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Central Sensitization

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https://www.readbyqxmd.com/read/29165234/blood-meal-analysis-of-phlebotomine-sandflies-diptera-psychodidae-phlebotominae-for-leishmania-spp-identification-and-vertebrate-blood-origin-central-tunisia-2015-2016
#1
Kaouther Jaouadi, Jihene Bettaieb, Amira Bennour, Sadok Salem, Wissem Ghawar, Mohamed Ridha Rjeibi, Neila Khabouchi, Jean-Paul Gonzalez, Mohamed Fethi Diouani, Afif Ben Salah
During the time periods of June 2015 and from July to August 2016, sandflies were collected among seven collection sites of the three leishmaniasis endemic villages of Sidi Bouzid, Tunisia. A total of 690 sandflies were captured and identified (380 males and 310 females). Four species belonging to genus Phlebotomus (Ph.) and two species belonging to genus Sergentomyia were identified. Leishmania DNA was detected in four out of 310 females (one Ph. sergenti and three Ph. papatasi). The overall sensitivity of the the Prepronociceptin gene detection reached 76%...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165104/simple-reaction-time-and-obesity-in-children-whether-there-is-a-relationship
#2
Akbar Moradi, Samad Esmaeilzadeh
OBJECTIVE: Reaction time (RT) testing is one of the oldest diagnostic methods used in modern psychology, and is known as simple and sensitive cognitive test. It has been recently reported that RT is related to obesity in young, adult and elderly individuals. However, most of the studies included small sample of participants, used just body mass index (BMI) as body obesity index, and did not consider some potential confounders such as age, socioeconomic status and physical activity in their studies...
March 14, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165080/tuberculosis-treated-by-multiple-drugs-an-overview
#3
Gyanendra Singh, Prashant Kesharwani, A K Shrivastava
Current tuberculosis (TB) treatment is established on an amalgamation of drugs that were evolved mostly in the central decades of the hind century. Cure rates are elevated for drug-sensitive strains of Mycobacterium tuberculosis (M.Tb) when the recommended complex and prolonged treatment protocols adhere. However, the difficulty in accurately prescribing and adhering to these protocols and the emergence of M. Tb strains resistant to multiple drugs and drug-drug interactions that interfere with optimal treatment of Tuberculosis and co-infected patients with the different disease has generated a pressing need for improved Tuberculosis therapies...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164719/circadian-variation-of-flexor-withdrawal-and-crossed-extensor-reflexes-in-patients-with-restless-legs-syndrome
#4
Chloe Dafkin, Andrew Green, Benita Olivier, Warrick Mckinon, Samantha Kerr
An evening state of spinal hyperexcitability has been proposed to be a possible cause of evening increases in restless legs syndrome symptoms. Thus, the objective of the current study was to assess the circadian variation in spinal excitability in patients with restless legs syndrome based on flexor withdrawal reflex and crossed extensor reflex responses. The reflexes were elicited on 12 participants with restless legs syndrome and 12 healthy control participants in the evening (PM) and the morning (AM). Reflex response magnitudes were measured electromyographically and kinematically...
November 22, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29164109/identification-of-directed-interactions-in-kinematic-data-during-running
#5
Giovana Y Nakashima, Theresa H Nakagawa, Ana F Dos Santos, Fábio V Serrão, Michel Bessani, Carlos D Maciel
The knowledge of motion dynamics during running activity is crucial to enhance the development of rehabilitation techniques and injury prevention programs. Recent studies investigated the interaction between joints, using several analysis techniques, as cross-correlation, sensitivity analysis, among others. However, the direction of the joints pairing is still not understood. This paper proposes a study of the influence direction pattern in healthy runners by using kinematic data together with partial directed coherence, a frequency approach of Granger causality...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29163668/sexual-and-reproductive-health-needs-and-risks-of-very-young-adolescent-refugees-and-migrants-from-myanmar-living-in-thailand
#6
Catherine Lee, Yasmina Aules, Samira Sami, Paw Kree Lar, Jennifer Schlect, Courtland Robinson
Background: The very young adolescent (VYA) population age 10-14 years is often neglected in the field of sexual and reproductive health (SRH) research due to the combined sensitivity of the topic and the young age group, resulting in little data about the SRH needs and concerns of VYA. In 2013, the Women's Refugee Commission (WRC), Johns Hopkins University (JHU), Adolescent and Reproductive Health Network (ARHN) and Karen Youth Organization (KYO) implemented qualitative participatory research to explore the SRH needs and risks of VYA...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29163350/differential-diagnosis-of-vertigo-in-the-emergency-department-a-prospective-validation-study-of-the-standing-algorithm
#7
Simone Vanni, Rudi Pecci, Jonathan A Edlow, Peiman Nazerian, Rossana Santimone, Giuseppe Pepe, Marco Moretti, Andrea Pavellini, Cosimo Caviglioli, Claudia Casula, Sofia Bigiarini, Paolo Vannucchi, Stefano Grifoni
