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Cervical incompetence treatment

N Sung, H J Byeon, M D Salazar Garcia, A Skariah, L Wu, S Dambaeva, K Beaman, A Gilman-Sachs, J Kwak-Kim
Alterations in normal balance of B cell subsets have been reported in various rheumatic diseases. In this study, we report a woman with a history of recurrent pregnancy losses (RPL) and infertility who had low levels of memory B cells. A 35-year-old woman with a history of RPL and infertility was demonstrated to have increased peripheral blood CD19+ B cells with persistently low levels of memory B cell subsets. Prior to the frozen donor egg transfer cycle, prednisone and intravenous immunoglobulin G (IVIg) treatment was initiated and patient achieved dichorionic diamniotic twin pregnancies...
September 28, 2016: Journal of Reproductive Immunology
Eun-Joo Joung, Eun-Byeol Go, Jae Young Kwack, Yong Soon Kwon
A 38-year-old nulliparous woman was referred to our clinic because of cervical incompetence at 19 weeks of gestation. Trans-abdominal cervicoisthmic cerclage was performed after failure of modified Shirodkar cerclage operation in the patient at 21 weeks of gestation via a laparotomic approach. Another 38-year-old patient, who underwent loop electrosurgical excision procedure conization for treatment of cervical dysplasia 4 years ago, presented for cervical incompetence. At 18 weeks of gestation, we performed trans-abdominal laparotomic cervicoisthmic cerclage without any post-operative complications...
July 2016: Obstetrics & Gynecology Science
Xiaowu Huang, Ning Ma, Tin-Chiu Li, Yan Guo, Dongmei Song, Yuting Zhao, Enlan Xia
OBJECTIVE: To evaluate the efficacy of simplified laparoscopic cervical cerclage (SLCC) in the prevention of miscarriage and preterm delivery in women with cervical incompetence who failed to have a live birth following a vaginal cervical cerclage in a previous pregnancy. STUDY DESIGN: From Dec 2010 to January 2015, a consecutive cases of 100 subjects with cervical incompetence but who failed to have a live birth following a vaginal cervical cerclage in a previous pregnancy underwent SLCC...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Haruka Nishida, Yoko Matsumoto, Kei Kawana, R James Christie, Mitsuru Naito, Beob Soo Kim, Kazuko Toh, Hyun Su Min, Yu Yi, Yu Matsumoto, Hyun Jin Kim, Kanjiro Miyata, Ayumi Taguchi, Kensuke Tomio, Aki Yamashita, Tomoko Inoue, Hiroe Nakamura, Asaha Fujimoto, Masakazu Sato, Mitsuyo Yoshida, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Nobuhiro Nishiyama, Kazunori Kataoka, Yutaka Osuga, Tomoyuki Fujii
Human papillomavirus (HPV) E6 and E7 oncogenes are essential for the immortalization and maintenance of HPV-associated cancer and are ubiquitously expressed in cervical cancer lesions. Small interfering RNA (siRNA) coding for E6 and E7 oncogenes is a promising approach for precise treatment of cervical cancer, yet a delivery system is required for systemic delivery to solid tumors. Here, an actively targeted polyion complex (PIC) micelle was applied to deliver siRNAs coding for HPV E6/E7 to HPV cervical cancer cell tumors in immune-incompetent tumor-bearing mice...
June 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
P L Tran, G Payet, G Barau, M Boukerrou
UNLABELLED: Cervical incompetency is one of the direct causes of neonatal morbidity and mortality; a unique and efficient treatment of which is cervical cerclage. The objective of this study was the evaluation of physicians' practice patterns concerning cerclage in Reunion Island, in order to reinforce the management and information of patients at risk. The indications and complications of cerclages effectuated in 2010 and 2011 were compared to the literature. MATERIAL AND METHODS: In this retrospective study, all the medical records of cerclage realized in Reunion Island during two years were collected and analyzed, specifically data concerning patients' cerclage, the complications, and the outcome of the pregnancy...
September 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
M Doret
OBJECTIVES: To propose guidelines for clinical practice for routine postnatal visit and after pathological pregnancies. MATERIALS AND METHODS: Bibliographic searches were performed with PubMed and Cochrane databases, and within international guidelines references. RESULTS: Postpartum visit should be planned 6 to 8 weeks after delivery and can be performed by an obstetrician, a gynecologist, a general practitioner or a midwife, when after normal pregnancy and delivery (Professional consensus)...
