keyword
https://read.qxmd.com/read/38289670/using-a-natural-language-processing-approach-to-support-rapid-knowledge-acquisition
#21
JOURNAL ARTICLE
Taneya Y Koonce, Dario A Giuse, Annette M Williams, Mallory N Blasingame, Poppy A Krump, Jing Su, Nunzia B Giuse
Implementing artificial intelligence to extract insights from large, real-world clinical data sets can supplement and enhance knowledge management efforts for health sciences research and clinical care. At Vanderbilt University Medical Center (VUMC), the in-house developed Word Cloud natural language processing system extracts coded concepts from patient records in VUMC's electronic health record repository using the Unified Medical Language System terminology. Through this process, the Word Cloud extracts the most prominent concepts found in the clinical documentation of a specific patient or population...
January 30, 2024: JMIR Medical Informatics
https://read.qxmd.com/read/38287733/using-theater-as-an-innovative-knowledge-translation-approach-for-health-research-a-scoping-review-protocol
#22
JOURNAL ARTICLE
Poppy Jackson, Alison Luke, Alex Goudreau, Shelley Doucet
OBJECTIVE: The objective of this review is to synthesize the existing literature on how theater has been used as a knowledge translation approach for health research and to identify the outcome measures employed for evaluation and the facilitators/challenges related to this approach. INTRODUCTION: The use of arts-based knowledge translation methods is relatively new in health research but has already shown to have positive impacts on knowledge, attitudes, policy, and practice...
January 30, 2024: JBI evidence synthesis
https://read.qxmd.com/read/38272787/comment-on-patient-and-operative-factors-influence-delayed-discharge-following-bariatric-surgery-in-an-enhanced-recovery-setting
#23
EDITORIAL
Poppy Addison
No abstract text is available yet for this article.
December 29, 2023: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38258741/quantum-gas-enabled-direct-mapping-of-active-current-density-in-percolating-networks-of-nanowires
#24
JOURNAL ARTICLE
Julia Fekete, Poppy Joshi, Thomas J Barrett, Timothy Martin James, Robert Shah, Amruta Gadge, Shobita Bhumbra, William Evans, Manoj Tripathi, Matthew Large, Alan B Dalton, Fedja Oručević, Peter Krüger
Electrically percolating nanowire networks are among the most promising candidates for next-generation transparent electrodes. Scientific interest in these materials stems from their intrinsic current distribution heterogeneity, leading to phenomena like percolating pathway rerouting and localized self-heating, which can cause irreversible damage. Without an experimental technique to resolve the current distribution and an underpinning nonlinear percolation model, one relies on empirical rules and safety factors to engineer materials...
January 23, 2024: Nano Letters
https://read.qxmd.com/read/38255686/new-set-of-est-str-markers-for-discrimination-of-related-papaver-somniferum-l-varieties
#25
JOURNAL ARTICLE
Šarlota Kaňuková, Katarína Ondreičková, Daniel Mihálik, Ján Kraic
Papaver somniferum L. is cultivated for its edible seeds and for the production of alkaloids. A serious problem in seed trade and processing is the intentional mixing of excellent food-quality seeds with non-food-grade-quality seeds. Tracking the correct or illegitimate handling of seeds requires an efficient method for discrimination and individualization of poppy varieties. As in human and animal forensics, DNA variable regions containing short tandem repeats (STRs) located either in non-coding DNA or in gene sequences (EST-STRs) are preferred markers for discrimination between genotypes...
December 31, 2023: Life
https://read.qxmd.com/read/38219675/how-to-improve-the-surveillance-of-the-taliban-ban-s-impact-on-european-drug-markets
#26
JOURNAL ARTICLE
Luca Giommoni
In April 2023, the Taliban banned poppy cultivation and the trade of all narcotics. This caused a 95% reduction in opium production. Usually, that would be good news. But there is a substantial worry: synthetic opioids might fill the void left by heroin. This is concerning because these drugs have led to health emergencies in areas where they are prevalent. This paper highlights the limitations of the current drug surveillance system in Europe and proposes improvements. It argues that reliance on secondary data is insufficient...
