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FoxM1

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https://www.readbyqxmd.com/read/28429752/lncrna-hit-promotes-cell-proliferation-of-non-small-cell-lung-cancer-by-association-with-e2f1
#1
L Yu, F Fang, S Lu, X Li, Y Yang, Z Wang
Lung cancer is the leading cause of cancer-related death around the world. Long noncoding RNA (lncRNA) has pivotal roles in cancer occurrence and development. However, only a few lncRNAs have been functionally characterized. In the present study, we investigated the effects of lncRNA-HIT (HOXA transcript induced by TGFβ) expression on non-small cell lung cancer (NSCLC) cell phenotype with the gain-of-function and loss-of-function assays. We found that ectopic expression or knockdown of lncRNA-HIT markedly increased or decreased NSCLC cell proliferation, respectively...
April 21, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28427185/transcriptional-landscape-of-human-cancers
#2
Mengyuan Li, Qingrong Sun, Xiaosheng Wang
The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively explored. However, the related exploration based on transcriptome data is lacking. In this study we explored gene expression profiles across 33 human cancer types using The Cancer Genome Atlas (TCGA) data. We identified consistently upregulated genes (such as E2F1, EZH2, FOXM1, MYBL2, PLK1, TTK, AURKA/B and BUB1) and consistently downregulated genes (such as SCARA5, MYOM1, NKAPL, PEG3, USP2, SLC5A7 and HMGCLL1) across various cancers...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427178/prognostic-value-of-foxm1-in-solid-tumors-a-systematic-review-and-meta-analysis
#3
Lijun Li, Dang Wu, Qun Yu, Lingdi Li, Pin Wu
Accumulated studies have provided controversial evidences of the association between Forkhead Box M1 (FOXM1) expression and survival of human solid tumors. To address this inconsistency, we performed a meta-analysis with 23 studies identified from PubMed and Medline. We found elevated FOXM1-protein expression was significantly associated with worse 3-year overall survival (OS) (OR = 3.30, 95% CI = 2.56 to 4.25, P < 0.00001) 5-year OS (OR =3.35, 95% CI = 2.64 to 4.26, P < 0.00001) and 10-year OS (OR = 5...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423516/the-addition-of-celecoxib-improves-the-antitumor-effect-of-cetuximab-in-colorectal-cancer-role-of-egfr-ras-foxm1-%C3%AE-catenin-signaling-axis
#4
Araceli Valverde, Jon Peñarando, Amanda Cañas, Laura M López-Sánchez, Francisco Conde, Silvia Guil-Luna, Vanessa Hernández, Carlos Villar, Cristina Morales-Estévez, Juan de la Haba-Rodríguez, Enrique Aranda, Antonio Rodríguez-Ariza
Here we showed that the addition of the COX-2 inhibitor celecoxib improved the antitumor efficacy in colorectal cancer (CRC) of the monoclonal anti-EGFR antibody cetuximab. The addition of celecoxib augmented the efficacy of cetuximab to inhibit cell proliferation and to induce apoptosis in CRC cells. Moreover, the combination of celecoxib and cetuximab was more effective than either treatment alone in reducing the tumor volume in a mouse xenograft model. The combined treatment enhanced the inhibition of EGFR signaling and altered the subcellular distribution of β-catenin...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420758/the-foxm1-inhibitor-rcm-1-suppresses-goblet-cell-metaplasia-and-prevents-il-13-and-stat6-signaling-in-allergen-exposed-mice
#5
Lifeng Sun, Xiaomeng Ren, I-Ching Wang, Arun Pradhan, Yufang Zhang, Hannah M Flood, Bo Han, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality worldwide. We performed a high-throughput screen to identify small molecules targeting a transcriptional network critical for the differentiation of goblet cells in response to allergens. We identified RCM-1, a nontoxic small molecule that inhibited goblet cell metaplasia and excessive mucus production in mice after exposure to allergens...
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28416635/vprbp-dcaf1-regulates-the-degradation-and-non-proteolytic-activation-of-the-cell-cycle-transcription-factor-foxm1
#6
Xianxi Wang, Anthony Arceci, Kelly Bird, Christine A Mills, Rajarshi Choudhury, Jennifer L Kernan, Chunxiao Zhou, Victoria Bae-Jump, Albert Bowers, Michael J Emanuele
The oncogenic transcription factor FoxM1 plays a vital role in cell cycle progression, is activated in numerous human malignancies and linked to chromosome instability. We characterize here a Cullin4-based E3 ubiquitin ligase and its substrate receptor VprBP/DCAF1 (CRL4(VprBP)) that we show regulate FoxM1 ubiquitylation and degradation. Paradoxically, we also found that the substrate receptor VprBP is a potent FoxM1 activator. VprBP depletion reduces expression of FoxM1 target genes and impairs mitotic entry, whereas ectopic VprBP expression strongly activates a FoxM1 transcriptional reporter...
