Gunvor Ekman-Ordeberg, Margareta Hellgren-Wångdahl, Annika Jeppson, Leena Rahkonen, Marie Blomberg, Karin Pettersson, Carina Bejlum, Malin Engberg, Mette Ludvigsen, Jukka Uotila, Kati Tihtonen, Gunilla Hallberg, Maria Jonsson
BACKGROUND: Slow progression of labor is a common obstetrical problem with multiple associated complications. Tafoxiparin is a depolymerized form of heparin with a molecular structure that eliminates the anticoagulant effects of heparin. We report on 2 phase II clinical studies of tafoxiparin in primiparas. Study 1 was an exploratory, first-in-pregnant-women study and study 2 was a dose-finding study. OBJECTIVE: Study 1 was performed to explore the effects on labor time of subcutaneous administration of tafoxiparin before onset of labor...
March 2024: American Journal of Obstetrics and Gynecology