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https://www.readbyqxmd.com/read/27919823/nerve-growth-factor-carbon-nanotube-complex-exerts-prolonged-protective-effects-in-an-in-vitro-model-of-ischemic-stroke
#1
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: The therapeutic potential of nerve growth factor (NGF) against the neurological disorders may be negatively affected by its short half-life. Based on the superior properties of carbon nanotubes (CNTs) for controlled drug delivery, we aimed to prepare CNT-NGF complex and evaluate its effect in an in vitro model of ischemic stroke. MATERIALS AND METHODS: Multi-walled CNTs (MWCNTs)-NGF complex was prepared using amino-functionalized COOH-MWCNTs and characterized by Fourier transform infrared spectroscopy and transmission electron microscopy...
December 2, 2016: Life Sciences
https://www.readbyqxmd.com/read/27913896/mesenchymal-stem-cells-with-enos-over-expression-enhance-cardiac-repair-in-rats-with-myocardial-infarction
#2
Leilei Chen, Yuan Zhang, Liangliang Tao, Zhijian Yang, Liansheng Wang
PURPOSE: Transplantation of mesenchymal stem cells (MSCs) is a promising therapeutic option for patients with acute myocardial infarction. METHODS: We show here that the ectopic overexpression of endothelial nitric oxide synthases (eNOS), an endothelial form of NOS, could enhance the ability of MSCs in treating ischemic heart damage after the occlusion of the coronary artery. RESULTS: Adenoviral delivery of human eNOS gene into mouse bone marrow-derived MSCs (BM-MSCs) conferred resistance to oxygen glucose deprivation (OGD)-induced cell death in vitro, and elevated the bioavailability of nitric oxide when injected into the myocardium in vivo...
December 3, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27910195/mulberrofuran-g-protects-ischemic-injury-induced-cell-death-via-inhibition-of-nox4-mediated-ros-generation-and-er-stress
#3
Sungeun Hong, Jaeyoung Kwon, Dong-Woo Kim, Hak Ju Lee, Dongho Lee, Woongchon Mar
The aim of this study was to investigate the neuroprotective effect of mulberrofuran G (MG) in in vitro and in vivo models of cerebral ischemia. MG was isolated from the root bark of Morus bombycis. MG inhibited nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzyme activity and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced NOX4 protein expression in SH-SY5Y cells. MG inhibited the expression of activated caspase-3 and caspase-9 and cleaved poly adenine dinucleotide phosphate-ribose polymerase in OGD/R-induced SH-SY5Y cells...
December 2, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27889750/metformin-protects-neurons-against-oxygen-glucose-deprivation-reoxygenation-induced-injury-by-down-regulating-mad2b
#4
Xianfang Meng, Guangpin Chu, Zhihua Yang, Ping Qiu, Yue Hu, Xiaohe Chen, Wenpeng Peng, Chen Ye, Fang-Fang He, Chun Zhang
BACKGROUND/AIMS: Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in hippocampal and cortical neurons and plays an important role in mediating high glucose-induced neurotoxicity. The present study investigated whether metformin modifies the expression of MAD2B and to exert its neuroprotective effects in primary cultured cortical neurons during oxygen-glucose deprivation/reoxygenation (OGD/R), a widely used in vitro model of ischemia/reperfusion...
November 11, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27885275/tdb-protects-vascular-endothelial-cells-against-oxygen-glucose-deprivation-reperfusion-induced-injury-by-targeting-mir-34a-to-increase-bcl-2-expression
#5
Li-Xi Liao, Ming-Bo Zhao, Xin Dong, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu
Prolonged ischemia can result in apoptotic death of vascular endothelial cells and lead to ischemic vascular diseases including vascular dementia, arteriosclerosis and brain oedema. Finding protective strategies to prevent this is therefore an urgent mission. Recent studies have shown that dysregulation of microRNAs (miRNAs) can lead to imbalance of Bcl-2 family proteins and mitochondrial dysfunction, leading to further damage of vascular cells under ischemic conditions. However, whether miRNAs can be used as a drug target for treating vascular diseases is not fully understood...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876485/cannabinoid-receptors-and-trpa1-on-neuroprotection-in-a-model-of-retinal-ischemia
#6
D S M Araújo, V S Miya-Coreixas, P Pandolfo, K C Calaza
Retinal ischemia is a pathological event present in several retinopathies such as diabetic retinopathy and glaucoma, leading to partial or full blindness with no effective treatment available. Since synthetic and endogenous cannabinoids have been studied as modulators of ischemic events in the central nervous system (CNS), the present study aimed to investigate the involvement of cannabinoid system in the cell death induced by ischemia in an avascular (chick) retina. We observed that chick retinal treatment with a combination of WIN 55212-2 and cannabinoid receptor antagonists (either AM251/O-2050 or AM630) decreased the release of lactate dehydrogenase (LDH) induced by retinal ischemia in an oxygen and glucose deprivation (OGD) model...
