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https://www.readbyqxmd.com/read/29323165/biotransformation-and-tissue-distribution-of-protopine-and-allocryptopine-and-effects-of-plume-poppy-total-alkaloid-on-liver-drug-metabolizing-enzymes
#1
Ya-Jun Huang, Pi Cheng, Zhuo-Yi Zhang, Shi-Jie Tian, Zhi-Liang Sun, Jian-Guo Zeng, Zhao-Ying Liu
In this study, the biotransformation in the plasma, urine and feces of rats following oral administration of protopine (PRO) and allocryptopine (ALL)were explored using HPLC-QqTOF MS. An HPLC-MS/MS method for the determination of tissues was developed and applied to the tissue distribution study in rats following intragastric administration of Plume Poppy Total Alkaloid for 3 weeks. A total of ten PRO metabolites and ten ALL metabolites were characterized in rats in vivo. Among these metabolites, six PRO metabolites and five ALL metabolites were reported for the first time...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310695/understanding-the-relationship-between-egg-and-antigen-based-diagnostics-of-schistosoma-mansoni-infection-pre-and-post-treatment-in-uganda
#2
Joaquín M Prada, Panayiota Touloupou, Moses Adriko, Edridah M Tukahebwa, Poppy H L Lamberton, T Déirdre Hollingsworth
BACKGROUND: Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29301019/mining-of-the-uncharacterized-cytochrome-p450-genes-involved-in-alkaloid-biosynthesis-in-california-poppy-using-a-draft-genome-sequence
#3
Kentaro Hori, Yasuyuki Yamada, Purwanto Ratmoyo, Yohei Minakuchi, Atsushi Toyoda, Hideki Hirakawa, Fumihiko Sato
Land plants produce specialized low-molecular-weight metabolites to adapt to various environmental stressors, such as ultraviolet radiation, pathogen infection, wounding, and animal feeding damage. Due to the large variety of stresses, plants produce various chemicals, particularly plant species-specific alkaloids, through specialized biosynthetic pathways. In this study, using a draft genome sequence and querying known biosynthetic cytochrome P450 (P450) enzyme-encoding genes, we characterized the P450 genes involved in benzylisoquinoline alkaloid (BIA) biosynthesis in California poppy (Eschscholzia californica), as P450s are key enzymes involved in the diversification of specialized metabolism...
December 29, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29289495/mechanism-of-action-pharmacokinetics-efficacy-and-safety-of-transarterial-therapies-using-ethiodized-oil-preclinical-review-in-liver-cancer-models
#4
Ron C Gaba, Regina M Schwind, Sebastien Ballet
PURPOSE: To systematically review mechanism of action, pharmacokinetics (PKs), efficacy, and safety of ethiodized oil-based locoregional therapy (LRT) for liver cancer in preclinical models. MATERIALS AND METHODS: A MEDLINE search was performed from 1988 to 2016. Search terms included hepatocellular carcinoma (HCC), HCC, liver-cell carcinoma, liver, hepatic, hepatocarcinoma, transarterial or chemoembolization, TACE, animal, Lipiodol, Ethiodol, iodized oil, and/or poppy-seed oil...
December 28, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29278749/thermodynamic-analysis-of-computed-pathways-integrated-into-the-metabolic-networks-of-e-coli-and-synechocystis-reveals-contrasting-expansion-potential
#5
Johannes Asplund-Samuelsson, Markus Janasch, Elton P Hudson
Introducing biosynthetic pathways into an organism is both reliant on and challenged by endogenous biochemistry. Here we compared the expansion potential of the metabolic network in the photoautotroph Synechocystis with that of the heterotroph E. coli using the novel workflow POPPY (Prospecting Optimal Pathways with PYthon). First, E. coli and Synechocystis metabolomic and fluxomic data were combined with metabolic models to identify thermodynamic constraints on metabolite concentrations (NET analysis). Then, thousands of automatically constructed pathways were placed within each network and subjected to a network-embedded variant of the max-min driving force analysis (NEM)...
December 23, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29273048/propel-implementation-of-an-evidence-based-pelvic-floor-muscle-training-intervention-for-women-with-pelvic-organ-prolapse-a-realist-evaluation-and-outcomes-study-protocol
#6
Margaret Maxwell, Karen Semple, Sarah Wane, Andrew Elders, Edward Duncan, Purva Abhyankar, Joyce Wilkinson, Douglas Tincello, Eileen Calveley, Mary MacFarlane, Doreen McClurg, Karen Guerrero, Helen Mason, Suzanne Hagen
BACKGROUND: Pelvic Organ Prolapse (POP) is estimated to affect 41%-50% of women aged over 40. Findings from the multi-centre randomised controlled "Pelvic Organ Prolapse PhysiotherapY" (POPPY) trial showed that individualised pelvic floor muscle training (PFMT) was effective in reducing symptoms of prolapse, improved quality of life and showed clear potential to be cost-effective. However, provision of PFMT for prolapse continues to vary across the UK, with limited numbers of women's health physiotherapists specialising in its delivery...
