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https://www.readbyqxmd.com/read/28160764/vaccination-attitudes-and-practices-of-integrative-medicine-physicians
#1
Laura Jean Buehning, Kenneth Michael Peddecord
Context • The growth of Internet-based information and social networking has increased the accessibility and importance of antivaccine information. That information has led to a questioning of vaccination schedules and policies by many individuals. Although the attitudes of complementary and alternative practitioners, such as homeopaths and chiropractic students, toward vaccination have been assessed, despite the growth of integrative medicine, no assessment of the attitudes and practices regarding vaccination of these physicians has been performed...
January 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28154539/temporal-association-of-certain-neuropsychiatric-disorders-following-vaccination-of-children-and-adolescents-a-pilot-case-control-study
#2
Douglas L Leslie, Robert A Kobre, Brian J Richmand, Selin Aktan Guloksuz, James F Leckman
BACKGROUND: Although the association of the measles, mumps, and rubella vaccine with autism spectrum disorder has been convincingly disproven, the onset of certain brain-related autoimmune and inflammatory disorders has been found to be temporally associated with the antecedent administration of various vaccines. This study examines whether antecedent vaccinations are associated with increased incidence of obsessive-compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder, attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder in a national sample of privately insured children...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28141725/acute-agitation-and-self-injury-in-a-5-year-old-with-autism
#3
Jason Schweitzer, Christine James, Willough Jenkins, Michael I Reiff, Martin T Stein
A 5-year-old nonverbal child with autism spectrum disorder (ASD) was admitted to inpatient pediatrics with new onset agitation and self-injurious behavior. His parents described him as a pleasant child without previous episodes of self-injury. Four days before admission, the parents noted new irritability followed by 2 days of self-injury to the face without clear precipitant. His hitting intensified with closed fist to face, and he required parental physical restraint to prevent further injury. Car rides and ibuprofen provided only temporary relief...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28137374/maternal-immune-activation-and-autism-spectrum-disorder-from-rodents-to-nonhuman-and-human-primates
#4
REVIEW
Milo Careaga, Takeshi Murai, Melissa D Bauman
A subset of women who are exposed to infection during pregnancy have an increased risk of giving birth to a child who will later be diagnosed with a neurodevelopmental or neuropsychiatric disorder. Although epidemiology studies have primarily focused on the association between maternal infection and an increased risk of offspring schizophrenia, mounting evidence indicates that maternal infection may also increase the risk of autism spectrum disorder. A number of factors, including genetic susceptibility, the intensity and timing of the infection, and exposure to additional aversive postnatal events, may influence the extent to which maternal infection alters fetal brain development and which disease phenotype (autism spectrum disorder, schizophrenia, other neurodevelopmental disorders) is expressed...
March 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28104272/-preventing-carer-burnout
#5
REVIEW
Isabelle de Montety, Edgar Moussaoui, Jean-Marc Baleyte
The issue of the burnout of carers of disabled family members has been raising concern for several years. It is essential to identify the signs of suffering in the carer in order to put in place adapted support which will also be beneficial for the person being cared for. Autism, a disability which has a significant impact on the family circle, is an example of a condition for which providing support to carers is essential.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28101530/integrative-analysis-of-disease-signatures-shows-inflammation-disrupts-juvenile-experience-dependent-cortical-plasticity
#6
Milo R Smith, Poromendro Burman, Masato Sadahiro, Brian A Kidd, Joel T Dudley, Hirofumi Morishita
Throughout childhood and adolescence, periods of heightened neuroplasticity are critical for the development of healthy brain function and behavior. Given the high prevalence of neurodevelopmental disorders, such as autism, identifying disruptors of developmental plasticity represents an essential step for developing strategies for prevention and intervention. Applying a novel computational approach that systematically assessed connections between 436 transcriptional signatures of disease and multiple signatures of neuroplasticity, we identified inflammation as a common pathological process central to a diverse set of diseases predicted to dysregulate plasticity signatures...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28091344/a-comprehensive-systematic-review-and-meta-analysis-of-pharmacological-and-dietary-supplement-interventions-in-paediatric-autism-moderators-of-treatment-response-and-recommendations-for-future-research
#7
A Masi, A Lampit, M M DeMayo, N Glozier, I B Hickie, A J Guastella
BACKGROUND: Autism spectrum disorders (ASDs) are pervasive and multifactorial neurodevelopmental conditions, characterized by impairments in social communication and interaction, and restricted, repetitive patterns of behaviour, interests or activities. Treatment options to ameliorate symptoms of ASDs are limited. Heterogeneity complicates the quest for personalized medicine in this population. Our aim was to investigate if there are baseline characteristics of patients that moderate response or trial design features that impede the identification of efficacious interventions for ASDs...
