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Nmda antogonist

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https://www.readbyqxmd.com/read/17089229/-has-ketamine-preemptive-analgesic-effect-in-patients-undergoing-abdominal-hysterectomy
#1
RANDOMIZED CONTROLLED TRIAL
Semra Karaman, Seden Kocabaş, Ciler Zincircioğlu, Vicdan Firat
The aim of this study was to determine if preemptive use of the NMDA receptor antogonist ketamine decreases postoperative pain in patients undergoing abdominal hystrectomy. A total of 60 patients admitted for total abdominal hysterectomy were included in this study after the approval of the ethic committee, and the patients were randomly classified into three groups. After standart general anaesthesia, before or after incision patients received bolus saline or ketamine. Group S received only saline while Group Kpre received ketamine 0...
July 2006: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/1676672/transition-from-normal-to-epileptiform-activity-in-kindled-rat-hippocampal-slices
#2
S M Bawin, W M Satmary, M D Mahoney, W R Adey
We previously demonstrated kindling of synchronized bursts (ISs) by repeated sine-wave stimulation (SW: 2-5 sec, 60 Hz, 20-50 microA, every 5 min) in the CA2/3 area of rat hippocampal slices. Here we report the behavior of individual CA2/3 neurons during the kindling procedure. Intra- and extracellular recordings were obtained concurrently before, during and following SW. Test pulses and SWs were applied in CA2/3 or CA1 stratum radiatum. Neuronal response to to intracellular stimulation was tested by 100 msec depolarizing dc pulses or by 2-20 sec sinusoidal currents...
March 1991: Epilepsy Research
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