Objective: We investigated the reliability and accuracy of a bedside diagnostic algorithm for patients presenting with vertigo/unsteadiness to the emergency department. Methods: We enrolled consecutive adult patients presenting with vertigo/unsteadiness at a tertiary hospital. STANDING, the acronym for the four-step algorithm we have previously described, based on nystagmus observation and well-known diagnostic maneuvers includes (1) the discrimination between SponTAneous and positional nystagmus, (2) the evaluation of the Nystagmus Direction, (3) the head Impulse test, and (4) the evaluation of equilibrium (staNdinG)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163208/circadian-alterations-in-a-murine-model-of-hypothalamic-glioma
#8
José M Duhart, Lucila Brocardo, Carlos S Caldart, Luciano Marpegan, Diego A Golombek
The mammalian circadian system is controlled by a central oscillator located in the suprachiasmatic nuclei (SCN) of the hypothalamus, in which glia appears to play a prominent role. Gliomas originate from glial cells and are the primary brain tumors with the highest incidence and mortality. Optic pathway/hypothalamic gliomas account for 4-7% of all pediatric intracranial tumors. Given the anatomical location, which compromises both the circadian pacemaker and its photic input pathway, we decided to study whether the presence of gliomas in the hypothalamic region could alter circadian behavioral outputs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163061/cyclodextrins-and-iatrogenic-hearing-loss-new-drugs-with-significant-risk
#9
REVIEW
Mark A Crumling, Kelly A King, R Keith Duncan
Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine, industry and basic sciences owing to their ability to solubilize and stabilize guest compounds. In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents. Recently, uncomplexed cyclodextrins have emerged as potent therapeutic compounds in their own right, based on their ability to sequester and mobilize cellular lipids. In particular, 2-hydroxypropyl-β-cyclodextrin (HPβCD) has garnered attention because of its cholesterol chelating properties, which appear to treat a rare neurodegenerative disorder and to promote atherosclerosis regression related to stroke and heart disease...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29163044/partial-aminoglycoside-lesions-in-vestibular-epithelia-reveal-broad-sensory-dysfunction-associated-with-modest-hair-cell-loss-and-afferent-calyx-retraction
#10
David R Sultemeier, Larry F Hoffman
Although the effects of aminoglycoside antibiotics on hair cells have been investigated for decades, their influences on the dendrites of primary afferent neurons have not been widely studied. This is undoubtedly due to the difficulty in disassociating pathology to dendritic processes from that resulting from loss of the presynaptic hair cell. This was overcome in the present investigation through development of a preparation using Chinchilla laniger that enabled direct perilymphatic infusion. Through this strategy we unmasked gentamicin's potential effects on afferent calyces...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29163027/mechanisms-of-osteoarthritic-pain-studies-in-humans-and-experimental-models
#11
REVIEW
Annett Eitner, Gunther O Hofmann, Hans-Georg Schaible
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However, the mechanisms of OA pain are poorly understood. This review addresses the mechanisms which are thought to be involved in OA pain, derived from studies on pain mechanisms in humans and in experimental models of OA. Three areas will be considered, namely local processes in the joint associated with OA pain, neuronal mechanisms involved in OA pain, and general factors which influence OA pain. Except the cartilage all structures of the joints are innervated by nociceptors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29162558/surgical-interventions-for-the-treatment-of-supracondylar-humerus-fractures-in-children-protocol-of-a-systematic-review
#12
Oreste Lemos Carrazzone, João Carlos Belloti, Fabio Teruo Matsunaga, Nacime Salomão Barbachan Mansur, Marcelo Hide Matsumoto, Flavio Faloppa, Marcel Jun Sugawara Tamaoki
BACKGROUND: The treatment of supracondylar humerus fracture in children (SHFC) is associated with complications such as functional deficit, residual deformity, and iatrogenic neurological damage. The standard treatment is closed reduction and percutaneous Kirschner wire fixation with different configurations. Despite this fact, there is still no consensus on the most effective technique for the treatment of these fractures. OBJECTIVE: The aim of this systematic review will be to evaluate the effect of surgical interventions on the treatment of Gartland type II and III SHFC by assessing function, complications, and error as primary outcomes...
November 21, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29161620/in-situ-elastic-strain-mapping-during-micromechanical-testing-using-ebsd
#13
Mark J McLean, William A Osborn
Compared to more commonly used strain measurement techniques, electron backscatter diffraction (EBSD) offers improved spatial resolution and measurement sensitivity. Additionally, EBSD can provide the full deformation tensor, whereas other techniques, such as digital image correlation (DIC), are limited to only in-plane strains and rotations. In this work, EBSD was used to measure strains and rotations in-situ during testing of a single-crystal silicon micromechanical test specimen. The theta-like specimen geometry was chosen due to the complex and spatially-varying strain states that exist in the circular frame of the sample during testing, as well as the nominally uniform strains in the central web...
