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Central Sensitization

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https://www.readbyqxmd.com/read/29351998/detection-of-experimental-and-clinical-immune-complexes-by-measuring-ship-1-recruitment-to-the-inhibitory-fc%C3%AE-riib
#1
Richard J Stopforth, Robert J Oldham, Alison L Tutt, Patrick Duriez, H T Claude Chan, Brock F Binkowski, Chad Zimprich, Dun Li, Philip G Hargreaves, Mei Cong, Venkat Reddy, Maria J Leandro, Geraldine Cambridge, Anja Lux, Falk Nimmerjahn, Mark S Cragg
Fc γ receptors (FcγR) are involved in multiple aspects of immune cell regulation, are central to the success of mAb therapeutics, and underpin the pathology of several autoimmune diseases. However, reliable assays capable of accurately measuring FcγR interactions with their physiological ligands, IgG immune complexes (IC), are limited. A method to study and detect IC interactions with FcγRs was therefore developed. This method, designed to model the signaling pathway of the inhibitory FcγRIIB (CD32B), used NanoLuc Binary Interaction Technology to measure recruitment of the Src homology 2 domain-containing inositol phosphatase 1 to the ITIM of this receptor...
January 19, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29351883/titanium-dioxide-nanoparticle-exposure-reduces-algal-biomass-and-alters-algal-assemblage-composition-in-wastewater-effluent-dominated-stream-mesocosms
#2
Moncie V Wright, Cole W Matson, Leanne S Baker, Benjamin T Castellon, Preston S Watkins, Ryan S King
A 5-week mesocosm experiment was conducted to investigate the toxicity of titanium dioxide nanoparticles (TiO2NPs) to periphytic algae in an environmentally-realistic scenario. We used outdoor experimental streams to simulate the characteristics of central Texas streams receiving large discharges of wastewater treatment plant effluent during prolonged periods of drought. The streams were continually dosed and maintained at two concentrations. The first represents an environmentally relevant concentration of 0...
January 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29351473/sympathetically-mediated-cardiac-responses-to-isolated-muscle-metaboreflex-activation-following-exercise-are-modulated-by-body-position-in-humans
#3
André L Teixeira, Mauricio Daher, Mayara Souza, Plinio Santos Ramos, James P Fisher, Lauro C Vianna
Isolated muscle metaboreflex activation with post-handgrip exercise ischemia (PEI) increases sympathetic nerve activity and partially maintains the exercise-induced increase in blood pressure, but a smaller heart rate (HR) response occurs. The cardiopulmonary baroreceptors, mechanically sensitive receptors that respond to changes in central blood volume and pressure, are strongly associated with changes in body position and upon activation elicit reflex sympathoinhibition. Here, we tested the hypothesis that postural changes modulate the sympathetically-mediated cardiac response to PEI in humans...
December 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351398/visceral-hypersensitivity-induced-by-optogenetic-activation-of-the-amygdala-in-conscious-rats
#4
Anthony C Johnson, Rocco Latorre, Casey O Ligon, Beverley Greenwood-Van Meerveld
In vivo optogenetics identifies brain circuits controlling behaviors in conscious animals by using light to alter neuronal function and offers a novel tool to study the brain-gut axis. Using adenoviral-mediated expression, we aimed to investigate whether photoactivation with channelrhodopsin (ChR2) or photoinhibition with halorhodopsin (HR3.0) of fibers originating from the central nucleus of the amygdala (CeA) at the bed nucleus of the stria terminalis (BNST) had any effect on colonic sensitivity. We also investigated whether that there was any deleterious effect of the adenovirus on the neuronal population or the neuronal phenotype within the CeA-BNST circuitry activated during the optogenetic stimulation...
