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https://www.readbyqxmd.com/read/28351029/cytopathological-changes-induced-by-the-crack-use-in-oral-mucosa
#1
Milena Binhame Albini, Ingra Taís Malacarne, Thiago Beltrami Dias Batista, Antônio Adilson Soares de Lima, Maria Angela Naval Machado, Aline Cristina Batista Rodrigues Johann, Edvaldo Antonio Ribeiro Rosa, Luciana Reis Azevedo-Alanis
AIMS: To evaluate cytological alterations, inflammation, and microbial charge of the oral mucosa epithelium in crack users in in terms of the amount and duration of use. METHODS: Two hundred thirty four crack users (case group) and 120 non-users (control group) participated in this study. Clinically healthy epithelial cells were collected from the posterior mouth floor, using the conventional exfoliative cytology. Some of the aspects evaluated were as follows: Papanicolaou classification, nuclear area (NA), cytoplasmic area (CA), nuclear/cytoplasmic area ratio (NA/CA), inflammation, microbial charge, keratinization, enucleated superficial cells, and binucleation...
March 29, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28350511/design-construction-and-evaluation-of-sensor-lock-an-electromechanical-stance-control-knee-joint
#2
Mokhtar Arazpour, Monireh Ahmadi Bani, Mina Baniasad, Mohammad Samadian, Navid Golchin
BACKGROUND AND AIM: Most currently-available stance control knee ankle foot orthoses (SCKAFOs) still need full knee extension to lock the knee joint, and they are still noisy, bulky, and heavy. Therefore, the aim of this study was to design, construct, and evaluate an original electromechanical SCKAFO knee joint that could feasibly solve these problems, and thus address the problems of current stance control knee joints with regards to their structure, function, cosmesis, and cost. METHOD: Ten able-bodied (AB) participants and two (knee ankle foot orthosis) KAFO users were recruited to participate in the study...
March 28, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28346653/how-successful-is-the-fitting-of-digital-hearing-aids-implications-for-the-allocation-of-resources-within-national-health-systems
#3
Petros V Vlastarakos, Alastair I Cameron, Thomas P Nikolopoulos
We conducted a retrospective study to determine the success rate of initial fittings in digital hearing aid (DHA) users. We also addressed the implications of national health systems' continuing to provide access to these devices. We identified 1,597 consecutively presenting adults who had undergone a first fitting or a new fitting (i.e., an upgrade from an analogue hearing aid in the first or second ear) of a behind-the-ear DHA during the previous year. We further sought to identify all nominal reprogram appointments that had taken place within 6 months after the first or new fitting; we found 460 such appointments (28...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28346490/effect-of-hiv-and-malaria-parasites-co-infection-on-immune-hematological-profiles-among-patients-attending-anti-retroviral-treatment-art-clinic-in-infectious-disease-hospital-kano-nigeria
#4
Feyisayo Ebenezer Jegede, Tinuade Ibijoke Oyeyi, Surajudeen Abiola Abdulrahman, Henry Akwen Mbah, Titilope Badru, Chinedu Agbakwuru, Oluwasanmi Adedokun
BACKGROUND: Human immunodeficiency virus (HIV) and malaria co-infection may present worse health outcomes in the tropics. Information on HIV/malaria co-infection effect on immune-hematological profiles is critical for patient care and there is a paucity of such data in Nigeria. OBJECTIVE: To evaluate immune-hematological profiles among HIV infected patients compared to HIV/malaria co-infected for ART management improvement. METHODS: This was a cross sectional study conducted at Infectious Disease Hospital, Kano...
2017: PloS One
https://www.readbyqxmd.com/read/28346451/sc3-consensus-clustering-of-single-cell-rna-seq-data
#5
Vladimir Yu Kiselev, Kristina Kirschner, Michael T Schaub, Tallulah Andrews, Andrew Yiu, Tamir Chandra, Kedar N Natarajan, Wolf Reik, Mauricio Barahona, Anthony R Green, Martin Hemberg
Single-cell RNA-seq enables the quantitative characterization of cell types based on global transcriptome profiles. We present single-cell consensus clustering (SC3), a user-friendly tool for unsupervised clustering, which achieves high accuracy and robustness by combining multiple clustering solutions through a consensus approach (http://bioconductor.org/packages/SC3). We demonstrate that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients.
