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JOURNAL ARTICLE
Go Ichikawa, Yasuyuki Negishi, Ryo Tsuchiya, Lilika Higuchi, Tatsunori Shiraishi, Mariko Ikeda, Hanako Kaseki, Rimpei Morita, Shunji Suzuki
BackgroundEndometriosis has several clinical features, including dysmenorrhea, infertility, and endometrioma (EMO). Although oxidative stress status is closely related to endometriosis, it is unclear how the balance between oxidative stress capacity and antioxidant capacity correlates with treatment of or factors that worsen endometriosis. In this study, we used peritoneal fluid from patients with EMO to investigate the role of oxidative stress capacity and antioxidant capacity.Materials and MethodsParticipants with EMO (n = 30) and without EMO (uterine myoma, n = 13) were enrolled...
March 2, 2024: Journal of Nippon Medical School
#22
JOURNAL ARTICLE
Yukari Nagao, Akira Yokoi, Kosuke Yoshida, Masami Kitagawa, Eri Asano-Inami, Tomoyasu Kato, Mitsuya Ishikawa, Yusuke Yamamoto, Hiroaki Kajiyama
OBJECTIVE: Uterine leiomyosarcoma (ULMS) is a rare malignant tumor, which is aggressive, and has a poor prognosis even during its early stages. Extracellular vesicles (EVs) carry cargo, such as microRNAs (miRNAs), which are involved in intercellular communication in the tumor microenvironment and other processes. Because there are no studies on EV-related miRNAs in ULMS, we identified EV-related miRNAs in ULMS and examined their function. METHODS: Small EVs (sEVs) and medium/large EVs (m/lEVs) were extracted from ULMS cells by ultracentrifugation and their basic characteristics were evaluated...
February 26, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#23
Toshiyuki Kakinuma, Kaoru Kakinuma, Rora Okamoto, Kaoru Yanagida, Michitaka Ohwada, Nobuhiro Takeshima
BACKGROUND: Microwave endometrial ablation (MEA) is a minimally invasive treatment method for heavy menstrual bleeding. However, additional treatment is often required after recurrence of uterine myomas treated with MEA. Additionally, because this treatment ablates the endometrium, it is not indicated for patients planning to become pregnant. To overcome these issues, we devised a method for ultrasound-guided microwave ablation of uterine myoma feeder vessels. We report three patients successfully treated for heavy menstrual bleeding, secondary to uterine myoma, using our novel method...
February 16, 2024: World Journal of Clinical Cases
#24
REVIEW
Eva Dreisler, Christian Seerup Frandsen, Lian Ulrich
Abnormal uterine bleeding is a frequent symptom in the perimenopause. Causes are numerous, ranging from physiological reactions due to decreasing/unstable ovarian function to premalignant and malignant conditions. Benign findings such as endometrial polyps and myomas increase with age, leading to more abnormal uterine bleeding in the perimenopause. Cervical and vaginal causes of abnormal uterine bleeding should be excluded by speculum examination. Sexually transmitted diseases or pregnancy should be ruled out...
February 22, 2024: Maturitas
#25
JOURNAL ARTICLE
Sithembinkosi Ndebele, Tecora Turner, Chuanhong Liao, Briseis Aschebrook-Kilfoy, Nina Randorf, Habibul Ahsan, Kunle Odunsi, Obianuju Sandra Madueke-Laveaux
(1) Objectives: To investigate the effect of individual-level, neighborhood, and environmental variables on uterine fibroid (UF) prevalence in a Chicago-based cohort. (2) Methods: Data from the Chicago Multiethnic Prevention and Surveillance Study (COMPASS) were analyzed. Individual-level variables were obtained from questionnaires, neighborhood variables from the Chicago Health Atlas, and environmental variables from NASA satellite ambient air exposure levels. The Shapiro-Wilk test, logistic regression models, and Spearman's correlations were used to evaluate the association of variables to UF diagnosis...