December 14, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29351076/parasites-in-stray-dogs-from-italy-prevalence-risk-factors-and-management-concerns
#5
Claudio De Liberato, Federica Berrilli, Livio Odorizi, Roberto Scarcella, Marco Barni, Cristina Amoruso, Alessia Scarito, Margherita Montalbano Di Filippo, Andrea Carvelli, Francesca Iacoponi, Paola Scaramozzino
Parasites are among the most common pathogens recorded in dogs. High prevalence rates are usually reported in stray and shelter dogs, as these animals are less likely to be tested and treated. In this study a survey was carried out on intestinal and lung parasites of stray dogs at the moment of the admission in a shelter in Central Italy. In the period June 2014-June 2015, 262 individual faecal samples were examined. Twelve parasitic taxa were detected. Helminths were more prevalent than protozoa (61.8% and 25...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29350556/rehabilitation-of-a-young-athlete-with-extension-based-low-back-pain-addressing-motor-control-impairments-and-central-sensitization
#6
John J Winslow, Mark Jackson, Andrew Getzin, Michael Costello
OBJECTIVE:   To describe the conservative management of a young athlete with extension-based (EB) low back pain (LBP). BACKGROUND:   We present the case of a 15-year-old female high school gymnast with a 4-year history of EB LBP. Magnetic resonance imaging revealed a healed spondylolysis and significant lumbar multifidi muscle (LMM) atrophy with fatty infiltrate. She had several courses of outpatient orthopaedic rehabilitation that focused on core muscle strengthening (improving activation and strength of the LMM and transversus abdominus muscle in a neutral pelvic position) without long-lasting improvement...
January 19, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29350549/abiraterone-acetate-and-its-use-in-the-treatment-of-metastatic-prostate-cancer-a-review
#7
Orazio Caffo, Antonello Veccia, Stefania Kinspergher, Francesca Maines
Abiraterone acetate, which targets enzymatic complexes playing a central role in steroidogenesis, demonstrated to increase survival significantly in both chemo-naive and docetaxel pretreated, becoming one of the drugs of choice for metastatic castration-resistant prostate cancer. More recently, this agent in combination to androgen deprivation therapy demonstrated to be efficacious also in metastatic castration-sensitive prostate cancer. The present review is aimed to outline the clinical development of abiraterone acetate, the pivotal trials which led to its approval for the clinical practice, new evidence about its efficacy in metastatic castration-sensitive prostate cancer, its place in the therapeutic landscape of prostate cancer and future directions of development...
January 19, 2018: Future Oncology
https://www.readbyqxmd.com/read/29350536/diagnostic-accuracy-of-functional-imaging-and-biochemical-tests-for-patients-presenting-with-chest-pain-to-the-emergency-department-a-systematic-review-and-meta-analysis
#8
Mario Iannaccone, Sebastiano Gili, Ovidio De Filippo, Salvatore D'Amico, Marco Gagliardi, Maurizio Bertaina, Silvia Mazzilli, Sara Rettegno, Federica Bongiovanni, Paolo Gatti, Fabrizio Ugo, Giacomo G Boccuzzi, Salvatore Colangelo, Silvia Prato, Claudio Moretti, Maurizio D'Amico, Patrizia Noussan, Roberto Garbo, David Hildick-Smith, Fiorenzo Gaita, Fabrizio D'Ascenzo
BACKGROUND: Non-invasive ischaemia tests and biomarkers are widely adopted to rule out acute coronary syndrome in the emergency department. Their diagnostic accuracy has yet to be precisely defined. METHODS: Medline, Cochrane Library CENTRAL, EMBASE and Biomed Central were systematically screened (start date 1 September 2016, end date 1 December 2016). Prospective studies (observational or randomised controlled trial) comparing functional/imaging or biochemical tests for patients presenting with chest pain to the emergency department were included...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29350435/from-micro-to-macro-structures-in-multiple-sclerosis-what-is-the-added-value-of-diffusion-imaging
#9
Mara Cercignani, Claudia Gandini Wheeler-Kingshott
Diffusion imaging has been instrumental in understanding damage to the central nervous system as a result of its sensitivity to microstructural changes. Clinical applications of diffusion imaging have grown exponentially over the past couple of decades in many neurological and neurodegenerative diseases, such as multiple sclerosis (MS). For several reasons, MS has been extensively researched using advanced neuroimaging techniques, which makes it an 'example disease' to illustrate the potential of diffusion imaging for clinical applications...