November 19, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27876208/betulinic-acid-protects-against-cerebral-ischemia-reperfusion-injury-by-activating-the-pi3k-akt-signaling-pathway
#7
Shujie Jiao, Hongcan Zhu, Ping He, Junfang Teng
Betulinic acid (BA), a naturally occurring pentacyclic lupane group triterpenoid, has been demonstrated to protect against ischemia/reperfusion-induced renal damage. However, the effects of BA on cerebral ischemia/reperfusion (I/R) injury remain unclear. Hence, this study was to investigate the effects of BA on oxygen and glucose deprivation/reperfusion (OGD/R) induced neuronal injury in rat hippocampal neurons. Our results showed that BA pretreatment greatly attenuated OGD/R-induced neuronal injury. BA also inhibited OGD/R-induced intracellular ROS production and MDA level in rat hippocampal neurons...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27865879/arachidonic-acid-has-protective-effects-on-oxygen-glucose-deprived-astrocytes-mediated-through-enhancement-of-potassium-channel-trek-1-activity
#8
Li Lu, Guangru Zhang, Chunli Song, Xuexi Wang, Weina Qian, Zhuanling Wang, Yanan Liu, Sheng Gong, Shuning Zhou
Polyunsaturated fatty acids (PUFAs) have neuroprotective effects against ischemic brain diseases. The newly discovered potassium channel "TREK-1" is a promising target for therapies against neurodegeneration. Arachidonic acid (AA) is an n-6 PUFA, as well as a potent TREK-1 activator. We previously showed that TREK-1 is expressed at high levels in astrocytes. However, the effect of AA on astrocytes in ischemia remains unknown. Here, we assessed the effects of 3-30μM AA on astrocyte apoptosis, glutamate uptake, and expression of the astrocytic glutamate transporter 1 (GLT-1) and TREK-1 under different conditions...
November 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27865878/bone-marrow-mesenchymal-stem-cells-decrease-chop-expression-and-neuronal-apoptosis-after-spinal-cord-injury
#9
Chuanlong Gu, Heyangzi Li, Chao Wang, Xinghui Song, Yuemin Ding, Mingzhi Zheng, Wei Liu, Yingying Chen, Xiaoming Zhang, Linlin Wang
Spinal cord injury (SCI) leads to irreversible neuronal loss and ultimately leads to paralysis. Bone marrow derived mesenchymal stem cells (BMSCs) have been demonstrated to be an effective approach to treat SCI. The present study was designed to investigate the role of BMSCs in rats with spinal cord injury and in oxygen-glucose deprivation (OGD) treated motor neurons. The results demonstrated that BMSCs could improve locomotor function and decrease expression of pro-apoptotic transcription factor C/EBP homologous protein (CHOP) and apoptosis after SCI...
November 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27855593/protective-effect-of-bendavia-ss-31-against-oxygen-glucose-deprivation-stress-induced-mitochondrial-damage-in-human-brain-microvascular-endothelial-cells
#10
Takahiko Imai, Keisuke Mishiro, Toshinori Takagi, Aoi Isono, Hideko Nagasawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mitochondria play a key role in cell survival by perfoming functions such as adenosine tri-phosphate (ATP) synthesis, regulation of apoptotic cell death, calcium storage. Hypoxic conditions induce mitochondrial dysfunction, which leads to endothelial injury in cerebral ischemia. Functional disorders include the following: collapse of mitochondrial membrane potential, reduction of ATP synthesis, and generation of reactive oxygen species (ROS). Bendavia, a novel tetra-peptide, has been reported to restrict the uncoupling of the mitochondrial membrane chain, protect the synthesis of ATP, and inhibit ROS generation...