April 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28413501/usp39-regulates-the-growth-of-smmc-7721-cells-via-foxm1
#7
Xianwen Yuan, Xitai Sun, Xiaolei Shi, Chunping Jiang, Decai Yu, Weiwei Zhang, Yitao Ding
The present study investigated ubiquitin specific peptidase 39 (USP39) gene knockdown on SMMC-7721 cells in vitro and in vivo, and the role of USP39 in regulating the growth of hepatocellular carcinoma (HCC). Two small interfering RNAs (siRNA) were constructed, which targeted the USP39 gene and control sequences were synthesized and inserted into a pGCSIL-GFP lentiviral vector. The full length of USP39 cDNA was amplified by polymerase chain reaction (PCR) and cloned into pEGFP-N2, and the recombinant plasmids were transfected into cells...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28408750/transcriptional-regulatory-networks-underlying-the-reprogramming-of-spermatogonial-stem-cells-to-multipotent-stem-cells
#8
Hoe-Su Jeong, Jinhyuk Bhin, Hyung Joon Kim, Daehee Hwang, Dong Ryul Lee, Kye-Seong Kim
Spermatogonial stem cells (SSCs) are germline stem cells located along the basement membrane of seminiferous tubules in testes. Recently, SSCs were shown to be reprogrammed into multipotent SSCs (mSSCs). However, both the key factors and biological networks underlying this reprogramming remain elusive. Here, we present transcriptional regulatory networks (TRNs) that control cellular processes related to the SSC-to-mSSC reprogramming. Previously, we established intermediate SSCs (iSSCs) undergoing the transition to mSSCs and generated gene expression profiles of SSCs, iSSCs and mSSCs...
April 14, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28401644/comprehensive-dissection-of-transcriptome-data-and-regulatory-factors-in-pancreatic-cancer-cells
#9
Bijan Akbari, Abdulshakour Mohammadnia, Moein Yaqubi, Ping Wee, Hamid Mahdiuni
Features of pancreatic cancers include high mortality rates caused by rapid tumor progression and a lack of effective therapy. Underpinning the molecular mechanisms involved in the alteration of the gene expression program in the pancreatic cancer remains to be understood. In the current study we performed a comprehensive analysis using 282 pancreatic tumor and normal samples from seven independent expression data sets to provide a better view on the interactions between different transcription factors (TFs) and the most affected biological pathways in pancreatic cancer...
April 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28401599/foxm1-transcription-factor-a-new-component-of-chronic-myeloid-leukemia-stem-cell-proliferation-advantage
#10
Manuela Mancini, Fausto Castagnetti, Simona Soverini, Elisa Leo, Caterina De Benedittis, Gabriele Gugliotta, Gianantonio Rosti, Luana Bavaro, Sara De Santis, Cecilia Monaldi, Margherita Martelli, Maria Alessandra Santucci, Michele Cavo, Giovanni Martinelli
FOXM1 transcription factor is a central component of tumor initiation, growth and progression due to its multiple effects on cell cycle, DNA repair, angiogenesis and invasion, chromatin, protein anabolism and cell adhesion. Moreover, FOXM1 interacts with β-catenin promoting its nuclear import and transcriptional activation. Here we show that FOXM1 is involved in the advantage of chronic myeloid leukemia hematopoiesis over the normal counterpart. FOXM1 hyper-activation associated with BCR-ABL1 results from phosphorylation by the fusion protein kinase-dependent activation of Polo-like kinase 1...
April 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28399407/messenger-rna-methylation-regulates-glioblastoma-tumorigenesis
#11
Deobrat Dixit, Qi Xie, Jeremy N Rich, Jing Crystal Zhao
Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N(6)-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.
April 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28393243/multiple-therapeutic-peptide-vaccines-for-patients-with-advanced-gastric-cancer
#12
Yoshiyuki Fujiwara, Kaoru Okada, Takeshi Omori, Keijiro Sugimura, Hiroshi Miyata, Masayuki Ohue, Shogo Kobayashi, Hidenori Takahashi, Hiroyuki Nakano, Chie Mochizuki, Katsuji Shimizu, Masahiko Yano, Yusuke Nakamura, Masaki Mori, Yuichiro Doki
We performed a clinical trial using HLA-A24-binding peptide vaccines containing a combination of novel cancer-testis antigens and anti-angiogenic peptides for advanced gastric cancer (GC). Thirty-five GC patients who had shown resistance to the standard therapy were enrolled in this clinical trial using vaccinations with a mixture of multiple peptides derived from DEPDC1, URLC10, FoxM1, Kif20A and VEGFR1. The safety, the overall survival (OS), and the immunological responses based on an ELISPOT assay were determined to assess differences in patients who were HLA-A24-positive [24(+)] and HLA-A24-negative [24(-)]...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28392805/cadherins-associate-with-distinct-stem-cell-related-transcription-factors-to-coordinate-the-maintenance-of-stemness-in-triple-negative-breast-cancer
#13
Chuanwei Yang, Xuemei Zhao, Naipeng Cui, Yulong Liang
