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Eric Seiti Yamanaka, Luis A Tortajada-Genaro, Nuria Pastor, Ángel Maquieira
The genotyping of a single-nucleotide polymorphism (SNP) is addressed through methods based on loop-mediated isothermal amplification (LAMP) combined with user-friendly optical read-outs to cover the current demand for point-of-care DNA biomarker detection. The modification of primer design and reaction composition improved the assay selectivity yielding allele-specific results and reducing false-positive frequency. Furthermore, the reduced cost, ease of use and effectiveness of colorimetric detection (solution and hybridisation chip formats) were availed for the image capture by a smartphone, reching high sensitivity...
March 8, 2018: Biosensors & Bioelectronics
Lindsay Glicksberg, Sumandeep Rana, Sarah Kerrigan
PURPOSE: Synthetic cathinones are encountered in a variety of antemortem and postmortem forensic toxicology investigations. Earlier experimental studies using fortified urine have evaluated analyte, temperature and pH-dependent variables associated with their stability. The purpose of this study was to compare experimental findings with those obtained using authentic urine from cathinone users. METHODS: In this report we compare cathinone concentrations in 180 authentic unpreserved urine specimens, following known periods of refrigerated storage...
March 8, 2018: Forensic Science International
Peng Bao, Hua-Wei Shen, Junming Huang, Haiqiang Chen
Micro-blogging systems have become one of the most important ways for information sharing. Network structure and users' interactions such as forwarding behaviors have aroused considerable research attention, while mention, as a key feature in micro-blogging platforms which can improve the visibility of a message and direct it to a particular user beyond the underlying social structure, is seldom studied in previous works. In this paper, we empirically study the mention effect in information diffusion, using the dataset from a population-scale social media website...
2018: PloS One
Salvador Martínez-Bartolomé, J Alberto Medina-Aunón, Miguel Ángel López-García, Carmen González-Tejedo, Gorka Prieto, Rosana Navajas, Emilio Salazar-Donate, Carolina Fernandez-Costa, John R Yates, Juan Pablo Albar
Mass spectrometry-based proteomics has evolved into a high-throughput technology where numerous large-scale datasets are generated from diverse analytical platforms. Furthermore, several scientific journals and funding agencies have emphasized the storage of proteomics data in public repositories to facilitate its evaluation, inspection and reanalysis. As a consequence, public proteomics data repositories are growing rapidly. However, tools are needed to integrate multiple proteomics datasets in order to compare different experimental features or to perform quality control analysis...
March 20, 2018: Journal of Proteome Research
Jason A Brant, Steven J Eliades, Hannah Kaufman, Jinbo Chen, Michael J Ruckenstein
OBJECTIVE: To evaluate high-performing cochlear implant patients' performance on AzBio sentence testing. METHODS: Retrospective review of prospectively collected database at a tertiary care hospital. Unilateral cochlear implant patients with AzBio testing were included. The primary outcome of interest was AzBio performance scores in quiet and at +10 and +5 decibels signal to noise (dB S/N). RESULTS: One hundred eighty five subjects met inclusion criteria with scores for AzBio in quiet, 114 at +10 dB S/N, and 66 at +5 dB S/N...
March 19, 2018: Otology & Neurotology
Seynabou Sougoufara, Omar Thiaw, Aurélie Cailleau, Nafissatou Diagne, Myriam Harry, Charles Bouganali, Pape M Sembène, Souleymane Doucoure, Cheikh Sokhna
The implementation of long-lasting insecticidal-treated bed nets (LLINs) has contributed to halving the mortality rate due to malaria since 2000 in sub-Saharan Africa. These tools are highly effective against indoor-feeding malaria vectors. Thus, to achieve the World Health Assembly's new target to reduce the burden of malaria over the next 15 years by 90%, it is necessary to understand how the spatiotemporal dynamics of malaria vectors and human exposure to bites is modified in the context of scaling up global efforts to control malaria transmission...
March 19, 2018: American Journal of Tropical Medicine and Hygiene
Jie Dong, Zhi-Jiang Yao, Lin Zhang, Feijun Luo, Qinlu Lin, Ai-Ping Lu, Alex F Chen, Dong-Sheng Cao
BACKGROUND: With the increasing development of biotechnology and informatics technology, publicly available data in chemistry and biology are undergoing explosive growth. Such wealthy information in these data needs to be extracted and transformed to useful knowledge by various data mining methods. Considering the amazing rate at which data are accumulated in chemistry and biology fields, new tools that process and interpret large and complex interaction data are increasingly important...