March 27, 2017: Nature Methods
https://www.readbyqxmd.com/read/28346131/lack-of-diversity-in-personal-health-record-evaluations-with-older-adult-participants-a-systematic-review-of-literature
#6
Laura Kneale, George Demiris
BACKGROUND: Older adults are not adopting personal health records (PHRs) at the same rates as other adult populations. Disparities in adoption rates are also reported in older adult subgroups. The variability in adoption may be because PHRs are not designed to meet older adult users. OBJECTIVE: We analyzed PHR evaluation studies to examine the characteristics and perspectives of older adult study participants to identify their self-reported needs. METHOD: We searched Medline, CINAHL, PsycINFO, and Embase for PHR evaluation studies that involved older adult participants...
January 15, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28346087/pubchem-bioassay
#7
Yanli Wang, Tiejun Cheng, Stephen H Bryant
High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technology has led to the generation of terabytes of data in screening laboratories. Despite the technology development toward HTS productivity, fewer efforts were devoted to HTS data integration and sharing. As a result, the huge amount of HTS data was rarely made available to the public...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28346016/dsl-prescriptive-targets-for-bone-conduction-devices-adaptation-and-comparison-to-clinical-fittings
#8
William E Hodgetts, Susan D Scollie
OBJECTIVE: To develop an algorithm that prescribes targets for bone conduction frequency response shape, compression, and output limiting, along with a clinical method that ensures accurate transforms between assessment and verification stages of the clinical workflow. DESIGN: Technical report of target generation and validation. STUDY SAMPLE: We recruited 39 adult users of unilateral percutaneous bone conduction hearing aids with a range of unilateral, bilateral, mixed and conductive hearing losses across the sample...
March 27, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28345678/laryngeal-manual-therapy-palpatory-evaluation-scale-a-preliminary-study-to-examine-its-usefulness-in-diagnosis-of-occupational-dysphonia
#9
Ewelina Woźnicka, Ewa Niebudek-Bogusz, Joanna Morawska, Justyna Wiktorowicz, Mariola Śliwińska-Kowalska
BACKGROUND: The aim of this study has been to assess the larynx and soft tissue around the vocal tract in a group of people with healthy voice, and in a group of patients with occupational dysphonia using the new laryngeal manual therapy palpatory evaluation scale (LMTPE). MATERIAL AND METHODS: The examinations were performed in a study (dysphonic) group of professional voice users who had developed voice disorders (N = 51) and in the control group of normophonic subjects (N = 50)...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345528/genetic-and-psychosocial-factors-for-benzodiazepine-addiction-an-analysis-based-on-the-results-of-the-authors-own-research-conducted-in-a-group-of-benzodiazepine-addicted-and-non-addicted-individuals
#10
Anna Konopka, Monika Mak, Anna Grzywacz, Sławomir Murawiec, Jerzy Samochowiec
PURPOSE: In spite of the fact that the addictive potential of benzodiazepine (BDZ) drugs has been known for a long time, benzodiazepine addiction remains a common problem for psychiatry to deal with. The etiology of benzodiazepine addiction is very complex. Among the risk factors, the course of the treatment, demographic status and psychological features of a patient seem to play an important role. The aim of this study was to investigate both psychological and genetic factors differentiating benzodiazepine addicts from non-addicted users...
March 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#11
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28344842/effectiveness-of-direct-safety-regulations-on-manufacturers-and-users-of-industrial-machines-its-implications-on-industrial-safety-policies-in-republic-of-korea
#12
Gi Heung Choi
BACKGROUND: Despite considerable efforts made in recent years, the industrial accident rate and the fatality rate in the Republic of Korea are much higher than those in most developed countries in Europe and North America. Industrial safety policies and safety regulations are also known to be ineffective and inefficient in some cases. METHODS: This study focuses on the quantitative evaluation of the effectiveness of direct safety regulations such as safety certification, self-declaration of conformity, and safety inspection of industrial machines in the Republic of Korea...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28344768/an-end-to-lifetime-blood-donation-ban-in-israel-for-msm-would-be-a-major-step-toward-a-science-based-policy-that-reduces-stigma
#13
EDITORIAL
Sean Cahill, Timothy Wang
In recent years, countries around the world have revised their blood donation policies regarding gay and bisexual men, and other men who have sex with men (MSM). The United States lifted the lifetime ban on MSM from donating blood in 2015, replacing it with a 1 year deferral policy allowing MSM to donate if they abstain from sex for 12 months. Other countries followed suit, while Italy and Spain have implemented deferral policies based on individual risk assessments regardless of sexual orientation. If Israel were to adopt a one year deferral policy for MSM, as recommended by Drs...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28344568/time-is-money-the-decision-making-of-smartphone-high-users-in-gain-and-loss-intertemporal-choice
#14
Zixuan Tang, Huijun Zhang, An Yan, Chen Qu
Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28344036/focus-the-interface-between-data-collection-and-data-processing-in-cryo-em
#15
Nikhil Biyani, Ricardo D Righetto, Robert McLeod, Daniel Caujolle-Bert, Daniel Castano-Diez, Kenneth N Goldie, Henning Stahlberg
We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing. Focus creates a user-friendly environment to import and manage data recorded by direct electron detectors and perform elemental image processing tasks in a high-throughput manner while new data is being acquired at the microscope. It provides the functionality required to remotely monitor the progress of data collection and data processing, which is essential now that automation in cryo-EM allows a steady flow of images of single particles, two-dimensional crystals, or electron tomography data to be recorded in overnight sessions...