January 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29350119/-medication-overuse-headache
#10
J A Pijpers, N J Wiendels, H Koppen, M D Ferrari, J Haan, G M Terwindt
- Medication-overuse headache is a highly prevalent disorder with a major impact on the quality of life.- Medication-overuse headache is defined as headache on ≥ 15 days per month with overuse of acute headache medication for ≥ 3 months. We talk about overuse in case of intake of simple analgesics on ≥ 15 days per month or triptans or combinations of analgesics on ≥ 10 days per month.- The underlying type of headache is usually migraine or tension-type headache.- One of the possible underlying mechanisms of medication-overuse headache is changed sensitivity as a consequence of central sensitisation...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29349847/increased-pain-sensitivity-in-migraine-and-tension-type-headache-coexistent-with-low-back-pain-a-cross-sectional-population-study
#11
S Ashina, R B Lipton, L Bendtsen, N Hajiyeva, D C Buse, A C Lyngberg, R Jensen
BACKGROUND: Low back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self-reported back pain in persons with and without primary headaches and examined pain sensitivity. METHOD: A population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self-administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (<15 headache days/month) (EH)...
January 19, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29348827/molecular-genetic-profiling-and-high-throughput-in-vitro-drug-screening-in-nut-midline-carcinoma-an-aggressive-and-fatal-disease
#12
Anja Stirnweiss, Joyce Oommen, Rishi S Kotecha, Ursula R Kees, Alex H Beesley
NUT midline carcinoma (NMC) is a rare and aggressive cancer, with survival typically less than seven months, that can arise in people of any age. Genetically, NMC is defined by the chromosomal fusion of NUTM1 with a chromatin-binding partner, typically the bromodomain-containing protein BRD4. However, little is known about other genetic aberrations in this disease. In this study, we used a unique panel of cell lines to describe the molecular-genetic features of NMC. Next-generation sequencing identified a recurring high-impact mutation in the DNA-helicase gene RECQL5 in 75% of lines studied, and biological signals from mutation-signature and network analyses consistent with a general failure in DNA-repair...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348674/variation-at-position-350-in-the-chikungunya-virus-6k-e1-protein-determines-the-sensitivity-of-detection-in-a-rapid-e1-antigen-test
#13
Aekkachai Tuekprakhon, Emi E Nakayama, Koen Bartholomeeusen, Orapim Puiprom, Tadahiro Sasaki, Ralph Huits, Natthanej Luplertlop, Nathamon Kosoltanapiwat, Pannamas Maneekan, Kevin K Ariën, Tatsuo Shioda, Pornsawan Leaungwutiwong
Chikungunya virus (CHIKV), a mosquito-borne pathogen, consists of three genotypes: East/Central/South African (ECSA), West African (WA), and Asian. Although a current rapid immunochromatographic (IC) test detecting CHIKV E1-antigen showed high sensitivity to ECSA-genotype viruses, it showed poor performance against the Asian-genotype virus that is spreading in the American continents. To understand the basis for the low performance of this IC test against Asian-genotype virus, we re-examined the anti-CHIKV monoclonal antibodies (mAbs) used in the assay for their interaction with E1-antigen of the three CHIKV genotypes...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347876/risk-of-overhydration-and-low-lean-tissue-index-as-measured-using-a-body-composition-monitor-in-patients-on-hemodialysis-a-systemic-review-and-meta-analysis
#14
Seun Deuk Hwang, Jin Ho Lee, Seoung Woo Lee, Joong Kyung Kim, Moon-Jae Kim, Joon Ho Song
Overhydration and sarcopenia, related to an individual's nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29347721/direct-verification-of-the-fluctuation-dissipation-relation-in-viscously-coupled-oscillators
#15
Shuvojit Paul, Abhrajit Laskar, Rajesh Singh, Basudev Roy, R Adhikari, Ayan Banerjee