December 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Rajiv Chadha, Niyaz Ahmed Khan, Shalu Shah, Nitin Pant, Amit Gupta, Subhasis Roy Choudhury, Pinaki Ranjan Debnath, Archana Puri
AIMS: To discuss the assessment and management of genitourinary (GU) tract abnormalities in 21 girls with Types I-III congenital pouch colon (CPC), studied over a period of 10 years. MATERIALS AND METHODS: Assessment included clinical and radiological assessment, examination under anesthesia (EUA), endoscopy of the lower GU tract, and evaluation of the surgical findings, operative procedures for the GU anomalies, and the results of management. RESULTS: Initial examination of the external genitalia showed a "clover-leaf" appearance (n = 6) and a single perineal opening (n = 6)...
July 2015: Journal of Indian Association of Pediatric Surgeons
Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Yushi Akashi, Miyuki Morishita, Asuka Sugio, Naohiro Kanayama, Tsuyoshi Saito
Pregnancy after radical trachelectomy (RT) has a high risk of prematurity and complications such as preterm premature rupture of the membrane and chorioamnionitis. Placing a cervical cerclage at the time of RT plays an important role in preventing such obstetrical complications. In patients who have trouble with the cervical cerclage, miscarriage during the second trimester seems to be inevitable. We have therefore started preconception transabdominal cerclage (TAC) for these patients. A 36-year-old Japanese woman who had a history of miscarriage due to trouble with the nylon thread used for cerclage, successfully delivered after TAC...
August 2015: Journal of Obstetrics and Gynaecology Research
Leonarda Ciancimino, Antonio Simone Laganà, Giovanna Imbesi, Benito Chiofalo, Alfredo Mancuso, Onofrio Triolo
BACKGROUND: Several techniques of emergency vaginal cerclage have been proposed in case of unexpected and abrupt cervical incompetence (CI), in order to prolong the pregnancy as much as possible and to reduce the adverse maternal-fetal outcomes. The aim of our study was to evaluate the effectiveness of emergency cervical cerclage, performed with the combined modified Shirodkar-McDonald technique. METHODS: We selected 12 cases of emergency vaginal cerclage, performed between January 1, 2008 and June 30, 2013...
May 2015: Journal of Clinical Medicine Research
Norbert Winer, Florence Bretelle, Marie-Victoire Senat, Caroline Bohec, Philippe Deruelle, Frank Perrotin, Laure Connan, Christophe Vayssière, Bruno Langer, Marianne Capelle, Shohreh Azimi, Raphael Porcher, Patrick Rozenberg
OBJECTIVE: The objective of the study was to evaluate the efficacy of 17 alpha-hydroxyprogesterone caproate (17OHP-C) in prolonging gestation in patients with a short cervix and other risk factors for preterm delivery, such as previous preterm birth, cervical surgery, uterine anomalies, or prenatal diethylstilbestrol (DES) exposure. STUDY DESIGN: This open-label, multicenter, randomized controlled trial included asymptomatic singleton pregnancies from 20(+0) through 31(+6) weeks of gestation with a cervical length less than 25 mm and a history of preterm delivery or cervical surgery or uterine malformation or prenatal DES exposure...
April 2015: American Journal of Obstetrics and Gynecology
Fidan Israfil-Bayli, Philip Toozs-Hobson, Christoph Lees, Mark Slack, Khaled Ismail
BACKGROUND: Cervical incompetence is one of the causes of preterm birth and mid-trimester pregnancy loss. Cervical cerclage is a surgical procedure to treat cervical incompetence. Cervical cerclage reduces the incidence of preterm birth in women at risk of recurrent preterm birth, without a statistically significant reduction in perinatal mortality or neonatal morbidity. Multifilament/braided sutures such as Mersilene tape have been traditionally used for cervical cerclage. Braided sutures, particularly mesh-like non-absorbable sutures, have been associated with an increased risk of infection and, hence, some obstetricians prefer to use monofilament/non-braided sutures...
2014: Trials
Hua Zhou, Liang Jiang, Feng Wei, Miao Yu, Fengliang Wu, Xiaoguang Liu, Zhongjun Liu, Gengting Dang
BACKGROUND: Chordomas of the upper cervical spine are rare and present unique surgical challenge. This study aimed to describe the clinical characteristics and surgical management of patients with chordomas of the upper cervical spine. METHODS: Twenty-one patients with chordomas of the upper cervical spine who were treated in Peking University Third Hospital from January 1999 to October 2012 were retrospectively analyzed. Survival was calculated by the Kaplan-Meier method and was compared between groups using the log-rank test...
2014: Chinese Medical Journal
R A Schubert, E Schleussner, J Hoffmann, A Fiedler, H Stepan, A Gottschlich
In spite of the continuous progress in prenatal care, 1 out of 10 babies is born too early--tendency rising worldwide. As a consequence of the heterogeneous aetiology of preterm birth, there is still no single and efficient interventional therapy. Cerclage is one option for pregnancies with cervical insufficiency, whereas the clinical benefit is discussed controversially. We analyzed in a retrospective study with 120 patients the effect of a cerclage intervention regarding pregnancy prolongation. Patients with cervical incompetence and Shirodkar cerclage were compared to those undergoing conservative treatment...
