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https://www.readbyqxmd.com/read/29607619/identification-and-metabolite-profiling-of-alkaloids-in-aerial-parts-of-papaver-rhoeas-by-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#1
Jae-Hyeon Oh, In Jin Ha, Min Young Lee, Eun-Ok Kim, Dain Park, Jun-Hee Lee, Seok-Geun Lee, Do-Wan Kim, Tae-Ho Lee, Eui-Ju Lee, Chang-Kug Kim
Papaver plants can produce diverse bioactive alkaloids. Papaver rhoeas Linnaeus (common poppy or corn poppy) is an annual flowering medicinal plant used for treating cough, sleep disorder, and as a sedative, pain relief, and food. It contains various powerful alkaloids like rhoeadine, benzylisoquinoline, and proaporphine. To investigate and identify alkaloids in the aerial parts of Papaver rhoeas, samples were collected at different growth stages and analyzed using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry...
April 2, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29563567/the-effects-of-promoter-variations-of-the-n-methylcanadine-1-hydroxylase-cyp82y1-gene-on-the-noscapine-production-in-opium-poppy
#2
Davar Abedini, Sajad Rashidi Monfared, Alireza Abbasi
Noscapine is an antitumor alkaloid produced in opium poppy (Papaver somniferum) and some members of the Papaveraceae family. It has been primarily used for its antitussive effects; more recently, its anticancer properties were shown. Herein, we detected an SSR embedded in the promoter region of the CYP82Y1 gene, which was found to be the first committed-step enzyme in the noscapine biosynthesis pathway, using the MISA program. Some collected ecotypes of P. somniferum were investigated for understanding of SSRs role in the regulation of gene expression and metabolite content...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29520812/nature-s-first-atypical-opioids-kratom-and-mitragynines
#3
R B Raffa, J V Pergolizzi, R Taylor, M H Ossipov
WHAT IS KNOWN AND OBJECTIVE: Advances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are "multimechanistic") and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic. At least two of the more-modern analgesics combine opioid and non-opioid mechanisms, and have become known as "atypical opioids." Less well known is that just as Nature evolved opioids, it also evolved atypical opioids, presaging modern drug discovery efforts...
March 8, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29462921/complete-chloroplast-genomes-of-papaver-rhoeas-and-papaver-orientale-molecular-structures-comparative-analysis-and-phylogenetic-analysis
#4
Jianguo Zhou, Yingxian Cui, Xinlian Chen, Ying Li, Zhichao Xu, Baozhong Duan, Yonghua Li, Jingyuan Song, Hui Yao
Papaver rhoeas L. and P. orientale L., which belong to the family Papaveraceae, are used as ornamental and medicinal plants. The chloroplast genome has been used for molecular markers, evolutionary biology, and barcoding identification. In this study, the complete chloroplast genome sequences of P. rhoeas and P. orientale are reported. Results show that the complete chloroplast genomes of P. rhoeas and P. orientale have typical quadripartite structures, which are comprised of circular 152,905 and 152,799-bp-long molecules, respectively...
February 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29433083/inhibition-of-phospholipases-influences-the-metabolism-of-wound-induced-benzylisoquinoline-alkaloids-in-papaver-somniferum-l
#5
Veronika Jablonická, Jörg Ziegler, Zuzana Vatehová, Desana Lišková, Ingo Heilmann, Marek Obložinský, Mareike Heilmann
Benzylisoquinoline alkaloids (BIAs) are important secondary plant metabolites and include medicinally relevant drugs, such as morphine or codeine. As the de novo synthesis of BIA backbones is (still) unfeasible, to date the opium poppy plant Papaver somniferum L. represents the main source of BIAs. The formation of BIAs is induced in poppy plants by stress conditions, such as wounding or salt treatment; however, the details about regulatory processes controlling BIA formation in opium poppy are not well studied...
January 31, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29416103/development-of-a-method-to-extract-opium-poppy-papaver-somniferum-l-dna-from-heroin
#6
Michael A Marciano, Sini X Panicker, Garrett D Liddil, Danielle Lindgren, Kevin S Sweder
This study is the first to report the successful development of a method to extract opium poppy (Papaver somniferum L.) DNA from heroin samples. Determining of the source of an unknown heroin sample (forensic geosourcing) is vital to informing domestic and foreign policy related to counter-narcoterrorism. Current profiling methods focus on identifying process-related chemical impurities found in heroin samples. Changes to the geographically distinct processing methods may lead to difficulties in classifying and attributing heroin samples to a region/country...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29415748/an-ethnobotanical-study-in-midyat-turkey-a-city-on-the-silk-road-where-cultures-meet
#7
Ali Akgul, Ayfer Akgul, Serdar G Senol, Hasan Yildirim, Ozcan Secmen, Yunus Dogan
BACKGROUND: Studies of ethnobotanical usages in south-eastern Turkey are rare. To widen this field of knowledge, we conducted an ethnobotanical study in Midyat (Mardin Province), Turkey. METHODS: The field study was completed during three years (2007-2010). Our aim was to document the ethnobotanical uses of local plants and to make an ethnobotanical inventory of uncommon plants using qualitative interviews. RESULTS: During field studies, 368 voucher specimens were collected in the investigated area...
