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"Central Sensitization"

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https://www.readbyqxmd.com/read/29781959/involvement-of-the-vgf-derived-peptide-tlqp-62-in-nerve-injury-induced-hypersensitivity-and-spinal-neuroplasticity
#1
Alexander G J Skorput, Xijing Zhang, Jonathan J Waataja, Cristina D Peterson, Maureen S Riedl, Kelley F Kitto, Hai Truong, Cecilia Huffman, Stephen R Salton, Carolyn A Fairbanks, Christopher N Honda, Lucy Vulchanova
Neuroplasticity in the dorsal horn following peripheral nerve damage contributes critically to the establishment of chronic pain. The neurosecretory protein VGF (non-acronymic) is rapidly and robustly upregulated following nerve injury, and therefore peptides generated from it are positioned to serve as signals for peripheral damage. The goal of this project was to understand the spinal modulatory effects of the C-terminal VGF derived peptide TLQP-62 at the cellular level and gain insight into the function of the peptide in the development of neuropathic pain...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29758384/disruption-of-shp1-nmda-receptor-signaling-in-spinal-cord-dorsal-horn-alleviated-inflammatory-pain
#2
Li Yang, Hu-Hu Bai, Zi-Yang Zhang, Jiang-Ping Liu, Zhan-Wei Suo, Xian Yang, Xiao-Dong Hu
Src-homology 2 domain-containing protein tyrosine phosphatase-1 (SHP1) is one of the non-receptor-like phosphatases that are highly enriched in hematopoietic cells. Although accumulating evidence has implicated the protein tyrosine phosphatases in the regulation of nociceptive transmission and plasticity, it is largely unknown whether SHP1 was expressed in pain-related spinal cord dorsal horn and engaged in the synaptic modification of nociceptive signals. Here we found that SHP1 was present in spinal neurons of rats and functionally coupled to GluN2A subunit-containing N-methyl-d-aspartate subtype of glutamate receptors, one of the key players in central sensitization of nociceptive behaviors...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29753112/patients-with-chronic-spinal-pain-benefit-from-pain-neuroscience-education-regardless-the-self-reported-signs-of-central-sensitization-secondary-analysis-of-a-randomized-controlled-multicentre-trial
#3
Anneleen Malfliet, Jeroen Kregel, Mira Meeus, Lieven Danneels, Barbara Cagnie, Nathalie Roussel, Jo Nijs
BACKGROUND: Pain neuroscience education is effective in chronic pain management. Central sensitization (i.e. generalized hypersensitivity) is often explained as underlying mechanism for chronic pain, because of its clinical relevance and influence on pain severity, prognosis, and treatment outcome. OBJECTIVES: To examine whether patients with more or fewer symptoms of central sensitization respond differently to pain neuroscience education. DESIGN: A secondary analysis of a multicentre, triple-blind randomized controlled trial SETTING: University hospital Ghent and University Hospital Brussels, Belgium...
May 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29751194/the-central-sensitization-inventory-and-pain-sensitivity-questionnaire-an-exploration-of-construct-validity-and-associations-with-widespread-pain-sensitivity-among-individuals-with-shoulder-pain
#4
Rogelio A Coronado, Steven Z George
BACKGROUND: The Central Sensitization Inventory (CSI) and Pain Sensitivity Questionnaire (PSQ) are alternatives to quantitative sensory testing (QST) for inferring central sensitization. OBJECTIVE: Explore 1) comparative validity of the CSI and PSQ with QST (construct validity) and pain-related psychological questionnaires (concurrent validity), and 2) associations with widespread pain sensitivity. METHODS: Seventy-eight participants with unilateral shoulder pain less than 6 months (mean ± SD age = 39...