August 2014: Zeitschrift Für Geburtshilfe und Neonatologie
Lu Luo, Shu-qin Chen, Hong-ye Jiang, Gang Niu, Qiong Wang, Shu-zhong Yao
OBJECTIVE: We introduce a modified surgical method for laparoscopic cervical cerclage (LCC) and compare the operative data and obstetric outcomes to those obtained by traditional vaginal cerclage (TVC). STUDY DESIGN: This is a prospective cohort study in a university-affiliated hospital from August 2008 through February 2013. Nineteen patients treated by LCC were prospectively monitored and the treatment outcomes were compared to a control group consisted of 25 patients that were retrospectively studied and treated with TVC using traditional McDonald suture...
August 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Togas Tulandi, Nadin Alghanaim, Ghaidaa Hakeem, Xianming Tan
The objective of this study was to evaluate the efficacy of abdominal cerclage via laparoscopy vs laparotomy and before vs after conception. We evaluated 16 studies of abdominal cerclage involving a total of 678 cases published between 1990 and 2013. We estimated the effect of laparotomy over laparoscopy and the effect of preconceptional over postconceptional cerclage using a generalized linear model by treating the success rates (third-trimester delivery and live birth) as dependent variables and laparotomy and preconceptional as independent factors...
November 2014: Journal of Minimally Invasive Gynecology
Jae Eun Shin, Min Jeong Kim, Guk Won Kim, Dae Woo Lee, Min Kyung Lee, Sa Jin Kim
Cervical incompetence is characterized by painless dilatation of the incompetent cervix and results in miscarriages and preterm delivery during second trimester. We report a 25-year-old patient, gravid 2, para 1, at 11 weeks' gestation with the diagnosis of cervical incompetence, in whom transvaginal cerclage was not technically possible and laparoscopic cervical cerclage was performed successfully. There were no operative or immediate postoperative complications. A healthy infant was delivered at 35 weeks by cesarean section...
May 2014: Obstetrics & Gynecology Science
Michal Koucký, Karin Malíčková, Tereza Cindrová-Davies, Anna Germanová, Antonín Pařízek, Marta Kalousová, Zdeněk Hájek, Tomáš Zima
Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regular contractions and/or cervical incompetence at 24-32 weeks' gestation were recruited into a prospective study. Each patient underwent transvaginal ultrasound examination of the cervical length, and regulatory T cells were quantified in peripheral blood samples by flow cytometry...
December 2014: Journal of Reproductive Immunology
Emily S Miller, Priya V Rajan, William A Grobman
OBJECTIVE: To compare outcomes of physical examination-indicated cerclage in women with twin gestations to those with singleton gestations and to identify whether risk factors for extremely preterm birth (before 28 weeks) differ between these 2 groups. STUDY DESIGN: This is a single institution retrospective cohort study of women who underwent a physical examination-indicated cerclage between Jan. 1, 1980, and Aug. 15, 2012. Differences in characteristics and outcomes were compared between women with twin and singleton gestations...
July 2014: American Journal of Obstetrics and Gynecology
Suthi Sangkarat, Irene Ruengkhachorn, Mongkol Benjapibal, Somsak Laiwejpithaya, Weerasak Wongthiraporn, Manee Rattanachaiyanont
AIM: To evaluate the operative, oncologic and obstetric outcomes of the loop electrosurgical excision procedure (LEEP) in cases with cervical neoplasia. MATERIALS AND METHODS: A retrospective cohort study was conducted on patients who were suspected of cervical neoplasia and therefore undergoing LEEP at Siriraj Hospital, Mahidol University, Thailand, during 1995-2000. Outcome measures included operative complications in 407 LEEP patients and long-term outcomes in the 248 patients with cervical intraepithelial neoplasia (CIN) who were treated with only LEEP...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
F Fuchs, F Audibert, M-V Senat
Progesterone was widely used in France during the 1980s and 1990s to prevent preterm birth until some published cases of cholestasis suddenly stopped its prescription. Since then, multiple randomized controlled trials have emerged and demonstrated the efficiency of the treatment but also its safety at low doses. In order to clarify its indications, we performed a current literature review. We analyzed literature data according to different categories of risk and different routes of administration. Results confirm that progesterone is an efficient treatment to prevent preterm birth in singleton gestation with short cervical length, and in singleton gestation with prior preterm birth with or without short cervical length...
February 2014: Gynécologie, Obstétrique & Fertilité
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