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https://www.readbyqxmd.com/read/29127656/altered-oscillatory-brain-dynamics-of-emotional-processing-in-young-binge-drinkers
#1
Siyuan Huang, Lee A Holcomb, Stephen M Cruz, Ksenija Marinkovic
Heavy episodic drinking, also termed binge drinking, is commonly practiced by young adults. It is accompanied by a range of cognitive, affective, and social problems, but the neural dynamics underlying changes in emotional functions is poorly understood. To investigate the behavioral and brain indices of affective processing as a function of binge drinking, young, healthy participants (23.3 ± 3.3 years) were assigned to two groups (n = 32 each) based on their drinking habits. Binge drinking (BD) participants reported drinking heavily with at least five binge episodes in the last 6 months, whereas light drinkers (LD) reported no more than one binge episode in the last 6 months...
November 10, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29117267/the-impact-of-cannabis-use-on-patients-enrolled-in-opioid-agonist-therapy-in-ontario-canada
#2
Alexandra M Franklyn, Joseph K Eibl, Graham J Gauthier, David C Marsh
BACKGROUND: With the Canadian government legalizing cannabis in the year 2018, the potential harms to certain populations-including those with opioid use disorder-must be investigated. Cannabis is one of the most commonly used substances by patients who are engaged in medication-assisted treatment for opioid use disorder, the effects of which are largely unknown. In this study, we examine the impact of baseline and ongoing cannabis use, and whether these are impacted differentially by gender...
2017: PloS One
https://www.readbyqxmd.com/read/29115817/low-cost-chemical-responsive-adhesive-sensing-chips
#3
Weirui Tan, Liyuan Zhang, Wei Shen
Chemical-responsive adhesive sensing chip is a new low-cost analytical platform, which uses adhesive tape loaded with indicator reagents to detect or quantify the target analytes by directly sticking the tape to the samples of interest. The chemical-responsive adhesive sensing chips can be used with paper to analyse aqueous samples; they can also be used to detect and quantify solid, particulate and powder analytes. The colorimetric indicators become immediately visible as the contact between the functionalized adhesives and target samples was made...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29097069/dose-related-ethanol-intake-cx43-and-nav1-5-remodeling-exploring-insights-of-altered-ventricular-conduction-and-qrs-fragmentation-in-excessive-alcohol-users
#4
Chung-Lieh Hung, Yu-Jun Lai, Po-Ching Chi, Liang-Chia Chen, Ya-Ming Tseng, Jen-Yuan Kuo, Cheng-I Lin, Yao-Chang Chen, Shing-Jong Lin, Hung-I Yeh
BACKGROUND: Chronic, excessive ethanol intake has been linked with various electrical instabilities, conduction disturbances, and even sudden cardiac death, but the underlying cause for the latter is insufficiently delineated. METHODS: We studied surface electrocardiography (ECG) in a community-dwelling cohort with moderate-to-heavy daily alcohol intake (grouped as >90g/day, ≤90g/day, and nonintake). RESULTS: Compared with nonintake, heavier alcohol users showed markedly widened QRS duration and higher prevalence of QRS fragmentation (64...
October 30, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29062186/lead-poisoning-due-to-herbal-medications
#5
Prashant Sakharkar
Many herbal products are harmless or possess minimal toxicity, whereas, some contain toxic ingredients that may not be identified due to lack of quality control or not listed on the label. Over the years, several case reports and studies have documented that herbal medications may contain ingredients that are toxic. Several studies have documented that some herbal medications contained high concentrations of heavy metals, such as lead, mercury, and arsenic. Publications of such case reports and studies have repeatedly reminded us that we have failed in our legal and civic duties of educating users of herbal medications and general population about the grave concerns posed by the herbal medications and their associated toxicities...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29061372/the-relationship-of-snus-use-to-diabetes-and-allied-conditions
#6
Peter N Lee, Alison J Thornton
A recent meta-analysis reported smoking to be associated with a 37% higher risk of type 2 diabetes in current smokers, rising to a 57% increase in heavy smokers, which declines on quitting. If the increase results from nicotine exposure, it is possible that using Swedish moist snuff ("snus"), which provides at least equivalent nicotine doses, might also increase diabetes risk. Following a recent publication reporting pooled results from five cohorts, we present a detailed meta-analysis of data from 18 studies...
October 20, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29058519/longitudinal-changes-in-cognition-in-young-adult-cannabis-users
#7
Mary P Becker, Paul F Collins, Ashley Schultz, Snežana Urošević, Brittany Schmaling, Monica Luciana
INTRODUCTION: Adolescent cannabis use (CU) is associated with impaired attention, executive function, and verbal learning/memory. These associations are generally observed in cross-sectional studies. Longitudinal studies of cannabis users are lacking. METHOD: The present study examines associations between CU and cognition over time in chronic daily adolescent-onset CUs, as compared to nonusing controls. Both groups completed a neuropsychological battery at study intake and again 2 years later...