February 7, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29408320/crystal-structure-of-thebaine-6-o-demethylase-from-the-morphine-biosynthesis-pathway
#8
Anna Kluza, Ewa Niedzialkowska, Katarzyna Kurpiewska, Zuzanna Wojdyla, Matthew Quesne, Ewa Kot, Przemyslaw J Porebski, Tomasz Borowski
Thebaine 6-O-demethylase (T6ODM) from Papaver somniferum (opium poppy), which belongs to the non-heme 2-oxoglutarate/Fe(II)-dependent dioxygenases (ODD) family, is a key enzyme in the morphine biosynthesis pathway. Initially, T6ODM was characterized as an enzyme catalyzing O-demethylation of thebaine to neopinone and oripavine to morphinone, however the substrate range of T6ODM was recently expanded to a number of various benzylisoquinoline alkaloids. Here, we present crystal structures of T6ODM in complexes with 2-oxoglutarate (T6ODM:2OG, PDB: 5O9W) and succinate (T6ODM:SIN, PDB: 5O7Y)...
February 2, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29402492/agrobacterium-bohemicum-sp-nov-isolated-from-poppy-seed-wastes-in-central-bohemia
#9
Jiří Zahradník, Jaroslav Nunvar, Hana Pařízková, Lucie Kolářová, Andrea Palyzová, Helena Marešová, Michal Grulich, Eva Kyslíková, Pavel Kyslík
Two non-pathogenic strains R89-1 and R90T isolated from poppy seed (Papaver somniferum L.) wastes were phenotypically and genotypically characterized. Multilocus sequence analysis (MLSA) was conducted with six genes (atpD, glnA, gyrB, recA, rpoB, 16S rRNA). The strains represented a new species which clustered with Agrobacterium rubi NBRC 13261T and Agrobacterium skierniewicense Ch11T type strains. MLSA was further accompanied by whole-genome phylogeny, in silico DNA-DNA hybridization (dDDH) and average nucleotide identity (ANI) analyses for both strains...
January 31, 2018: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29248451/features-and-outcomes-of-drugs-for-combination-therapy-as-multi-targets-strategy-to-combat-alzheimer-s-disease
#10
REVIEW
Atish Kumar Sahoo, Jagnehswar Dandapat, Umesh Chandra Dash, Satish Kanhar
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD), a deleterious neurodegenerative disorder that impairs memory, cognitive functions and may lead to dementia in late stage of life. The pathogenic cause of AD remains incompletely understood and FDA approved drugs are partial inhibitors rather than curative. Most of drugs are synthetic or natural products as galanthamine is an alkaloid obtained from Galanthus spp. Huperzine A, an alkaloid found in Huperzia spp., gingkolides a diterpenoids from Gingko biloba and many ethnobotanicals like Withania somnifera (L...
April 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29183612/suitable-reference-genes-for-accurate-gene-expression-analysis-in-papaver-rhoeas-under-2-4-d-herbicide-stress
#11
L Scarabel, A Milani, S Panozzo, A Rasori
Resistance to 2,4-D (2,4-diclorophenoxyacetic acid) herbicide is increasing in various dicotyledonous weed species, including Papaver rhoeas, a weed infesting Southern European wheat crops. Non-target-site resistance to this herbicide is governed by a range of genes involved in herbicide stress response. To enable reliable measurement of gene expression levels in herbicide-resistant and susceptible plants it is necessary to normalize qPCR data using internal control genes with stable expression. In an attempt to find the best reference genes, the stability of seven candidate reference genes was assessed in plants resistant and susceptible to 2,4-D, subjected or not to herbicide stress...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29125236/library-of-norcoclaurine-synthases-and-their-immobilization-for-biocatalytic-transformations
#12
Horst Lechner, Pablo Soriano, Roman Poschner, Helen C Hailes, John M Ward, Wolfgang Kroutil
Norcoclaurine synthases (NCS), catalyzing a Pictet-Spengler reaction in plants as one of the first enzymes in the biosynthetic benzylisoquinoline pathway, are investigated for biocatalytic transformations. The library of NCS available is extended by two novel NCSs from Argemone mexicana (AmNCS1, AmNCS2) and one new NCS from Corydalis saxicola (CsNCS); furthermore, it is shown that the NCS from Papaver bracteatum (PbNCS) is a highly productive catalyst leading to the isoquinoline product with up to >99% e...
November 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29081011/characterization-of-fungi-causing-lesion-blight-on-papaver-dubium-in-iran
#13
Parisa Razaghi, Doustmorad Zafari
Papaver dubium (common name, blindeyes, Papaveraceae) is widespread throughout Europe and America and is an important weed in western Iran. Since 2009, a blight disease has occurred in several areas in Hamedan Province, Iran, causing significant damage to plants of P. dubium. Small, yellow-brown lesions appeared on lower leaves and eventually expanded to the whole plant, resulting in necrosis and complete wilting. This study was conducted to identify the causal agent(s) of the blight disease on blindeyes plants...