January 13, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38195593/sanguinarine-chloride-induces-ferroptosis-by-regulating-ros-bach1-hmox1-signaling-pathway-in-prostate-cancer
#27
JOURNAL ARTICLE
Shanhui Liu, Yan Tao, Shan Wu, Jiawei Lin, Shengjun Fu, Jianzhong Lu, Jing Zhang, Beitang Fu, Erdong Zhang, Jing Xu, Jiaxuan Wang, Lanlan Li, Lei Zhang, Zhiping Wang
BACKGROUND: Sanguinarine chloride (S.C) is a benzophenanthrine alkaloid derived from the root of sanguinaria canadensis and other poppy-fumaria species. Studies have reported that S.C exhibits antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects, which contribute to its anti-cancer properties. Recent studies suggested that the antitumor effect of S.C through inducing ferroptosis in some cancers. Nevertheless, the precise mechanism underlying the regulation of ferroptosis by S...
January 9, 2024: Chinese Medicine
https://read.qxmd.com/read/38194775/an-19-f-nmr-fragment-based-approach-for-the-discovery-and-development-of-brca2-rad51-inhibitors-to-pursuit-synthetic-lethality-in-combination-with-parp-inhibition-in-pancreatic-cancer
#28
JOURNAL ARTICLE
Samuel H Myers, Laura Poppi, Francesco Rinaldi, Marina Veronesi, Andrea Ciamarone, Viola Previtali, Greta Bagnolini, Fabrizio Schipani, Jose Antonio Ortega Martínez, Stefania Girotto, Giuseppina Di Stefano, Fulvia Farabegoli, Naomi Walsh, Francesca De Franco, Marinella Roberti, Andrea Cavalli
The BRCA2-RAD51 interaction remains an intriguing target for cancer drug discovery due to its vital role in DNA damage repair mechanisms, which cancer cells become particularly reliant on. Moreover, RAD51 has many synthetically lethal partners, including PARP1-2, which can be exploited to induce synthetic lethality in cancer. In this study, we established a 19 F-NMR-fragment based approach to identify RAD51 binders, leading to two initial hits. A subsequent SAR program identified 46 as a low micromolar inhibitor of the BRCA2-RAD51 interaction...
December 31, 2023: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38189106/making-oral-comprehension-interventions-tidier-a-narrative-synthesis-of-interventions-improving-comprehension-in-children-from-1-to-5-years-with-language-difficulties
#29
REVIEW
Katherine Shobbrook, Poppy Young, Suzanne Beeke, Wendy Best
BACKGROUND: Oral comprehension difficulties are prevalent in preschool children with language difficulties and are frequently the target of speech and language therapy (SLT) intervention. To support the implementation of research to practice, there is a need to identify effective interventions for this population and to describe their components. To date, reviews of oral comprehension intervention have not used inclusion criteria aligned with common clinical practice, particularly in the United Kingdom...
January 8, 2024: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/38183860/the-baltic-and-nordic-responses-to-the-first-taliban-poppy-ban-implications-for-europe-synthetic-opioids-today
#30
JOURNAL ARTICLE
Jonathan P Caulkins, Amund Tallaksen, Jirka Taylor, Beau Kilmer, Peter Reuter
The 2000-2001 and the 2022-2023 Taliban opium bans were and could be two of the largest ever disruptions to a major illegal drug market. To help understand potential implications of the current ban for Europe, this paper analyzes how opioid markets in seven Baltic and Nordic countries responded to the earlier ban, using literature review, key informant interviews, and secondary data analysis. The seven nations' markets responded in diverse ways, including rebounding with the same drug (heroin in Norway), substitution to a more potent opioid (fentanyl replacing heroin in Estonia), and substitution to one with lower risk of overdose (buprenorphine replacing heroin in Finland)...