February 14, 2024: International Journal of Environmental Research and Public Health
#26
Roberta Fusco, Chiara Tesi, Paolo Spina, Ezio Fulcheri, Marta Licata
OBJECTIVE: To develop a differential diagnosis of a mass retrieved alongside skeletal remains in the crypt of the church of Santissima Annunziata of Valenza (Province of Alessandria, Northern Italy). MATERIAL: A calcified mass measuring 40 × 39 mm and 17.62 × 16.3817.62 × 16.38 mm. METHOD: The analysis utilized macroscopic assessment and histologic examination (including histochemical and immunohistochemical analyses)...
February 19, 2024: International Journal of Paleopathology
#27
JOURNAL ARTICLE
Kacey M Hamilton, Connie Liao, Gabriel Levin, Moshe Barnajian, Yosef Nasseri, Catherine Bresee, Mireille D Truong, Kelly N Wright, Matthew T Siedhoff, Raanan Meyer
BACKGROUND: Uterine fibroids are the most common benign tumors affecting females. Laparoscopic myomectomy is the standard surgical treatment for most women who wish to retain their uterus. The most common complication of myomectomy is excessive bleeding. However, risk factors for hemorrhage in laparoscopic myomectomy are not well studied and no risk stratification tool specific to the need for blood transfusion in laparoscopic myomectomy currently exists in the literature. STUDY OBJECTIVES: To identify risk factors for intraoperative and postoperative blood transfusion during laparoscopic myomectomies and to develop a risk stratification tool for the risk of blood transfusion...
February 14, 2024: American Journal of Obstetrics and Gynecology
#28
JOURNAL ARTICLE
Seyeon Won, Kidong Kim, Keun Ho Lee, Tae-Joong Kim, Taehun Kim, Jong Ha Hwang, Hyun Park, Min Kyu Kim, Dae Gy Hong, Yong Jung Song, Seok Ju Seong
BACKGROUND: ArtiSential, a class of innovative laparoscopic instrument, has been developed to overcome the limitations of conventional laparoscopic surgery by enabling free, 360°-unrestricted movement of the wrist joint, as in robotic surgery. OBJECTIVE: The aim of the present study was to describe the initial experiences with these devices in myomectomy and to report the surgical outcomes. METHODS: A total of 77 women undergoing laparoscopic or robotic myomectomy between January 2021 and June 2022 were included in this multicenter prospective study...
February 15, 2024: International Journal of Gynaecology and Obstetrics
#29
Rika Yoshida, Yuko Makihara, Akina Miyamoto, Hisatoshi Araki, Shinji Ando, Takeshi Yoshizako, Aki Oride, Yasushi Kaji
A 43-year-old woman, with a history of uterine fibroids and multiple myomectomy, presented with acute lower abdominal pain. Computed tomography revealed multiple tumors, including a high-density mass in the left lower abdomen indicative of a parasitic leiomyoma undergoing red degeneration. This uncommon condition is due to acute occlusion, often caused by peripheral venous thrombosis at the fibroid edge. The diagnosis was corroborated by distinctive findings on magnetic resonance imaging and computed tomography...
April 2024: Radiology Case Reports
#30
REVIEW
Andrea Etrusco, Antonio Simone Laganà, Vito Chiantera, Sandro Gerli, Jose Carugno, Felice Sorrentino, Gaetano Riemma, Amerigo Vitagliano, Alessandro Favilli
BACKGROUND: Hysteroscopy represents the gold standard for the diagnosis and treatment of intrauterine pathologies. The advent of the mini-resectoscope heralded a new era in intrauterine surgery, both in inpatient and outpatient settings. OBJECTIVES: To evaluate the effectiveness, safety, and feasibility of the mini-resectoscope for the treatment of intrauterine pathologies. SEARCH STRATEGY: Electronic databases were searched for English-language trials describing surgical procedures for uterine pathologies performed with a mini-resectoscope until 30 April 2023...