January 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28074464/investigation-of-hand-function-among-children-diagnosed-with-autism-spectrum-disorder-with-upper-extremity-trauma-history
#8
Meral Huri, Sedef Şahin, Hülya Kayıhan
BACKGROUND: The present study was designed to compare hand function in autistic children with history of upper extremity trauma with that of autistic children those who do not have history of trauma. METHODS: The study group included total of 65 children diagnosed with autism spectrum disorder (ASD) and was divided into 2 groups: children with trauma history (Group I) and control group (Group II) (Group I: n=28; Group II: n=37). Hand function was evaluated with 9-Hole Peg Test and Jebsen Hand Function Test...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28074355/evaluation-of-visual-pedagogy-in-dental-check-ups-and-preventive-practices-among-6-12-year-old-children-with-autism
#9
Firoozeh Nilchian, Fereshteh Shakibaei, Zeinab Taghi Jarah
This study was aimed to evaluate the impact of visual pedagogy in dental check-ups and preventive practices among children with autism aged 6-12. In this randomized double-blind clinical trial, the cooperation of 40 children with autism age 6-12. The selected children were equally divided into two groups of case and control (n = 20). The obtained data were analyzed by statistical tests, including Chi square and independent t test. The results of Cochran showed a significant increase in children's cooperation with regard to fluoride therapy in the case group by repeating the visit and training sessions (p ≤ 0...
January 10, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28039324/topoisomerase-3%C3%AE-is-the-major-topoisomerase-for-mrnas-and-linked-to-neurodevelopment-and-mental-dysfunction
#10
Muzammil Ahmad, Weiping Shen, Wen Li, Yutong Xue, Sige Zou, Dongyi Xu, Weidong Wang
Human cells contain five topoisomerases in the nucleus and cytoplasm, but which one is the major topoisomerase for mRNAs is unclear. To date, Top3β is the only known topoisomerase that possesses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-binding protein, FMRP, to promote synapse formation; and Top3β gene deletion has been linked to schizophrenia. Here, we show that Top3β is also the most abundant mRNA-binding topoisomerase in cells. Top3β, but not other topoisomerases, contains a distinctive RNA-binding domain; and deletion of this domain diminishes the amount of Top3β that associates with mRNAs, indicating that Top3β is specifically targeted to mRNAs by its RNA binding domain...
December 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/28035928/consecutive-analysis-of-bace1-function-on-developing-and-developed-neuronal-cells
#11
Yuji Kamikubo, Nobumasa Takasugi, Kazue Niisato, Yoshie Hashimoto, Takashi Sakurai
The amyloid-β protein precursor (AβPP) is cleaved by a transmembrane protease termed β-site AβPP cleavage enzyme (BACE1), which is being explored as a target for therapy and prevention of Alzheimer's disease (AD). Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism-like phenotype. These lines of evidence indicate that the inhibition of BACE1 causes adverse side effects during the neurodevelopmental stage...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28031963/folic-acid-supplementation-what-is-new-fetal-obstetric-long-term-benefits-and-risks
#12
REVIEW
Hind N Moussa, Susan Hosseini Nasab, Ziad A Haidar, Sean C Blackwell, Baha M Sibai
The association between folic acid supplementation, prior to conception and/or during pregnancy and pregnancy outcomes, has been the subject of numerous studies. The worldwide recommendation of folic acid is at least 0.4 mg daily for all women of reproductive age, and 4-5 mg in high-risk women. In addition, evidence shows that folic acid supplementation could modulate other adverse pregnancy outcomes, specifically, in pregnancies complicated by seizure disorders, preeclampsia, anemia, fetal growth restriction and autism...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28018171/association-of-cell-adhesion-molecules-contactin-6-and-latrophilin-1-regulates-neuronal-apoptosis
#13
Amila Zuko, Asami Oguro-Ando, Harm Post, Renske L R E Taggenbrock, Roland E van Dijk, A F Maarten Altelaar, Albert J R Heck, Alexander G Petrenko, Bert van der Zwaag, Yasushi Shimoda, R J Pasterkamp, J P H Burbach
In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders patients, we set out to examine pathways underlying functions of Cntn6 using a proteomics approach. We identified the cell adhesion GPCR latrophilin-1 (Lphn1, a.k.a. CIRL1/CL, ADGRL1) as a binding partner for Cntn6 forming together a heteromeric cis-complex. Lphn1 expression in cultured neurons caused reduction in neurite outgrowth and increase in apoptosis, which was rescued by coexpression of Cntn6...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27984183/repeated-prenatal-exposure-to-valproic-acid-results-in-cerebellar-hypoplasia-and-ataxia
#14
Stacey L Main, Randy J Kulesza
Autism spectrum disorder (ASD) is a developmental brain disorder characterized by restricted and repetitive patterns of behavior, social and communication defects, and is commonly associated with difficulties with motor coordination. The etiology of ASD, while mostly idiopathic, has been linked to hereditary factors and teratogens, such as valproic acid (VPA). VPA is used clinically to treat epilepsy, mood disorders, and in the prevention of migraines. The use of VPA during pregnancy significantly increases the risk of ASD in the offspring...