December 22, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29235850/a-digital-protocol-for-chemical-analysis-at-ultra-low-concentrations-by-surface-enhanced-raman-scattering
#7
Carlos Diego L de Albuquerque, Regivaldo Gomes Sobral Filho, Ronei Jesus Poppi, Alexandre G Brolo
Single molecule surface-enhanced Raman Spectroscopy (SM-SERS) has the potential to revolutionize quantitative analysis at ultra-low concentrations (less than 1 nM). However, there are no established protocols to generalize the application of this technique in analytical chemistry. Here, a protocol for quantification at ultra-low concentrations using SM-SERS is proposed. The approach aims to take advantage of the stochastic nature of the single-molecule regime to achieved lower limits of detection (LOD) and quantification (LOQ)...
December 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29220602/an-observational-study-of-treatment-seeking-users-of-natural-opiates-from-india
#8
Arpit Parmar, Vaibhav Patil, Siddharth Sarkar, Ravindra Rao
BACKGROUND: The type of opioid used influences the severity and complications experienced. Natural opiates (opium and poppy husk) use is a socio-culturally accepted phenomenon reported in India. However, studies on their profile, quality of life, and addiction severity are limited. OBJECTIVES: The objective of this cross-sectional, observational study was to assess the socio-demographic profile, clinical profile, addiction severity, and quality of life of treatment-seeking natural opiate users...
December 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29202948/queen-anne-s-lace-gooseneck-loosestrife-untitled-poppy-maidenhair-fern-blushing-deathcap-untitled-trillium-and-untitled-trillium-pear-blossom-salamander-by-victor-schrager
#9
Margaret R Wentz
Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author.
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29197426/phenotypic-and-genotypic-monitoring-of-schistosoma-mansoni-in-tanzanian-schoolchildren-five-years-into-a-preventative-chemotherapy-national-control-programme
#10
Charlotte M Gower, Florian Gehre, Sara R Marques, Poppy H L Lamberton, Nicholas J Lwambo, Joanne P Webster
BACKGROUND: Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Chemotherapy (PC). Large-scale PC programmes exert prolonged selection pressures on parasites with the potential for, direct and/or indirect, emergence of drug resistance. Molecular methods can help monitor genetic changes of schistosome populations over time and in response to drug treatment, as well as estimate adult worm burdens through parentage analysis...
December 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29169033/mapping-complex-mind-states-eeg-neural-substrates-of-meditative-unified-compassionate-awareness
#11
Poppy L A Schoenberg, Andrea Ruf, John Churchill, Daniel P Brown, Judson A Brewer
Specific mental training cultivates diminished self-reference, encompassing non-duality, emptiness, awakened-awareness, and compassionate experiences. We aimed to elucidate the neural substrates of four distinct, interdependent Essence-of-Mind states: (1) timelessness, (2) non-preference, non-duality, non-conceptualization, (3) the view of luminosity and limitlessness, (4) unified compassionate experience of oneness (stable awakened-awareness). EEG data were collected from 30 advanced meditators concomitant to eyes-open/eyes-closed resting baseline, followed by 60-min of instructed practice...
November 20, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29166188/enhancement-of-pulmonary-tuberculosis-prevention-behavior-with-role-play-among-elementary-school-students
#12
Evi Supriatun, Astuti Yuni Nursasi, Poppy Fitriyani
Tuberculosis as an infectious disease is increasing in both the number of cases and severity of impact, and the number of cases among school-aged children is also increasing. Health promotion campaigns in schools have not been intensive, and there is poor behavior in tuberculosis prevention. Role play-playing roles actively with provided materials-is one health education method that can empower school-aged children to understand tuberculosis prevention. The purpose of this research is to identify the influence of role playing on tuberculosis transmission prevention in school-aged children...
2017: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29134077/investigation-of-the-acid-base-behaviour-of-the-opium-alkaloid-thebaine-in-lc-esi-ms-mobile-phase-by-nmr-spectroscopy
#13
Michelle G Carlin, John R Dean, Jonathan L Bookham, Justin J B Perry
As part of a research programme to establish an analytical method for the simultaneous detection of the five major opium alkaloids in poppy seeds by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) it was discovered that the inclusion of thebaine produced two peaks for the same compound. This was in contrast to the effective simultaneous detection, by LC-ESI-MS, of morphine, codeine, papaverine and noscapine. The presence of these two peaks for thebaine was investigated using nuclear magnetic resonance spectroscopy with deuterated solvents to emulate the mobile phase conditions experienced...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29118699/performance-and-usability-of-various-robotic-arm-control-modes-from-human-force-signals
#14
Sébastien Mick, Daniel Cattaert, Florent Paclet, Pierre-Yves Oudeyer, Aymar de Rugy
Elaborating an efficient and usable mapping between input commands and output movements is still a key challenge for the design of robotic arm prostheses. In order to address this issue, we present and compare three different control modes, by assessing them in terms of performance as well as general usability. Using an isometric force transducer as the command device, these modes convert the force input signal into either a position or a velocity vector, whose magnitude is linearly or quadratically related to force input magnitude...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29117706/the-role-of-metabolite-sensing-g-protein-coupled-receptors-in-inflammation-and-metabolic-disease
#15
Carlota Recio, Daniel Lucy, Poppy Iveson, Asif J Iqbal, Sophia Valaris, Graham Wynne, Angela J Russell, Robin Choudhury, Chris O'Callaghan, Claudia Monaco, David Robert Greaves
Great attention has been placed on the link between metabolism and immune function giving rise to the term "immunometabolism". It is widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, diabetes and atherosclerosis. Therefore, identifying the mechanisms and mediators that are involved in the regulation of both inflammation and metabolic homeostasis is of high scientific and therapeutic interest. G protein-coupled receptors (GPCRs) that signal in response to metabolites have emerged as attractive therapeutic targets in inflammatory disease...