January 4, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38154885/healthcare-resource-utilisation-and-costs-of-hospitalisation-and-primary-care-among-adults-with-covid-19-in-england-a-population-based-cohort-study
#31
JOURNAL ARTICLE
Jingyan Yang, Kathleen Michelle Andersen, Kiran K Rai, Theo Tritton, Tendai Mugwagwa, Maya Reimbaeva, Carmen Tsang, Leah J McGrath, Poppy Payne, Bethany Emma Backhouse, Diana Mendes, Rebecca Butfield, Kevin Naicker, Mary Araghi, Robert Wood, Jennifer L Nguyen
OBJECTIVES: To quantify direct costs and healthcare resource utilisation (HCRU) associated with acute COVID-19 in adults in England. DESIGN: Population-based retrospective cohort study using Clinical Practice Research Datalink Aurum primary care electronic medical records linked to Hospital Episode Statistics secondary care administrative data. SETTING: Patients registered to primary care practices in England. POPULATION: 1 706 368 adults with a positive SARS-CoV-2 PCR or antigen test from August 2020 to January 2022 were included; 13 105 within the hospitalised cohort indexed between August 2020 and March 2021, and 1 693 263 within the primary care cohort indexed between August 2020 and January 2022...
December 28, 2023: BMJ Open
https://read.qxmd.com/read/38150400/correction-to-urine-and-hair-drug-test-results-associated-with-daily-consumption-of-codeine-predominant-poppy-seed-food-products
#32
(no author information available yet)
No abstract text is available yet for this article.
December 27, 2023: Journal of Analytical Toxicology
https://read.qxmd.com/read/38148687/introduction-to-the-special-issue-goal-direction-and-habit-in-operant-behavior
#33
JOURNAL ARTICLE
Poppy Watson, Eric A Thrailkill, Laura H Corbit, Mark E Bouton
No abstract text is available yet for this article.
December 26, 2023: Journal of the Experimental Analysis of Behavior
https://read.qxmd.com/read/38134456/improved-owner-quality-of-life-following-surgical-repair-of-canine-myxomatous-mitral-valve-disease
#34
JOURNAL ARTICLE
Catrina Pennington, Poppy Bristow, Xavier Navarro-Cubas, Tsumugi Anne Kurosawa
OBJECTIVE: To determine quality-of-life changes in owners of dogs undergoing mitral valve repair for myxomatous mitral valve disease, up to 12 months postoperatively. SAMPLE: Owners of 26 dogs undergoing mitral valve repair at a single UK veterinary referral hospital. METHODS: Dogs underwent mitral valve repair under cardiopulmonary bypass as previously described. Owner quality of life was assessed by self-completion of a previously validated questionnaire preoperatively and at 1, 3, 6, and 12 months postoperatively...
December 22, 2023: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38133176/design-and-optimisation-of-sustainable-sample-treatments-based-on-ultrasound-assisted-extraction-and-strong-cation-exchange-purification-with-functionalised-sba-15-for-opium-alkaloids-in-ground-poppy-seeds
#35
JOURNAL ARTICLE
Gema Casado-Hidalgo, Sonia Morante-Zarcero, Damián Pérez-Quintanilla, Isabel Sierra
An analysis methodology was optimised and validated for the quantification of opium alkaloids (OAs) in ground poppy seeds. This involved ultrasound-assisted extraction (UAE) and solid-phase extraction (SPE) purification before analysis using a high-performance liquid chromatography mass spectrometry detector (HPLC-MS/MS). UAE was optimised through the design of experiments with three factors and a three-level full factorial design. For SPE optimisation, a commercial material was compared with a previously synthesised material of SBA-15 silica functionalised with sulfonic groups (SBA-15-SO3 - )...
November 24, 2023: Toxins
https://read.qxmd.com/read/38113517/health-care-resource-utilization-and-costs-associated-with-covid-19-among-pediatrics-managed-in-the-community-or-hospital-setting-in-england-a-population-based-cohort-study
#36
JOURNAL ARTICLE
Jingyan Yang, Kathleen M Andersen, Kiran K Rai, Theo Tritton, Tendai Mugwagwa, Carmen Tsang, Maya Reimbaeva, Leah J McGrath, Poppy Payne, Bethany Backhouse, Diana Mendes, Rebecca Butfield, Robert Wood, Jennifer L Nguyen
BACKGROUND: Although COVID-19 morbidity is significantly lower in pediatrics than in adults, the risk of severe COVID-19 may still pose substantial health care resource burden. This study aimed to describe health care resource utilization (HCRU) and costs associated with COVID-19 in pediatrics 1-17 years old in England. METHODS: A population-based retrospective cohort study of pediatrics with COVID-19 using Clinical Practice Research Datalink (CPRD Aurum) primary care data and, where available, linked Hospital Episode Statistics Admitted Patient Care secondary care data...
