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https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#1
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102362/evaluation-of-region-selective-bilirubin-induced-brain-damage-as-a-basis-for-a-pharmacological-treatment
#2
Matteo Dal Ben, Cristina Bottin, Fabrizio Zanconati, Claudio Tiribelli, Silvia Gazzin
The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography of bilirubin-induced damage. By applying the organotypic brain culture (OBC: preserving in vitro the cellular complexity, connection and architecture of the in vivo brain) technique to study hyperbilirubinemia, we mapped the regional target of bilirubin-induced damage, demonstrated a multifactorial toxic action of bilirubin, and used this information to evaluate the efficacy of drugs applicable to newborns to protect the brain...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101414/anti-confocal-assessment-of-middle-ear-inflammation
#3
David S Jung, John A Crowe, John P Birchall, Michael G Somekh, Chung W See
To improve the diagnostic prediction of recurrence of otitis media with effusion after surgery, an anti-confocal system combined with spectroscopic measurements is proposed to reject unwanted signals from the eardrum and assess the blood content. The anti-confocal system was experimentally evaluated on both optical middle ear phantom and human skin. Results showed effective rejection of signals from the eardrum using a central stop replacing the confocal pinhole, while still detecting signals from the middle ear mucosa...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100843/pathophysiology-and-molecular-basis-of-selected-metabolic-abnormalities-in-huntington-s-disease
#4
Jolanta Krzysztoń-Russjan
Huntington's disease (HD) is an incurable, devastating neurodegenerative disease with a known genetic background and autosomally dominant inheritance pattern. HTT gene mutation (mHTT) is associated with polymorphic fragment elongation above 35 repeats of the CAG triplet. The mHTT product is an altered protein with a poly-Q elongated fragment, with the highest expression determined in the central nervous system (CNS) and with differentiated expression outside the CNS. A drastic loss of striatal and deeper layers of the cerebral cortex neurons was determined in the CNS, but muscle and body weight mass loss with dysfunction of many organs was also observed...
December 30, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28100749/promoted-interaction-of-c-ebp%C3%AE-with-demethylated-cxcr3-gene-promoter-contributes-to-neuropathic-pain-in-mice
#5
Bao-Chun Jiang, Li-Na He, Xiao-Bo Wu, Hui Shi, Wen-Wen Zhang, Zhi-Jun Zhang, De-Li Cao, Chun-Hua Li, Jun Gu, Yong-Jing Gao
: DNA methylation has been implicated in the pathogenesis of chronic pain. However, the specific genes regulated by DNA methylation under neuropathic pain condition remain largely unknown. Here we investigated how chemokine receptor CXCR3 is regulated by DNA methylation and how it contributes to neuropathic pain induced by spinal nerve ligation (SNL) in mice. SNL increased Cxcr3 mRNA and protein expression in the neurons of the spinal cord. Meanwhile, the CpG (5'-cytosine-phosphate-guanine-3') island in the Cxcr3 gene promoter region was demethylated, and the expression of DNA methyltransferase 3b (DNMT3b) was decreased...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100734/does-the-superior-colliculus-control-perceptual-sensitivity-or-choice-bias-during-attention-evidence-from-a-multialternative-decision-framework
#6
Devarajan Sridharan, Nicholas A Steinmetz, Tirin Moore, Eric I Knudsen
: Distinct networks in the forebrain and the midbrain coordinate to control spatial attention. The critical involvement of the superior colliculus (SC)-the central structure in the midbrain network-in visuospatial attention has been shown by four seminal, published studies in monkeys (Macaca mulatta) performing multialternative tasks. However, due to the lack of a mechanistic framework for interpreting behavioral data in such tasks, the nature of the SC's contribution to attention remains unclear...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100479/evidence-of-central-sensitisation-in-those-with-dry-eye-symptoms-and-neuropathic-like-ocular-pain-complaints-incomplete-response-to-topical-anaesthesia-and-generalised-heightened-sensitivity-to-evoked-pain
#7
Ashley M Crane, William Feuer, Elizabeth R Felix, Roy C Levitt, Allison L McClellan, Konstantinos D Sarantopoulos, Anat Galor
OBJECTIVE: To evaluate how closely neuropathic-like ocular pain (NOP) symptoms align with a metric of central sensitisation (ie, the presence of persistent ocular pain after topical anaesthetic placement) in individuals with dry eye (DE) symptoms. DESIGN: Cross-sectional study of 224 individuals with DE symptoms seen in the Miami Veterans Affairs eye clinic. An evaluation was performed consisting of questionnaires regarding DE symptoms, NOP descriptors and evoked pain sensitivity testing on the forehead and forearm, followed by a comprehensive ocular surface examination including corneal mechanical sensitivity testing...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28100041/contrasting-growth-forecasts-across-the-geographical-range-of-scots-pine-due-to-altitudinal-and-latitudinal-differences-in-climatic-sensitivity
#8
Luis Matías, Juan C Linares, Ángela Sánchez-Miranda, Alistair S Jump
Ongoing changes in global climate are altering ecological conditions for many species. The consequences of such changes are typically most evident at the edge of a species' geographical distribution, where differences in growth or population dynamics may result in range expansions or contractions. Understanding population responses to different climatic drivers along wide latitudinal and altitudinal gradients is necessary in order to gain a better understanding of plant responses to ongoing increases in global temperature and drought severity...