March 23, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28343746/preliminary-development-of-an-advanced-modular-pressure-relief-cushion-testing-and-user-evaluation
#16
Tyler Freeto, Steven J Mitchell, Kath M Bogie
STUDY AIM: Effective pressure relief cushions are identified as a core assistive technology need by the World Health Organization Global Cooperation on Assistive Technology. High quality affordable wheelchair cushions could provide effective pressure relief for many individuals with limited access to advanced assistive technology. MATERIALS: Value driven engineering (VdE) principles were employed to develop a prototype modular cushion. Low cost dynamically responsive gel balls were arranged in a close packed array and seated in bilayer foam for containment and support...
March 20, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28343063/motives-for-illicit-prescription-drug-use-among-university-students-a-systematic-review-and-meta-analysis
#17
REVIEW
Trevor Bennett, Katy Holloway
BACKGROUND: There is a growing body of research on the motives for prescription drug misuse (PDM) among university students. However, the overall findings of this research are hard to decipher. Studies use different methods, they examine different drug types, the motives are phrased in various ways, and the results differ widely. In order to make sense of this body of knowledge, it is necessary to synthesise the results across studies and draw out conclusions. METHODS: The research comprises a systematic review and meta-analysis of studies on the motives of university students for illicit use of four different types of prescription medication (stimulants, analgesics, tranquillisers and sedatives)...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28342716/immediate-postpartum-intrauterine-device-and-implant-program-outcomes-a-prospective-analysis
#18
Jennifer L Eggebroten, Jessica N Sanders, David K Turok
BACKGROUND: In-hospital placement of intrauterine devices (IUD) and contraceptive implants following vaginal and cesarean delivery is increasingly popular and responds to maternal motivation for highly effective postpartum contraception. Immediate postpartum IUD insertion is associated with higher expulsion than interval placement, but emerging evidence suggests that the LNG IUD may have a higher expulsion rate than the Cu IUD. OBJECTIVE: This study evaluated in-hospital provision, expulsion and six month continuation of immediate postpartum copper T380 IUDs (Cu IUD), levonorgestrel (LNG) IUDs, and contraceptive implants...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28342630/statins-attenuate-but-do-not-eliminate-the-reverse-epidemiology-of-total-serum-cholesterol-in-patients-with-non-ischemic-chronic-heart-failure
#19
Hanna Fröhlich, Nandita Raman, Tobias Täger, Dieter Schellberg, Kevin M Goode, Syed Kazmi, Morten Grundtvig, Torstein Hole, John G F Cleland, Hugo A Katus, Stefan Agewall, Andrew L Clark, Dan Atar, Lutz Frankenstein
BACKGROUND: In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival - while statin usage is not. The impact of statin treatment on the "reverse epidemiology" of cholesterol is unclear. METHODS: 2992 consecutive patients with non-ischemic CHF due to left ventricular systolic dysfunction from the Norwegian CHF Registry and the CHF Registries of the Universities of Hull, UK, and Heidelberg, Germany, were studied...
March 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28342407/music-and-natural-sounds-in-an-auditory-steady-state-response-based-brain-computer-interface-to-increase-user-acceptance
#20
Jeong Heo, Hyun Jae Baek, Seunghyeok Hong, Min Hye Chang, Jeong Su Lee, Kwang Suk Park
Patients with total locked-in syndrome are conscious; however, they cannot express themselves because most of their voluntary muscles are paralyzed, and many of these patients have lost their eyesight. To improve the quality of life of these patients, there is an increasing need for communication-supporting technologies that leverage the remaining senses of the patient along with physiological signals. The auditory steady-state response (ASSR) is an electro-physiologic response to auditory stimulation that is amplitude-modulated by a specific frequency...
March 18, 2017: Computers in Biology and Medicine
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