December 18, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38111670/the-ethyl-acetate-extract-of-vernonia-amygdalina-leaf-ameliorates-gemcitabine-effect-against-migration-and-invasion-of-panc-1-cells-via-down-regulation-the-vegf-cox-2-and-ras-mek-pathways
#37
JOURNAL ARTICLE
Poppy Anjelisa Zaitun Hasibuan, Jane Melita Keliat, Muhammad Fauzan Lubis, Annisa Nasution
Individuals diagnosed with cancer often turn to the use of herbal remedies with the intention of treating and ameliorating the condition, impeding the progression of metastasis, enhancing immune function, mitigating stress, and inducing relaxation. Recently, medicinal plants were combined with conventional chemotherapy to decrease the side effects and increase the effectiveness of chemotherapy. This study showed the effectiveness of gemcitabine (Gem) was significantly increased after being used together with ethyl acetate extract obtained from Vernonia amygdalina (Eav) leaves...
January 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38109712/a-cornucopia-of-diversity-ranunculales-as-a-model-lineage
#38
JOURNAL ARTICLE
Annette Becker, Julien B Bachelier, Laetitia Carrive, Natalia Conde E Silva, Catherine Damerval, Cédric Del Rio, Yves Deveaux, Verónica S Di Stilio, Yan Gong, Florian Jabbour, Elena M Kramer, Sophie Nadot, Natalia Pabón-Mora, Wei Wang
The Ranunculales are a hyperdiverse lineage in many aspects of their phenotype, including growth habit, floral and leaf morphology, reproductive mode and specialized metabolism. Many Ranunculales species, such as opium poppy and goldenseal have a high medicinal value. In addition, the order includes a large number of commercially important ornamental plants, such as columbines and larkspurs. The phylogenetic position of the order with respect to monocots and core eudicots and the diversity within this lineage make the Ranunculales an excellent group for studying evolutionary processes by comparative studies...
December 18, 2023: Journal of Experimental Botany
https://read.qxmd.com/read/38088446/reference-genome-for-the-mojave-poppy-bee-perdita-meconis-a-specialist-pollinator-of-conservation-concern
#39
JOURNAL ARTICLE
Rena M Schweizer, Colleen G Meidt, Ligia R Benavides, Joseph S Wilson, Terry L Griswold, Sheina B Sim, Scott M Geib, Michael G Branstetter
The Mojave poppy bee, Perdita meconis Griswold (Hymenoptera: Anthophila: Andrenidae), is a species of conservation concern that is restricted to the eastern Mojave Desert of North America. It is a specialist pollinator of two poppy genera, Arctomecon and Argemone (Papaveraceae), and is being considered for listing under the US Endangered Species Act along with one of its pollinator hosts, the Las Vegas bearpoppy (Arctomecon californica). Here, we present a near chromosome-level genome of the Mojave poppy bee to provide a genomic resource that will aid conservation efforts and future research...
December 13, 2023: Journal of Heredity
https://read.qxmd.com/read/38077033/human-mutations-in-high-confidence-tourette-disorder-genes-affect-sensorimotor-behavior-reward-learning-and-striatal-dopamine-in-mice
#40
Cara Nasello, Lauren A Poppi, Junbing Wu, Tess F Kowalski, Joshua K Thackray, Riley Wang, Angelina Persaud, Mariam Mahboob, Sherry Lin, Rodna Spaseska, C K Johnson, Derek Gordon, Fadel Tissir, Gary A Heiman, Jay A Tischfield, Miriam Bocarsly, Max A Tischfield
UNLABELLED: Tourette disorder (TD) is poorly understood, despite affecting 1/160 children. A lack of animal models possessing construct, face, and predictive validity hinders progress in the field. We used CRISPR/Cas9 genome editing to generate mice with mutations orthologous to human de novo variants in two high-confidence Tourette genes, CELSR3 and WWC1 . Mice with human mutations in Celsr3 and Wwc1 exhibit cognitive and/or sensorimotor behavioral phenotypes consistent with TD. Sensorimotor gating deficits, as measured by acoustic prepulse inhibition, occur in both male and female Celsr3 TD models...
November 28, 2023: bioRxiv
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