January 18, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28099332/lung-ultrasound-for-the-diagnosis-of-pneumonia-in-adults-a-meta-analysis
#9
Ling Long, Hao-Tian Zhao, Zhi-Yang Zhang, Guang-Ying Wang, He-Ling Zhao
BACKGROUND: Pneumonia is a common and serious infectious disease that can cause high mortality. The role of lung ultrasound (LUS) in the diagnosis of pneumonia is becoming more and more important. METHODS: In the present study, we collected existing evidence regarding the use of LUS to diagnose pneumonia in adults and conducted a systematic review to summarize the technique's diagnostic accuracy. We specifically searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Embase databases and retrieved outcome data to evaluate the efficacy of LUS for the diagnosis of pneumonia compared with chest radiography or chest computed tomography...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098787/pathological-impairment-cell-cycle-arrest-and-apoptosis-of-thymus-and-bursa-of-fabricius-induced-by-aflatoxin-contaminated-corn-in-broilers
#10
Xi Peng, Shiping Bai, Xuemei Ding, Keying Zhang
This study aimed to evaluate the comparative effects of aflatoxin-contaminated corn on the thymus and bursa of Fabricius (BF) in chickens by detecting histopathological lesions, cell cycle phase distribution and apoptosis. A total of 900 COBB500 male broilers were randomly allocated into five groups. The experiment lasted for six weeks and the five dietary treatments consisted of uncontaminated corn (control), 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098400/role-of-contrast-enhanced-sonography-in-the-evaluation-of-axillary-lymph-nodes-in-breast-carcinoma-a-monocentric-study
#11
Giacomo Agliata, Gianluca Valeri, Giulio Argalia, Elisa Tarabelli, Gian Marco Giuseppetti
OBJECTIVES: To evaluate the diagnostic performance of contrast-enhanced sonography for characterization of the lymph node status (metastatic or not) in patients with breast carcinomas by comparison with sentinel lymph node biopsy. METHODS: From January to August 2015, 50 female patients with a histologic diagnosis of invasive breast carcinoma were prospectively examined by ipsilateral axillary contrast-enhanced sonography. The test was performed by a single radiologist using an ultrasound system with a broadband 8-12-MHz, 38-mm high-resolution linear transducer...
January 18, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28097715/c-di-amp-modulates-listeria-monocytogenes-central-metabolism-to-regulate-growth-antibiotic-resistance-and-osmoregulation
#12
Aaron T Whiteley, Nicholas E Garelis, Bret N Peterson, Philip H Choi, Liang Tong, Joshua J Woodward, Daniel A Portnoy
Cyclic di-adenosine monophosphate (c-di-AMP) is a conserved nucleotide second messenger critical for bacterial growth and resistance to cell wall-active antibiotics. In Listeria monocytogenes, the sole diadenylate cyclase, DacA, is essential in rich, but not synthetic media and ΔdacA mutants are highly sensitive to the β-lactam antibiotic cefuroxime. In this study, loss of function mutations in the oligopeptide importer (oppABCDF) and glycine betaine importer (gbuABC) allowed ΔdacA mutants to grow in rich medium...