November 17, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27854008/low-dose-ethanol-preconditioning-protects-against-oxygen-glucose-deprivation-reoxygenation-induced-neuronal-injury-by-activating-large-conductance-ca-2-activated-k-channels-in-vitro
#11
Fang Su, An-Chen Guo, Wei-Wei Li, Yi-Long Zhao, Zheng-Yi Qu, Yong-Jun Wang, Qun Wang, Yu-Lan Zhu
Increasing evidence suggests that low to moderate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion; however, the underlying mechanism has not been elucidated. In the present study, we showed that expression of the neuronal large-conductance, Ca(2+)-activated K(+) channel (BKCa) α-subunit was upregulated in cultured neurons exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) compared with controls. Preconditioning with low-dose ethanol (10 mmol/L) increased cell survival rate in neurons subjected to OGD/R, attenuated the OGD/R-induced elevation of cytosolic Ca(2+) levels, and reduced the number of apoptotic neurons...
November 16, 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27852417/-influences-of-dna-methylation-upon-neuroglobin-sustained-expression-in-oxygen-glucose-deprivation-model
#12
L N Zhang, S B Hu, S Y Deng, C X Chen, L Wu, Q Y Peng, L Huang, Y H Ai
Objective: To investigate the influences of genomic DNA methylation upon neuroglobin sustained expression in oxygen- glucose deprivation model. Methods: With A549 cell strain as the research object, the control group were cultivated in the complete medium containing 10 μmol/L of 5-azacytidine for 4 days, and the control group was cultivated in the complete medium for 4 days.Then carried out oxygen glucose deprivation treatment for 4 h.Detecting neuroglobin expression, DNA methyltransferase expression, cell inhibition ratio and DNA methylation level at different time points...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27845243/in-vitro-detection-of-oxygen-and-glucose-deprivation-induced-neurodegeneration-and-pharmacological-neuroprotection-based-on-hippocampal-stratum-pyramidale-width
#13
Pınar Öz, Hale Saybaşılı
Ischemia is one of the most prominent risk factors of neurodegenerative diseases such as Alzheimer's disease. The effects of oxygen and glucose depletion in hippocampal tissue due to ischemia can be mimicked in vitro using the oxygen and glucose deprivation (OGD) model. In this study, we applied OGD on acute rat hippocampal slices in order to design an elementary yet quantitative histological technique that compares the neuroprotective effects of (l)-carnitine to known neuroprotectors, such as the N-methyl-d-aspartate (NMDA) receptor antagonist memantine and the gamma-aminobutyric acid (GABA)-B receptor agonist baclofen...
November 11, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27844279/lncrna-n1lr-enhances-neuroprotection-against-ischemic-stroke-probably-by-inhibiting-p53-phosphorylation
#14
Zhuomin Wu, Ping Wu, Xialin Zuo, Na Yu, Yixin Qin, Qian Xu, Shuai He, Bohong Cen, Wenjie Liao, Aimin Ji
In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical roles in a broad range of cell biological processes. However, the activities of lncRNAs during ischemic stroke remain largely unknown. In this study, we carried out a genome-wide lncRNA microarray analysis in rat brains with ischemia/reperfusion (I/R) injury. The results revealed the differential expression of a subset of lncRNAs. Through the construction of lncRNA-mRNA co-expression networks, we identified lncRNA-N1LR as a novel I/R-induced lncRNA...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27844252/effect-of-puerarin-on-transcriptome-of-astrocyte-during-oxygen-glucose-deprivation-reoxygenation-injury
#15
Shuyong Wei, Jie Tong, Qiang Xue, Yang Liu, Xiaoyu Xu
Stroke is a serious disease with complex pathomechanism and limited therapeutic effect in clinic. Our previous research has found obvious therapeutic effect of Puerarin (Pur) on stroke injury of rat. The aim of this study is to investigate the transcriptome changes of oxygen-glucose deprivation/reoxygenation (OGD/R)-injured astrocytes before and after the intervention of Pur. Cells activity and apoptosis detection indicated that the activity of OGD/R-injured astrocytes was improved, and the apoptosis was ameliorated by Pur...