October 27, 2016: Neuroscience
https://www.readbyqxmd.com/read/27956832/assessment-of-suicidality-in-children-and-adolescents-with-diagnosis-of-high-functioning-autism-spectrum-disorder-in-a-turkish-clinical-sample
#15
Sevcan Karakoç Demirkaya, Mustafa Deniz Tutkunkardaş, Nahit Motavalli Mukaddes
OBJECTIVES: Considering that suicide is one of the most common reasons of adolescent death worldwide, there is a lack of clinical awareness on suicidal behaviors of children and adolescents with autism spectrum disorder (ASD). The present study aims to assess the rate of suicidality (suicidal ideation, behaviors and attempts) and associated risk factors for suicidality in high functioning ASD. METHODS: Medical records of 55 adolescents (six girls, 49 boys), aged between 7-20 years, with diagnosis of ASD were reviewed...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27932026/gene-environment-interactions-in-cortical-interneuron-development-and-dysfunction-a-review-of-preclinical-studies
#16
REVIEW
Lydia J Ansen-Wilson, Robert J Lipinski
Cortical interneurons (cINs) are a diverse group of locally projecting neurons essential to the organization and regulation of neural networks. Though they comprise only ∼20% of neurons in the neocortex, their dynamic modulation of cortical activity is requisite for normal cognition and underlies multiple aspects of learning and memory. While displaying significant morphological, molecular, and electrophysiological variability, cINs collectively function to maintain the excitatory-inhibitory balance in the cortex by dampening hyperexcitability and synchronizing activity of projection neurons, primarily through use of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)...
December 5, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27904610/effects-of-air-pollution-on-human-health-and-practical-measures-for-prevention-in-iran
#17
REVIEW
Adel Ghorani-Azam, Bamdad Riahi-Zanjani, Mahdi Balali-Mood
Air pollution is a major concern of new civilized world, which has a serious toxicological impact on human health and the environment. It has a number of different emission sources, but motor vehicles and industrial processes contribute the major part of air pollution. According to the World Health Organization, six major air pollutants include particle pollution, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead. Long and short term exposure to air suspended toxicants has a different toxicological impact on human including respiratory and cardiovascular diseases, neuropsychiatric complications, the eyes irritation, skin diseases, and long-term chronic diseases such as cancer...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27895322/gestational-vitamin-d-deficiency-and-autism-related-traits-the-generation-r-study
#18
A A E Vinkhuyzen, D W Eyles, T H J Burne, L M E Blanken, C J Kruithof, F Verhulst, V W Jaddoe, H Tiemeier, J J McGrath
There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. The association between gestational vitamin D deficiency and a continuous measure of autism-related traits at ~6 years (Social Responsiveness Scale; SRS) was determined in a large population-based cohort of mothers and their children (n=4229)...
November 29, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27892236/1-in-100-babies-the-fetal-alcohol-spectrum-disorder-pathway
#19
Kerry Lyons
Alcohol consumed during pregnancy is the nation's leading preventable cause of developmental disabilities and birth defects. One in 100 babies is estimated to be born with alcohol-related damage, according to the World Health Organization. Fetal alcohol spectrum disorders (FASDs) are more common than autism but are under-diagnosed.
November 23, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27891365/visual-function-and-ocular-status-in-children-with-disabilities-in-special-schools-of-northern-india
#20
Gurvinder Kaur, Satish Thomas, Mahesh Jindal, S M Bhatti
INTRODUCTION: Children with disabilities (other than visual impairment) are at a higher risk of visual impairment as compared to normal population. Majority of the ocular disorders, like refractive errors and strabismus, are easily treatable. As these children depend on their visual inputs for social and academic activities, an early detection and prompt treatment of even a minor visual problem is of utmost importance for them. AIM: To assess the visual function and ocular status of children with disabilities other than visual impairment and to identify the preventable and treatable causes of visual impairment...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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