January 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28096850/expression-analysis-of-multiple-genes-may-involve-in-antimony-resistance-among-leishmania-major-clinical-isolates-from-fars-province-central-iran
#13
Nafiseh Ghobakhloo, Mohammad Hossein Motazedian, Majid Fardaei
BACKGROUND: Treatment of Cutaneous Leishmaniasis (CL) is being faced with serious difficulties in Fars Province, due to emerging of resistance against meglumine antimonite (Glucantime®). In this context, determining some biomarkers for drug sensitivity monitoring seems to be highly essential. Different studies have been carried out to decipher the genes might be involved in antimony resistant phenotype in Leishmania spp. Here, we selected three genes: AQP (as drug transporter), TDR-1-1(as drug activator), and γ-GCS (inducing reduction environment) for comparative expression analysis on clinical resistant and sensitive isolates of L...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28095761/the-caring-encounter-in-nursing
#14
Gunilla Holopainen, Lisbet Nyström, Anne Kasén
BACKGROUND: The concept 'encounter' occurs in caring literature as a synonym for dialogue and relation describing deeper levels of interaction between patient and nurse. In nursing and caring research, the concept 'caring encounter' is often used without further reflection on the meaning of the concept. Encounters are, however, continuously taking place in the world of caring, which calls for a clarification of the concept. OBJECTIVES: This study is an analysis of the concept of caring encounter in nursing from the patients' and nurses' point of view...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28095758/ethical-difficulties-in-healthcare
#15
Cinzia Leuter, Carmen La Cerra, Santina Calisse, Danila Dosa, Cristina Petrucci, Loreto Lancia
BACKGROUND: Advances in biomedical sciences, technologies and care practices have resulted in an increase in ethical problems and a resulting growth of difficulties encountered by health workers in their professional activity. OBJECTIVE: The main objective of this study was to analyse knowledge in the ethical field and experience with and the propensity for using ethics consultations by nurses and physicians. METHODS: Between March and June 2014, a cross-sectional observational study was conducted on a sample of 351 nurses and 128 physicians in four central Italian hospitals...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28095479/central-role-of-il-23-and-il-17-producing-eosinophils-as-immunomodulatory-effector-cells-in-acute-pulmonary-aspergillosis-and-allergic-asthma
#16
Evelyn Santos Guerra, Chrono K Lee, Charles A Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R Huh, Christian Mueller, Stuart M Levitz
Aspergillus fumigatus causes invasive pulmonary disease in immunocompromised hosts and allergic asthma in atopic individuals. We studied the contribution of lung eosinophils to these fungal diseases. By in vivo intracellular cytokine staining and confocal microscopy, we observed that eosinophils act as local sources of IL-23 and IL-17. Remarkably, mice lacking eosinophils had a >95% reduction in the percentage of lung IL-23p19+ cells as well as markedly reduced IL-23 heterodimer in lung lavage fluid. Eosinophils killed A...
January 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28094431/chordoma-immunohistochemical-analysis-of-brachury
#17
İbrahim Sun, Mustafa Güdük, Bülent Güçyetmez, Özlem Yapicier, M Necmettin Pamir
AIM: Chordomas are rare, slow growing but locally aggressive malignancies of the axial skeleton. Skull base chordomas, due to their intricate anatomical localization pose significant challenges to managing physician. In classical and chondroid chordomas the disease course cannot be reliably determined using only morphological criteria. Brachyury (T Gene) was shown to play a central role in chordoma pathogenesis and several studies have also shown that this gene also caries potential as a prognostic biomarker...
December 12, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28092737/complex-molecular-changes-induced-by-chronic-progestogens-exposure-in-roach-rutilus-rutilus
#18
Gabor Maasz, Zita Zrinyi, Peter Takacs, Sandor Lovas, Istvan Fodor, Tibor Kiss, Zsolt Pirger
In our previous study, we measured 0.23-13.67ng/L progestogens (progesterone, drospirenone, levonorgestrel) in natural waters in the catchment area of the largest shallow lake of Central Europe, Lake Balaton. Progestogen contaminations act as potent steroids with mixed progestagenic, androgenic and mild estrogenic effects that is why our aim was to investigate the morphological and molecular effects of mixture of progesterone, drospirenone, and levonorgestrel in environmentally relevant (10ng/L) and higher (50 and 500ng/L) exposure concentrations in common roach, Rutilus rutilus...
January 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28092638/mr-elastography-to-measure-the-effects-of-cancer-and-pathology-fixation-on-prostate-biomechanics-and-comparison-with-t-1-t-2-and-adc
#19
Deirdre M McGrath, Jenny Lee, Warren D Foltz, Navid Samavati, Theo van der Kwast, Michael A S Jewett, Peter Chung, Cynthia Ménard, Kristy K Brock
MRI is under evaluation for image-guided intervention for prostate cancer. The sensitivity and specificity of MRI parameters is determined via correlation with the gold-standard of histopathology. Whole-mount histopathology of prostatectomy specimens can be digitally registered to in vivo imaging for correlation. When biomechanical-based deformable registration is employed to account for deformation during histopathology processing, the ex vivo biomechanical properties are required. However, these properties are altered by pathology fixation, and vary with disease...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28092404/metformin-versus-myoinositol-which-is-better-in-obese-pcos-patients-a-randomized-controlled-crossover-study
#20
Valeria Tagliaferri, Daniela Romualdi, Valentina Immediata, Simona De Cicco, Christian Di Florio, Antonio Lanzone, Maurizio Guido
CONTEXT: due to the central role of metabolic abnormalities in the pathophysiology of PCOS, insulin sensitising agents have been proposed as a feasible treatment option. OBJECTIVE: to investigate which is the more effective between metformin and myoinositol on hormonal, clinical and metabolic parameters in obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: crossover randomized-controlled study. PATIENTS: Thirty-four PCOS obese women (age: 25...
January 16, 2017: Clinical Endocrinology
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