keyword
https://read.qxmd.com/read/34256045/levo-tetrahydropalmatine-a-new-potential-medication-for-methamphetamine-addiction-and-neurotoxicity
#1
REVIEW
Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wang
Levo-tetrahydropalmatine (l-THP) is mainly derived from the dried tuber of the Papaveraceae plant Corydalis, also called Corydalis B, which is a drug with analgesic, hypnotic, sedative and other effects. Methamphetamine (METH) belongs to the central nervous stimulant and is a highly addictive drug. It is an urgent problem to study the mechanism of methamphetamine neurotoxicity and to search for the therapeutic targets of the METH addiction. This review is aimed to discuss the pharmacological mechanism and the protective effects of l-THP on METH-induced neurotoxicity, and to explore the therapeutic prospects of l-THP for METH addiction to provide an innovative application of l-THP in clinic...
October 2021: Experimental Neurology
https://read.qxmd.com/read/32850291/role-of-natural-products-in-mitigation-of-toxic-effects-of-methamphetamine-a-review-of-in-vitro-and-in-vivo-studies
#2
REVIEW
Mohammad Moshiri, Ali Roohbakhsh, Mahdi Talebi, Milad Iranshahy, Leila Etemad
Objective: Methamphetamine (METH) increases dopamine, norepinephrine and serotonin concentrations in the synaptic cleft, and induces hyperactivity. The current management of acute METH poisoning relies on supportive care and no specific antidote is available for treatment. The main objective of this review was to present the evidence for effectiveness of the herbal medicine in alleviating the adverse effects of METH abuse. Materials and Methods: Literature search was performed using the following electronic databases: MEDLINE, Scopus, PubMed and EMBASE...
July 2020: Avicenna Journal of Phytomedicine
https://read.qxmd.com/read/31398456/levo-tetrahydropalmatine-attenuates-methamphetamine-reward-behavior-and-the-accompanying-activation-of-erk-phosphorylation-in-mice
#3
JOURNAL ARTICLE
Hongliang Su, Tingting Sun, Xiao Wang, Yan Du, Na Zhao, Jie Zhu, Jiangwei Yan, Teng Chen, Keming Yun
Levo-tetrahydropalmatine (L-THP) is the main active ingredient of traditional Chinese herbal medicine Corydalis and Stephania, which have been used for sedative, neuroleptic, and analgesic purposes. Previous studies have demonstrated that L-THP has antagonistic activation on dopamine receptors. Despite its effectiveness on treating drug addiction, L-THP's underlying molecular mechanisms in modulating methamphetamine (METH) reward behavior remain unclear. In order to clarify the mechanisms behind, we designed an experiment of conditioned place preference (CPP) to investigate the effects of L-THP on METH-induced CPP in mice...
January 1, 2020: Neuroscience Letters
https://read.qxmd.com/read/29523775/a-case-of-levo%C3%AF-oxacin-induced-hepatotoxicity
#4
JOURNAL ARTICLE
Michael Schloss, Daniel Becak, Sebastian T Tosto, Arash Velayati
BACKGROUND Levofloxacin covers a broad spectrum of pathogens and is readily prescribed by clinicians. Hepatotoxicity is a known but unusual complication of levofloxacin use. Here, we present a case of severe transaminitis caused by levofloxacin. CASE REPORT A young man in his thirties with a history of asthma, chronic alcoholism, methamphetamine intravenous drug abuse (IVDA), and non-compliant insulin-dependent diabetes mellitus (IDDM) presented to an emergency department with suicidal ideation. Vital signs were stable and the patient was noted to have cellulitis of the right forearm, for which cultures were drawn, and he received IV clindamycin...
March 10, 2018: American Journal of Case Reports
https://read.qxmd.com/read/29447954/the-inhibitory-effect-of-levo-tetrahydropalmatine-on-the-methamphetamine-induced-spatial-memory-impairment-in-mice
#5
JOURNAL ARTICLE
Guofen Cao, Yongai Zhang, Li Zhu, Jie Zhu, Na Zhao, Nan Dong, Yonghui Dang, Yanjiong Chen, Teng Chen
Methamphetamine (METH) administration results in addiction and memory impairment. Previous studies have suggested that levo-tetrahydropalmatine (l-THP), an alkaloid purified from the Chinese herb Corydalis, attenuates the behavioral changes induced by METH. Therefore, in this study, we explored whether l-THP could also protect against the METH-induced memory impairment examined using the Morris water maze (MWM). We found that low dose of METH (1.0 mg/kg) treated for 20 consecutive days prior to the MWM experiment impaired spatial memory retention but not acquisition in mice...