May 3, 2018: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29750060/fascial-preadipocytes-another-missing-piece-of-the-puzzle-to-understand-fibromyalgia
#5
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon
Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries' population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29746857/women-undergoing-third-line-overactive-bladder-treatment-demonstrate-elevated-thermal-temporal-summation
#6
W Stuart Reynolds, Casey Kowalik, Joshua Cohn, Melissa Kaufman, Alan Wein, Roger Dmochowski, Stephen Bruehl
PURPOSE: To determine if women with overactive bladder (OAB) requiring 3rd line therapy demonstrate greater central sensitization, indexed by temporal summation to heat pain stimuli, than those with OAB. MATERIALS AND METHODS: We recruited 39 adult women with OAB from the Urology clinic who were planning to undergo interventional therapy for medication refractory OAB with either onabotulinumtoxinA bladder injection or sacral neuromodulation and 55 women with OAB, either newly seen in our Urology clinic or responding to advertisements for study participation...
May 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29742751/slowly-repeated-evoked-pain-srep-as-a-marker-of-central-sensitization-in-fibromyalgia-diagnostic-accuracy-and-reliability-in-comparison-with-temporal-summation-of-pain
#7
Pablo de la Coba, Stephen Bruehl, Carmen María Gálvez-Sánchez, Gustavo A Reyes Del Paso
OBJECTIVE: This study examined the diagnostic accuracy and test-retest reliability of a novel dynamic evoked pain protocol (slowly repeated evoked pain; SREP) compared to temporal summation of pain (TSP), a standard index of central sensitization. METHODS: Thirty-five fibromyalgia (FM) and 30 rheumatoid arthritis (RA) patients completed, in pseudorandomized order, a standard mechanical TSP protocol (10 stimuli of 1s duration at the thenar eminence using a 300g monofilament with 1s interstimulus interval) and the SREP protocol (9 suprathreshold pressure stimuli of 5s duration applied to the fingernail with a 30s interstimulus interval)...
May 1, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29730970/spinal-glial-adaptations-occur-in-a-minimally-invasive-mouse-model-of-endometriosis-potential-implications-for-lesion-etiology-and-persistent-pelvic-pain
#8
Kelsi N Dodds, Elizabeth A H Beckett, Susan F Evans, Mark R Hutchinson
Glial adaptations within the central nervous system are well known to modulate central sensitization and pain. Recently, it has been suggested that activity of glial-related proinflammatory cytokines may potentiate peripheral inflammation, via central neurogenic processes. However, a role for altered glial function has not yet been investigated in the context of endometriosis, a chronic inflammatory condition in women associated with peripheral lesions, often manifesting with persistent pelvic pain. Using a minimally invasive mouse model of endometriosis, we investigated associations between peripheral endometriosis-like lesions and adaptations in central glial reactivity...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29729247/ionic-plasticity-and-pain-the-loss-of-descending-serotonergic-fibers-after-spinal-cord-injury-transforms-how-gaba-affects-pain
#9
Yung-Jen Huang, James W Grau
Activation of pain (nociceptive) fibers can sensitize neural circuits within the spinal cord, inducing an increase in excitability (central sensitization) that can foster chronic pain. The development of spinally-mediated central sensitization is regulated by descending fibers and GABAergic interneurons. In adult animals, the co-transporter KCC2 maintains a low intracellular concentration of the anion Cl- . As a result, when the GABA-A receptor is engaged, Cl- flows in the neuron which has a hyperpolarizing (inhibitory) effect...
May 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29722602/low-level-laser-therapy-and-interferential-current-in-patients-with-knee-osteoarthritis-a-randomized-controlled-trial-protocol
#10
Renata Alqualo-Costa, Gustavo R Thomé, Mônica R Perracini, Richard E Liebano
The aim of this study is to investigate the effects of low-level laser therapy and interferential current (IFC) on pain intensity, central sensitization, muscle strength and functional capacity in patients with knee osteoarthritis. Participants will be patients aged between 50 and 80 years, with knee osteoarthritis, pain intensity ranging from 3 to 8 points (0-10 scale), Lequesne Algofunctional Index ranging from 5 to 15 points, and Kellgren & Lawrence grade ≥2. A total of 168 patients will be randomly allocated into four groups as follows: active IFC + laser sham (G1), IFC sham + active laser (G2), active IFC + laser (G3) and IFC + laser sham (G4)...