March 20, 2018: Journal of Cheminformatics
Tamara J Somers, Sarah A Kelleher, Caroline S Dorfman, Rebecca A Shelby, Hannah M Fisher, Krista Rowe Nichols, Keith M Sullivan, Nelson J Chao, Gregory P Samsa, Amy P Abernethy, Francis J Keefe
BACKGROUND: Pain is a challenge for patients following hematopoietic stem cell transplantation (HCT). OBJECTIVE: This study aimed to develop and test the feasibility, acceptability, and initial efficacy of a Web-based mobile pain coping skills training (mPCST) protocol designed to address the needs of HCT patients. METHODS: Participants had undergone HCT and reported pain following transplant (N=68). To guide intervention development, qualitative data were collected from focus group participants (n=25) and participants who completed user testing (n=7)...
March 19, 2018: JMIR MHealth and UHealth
Jonathan K Noel, Thomas F Babor, James J Grady
Aims: The current study was conducted to investigate how changes in the content of a social media ad, user engagement values associated with the ad and user-generated comments (UGCs) associated with the ad can influence the appeal (i.e. source appeal, informational appeal and emotional appeal) of a social media ad. Short summary: Facebook beer ads that violated the guidelines of a relevant marketing code were rated as more emotionally appealing compared to Facebook beer ads that did not violated the guidelines...
March 15, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
Jean Courtemanche, Samson King, David Bouck
The application of 3D printing and microcontrollers allows users to rapidly engineer novel hardware solutions useful in a laboratory environment. 3D printing is transformative as it enables the rapid fabrication of adapters, housings, jigs, and small structural elements. Microcontrollers allow for the creation of simple, inexpensive machines that receive input from one or more sensors to trigger a mechanical or electrical output. Bringing these technologies together, we have developed custom solutions that improve capabilities and reduce costs, errors, and human intervention...
March 1, 2018: SLAS Technology
Esther López Del Cerro, Carolina Serrano Diana, Ana María Castillo Cañadas, Esteban González Mirasol, Francisco García Santos, María Teresa Gómez García, Gaspar González de Merlo
The use of long-acting contraceptive methods is on the rise. The aim of this study was to describe the main variables (effectiveness, tolerability, menstrual bleeding) associated with the use of subdermal contraceptive implants and to investigate the influence of age on these variables. This was a descriptive, retrospective, observational study of 221 cases of contraceptive implants inserted at a Spanish hospital between 2006 and 2015. The mean age of implant users was 31.2 ± 7.5 years. Effectiveness was 100% and good tolerability was recorded for 86...
March 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
John E Downey, Nathaniel Schwed, Steven M Chase, Andrew B Schwartz, Jennifer L Collinger
Intracortical brain-computer interfaces (BCIs) are being developed to assist people with motor disabilities in communicating and interacting with the world around them. This technology relies on recordings from the primary motor cortex, which may vary from day to day. 
 Approach: Here we quantify, in two long-term BCI subjects, the length of time that action potentials from the same neuron, or group of neurons, can be recorded from motor cortex. 
 Main Results: These action potentials, are identified by their extracellular waveforms and may change within a single day, although some of these identified units can be identified consistently for weeks and even months...
March 19, 2018: Journal of Neural Engineering
Victoria Shelus, Nicki Ashcroft, Sarah Burgess, Monica Giuffrida, Victoria Jennings
CONTEXT: Given the proportion of Kenyan women not using hormonal contraceptives, the country appears to have a substantial need for a modern, natural family planning option. The CycleBeads® mobile phone application (app), a digital platform for the Standard Days Method® of family planning, could help address this issue. METHODS: After the CycleBeads app was promoted in Kenya in May-June 2015, a three-month pilot study was conducted to collect quantitative and qualitative data from 185 female app users...
September 1, 2017: International Perspectives on Sexual and Reproductive Health
Koren Hanson, Kevin P Haggerty, Charles B Fleming, Martie L Skinner, Mary Casey-Goldstein, W Alex Mason, Ronald W Thompson, Cleve Redmond
OBJECTIVE: As legalization of nonmedical retail marijuana increases, states are implementing public health campaigns designed to prevent increases in youth marijuana use. This study investigated which types of marijuana-related messages were rated most highly by parents and their teens and whether these preferences differed by age and marijuana use. METHOD: Nine marijuana-focused messages were developed as potential radio, newspaper, or television announcements...