October 28, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29033916/contribution-of-ruminal-fungi-archaea-protozoa-and-bacteria-to-the-methane-suppression-caused-by-oilseed-supplemented-diets
#14
Shaopu Wang, Katrin Giller, Michael Kreuzer, Susanne E Ulbrich, Ueli Braun, Angela Schwarm
Dietary lipids can suppress methane emission from ruminants, but effects are variable. Especially the role of bacteria, archaea, fungi and protozoa in mediating the lipid effects is unclear. In the present in vitro study, archaea, fungi and protozoa were selectively inhibited by specific agents. This was fully or almost fully successful for fungi and protozoa as well as archaeal activity as determined by the methyl-coenzyme M reductase alpha subunit gene. Five different microbial treatments were generated: rumen fluid being intact (I), without archaea (-A), without fungi (-F), without protozoa (-P) and with bacteria only (-AFP)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28975129/retraction-structural-basis-of-the-substrate-specificity-and-enzyme-catalysis-of-a-papaver-somniferum-tyrosine-decarboxylase
#15
(no author information available yet)
[This retracts the article on p. 5 in vol. 4, PMID: 28232911.].
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28955370/enhanced-2-4-d-metabolism-in-two-resistant-papaver-rhoeas-populations-from-spain
#16
Joel Torra, Antonia M Rojano-Delgado, Jordi Rey-Caballero, Aritz Royo-Esnal, Maria L Salas, Rafael De Prado
Corn poppy (Papaver rhoeas), the most problematic broadleaf weed in winter cereals in Southern Europe, has developed resistance to the widely-used herbicide, 2,4-D. The first reported resistance mechanism in this species to 2,4-D was reduced translocation from treated leaves to the rest of the plant. However, the presence of other non-target site resistance (NTSR) mechanisms has not been investigated up to date. Therefore, the main objective of this research was to reveal if enhanced 2,4-D metabolism is also present in two Spanish resistant (R) populations to synthetic auxins...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28754627/therapeutic-potentials-of-natural-compounds-acting-on-cyclic-nucleotide-phosphodiesterase-families
#17
REVIEW
Abdurazzag Abusnina, Claire Lugnier
Intracellular cyclic AMP and/or cyclic GMP are characterized in the 1960th. These second messengers, hydrolysed specifically by cyclic nucleotide phosphodiesterase (PDE), play a major role in intracellular signalling. Natural products have been a rich source of drug discovery, Theophylline and Methylxanthine originated from tea leaves used for asthma treatment, whereas, Papaverine, a natural isoquinolein originated from Papaver somniferum traditionally used in impotency, altogether as caffeine where firstly described as PDE-inhibiting compounds...
November 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28744243/the-odyssey-of-dental-anxiety-from-prehistory-to-the-present-a-narrative-review
#18
REVIEW
Enrico Facco, Gastone Zanette
Dental anxiety (DA) can be considered as a universal phenomenon with a high prevalence worldwide; DA and pain are also the main causes for medical emergencies in the dental office, so their prevention is an essential part of patient safety and overall quality of care. Being DA and its consequences closely related to the fight-or-flight reaction, it seems reasonable to argue that the odyssey of DA began way back in the distant past, and has since probably evolved in parallel with the development of fight-or-flight reactions, implicit memory and knowledge, and ultimately consciousness...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28729873/ageratum-enation-virus-infection-induces-programmed-cell-death-and-alters-metabolite-biosynthesis-in-papaver-somniferum
#19
Ashish Srivastava, Lalit Agrawal, Rashmi Raj, Meraj Jaidi, Shri K Raj, Swati Gupta, Ritu Dixit, Poonam C Singh, Tusha Tripathi, Om P Sidhu, Brahma N Singh, Sudhir Shukla, Puneet S Chauhan, Susheel Kumar
A previously unknown disease which causes severe vein thickening and inward leaf curl was observed in a number of opium poppy (Papaver somniferum L.) plants. The sequence analysis of full-length viral genome and associated betasatellite reveals the occurrence of Ageratum enation virus (AEV) and Ageratum leaf curl betasatellite (ALCB), respectively. Co-infiltration of cloned agroinfectious DNAs of AEV and ALCB induces the leaf curl and vein thickening symptoms as were observed naturally. Infectivity assay confirmed this complex as the cause of disease and also satisfied the Koch's postulates...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28633584/variation-of-alkaloid-contents-and-antimicrobial-activities-of-papaver-rhoeas-l-growing-in-turkey-and-northern-cyprus
#20
İlkcan Çoban, Gizem Gülsoy Toplan, Berna Özbek, Çağlayan Unsal Gürer, Günay Sarıyar
CONTEXT: Papaver rhoeas L. (Papaveraceae) corn poppy, widely distributed in Turkey, is used to make a cough syrup for children, as a tea for disturbed sleep, for pain relief and as a sedative in folk medicine. OBJECTIVE: Samples of P. rhoeas collected from eight different locations in Turkey and three from northern Cyprus were investigated for their alkaloid content and screened for their antimicrobial activities. MATERIALS AND METHODS: From the aerial parts of P...
December 2017: Pharmaceutical Biology
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