November 8, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29113053/hplc-analysis-and-biochemical-characterization-of-lox-from-eschscholtzia-californica-cham
#16
Renáta Kollárová, Ivana Holková, Drahomíra Rauová, Barbora Bálintová, Peter Mikuš, Marek Obložinský
BACKGROUND: Plant lipoxygenases (LOXs, EC 1.13.11.12) are involved in lipid degradation, regulation of growth and development, senescence, and defence reactions. LOX represents the starting enzyme of the octadecanoid pathway. The aim of the work was to purify LOX from California poppy (Eschscholtzia californica Cham.), to determine its biochemical properties and to identify and quantify the products of LOX reaction with unsaturated fatty acids. METHODS: LOX from California poppy seedlings was purified by hydrophobic chromatography (Phenyl-Sepharose CL-4B) and by ion-exchange chromatography (Q-Sepharose)...
November 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29100015/an-endosirna-based-repression-mechanism-counteracts-transposon-activation-during-global-dna-demethylation-in-embryonic-stem-cells
#17
Rebecca V Berrens, Simon Andrews, Dominik Spensberger, Fátima Santos, Wendy Dean, Poppy Gould, Jafar Sharif, Nelly Olova, Tamir Chandra, Haruhiko Koseki, Ferdinand von Meyenn, Wolf Reik
Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs). Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-based mechanism involved in suppression of TE transcription. In ESCs with DNA demethylation induced by acute deletion of Dnmt1, we saw an increase in sense transcription at TEs, resulting in an abundance of sense/antisense transcripts leading to high levels of ARGONAUTE2 (AGO2)-bound small RNAs...
November 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29080499/visible-and-near-infrared-spectroscopy-coupled-to-random-forest-to-quantify-some-soil-quality-parameters
#18
Felipe Bachion de Santana, André Marcelo de Souza, Ronei Jesus Poppi
This study evaluates the use of visible and near infrared spectroscopy (Vis-NIRS) combined with multivariate regression based on random forest to quantify some quality soil parameters. The parameters analyzed were soil cation exchange capacity (CEC), sum of exchange bases (SB), organic matter (OM), clay and sand present in the soils of several regions of Brazil. Current methods for evaluating these parameters are laborious, timely and require various wet analytical methods that are not adequate for use in precision agriculture, where faster and automatic responses are required...
October 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29077729/modulation-of-benzylisoquinoline-alkaloid-biosynthesis-by-heterologous-expression-of-cjwrky1-in-eschscholzia-californica-cells
#19
Yasuyuki Yamada, Tomoe Shimada, Yukiya Motomura, Fumihiko Sato
Transcription factors control many processes in plants and have high potentials to manipulate specialized metabolic pathways. Transcriptional regulation of the biosynthesis of monoterpenoid indole alkaloids (MIAs), nicotine alkaloids, and benzylisoquinoline alkaloids (BIAs) has been characterized using Catharanthus roseus, Nicotiana and Coptis plants. However, metabolic engineering in which specific transcription factors are used in alkaloid biosynthesis is limited. In this study, we characterized the effects of ectopic expression of CjWRKY1, which is a transcriptional activator with many targets in BIA biosynthesis in Coptis japonica (Ranunculaceae) and Eschscholzia californica (California poppy, Papaveraceae)...
2017: PloS One
https://www.readbyqxmd.com/read/29055867/pre-surgical-mapping-of-eloquent-cortex-for-paediatric-epilepsy-surgery-candidates-evidence-from-a-review-of-advanced-functional-neuroimaging
#20
REVIEW
Sarah Collinge, Garreth Prendergast, Steven T Mayers, David Marshall, Poppy Siddell, Elizabeth Neilly, Colin D Ferrie, Gayatri Vadlamani, Jeremy Macmullen-Price, Daniel J Warren, Arshad Zaman, Paul Chumas, John Goodden, Matthew C H J Morrall
PURPOSE: A review of all published evidence for mapping eloquent (motor, language and memory) cortex using advanced functional neuroimaging (functional magnetic resonance imaging [fMRI] and magnetoencephalography [MEG]) for paediatric epilepsy surgery candidates has not been conducted previously. Research in this area has predominantly been in adult populations and applicability of these techniques to paediatric populations is less established. METHODS: A review was performed using an advanced systematic search and retrieval of all published papers examining the use of functional neuroimaging for paediatric epilepsy surgery candidates...
November 2017: Seizure: the Journal of the British Epilepsy Association
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