February 5, 2024: International Journal of Gynaecology and Obstetrics
#31
Charlotte Sonigo, Geoffroy Robin, Florence Boitrelle, Eloïse Fraison, Nathalie Sermondade, Emmanuelle Mathieu d' Argent, Pierre-Emmanuel Bouet, Charlotte Dupont, Hélène Creux, Maeliss Peigné, Olivier Pirrello, Sabine Trombert, Emmanuel Lecorche, Ludivine Dion, Laurence Rocher, Emmanuel Arama, Valérie Bernard, Margaux Monnet, Laura Miquel, Eva Birsal, Stéphanie Haïm Boukobza, Ingrid Plotton, Célia Ravel, Véronika Grzegorczyk Martin, Eric Huyghe, Hugo G A Dupuis, Tiphaine Lefevre, Florence Leperlier, Léna Bardet, Imane Lalami, Camille Robin, Virginie Simon, Laura Dijols, Justine Riss, Antoine Koch, Clément Bailly, Constance Rio, Marine Lebret, Margaux Jegaden, Hervé Fernandez, Jean-Luc Pouly, Antoine Torre, Jean-Marie Antoine, Blandine Courbiere
OBJECTIVE: To update the 2010 CNGOF clinical practice guidelines for the first-line management of infertile couples. MATERIALS AND METHODS: Five major themes (first-line assessment of the infertile woman, first-line assessment of the infertile man, prevention of exposure to environmental factors, initial management using ovulation induction regimens, first-line reproductive surgery) were identified, enabling 28 questions to be formulated using the PICO (Patients, Intervention, Comparison, Outcome) format...
February 2, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
#32
JOURNAL ARTICLE
Ayodele Adegbite Olaleye, Joshua Adeniyi Adebayo, Justus Ndulue Eze, Leonard Ogbonna Ajah, Chidebe Christian Anikwe, John O Egede, Chidi Ikenna Ebere
BACKGROUND: Myomectomy can be associated with life-threatening conditions such as bleeding. Excessive bleeding usually necessitates blood transfusion. Interventions to reduce bleeding during myomectomy will help reduce the need for blood transfusion with its associated complications. Tranexamic acid has been used to reduce bleeding in other surgical procedures, and its usage during myomectomy merits evaluation. OBJECTIVE: To assess the efficacy of tranexamic acid in reducing myomectomy-associated blood loss...
2024: International Journal of Reproductive Medicine
#33
Tamilselvi Sethupathy, Madhankumar Madathupalayam, Krithika Arun Prasad
The prevalence of isthmocele or caesarean scar niche is increasing nowadays. This is largely attributed to the increasing rate of caesarean deliveries globally, although the growing awareness among gynaecologists and assisted reproductive technology specialists may contribute to the more frequent diagnosis of isthmocele. Although the presenting complaints, diagnosis, and management of isthmocele are discussed extensively in the literature, this case of large isthmocele with a large degenerated false broad ligament myoma, which caused diagnostic dilemma both preoperatively and postoperatively, needs a special mention...
December 2023: Curēus
#34
REVIEW
Georgios Michos, Themistoklis Dagklis, Evangelos Papanikolaou, Ioannis Tsakiridis, Kyriakos Oikonomou, Apostolos M Mamopoulos, Ioannis A Kalogiannidis, Apostolos Athanasiadis
Uterine leiomyomas are the most common benign tumors of the female genital track, causing various symptoms and problems, including a possible impact on fertility. The relationship between fibroids and infertility has long been a debate among gynecologists. Management of fibroids in women with otherwise unexplained infertility worldwide lacks standardized, evidence-based guidelines. Therefore, a review of guidelines from the Royal Australian and New Zealand College of Obstetricians and Gynecologists, the American College of Obstetricians and Gynecologists, the Society of Obstetricians and Gynecologists of Canada, the Collège National des Gynécologues et Obstétriciens Français, and the American Society of Reproductive Medicine was conducted...
December 2023: Curēus
#35
REVIEW
Stefano Cianci, Ferdinando Antonio Gulino, Vittorio Palmara, Marco La Verde, Carlo Ronsini, Paola Romeo, Sara Occhipinti, Giosuè Giordano Incognito, Vito Andrea Capozzi, Stefano Restaino, Giuseppe Vizzielli, Marco Palumbo
Background and Objectives: Uterine myomas represent one of the most prevalent pathologies affecting the female population. These benign neoplasms originate from the smooth muscular cells of the uterus, and they can be either single or multiple. Often associated with debilitating symptoms such as pelvic heaviness, pain, constipation, and urinary dysfunctions, the surgical management of myomectomy exhibits considerable variability. This diversity in approaches is influenced by factors such as the number and size of myomas, the patient's age, and overall clinical conditions...