October 23, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29056767/cross-commodity-delay-discounting-of-alcohol-and-money-in-alcohol-users
#8
Lara N Moody, Allison N Tegge, Warren K Bickel
Despite real-world implications, the pattern of delay discounting in alcohol users when the commodities now and later differ has not been well characterized. In this study, 60 participants on Amazon's Mechanical Turk completed the Alcohol Use Disorder Identification Test (AUDIT) to assess severity of use and completed four delay discounting tasks between hypothetical, equivalent amounts of alcohol and money available at five delays. The tasks included two cross-commodity (alcohol now-money later and money now-alcohol later) and two same-commodity (money now-money later and alcohol now-alcohol later) conditions...
June 2017: Psychological Record
https://www.readbyqxmd.com/read/29049898/in-situ-gelation-of-sodium-alginate-supported-on-melamine-sponge-for-efficient-removal-of-copper-ions
#9
Yi Feng, Yayan Wang, Yaquan Wang, Xiong-Fei Zhang, Jianfeng Yao
Sodium alginate-melamine sponge composites were fabricated by in-situ gelation of sodium alginate supported on the commercial melamine sponge (MS). MS serves as the three-dimensional skeleton for alginate coating and can effectively avoid the shrink of alginate, and thus makes the alginate-MS composites user-friendly and facile to recover. In the adsorption test, the adsorption process is pseudo-second order and matches the Langmuir model with the maximum adsorption capacity of 90.1mg/g for copper ions. The alginate-MS is recyclable and presents enhanced mechanical properties compared with those of pristine MS...
October 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29049354/inverse-association-of-marijuana-use-with-nonalcoholic-fatty-liver-disease-among-adults-in-the-united-states
#10
Donghee Kim, Won Kim, Min-Sun Kwak, Goh Eun Chung, Jeong Yoon Yim, Aijaz Ahmed
BACKGROUND & AIMS: The impact of marijuana on nonalcoholic fatty liver disease (NAFLD) is largely unknown. We studied the association between marijuana and NAFLD utilizing cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) from 2005-2014 and NHANES III (1988-1994). METHODS: Suspected NAFLD was diagnosed if serum alanine aminotransferase (ALT) was > 30 IU/L for men and > 19 IU/L for women in the absence of other liver diseases (NHANES 2005-2014)...
2017: PloS One
https://www.readbyqxmd.com/read/29042513/distress-and-rumor-exposure-on-social-media-during-a-campus-lockdown
#11
Nickolas M Jones, Rebecca R Thompson, Christine Dunkel Schetter, Roxane Cohen Silver
During crisis events, people often seek out event-related information to stay informed of what is happening. However, when information from official channels is lacking or disseminated irregularly, people may be at risk for exposure to rumors that fill the information void. We studied information-seeking during a university lockdown following an active-shooter event. In study 1, students in the lockdown (n = 3,890) completed anonymous surveys 1 week later. Those who indicated receiving conflicting information about the lockdown reported greater acute stress [standardized regression coefficient (b) = 0...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29041922/institute-collection-and-analysis-of-nanobodies-ican-a-comprehensive-database-and-analysis-platform-for-nanobodies
#12
Jing Zuo, Jian Li, Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie
BACKGROUND: Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae. As a novel class of antibody, they show many advantages compared with traditional antibodies such as smaller size, higher stability, improved specificity, more easily expressed in microorganisms. These unusual hallmarks make them as promising tools in basic research and clinical practice. Although thousands of nanobodies are known to be published, no single database provides searchable, unified annotation and integrative analysis tools for these various nanobodies...
October 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29038738/a-case-of-infective-endocarditis-and-spinal-epidural-abscess-caused-by-streptococcus-mitis-bacteremia
#13
Victoria S Byrd, Attila S Nemeth
A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Labs revealed leukocytosis, anemia, thrombocytopenia, and elevated liver function tests and INR. Endoscopy demonstrated antral ulcers, duodenitis, and esophagitis. Blood cultures were obtained and broad-spectrum antibiotics started; cultures later grew Streptococcus mitis, and antibiotic coverage was narrowed...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29038072/amenorrhea-rates-and-predictors-during-one-year-of-levonorgestrel-52mg-intrauterine-system-use
#14
Philip D Darney, Gretchen S Stuart, Michael A Thomas, Carrie Cwiak, Andrea Olariu, Mitchell D Creinin
OBJECTIVE: Evaluate amenorrhea patterns and predictors of amenorrhea during the first year after levonorgestrel 52mg intrauterine system (IUS) placement. STUDY DESIGN: This cohort analysis includes 1714 nulliparous and parous women who received a Liletta® levonorgestrel 52mg IUS in a multicenter trial to evaluate efficacy and safety for up to 8years. Participants maintained a daily diary with bleeding information. We assessed bleeding patterns in 90-day intervals; amenorrhea was defined as no bleeding or spotting in the preceding 90days...