The fluctuation-dissipation relation, a central result in nonequilibrium statistical physics, relates equilibrium fluctuations in a system to its linear response to external forces. Here we provide a direct experimental verification of this relation for viscously coupled oscillators, as realized by a pair of optically trapped colloidal particles. A theoretical analysis, in which interactions mediated by slow viscous flow are represented by nonlocal friction tensors, matches experimental results and reveals a frequency maximum in the amplitude of the mutual response which is a sensitive function of the trap stiffnesses and the friction tensors...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346293/fabry-perot-interferometric-high-temperature-sensing-up-to-1200-%C3%A2-c-based-on-a-silica-glass-photonic-crystal-fiber
#16
Haihu Yu, Ying Wang, Jian Ma, Zhou Zheng, Zhuozhao Luo, Yu Zheng
A Fabry-Perot interferometric sensor for temperature measurement was fabricated based on a silica glass solid-core photonic crystal fiber with a central air-bore. By splicing a stub of photonic crystal fiber to a standard single-mode fiber, an intrinsic Fabry-Perot cavity was formed inside the photonic crystal fiber. Sensing experiment results show that the sensor can work stably for a consecutive 24 h under temperatures up to 1100 °C, and the short-term operation temperature can reach as high as 1200 °C (<30 min)...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346241/chronic-central-serous-chorioretinopathy-early-and-late-morphological-and-functional-changes-after-verteporfin-photodynamic-therapy
#17
Pierluigi Iacono, Massimiliano Tedeschi, Barbara Boccassini, Adele Chiaravalloti, Monica Varano, Mariacristina Parravano
PURPOSE: To describe early and late morphological and functional changes in subjects receiving photodynamic therapy (PDT) for chronic central serous chorioretinopathy. METHODS: Patients with chronic central serous chorioretinopathy were prospectively enrolled and received standard PDT. At the baseline examination, each subject underwent complete ophthalmological examination, including best-corrected visual acuity (BCVA) assessment, fluorescein angiography and indocyanine green angiography, spectral domain optical coherence tomography, and microperimetry...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29345970/the-prevalence-and-significance-of-staphylococcus-aureus-in-patients-with-non-cystic-fibrosis-bronchiectasis
#18
Mark L Metersky, Timothy R Aksamit, Alan Barker, Radmila Choate, Charles L Daley, Leigh A Daniels, Angela DiMango, Edward Eden, David Griffith, Margaret Johnson, Michael Knowles, Anne E O'Donnell, Kenneth Olivier, Matthias Salathe, Byron Thomashow, Gregory Tino, Gerard Turino, Kevin L Winthrop, David Mannino
RATIONALE: Staphylococcus aureus is commonly cultured from the sputum of patients with bronchiectasis, however little is known about the prevalence of the organism in these patients, the characteristics of patients who have grown the organism or its implications. OBJECTIVES: Determine the relationship between S. aureus and pulmonary function, frequency of exacerbations and frequency of hospitalization in patients with bronchiectasis Methods: The Bronchiectasis Research Registry is a database of adults with non-cystic fibrosis bronchiectasis identified from 13 sites within the United States...
January 18, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29345639/emergent-constraint-on-equilibrium-climate-sensitivity-from-global-temperature-variability
#19
Peter M Cox, Chris Huntingford, Mark S Williamson
Equilibrium climate sensitivity (ECS) remains one of the most important unknowns in climate change science. ECS is defined as the global mean warming that would occur if the atmospheric carbon dioxide (CO2) concentration were instantly doubled and the climate were then brought to equilibrium with that new level of CO2. Despite its rather idealized definition, ECS has continuing relevance for international climate change agreements, which are often framed in terms of stabilization of global warming relative to the pre-industrial climate...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29344025/insulin-resistance-in-kidney-disease-is-there-a-distinct-role-separate-from-that-of-diabetes-or-obesity
#20
REVIEW
Adam Whaley-Connell, James R Sowers
Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas...
December 2017: Cardiorenal Medicine
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