May 3, 2018: Pain Management
https://www.readbyqxmd.com/read/29712506/-express-spinal-cxcl9-and-cxcl11-are-not-involved-in-neuropathic-pain-despite-an-upregulation-in-the-spinal-cord-following-spinal-nerve-injury
#11
Xiao-Bo Wu, Li-Na He, Bao-Chun Jiang, Hui Shi, Xue-Qiang Bai, Wen-Wen Zhang, Yong-Jing Gao
Chemokines-mediated neuroinflammation in the spinal cord plays a critical role in the pathogenesis of neuropathic pain. Chemokine CXCL9, CXCL10 and CXCL11 have been identified as a same subfamily chemokine which bind to CXC chemokine receptor 3 (CXCR3) to exert functions. Our recent work found that CXCL10 is upregulated in spinal astrocytes after spinal nerve ligation (SNL), and acts on CXCR3 on neurons to contribute to central sensitization and neuropathic pain, but less is known about CXCL9 and CXCL11 in the maintenance of neuropathic pain...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29710099/effect-of-pain-neuroscience-education-combined-with-cognition-targeted-motor-control-training-on-chronic-spinal-pain-a-randomized-clinical-trial
#12
Anneleen Malfliet, Jeroen Kregel, Iris Coppieters, Robby De Pauw, Mira Meeus, Nathalie Roussel, Barbara Cagnie, Lieven Danneels, Jo Nijs
Importance: Effective treatments for chronic spinal pain are essential to reduce the related high personal and socioeconomic costs. Objective: To compare pain neuroscience education combined with cognition-targeted motor control training with current best-evidence physiotherapy for reducing pain and improving functionality, gray matter morphologic features, and pain cognitions in individuals with chronic spinal pain. Design, Setting, and Participants: Multicenter randomized clinical trial conducted from January 1, 2014, to January 30, 2017, among 120 patients with chronic nonspecific spinal pain in 2 outpatient hospitals with follow-up at 3, 6, and 12 months...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29706009/relations-between-a-standardized-experimental-stressor-and-cutaneous-sensory-function-in-patients-with-chronic-pruritus-and-healthy-controls
#13
G Schneider, A Stumpf, M Burgmer, L Volmering, P Broecker, S Ständer
BACKGROUND: While chronic pruritus (CP) is a frequent symptom, many aspects of its underlying pathophysiological mechanisms still need elucidation. Research on sensory cutaneous function and on the influence of stress has been conducted mainly in patients with atopic dermatitis but is lacking for patients with CP. OBJECTIVE: To assess whether a standardized social stressor influences cutaneous sensory function in patients with CP in comparison to healthy controls (HC) METHODS: Case-control study; 33 CP and 30 HC were submitted to the standardized Quantitative Sensory Testing protocol before and after the Trier Social Stress Test and one hour later...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29695926/pre-emptive-multimodal-analgesia-with-tramadol-and-ketamine-lidocaine-infusion-for-suppression-of-central-sensitization-in-a-dog-model-of-ovariohysterectomy
#14
Ubedullah Kaka, Nor-Alimah Rahman, Adamu Abdul Abubakar, Yong Meng Goh, Sharida Fakurazi, Mohamed Ariff Omar, Hui Cheng Chen
Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol (T) groups. Both groups received intravenous tramadol 4 mg/kg body weight as premedication. Immediately after induction, the KLT group received ketamine and lidocaine at 0...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29682056/occipital-neuralgia-from-c2-cavernous-malformation
#15
Sang-Woo Ha, Jin-Gyu Choi, Byung-Chul Son
A unique case is presented of chronic occipital neuralgia (ON) caused by cavernous malformation (CM) in the intramedullary C2 spinal cord and subsequent pain relief and remodeling of allodynic pain following dorsal root rhizotomy. A 53-year-old male presented with a 30-year history of chronic allodynic, paroxysmal lancinating pain in the greater and lesser occipital nerves. Typically, the pain was aggravated with neck extension and head movement. Magnetic resonance imaging showed a CM in the right posterolateral side of the intramedullary C2 cord...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681177/-preemptive-and-preventive-analgesia-an-important-element-in-perioperative-pain-management