October 13, 2017: Contraception
https://www.readbyqxmd.com/read/29030801/deep-arm-ear-ecg-image-learning-for-highly-wearable-biometric-human-identification
#15
Qingxue Zhang, Dian Zhou
In this study, to advance smart health applications which have increasing security/privacy requirements, we propose a novel highly wearable ECG-based user identification system, empowered by both non-standard convenient ECG lead configurations and deep learning techniques. Specifically, to achieve a super wearability, we suggest situating all the ECG electrodes on the left upper-arm, or behind the ears, and successfully obtain weak but distinguishable ECG waveforms. Afterwards, to identify individuals from weak ECG, we further present a two-stage framework, including ECG imaging and deep feature learning/identification...
October 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29030717/baseline-cigarette-smoking-status-as-a-predictor-of-virologic-suppression-and-cd4-cell-count-during-one-year-follow-up-in-substance-users-with-uncontrolled-hiv-infection
#16
Theresa Winhusen, Daniel J Feaster, Rui Duan, Jennifer L Brown, Eric S Daar, Raul Mandler, Lisa R Metsch
Cigarette smoking is prevalent in people living with HIV/AIDS (PLHIV) who abuse alcohol and/or illicit substances. This study evaluated whether smoking is predictive of virologic non-suppression (> 200 copies/mL) and low CD4 count (< 200 cells/mm(3)) during 1-year follow-up in medically hospitalized, substance-using PLHIV recruited for a multi-site trial. Smoking status was assessed with the Heaviness of Smoking Index (HSI). Analyses revealed that, controlling for baseline differences and adherence to antiretroviral therapy, non-smokers (n = 237), compared to smokers scoring in the medium-to-high range on the HSI (n = 386), were significantly more likely to achieve viral suppression (OR 1...
October 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#17
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29021113/association-between-alcohol-consumption-and-injection-and-sexual-risk-behaviors-among-people-who-inject-drugs-in-rural-puerto-rico
#18
Melissa Welch-Lazoritz, Dane Hautala, Patrick Habecker, Kirk Dombrowski
Although alcohol use has been associated with risky behavior generally, the relationship between alcohol use and multiple types of risk behaviors that could lead to the acquisition and transmission of HIV and hepatitis C (HCV) among people who inject drugs (PWID) has not been fully examined. The current study seeks to contribute to the understanding of how alcohol use is related to both injection risk and sexual risk, among a non-treatment, cross-sectional sample of mostly male PWID in rural Puerto Rico (n=315)...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29016726/genetic-polymorphisms-of-alcohol-metabolizing-enzymes-and-alcohol-consumption-are-associated-with-asymptomatic-cardiac-remodeling-and-subclinical-systolic-dysfunction-in-large-community-dwelling-asians
#19
Chung-Lieh Hung, Shun-Chuan Chang, Sheng-Hsiung Chang, Po-Ching Chi, Yu-Jun Lai, Shih-Wei Wang, Yih-Jer Wu, Hung-I Yeh, Shing-Jong Lin, Che-Hong Chen, Daria Mochly-Rosen, Li-Yu Wang
Aims: Excessive consumption of alcoholic beverages is associated with cardiac remodeling and cardiomyopathy. We examined the possible association of alcohol use, common Asian genetic variants in genes involved in alcohol metabolism, and cardiac structures/functions alterations. Methods: A prospective, community-dwelling survey among individuals with available complete echocardiography examined the associations of alcohol use, cardiac structure/functions, and three common alcohol metabolizing genetic variants, including aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) and cytochrome P450 (CYP) isoform 2E1 (CYP2E1)...
August 31, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28987516/cannabis-can-augment-thrombolytic-properties-of-rtpa-case-report-of-an-intracranial-hemorrhage-in-a-heavy-cannabis-user
#20
Amar Shere, Hemant Goyal
Cannabis is one of the most commonly used illicit drugs in the United States and is considered to have several adverse health effects. There is evidence suggesting that its recreational use is associated with both increased cardio- and cerebrovascular events. Recently, multiple cases of ischemic and hemorrhagic strokes associated with cannabis use were reported in the literature (Goyal et al., 2017). It has been suggested that cannabis can affect cerebral auto-regulation and vascular tone leading to vasoconstriction and acute ischemic stroke...
September 28, 2017: American Journal of Emergency Medicine
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