December 28, 2023: Medicina
#36
JOURNAL ARTICLE
Mateusz de Mezer, Anna Markowska, Janina Markowska, Monika Krzyżaniak, Beniamin Grabarek, Filip Pokusa, Jakub Żurawski
BACKGROUND: SERPINA3 (α-1-antichymotrypsin, AACT, ACT) is produced by the liver and released into plasma in an anti-inflammatory response and plays a role as a modulator of extracellular matrix (ECM) by inhibiting serine proteases. Numerous studies proved an increased level of SERPINA3 in many types of cancer, which could be linked to SERPINA3's anti-apoptotic function. AIM: In the context of progressive ECM fibrosis during the development of uterine fibroids, which are one of the most common hypertrophic changes within the uterus, it is interesting to describe the level of SERPINA3 protein in this type of lesion and the surrounding tissues...
January 9, 2024: Current Pharmaceutical Biotechnology
#37
JOURNAL ARTICLE
Xiaoran Zhao, Haixia Pan, Wenpei Bai, Bin Li, Hongqiang Wang, Meng Zhang, Yanan Li, Dongdong Zhang, Haotian Geng, Minghuang Chen
Medical image segmentation algorithms based on deep learning has achieved good segmentation results in recent years, but it requires a large amount of labeled data. When performing pixel-level labeling on medical images, labeling a target requires marking ten or even hundreds of points along its edge, which requires a lot of time and labor costs. In order to reduce the labeling cost, we utilize a click-
based interactive segmentation method to generate high-quality segmentation labels. However, current interactive segmentation algorithms, only the interaction information clicked by the user and the image features are fused as the input of the backbone
network (so-called early fusion)...
January 10, 2024: Physics in Medicine and Biology
#38
JOURNAL ARTICLE
Qiao-Hong Dai, Lu Zhang, An-Er Chen
BACKGROUND: In this study, the prognostic and reproductive outcomes of women who underwent excision of uterine myomas and were sutured using different techniques while undergoing a cesarean section were investigated. METHODS: A total of 299 females who underwent cesarean section between January 2015 and June 2022 due to a scarred uterus were enrolled in this study. These participants were segregated into two categories: the experimental group (comprising 155 cases) in which uterine myoma (single lesion) was excised during the cesarean procedure, and the control group (consisting of 144 cases) in which only the cesarean section was conducted...
January 2, 2024: BMC Women's Health
#39
JOURNAL ARTICLE
Fatemeh Tabatabaei, Saghar Babadi, Shima Nourigheimasi, Arshin Ghaedi, Monireh Khanzadeh, Aida Bazrgar, Morad Kohandel Gargari, Shokoufeh Khanzadeh
BACKGROUND: This systematic review and meta-analysis aimed to determine the potential value of neutrophil to lymphocyte ratio (NLR) as an assessment tool in the clinical distinction between uterine sarcoma and uterine leiomyoma. METHODS: We comprehensively searched Web of Science, Scopus, and PubMed for relevant papers published before March 19, 2023. The standardized mean difference (SMD) was provided, along with a 95% confidence interval (CI). The random-effects model was employed to derive pooled effects due to the high levels of heterogeneity...
January 2, 2024: BMC Cancer
#40
JOURNAL ARTICLE
Minghuang Chen, Weiya Kong, Bin Li, Zongmei Tian, Cong Yin, Meng Zhang, Haixia Pan, Wenpei Bai
BACKGROUND: The application of artificial intelligence (AI) powered algorithm in clinical decision-making is globally popular among clinicians and medical scientists. In this research endeavor, we harnessed the capabilities of AI to enhance the precision of hysteroscopic myomectomy procedures. METHODS: Our multidisciplinary team developed a comprehensive suite of algorithms, rooted in deep learning technology, addressing myomas segmentation tasks. We assembled a cohort comprising 56 patients diagnosed with submucosal myomas, each of whom underwent magnetic resonance imaging (MRI) examinations...
2023: Frontiers in Oncology
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