates-of-adherence-among-hiv-positive-mothers-with-low-viral-suppression
#14
Tamara Nsubuga-Nyombi, Simon Sensalire, Esther Karamagi, Judith Aloyo, John Byabagambi, Mirwais Rahimzai, Linda Kisaakye Nabitaka, Jacqueline Calnan
BACKGROUND: As part of efforts to improve the prevention of mother-to-child transmission in Northern Uganda, we explored reasons for poor viral suppression among 122 pregnant and lactating women who were in care, received viral load tests, but had not achieved viral suppression and had more than 1000 copies/mL. Understanding the patient factors associated with low viral suppression was of interest to the Ministry of Health to guide the development of tools and interventions to achieve viral suppression for pregnant and lactating women newly initiating on ART as well as those on ART with unsuppressed viral load...
March 31, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29603813/enhanced-self-monitoring-blood-glucose-in-non-insulin-requiring-type-2-diabetes-a-qualitative-study-in-primary-care
#15
Dana Elisabeth Brackney
AIMS AND OBJECTIVES: To contribute to both theoretical and practical understanding of the role of self-monitoring blood glucose for self-management by describing the experience of people with non-insulin requiring Type 2 diabetes in an enhanced structured self-monitoring blood glucose intervention. BACKGROUND: The complex context of self-monitoring blood glucose in Type 2 diabetes requires a deeper understanding of the clients' illness experience with structured self-monitoring of blood glucose...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29602866/expanding-access-to-injectable-contraception-results-from-pilot-introduction-of-subcutaneous-depot-medroxyprogesterone-acetate-dmpa-sc-in-4-african-countries
#16
Anna Stout, Siri Wood, George Barigye, Alain Kaboré, Daouda Siddo, Ida Ndione
PATH partnered with the United Nations Population Fund (UNFPA) and country ministries of health (MOHs) to coordinate pilot introductions of subcutaneous depot medroxyprogesterone acetate (subcutaneous DMPA or DMPA-SC, brand name Sayana Press) in Burkina Faso, Niger, Senegal, and Uganda from July 2014 through June 2016 in order to expand the range of methods available to women, particularly in remote locations. The pilot introductions aimed to answer key questions that would inform decisions about future investments in DMPA-SC and scaling up product availability and service-delivery innovations nationally...
March 21, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29589780/what-are-private-sector-physiotherapists-perceptions-regarding-interprofessional-and-intraprofessional-work-for-managing-low-back-pain
#17
Kadija Perreault, Clermont E Dionne, Michel Rossignol, Stéphane Poitras, Diane Morin
In the last decades, interactions between health professionals have mostly been discussed in the context of interprofessional teamwork where professionals work closely together and share a team identity. Comparatively, little work has been done to explore interactions that occur between professionals in contexts where traditionally formal structures have been less supporting the implementation of interprofessional teamwork, such as in the private healthcare sector. The objective of this study was to identify private sector physiotherapists' perceptions of interprofessional and intraprofessional work regarding interventions for adults with low back pain...
March 28, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29563764/abnormal-foot-position-and-standing-and-walking-ability-in-rett-syndrome-an-exploratory-study
#18
Hanneke E Borst, Gillian S Townend, Mirjam van Eck, Eric Smeets, Mariëlle van den Berg, Aleid Laan, Leopold M G Curfs
This study aimed to determine whether there is a relationship between abnormal foot position and standing and walking ability in individuals with Rett syndrome (RTT), a rare neurological condition primarily affecting females, often accompanied by impaired gross motor function and musculoskeletal deformities. Through means of an online survey, physiotherapists were asked to share information about their work and experience with individuals with RTT. They were asked about their clients' scores on the Rett Syndrome Gross Motor Scale and measures of their foot deformity, passive range of motion of dorsiflexion of the foot, use of supportive footwear, pressure load on the foot, and symmetry in weight bearing...
2018: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/29559495/liftoff-the-blossoming-of-contraceptive-implant-use-in-africa
#19
Roy Jacobstein
This article draws from national surveys of every sub-Saharan African country with at least 1 recent survey published between 2015 and 2017 and 2 prior surveys from 2003 to 2014. Twelve countries comprising over 60% of the region's population met these inclusion criteria. The analysis considers recent and longer-term changes in 3 key variables: modern contraceptive prevalence rate (mCPR), method-specific prevalence, and a method's share of the current modern method mix. As recently as 2011, implant CPR in sub-Saharan Africa was only 1...
March 20, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29550154/playing-it-safe-legal-and-clandestine-abortions-among-adolescents-in-ethiopia
#20
Elizabeth Sully, Yohannes Dibaba, Tamara Fetters, Nakeisha Blades, Akinrinola Bankole
PURPOSE: The 2005 expansion of the Ethiopian abortion law provided minors access to legal abortions, yet little is known about abortion among adolescents. This paper estimates the incidence of legal and clandestine abortions and the severity of abortion-related complications among adolescent and nonadolescent women in Ethiopia in 2014. METHODS: This paper uses data from three surveys: a Health Facility Survey (n = 822) to collect data on legal abortions and postabortion complications, a Health Professionals Survey (n = 82) to estimate the share of clandestine abortions that resulted in treated complications, and a Prospective Data Survey (n = 5,604) to collect data on abortion care clients...
March 7, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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