March 2018: Journal of Studies on Alcohol and Drugs
Hayley Treloar Padovano, Robert Miranda
OBJECTIVE: The present study used youth's in vivo reports of subjective responses to cannabis while smoking in their natural environments to identify real-world mechanisms of topiramate treatment for cannabis misuse. METHOD: Participants were 40 cannabis users (≥ twice weekly in past 30 days), ages 15-24 years (47.5% female), with at least one cannabis use episode during the final 3 weeks of a 6-week, randomized clinical trial. Youth reported subjective "high" while smoking, stimulation, sedation, stress, craving, and grams of marijuana used in the natural environment via wireless electronic devices...
March 2018: Journal of Studies on Alcohol and Drugs
Viktoriya L Nikolova, Keerati Pattanaseri, Diego Hidalgo-Mazzei, David Taylor, Allan H Young
BACKGROUND: Lithium is widely used for the treatment of bipolar disorder. Owing to its narrow therapeutic index and side-effect profile, regular monitoring of serum levels, renal and thyroid function has been recommended by all major guidelines on lithium use. OBJECTIVES: We investigated whether lithium monitoring during maintenance phase treatment in clinical practice meets the latest recommendation by the National Institute for Health and Clinical excellence (i...
March 1, 2018: Journal of Psychopharmacology
M Amine Amiche, Shahab Abtahi, Johanna H M Driessen, Peter Vestergaard, Frank de Vries, Suzanne M Cadarette, Andrea M Burden
We examined the effect of cumulative exposure to high doses of oral glucocorticoids on fracture risk. Compared to short-course users (daily dose ≥ 15 mg + cumulative < 1 g), heavy users (daily dose ≥ 15 mg + cumulative dose ≥ 1 g) had the highest risk of fracture. These patients should be monitored for fracture management strategies. PURPOSE: The effect of cumulative exposure to high daily doses of oral glucocorticoids on fracture risk remains debated. We therefore aimed to examine the hip fracture risk associated with short courses and heavy use of high-dosed oral glucocorticoids...
March 18, 2018: Archives of Osteoporosis
John W Kakareka, Anthony Z Faranesh, Randall H Pursley, Adrienne Campbell-Washburn, Daniel A Herzka, Toby Rogers, Josh Kanter, Kanishka Ratnayaka, Robert J Lederman, Thomas J Pohida
Hemodynamic recording during interventional cardiovascular procedures is essential for procedural guidance, monitoring patient status, and collection of diagnostic information. Recent advances have made interventions guided by magnetic resonance imaging (MRI) possible and attractive in certain clinical scenarios. However, in the MRI environment, electromagnetic interference (EMI) can cause severe distortions and artifacts in acquired hemodynamic waveforms. The primary aim of this paper was to develop and validate a system to minimize EMI on electrocardiogram (ECG) and invasive blood pressure (IBP) signals...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Luisa Flohr, Shaylene Beaudry, K Taneille Johnson, Nicholas West, Catherine M Burns, J Mark Ansermino, Guy A Dumont, David Wensley, Peter Skippen, Matthias Gorges
The pediatric intensive care unit (ICU) is a complex environment, in which a multidisciplinary team of clinicians (registered nurses, respiratory therapists, and physicians) continually observe and evaluate patient information. Data are provided by multiple, and often physically separated sources, cognitive workload is high, and team communication can be challenging. Our aim is to combine information from multiple monitoring and therapeutic devices in a mobile application, the VitalPAD , to improve the efficiency of clinical decision-making, communication, and thereby patient safety...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Qindong Sun, Nan Wang, Shancang Li, Hongyi Zhou
Recently, the online social networks (OSNs) have received considerable attentions as a revolutionary platform to offer users massive social interaction among users that enables users to be more involved in their own healthcare. The OSNs have also promoted increasing interests in the generation of analytical, data models in health informatics. This paper aims at developing an obesity identification, analysis, and estimation model, in which each individual user is regarded as an online social network 'sensor' that can provide valuable health information...
March 15, 2018: Journal of Biomedical Informatics
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