November 14, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27831543/a-distinct-colon-derived-breath-metabolome-is-associated-with-inflammatory-bowel-disease-but-not-its-complications
#16
Florian Rieder, Satya Kurada, David Grove, Frank Cikach, Rocio Lopez, Nishaben Patel, Amandeep Singh, Naim Alkhouri, Bo Shen, Aaron Brzezinski, Mark Baker, Claudio Fiocchi, Raed A Dweik
OBJECTIVES: The accuracy of available noninvasive biomarkers for diagnosis, stratification, and prediction of inflammatory bowel disease (IBD) courses is limited. We analyzed volatile organic compounds (VOCs) in the breath of IBD patients and controls for diagnosis and differentiation of IBD as well as their link with disease location, activity, and phenotype. METHODS: A prospective study of diagnostic testing was conducted, recruiting Crohn's disease (CD), ulcerative colitis (UC), other inflammatory gastrointestinal diseases (OGDs), and healthy controls (HCs), as well as subjects with ileal pouch anal anastomosis (IPAA)...
November 10, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27826749/trpc3-6-7-knockdown-protects-the-brain-from-cerebral-ischemia-injury-via-astrocyte-apoptosis-inhibition-and-effects-on-nf-%C3%B0%C2%BAb-translocation
#17
Xiaoyun Chen, Min Lu, Xiju He, Le Ma, Lutz Birnbaumer, Yanhong Liao
Ischemia contributes significantly to morbidity and mortality associated with many common neurological diseases. Calcium overload is an important mechanism of cerebral ischemia and reperfusion (I/R) injury. Despite decades of intense research, an effective beneficial treatment of stroke remains limited; few therapeutic strategies exist to combat the consequences of cerebral ischemia. Traditionally, a "neurocentric" view has dominated research in this field. Evidence is now accumulating that glial cells, especially astrocytes, play an important role in the pathophysiology of cerebral ischemia...
November 8, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27826106/differential-spread-of-anoxic-depolarization-contributes-to-the-pattern-of-neuronal-injury-after-oxygen-and-glucose-deprivation-ogd-in-the-substantia-nigra-in-rat-brain-slices
#18
Rashika N Karunasinghe, Angus C Grey, Ravindra Telang, Srdjan M Vlajkovic, Janusz Lipski
Anoxic depolarization (AD) is an acute event evoked by brain ischemia, involving a profound loss of cell membrane potential and swelling that spreads over susceptible parts of the gray matter. Its occurrence is a strong predictor of the severity of neuronal injury. Little is known about this event in the Substantia Nigra, a midbrain nucleus critical for motor control. We tested the effects of oxygen and glucose deprivation (OGD), an in vitro model of brain ischemia, in rat midbrain slices. AD developed within 4min from OGD onset and spread in the Substantia Nigra pars reticulata (SNr), but not through the Substantia Nigra pars compacta (SNc)...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27825902/neuroprotective-effects-of-clarithromycin-against-neuronal-damage-in-cerebral-ischemia-and-in-cultured-neuronal-cells-after-oxygen-glucose-deprivation
#19
Yasuo Katayama, Toshiki Inaba, Chikako Nito, Satoshi Suda, Masayuki Ueda
AIMS: Rats subjected to transient focal ischemia and cultured neuronal cells subjected to oxygen-glucose deprivation (OGD) were treated with clarithromycin (CAM) to evaluate the effects of CAM in protecting against neuronal damage. MAIN METHODS: Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 90min and then reperfused. Each animal was given an oral dose clarithromycin (CAM, 100mg/kg) or vehicle alone just after the ischemia was commenced...
November 5, 2016: Life Sciences
https://www.readbyqxmd.com/read/27823628/leonurine-ameliorates-cognitive-dysfunction-via-antagonizing-excitotoxic-glutamate-insults-and-inhibiting-autophagy
#20
Chunhua Liu, Hongqiang Yin, Jing Gao, Xiaxia Xu, Tao Zhang, Zhuo Yang
BACKGROUND: Chronic cerebral hypoperfusion is related with cognitive deficits in different types of dementia. PURPOSE: In this study, we aimed to investigate the effect and potential mechanisms of leonurine on chronic cerebral hypoperfusion both in vitro and in vivo. STUDY DESIGN: Chronic cerebral hypoperfusion was duplicated by oxygen-glucose deprivation (OGD) in vitro and by ligation of bilateral common carotid arteries (2-VO) in vivo. METHODS: In in vitro study, there were control group, OGD group, OGD+ 100µM leonurin group, and OGD+ 10µM donepezil group...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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