April 13, 2018: Neuroscience Letters
https://read.qxmd.com/read/26869715/improved-chiral-separation-of-methamphetamine-enantiomers-using-csp-lc-ms-ms
#6
JOURNAL ARTICLE
Lauren F Ward, Jeffrey R Enders, David S Bell, Hugh M Cramer, Frank N Wallace, Gregory L McIntire
To determine the true enantiomeric composition of methamphetamine urine drug testing results, chiral separation of dextro (D) and levo (L) enantiomers is necessary. While enantiomeric separation of methamphetamine has traditionally been accomplished using gas chromatography-mass spectrometry (GC-MS), chiral separation of D- and L-methamphetamine by chiral stationary phase (CSP) liquid chromatography-mass spectrometry/mass spectrometry (LC-MS-MS) has proved more reliable. Chirally selective detection of methamphetamine by GC-MS is often performed using L-N-trifluoroacetyl-prolyl chloride (TPC)...
May 2016: Journal of Analytical Toxicology
https://read.qxmd.com/read/26806555/levo-tetrahydropalmatine-a-natural-mixed-dopamine-receptor-antagonist-inhibits-methamphetamine-self-administration-and-methamphetamine-induced-reinstatement
#7
JOURNAL ARTICLE
Xiaokang Gong, Kai Yue, Baomiao Ma, Junqiao Xing, Yongping Gan, Daisong Wang, Guozhang Jin, Chaoying Li
Despite the high prevalence of methamphetamine (METH) use, no FDA-approved pharmacological treatment is currently available for individuals with a METH addiction. Levo-tetrahydropalmatine (l-THP) is an alkaloid substance derived from corydalis and stephania that has been used in traditional Asian medicine for its analgesic, sedative and hypnotic properties. Previous pharmacological studies of l-THP indicated that it not only binds to D1 and D2 receptors but also has a low affinity for D3 receptors and may function as an antagonist...
May 2016: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/24269936/levo-tetrahydropalmatine-attenuates-the-development-and-expression-of-methamphetamine-induced-locomotor-sensitization-and-the-accompanying-activation-of-erk-in-the-nucleus-accumbens-and-caudate-putamen-in-mice
#8
JOURNAL ARTICLE
N Zhao, Y Chen, J Zhu, L Wang, G Cao, Y Dang, C Yan, J Wang, T Chen
Levo-tetrahydropalmatine (l-THP) is an alkaloid purified from corydalis and has been used in many traditional Chinese herbal preparations for its analgesic, sedative, and hypnotic properties. Previous studies indicated that l-THP has modest antagonist activity against dopamine receptors and thus it might have potential therapeutic effects on drug addiction. However, whether and how l-THP contributes to methamphetamine (METH)-induced locomotor sensitization remains unclear. Therefore, the current study aims to examine the roles of l-THP in the development and expression of METH-induced locomotor sensitization as well as the accompanying extracellular-regulated kinase (ERK) activation in the nucleus accumbens (NAc), caudate putamen (CPu) and prefrontal cortex (PFc) in mice...
January 31, 2014: Neuroscience
https://read.qxmd.com/read/23711566/roles-of-levo-tetrahydropalmatine-in-modulating-methamphetamine-reward-behavior
#9
JOURNAL ARTICLE
Hong-Liang Su, Jie Zhu, Yan-Jiong Chen, Na Zhao, Wei Han, Yong-Hui Dang, Ming Xu, Teng Chen
Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice...
June 13, 2013: Physiology & Behavior
https://read.qxmd.com/read/19368765/the-levo-enantiomer-of-amphetamine-increases-memory-consolidation-and-gene-expression-in-the-hippocampus-without-producing-locomotor-stimulation
#10
JOURNAL ARTICLE
Kjesten A Wiig, Jonathan R Whitlock, Mel H Epstein, Randall L Carpenter, Mark F Bear
Dextro-amphetamine enhances memory and other cognitive functions in animals and humans. The use of d-amphetamine as a memory enhancer, however, is limited by a robust stimulatory side-effect profile caused by release of dopamine. The levo enantiomer of amphetamine has been shown to be considerably less effective as a dopamine releaser and less potent in producing the stimulatory effects characteristic of d-amphetamine. In order to determine whether l-amphetamine and the structurally related compound, l-methamphetamine, retain cognitive-enhancing effects despite their lack of stimulatory activity, we administered the compounds to rats prior to activity monitoring experiments, and in different animals, immediately after training on inhibitory avoidance and object recognition tasks...
July 2009: Neurobiology of Learning and Memory
https://read.qxmd.com/read/3366062/bizarre-behavior-following-the-ingestion-of-levo-desoxyephedrine
#11
JOURNAL ARTICLE
R L Ferrando, E McCorvey, W A Simon, D M Stewart
This is the first reported case of transvestism in a heterosexual male that occurred only after ingestion of the contents of six to eight Vicks inhalers. The patient's gender cross-dressing was associated with sexual excitement and masturbatory behavior. This case is consistent with other cases of gender cross-dressing and sexual excitement following inhaler abuse, but in the previous cases reported the subjects were homosexual men. Levo-desoxyephedrine, also known as levo-methamphetamine, the main active ingredient in Vicks Inhalers, is known to have amphetamine-like properties...
March 1988: Drug Intelligence & Clinical Pharmacy
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