#16
Balázs Szedlák, Calin Mitre, Béla Fülesdi
In this review, the definition and history of preemptive analgesia and the progress of its conception will be summarized. In the physiology-pathophysiology chapter, central sensitization, the key component of the evolution of postoperative pain, and the neurochemical processes in its background will be explored. Tissue damage caused by surgical incision consists of mechanical and inflammatory components, and it has high importance in the postoperative pain management. The preemptive approach of pain management means more than just preincisional analgesia, it includes the application of multifactious synergistic medication at the same time accordingly...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29629590/higher-preoperative-sensitivity-to-pain-and-pain-at-rest-are-associated-with-worse-functional-outcome-after-stemless-total-shoulder-arthroplasty
#17
B Kadum, C Inngul, R Ihrman, G O Sjödén, A S Sayed-Noor
Aims The aims of this study were to investigate any possible relationship between a preoperative sensitivity to pain and the degree of pain at rest and on exertion with postoperative function in patients who underwent stemless total shoulder arthroplasty (TSA). Patients and Methods In this prospective study, we included 63 patients who underwent stemless TSA and were available for evaluation one year postoperatively. There were 31 women and 32 men; their mean age was 71 years (53 to 89). The pain threshold, which was measured using a Pain Matcher (PM) unit, the degree of pain (visual analogue scale at rest and on exertion, and function using the short version of the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH), were recorded preoperatively, as well as three and 12 months postoperatively...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29628771/activation-of-spinal-dorsal-horn-p2y-13-receptors-can-promote-the-expression-of-il-1%C3%AE-and-il-6-in-rats-with-diabetic-neuropathic-pain
#18
Rui Zhou, Tao Xu, XiaoHong Liu, YuanShou Chen, DeYing Kong, Hong Tian, Mingxia Yue, Dujuan Huang, Junwei Zeng
Objective: The dorsal horn P2Y13 receptor is involved in the development of pain behavior induced by peripheral nerve injury. It is unclear whether the expression of proinflammatory cytokines interleukin (IL)-1β and IL-6 at the spinal dorsal horn are influenced after the activation of P2Y13 receptor in rats with diabetic neuropathic pain (DNP). Methods: A rat model of type 1 DNP was induced by intraperitoneal injection of streptozotocin (STZ). We examined the expression of P2Y13 receptor, Iba-1, IL-1β, IL-6, JAK2, STAT3, pTyr1336 , and pTyr1472 NR2B in rat spinal dorsal horn...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29619540/understanding-osteoporotic-pain-and-its-pharmacological-treatment
#19
REVIEW
R Vellucci, R Terenzi, J A Kanis, H G Kress, R D Mediati, J-Y Reginster, R Rizzoli, M L Brandi
Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. The aim of this paper is to summarize the pathogenesis and systemic treatment of osteoporotic pain. This narrative review summarizes the main pathogenetic aspects of osteoporotic pain and the cornerstones of its treatment...
April 4, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29608037/pain-and-structural-alterations-in-knee-joints-in-patients-with-haemophilia
#20
S Krüger, M Hoffmeister, T Hilberg
INTRODUCTION: Patients with haemophilia (PwH) suffer from haemophilic arthropathy which leads to an enhanced pain sensitivity. The aim of this study was to determine whether the individual pain condition in terms of pressure pain thresholds (PPT) at the knee joints is linked to changes of underlying anatomical structures in PwH. MATERIAL AND METHODS: Eleven landmarks at both knee joints of 36 PwH and 36 controls were examined in terms of PPT and ultrasound sonography (US)...
April 2, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
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