November 14, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29160927/climate-change-impacts-on-selected-global-rangeland-ecosystem-services
#14
Randall B Boone, Richard T Conant, Jason Sircely, Philip K Thornton, Mario Herrero
Rangelands are Earth's dominant land cover and are important providers of ecosystem services. Reliance on rangelands is projected to grow, thus understanding the sensitivity of rangelands to future climates is essential. We used a new ecosystem model of moderate complexity that allows, for the first time, to quantify global changes expected in rangelands under future climates. The mean global annual net primary production (NPP) may decline by 10 g C m(-2) yr(-1) in 2050 under Representative Concentration Pathway (RCP) 8...
November 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29160612/central-sensitization-nice-to-know
#15
Michele Curatolo
No abstract text is available yet for this article.
November 21, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29160517/prevalence-and-antibiogram-of-methicillin-resistant-staphylococcus-aureus-isolated-from-medical-device-related-infections-a-retrospective-study-in-lahore-pakistan
#16
Muhammad Sohail, Zakia Latif
INTRODUCTION: With the advancement of medicine and surgery, various types of medical devices have become part of treatment strategies. METHODS: Identification and antimicrobial sensitivity testing were done according to CLSI guidelines following standard microbiological practices. RESULTS: Urinary catheter infections (31%) were most frequent followed by central venous catheter (18%) and orthopedic implants (15%). Methicillin resistant Staphylococcus aureus (MRSA) was a major cause of device-related infection after Escherichia coli (21%); other pathogens were Klebsiella pneumoniae (14%), Pseudomonas spp...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29159486/program-components-of-psychosocial-interventions-in-foster-and-kinship-care-a-systematic-review
#17
REVIEW
Jacqueline Kemmis-Riggs, Adam Dickes, John McAloon
Foster children frequently experience early trauma that significantly impacts their neurobiological, psychological and social development. This systematic review examines the comparative effectiveness of foster and kinship care interventions. It examines the components within each intervention, exploring their potential to benefit child and carer well-being, particularly focussing on child behaviour problems, and relational functioning. Systematic searches of electronic databases included PsycINFO, MEDLINE, Web of Science Core Collection, the Cochrane Collaborations Register of Controlled Trials (CENTRAL) and Scopus to identify randomised or quasi-randomised trials of psychosocial foster/kinship care interventions, published between 1990 and 2016...
November 20, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/29158337/a-single-residue-mutation-in-the-g%C3%AE-q%C3%A2-subunit-of-the-g-protein-complex-causes-blindness-in-drosophila
#18
Jinguo Cao, Murali K Bollepalli, Yuhui Hu, Jin Zhang, Qiang Li, Hongmei Li, Hua Chang, Feng Xiao, Roger C Hardie, Yikang S Rong, Wen Hu
Heterotrimeric G proteins play central roles in many signaling pathways, including the phototransduction cascade in animals. However, the degree of involvement of the G protein subunit Gαq is not clear since animals with strong loss of function mutations previously reported remain responsive to light stimuli. We recovered a new allele of Gαq in Drosophila that abolishes light response in a conventional ERG assay, and reduces sensitivity in whole-cell recordings of dissociated cells by at least 5 orders of magnitude...
November 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29157402/effective-utilization-of-mri%C3%A2-in-the-diagnosis-and-management-of-multiple-sclerosis
#19
REVIEW
Antonio Giorgio, Nicola De Stefano
MRI is the most important tool for diagnosis and management of patients with multiple sclerosis (MS). MRI shows high sensitivity for detection of white matter lesions in the central nervous system and specificity for lesion dissemination in space and time. MRI is also used for tracking disease activity, prognostic evaluation, and monitoring the efficacy and safety of disease-modifying treatments. Nonconventional MRI measures (eg, brain atrophy) and quantitative measures of advanced MRI can capture features of MS beyond WM lesions but are not currently implemented in clinical practice...
February 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29157370/bayesian-estimation-of-true-prevalence-sensitivity-and-specificity-of-three-diagnostic-tests-for-detection-of-escherichia-coli-o157-in-cattle-feces
#20
Pius S Ekong, Michael W Sanderson, Nora M Bello, Lance W Noll, Natalia Cernicchiaro, David G Renter, Jianfa Bai, T G Nagaraja
Cattle are a reservoir for Escherichia coli O157 and they shed the pathogen in their feces. Fecal contaminants on the hides can be transferred onto carcasses during processing at slaughter plants, thereby serving as a source of foodborne infection in humans. The detection of E. coli O157 in cattle feces is based on culture, immunological, and molecular methods We evaluated the diagnostic sensitivity and specificity of one culture- and two PCR-based tests for the detection of E. coli O157 in cattle feces, and its true prevalence using a Bayesian implementation of latent class models...
December 1, 2017: Preventive Veterinary Medicine
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