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with poor prognosis and is enriched in cancer stem cells (CSCs). However, it is not completely understood how the CSCs were maintained in TNBC. In this study, by analyzing The Cancer Genome Atlas (TCGA) provisional datasets and several small-size breast datasets, we found that cadherins (CDHs) 2, 4, 6, and 17 were frequently amplified/overexpressed in 47% of TNBC while E-cadherin (CDH1) was downregulated/mutated at 10%. The alterations of CDH2/4/6/17 were strongly associated with the elevated levels of several stem cell-related transcription factors (SC-TFs) including FOXM1, MCM2, WWTR1, SNAI1, and SOX9...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28378765/a-lignan-induces-lysosomal-dependent-degradation-of-foxm1-protein-to-suppress-%C3%AE-catenin-nuclear-translocation
#14
Guang-Zhi Dong, Ji Hye Jeong, Yu-Ih Lee, Yeong Eun Han, Jung Sook Shin, Yoon-Jung Kim, Raok Jeon, Young Hwa Kim, Tae Jun Park, Keun Il Kim, Jae-Ha Ryu
Colon cancer is one of the most common cancers. In this study, we isolated a lignan [(-)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS] from Alnus japonica (Betulaceae) and investigated its biological activity and mechanism of action on colon cancer. DFS reduced the viability of colon cancer cells and induced cell cycle arrest. DFS also suppressed β-catenin nuclear translocation and β-catenin target gene expression through a reduction in FoxM1 protein. To assess the mechanism of the action of DFS, we investigated the effect of DFS on endogenous and exogenous FoxM1 protein degradation in colon cancer cells...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376490/overexpression-of-foxm1-is-a-potential-prognostic-marker-in-male-breast-cancer
#15
Syrine Abdeljaoued, Ilhem Bettaieb, Meher Nasri, Olfa Adouni, Aida Goucha, Olfa El Amine, Hammouda Boussen, Khaled Rahal, Amor Gamoudi
BACKGROUND: Several studies have outlined biological differences between female and male breast cancer (MBC) and concluded that MBC should be considered as an entirely separate disease. Whether FOXM1 has any indication for prognosis in MBC patients remains unknown. We sought to examine the expression levels of FOXM1 in MBC and to identify the relationship between FOXM1 expression and patient survival. PATIENTS AND METHODS: FOXM1 expression was evaluated in a total of 130 MBC specimens...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28371822/elabela-apj-axis-protects-from-pressure-overload-heart-failure-and-angiotensin-ii-induced-cardiac-damage
#16
Teruki Sato, Chitose Sato, Ayumi Kadowaki, Hiroyuki Watanabe, Lena Ho, Junji Ishida, Tomokazu Yamaguchi, Akinori Kimura, Akiyoshi Fukamizu, Josef M Penninger, Bruno Reversade, Hiroshi Ito, Yumiko Imai, Keiji Kuba
Aims: : Elabela/Toddler/Apela (ELA) has been identified as a novel endogenous peptide ligand for APJ/Apelin receptor/Aplnr. ELA plays a crucial role in early cardiac development of zebrafish as well as in maintenance of self-renewal of human embryonic stem cells. Apelin was the first identified APJ ligand, and exerts positive inotropic heart effects and regulates the renin-angiotensin system. The aim of this study was to investigate the biological effects of ELA in the cardiovascular system...
March 23, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28363914/alkbh5-drives-foxm1-expression-to-promote-brain-tumor-stem-cell-growth
#17
(no author information available yet)
The mRNA demethylase ALKBH5 promotes glioblastoma stem cell growth and tumorigenesis.
March 31, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28361350/foxm1-transcriptionally-regulates-expression-of-integrin-%C3%AE-1-in-triple-negative-breast-cancer
#18
Zuhal Hamurcu, Nermin Kahraman, Ahmed Ashour, Bulent Ozpolat
PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with early metastasis, drug resistance, and poor patient survival. Fork head box M1 (FOXM1) is considered as an emerging molecular target due to its oncogenic role and high overexpression profile in 85% in TNBC. However, molecular mechanisms by which FOXM1 transcription factor mediate its oncogenic effects are not fully understood. Integrin β1 is often upregulated in invasive breast cancers and associated with poor clinical outcome and shorter overall patient survival in TNBC...
March 30, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28358012/suppression-of-foxm1-transcriptional-activities-via-a-single-stranded-dna-aptamer-generated-by-selex
#19
Qin Xiang, Guixiang Tan, Xia Jiang, Kuangpei Wu, Weihong Tan, Yongjun Tan
The transcription factor FOXM1 binds to its consensus sequence at promoters through its DNA binding domain (DBD) and activates proliferation-associated genes. The aberrant overexpression of FOXM1 correlates with tumorigenesis and progression of many cancers. Inhibiting FOXM1 transcriptional activities is proposed as a potential therapeutic strategy for cancer treatment. In this study, we obtained a FOXM1-specific single stranded DNA aptamer (FOXM1 Apt) by SELEX with a recombinant FOXM1 DBD protein as the target of selection...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28349111/dataset-of-the-human-homologues-and-orthologues-of-lipid-metabolic-genes-identified-as-daf-16-targets-their-roles-in-lipid-and-energy-metabolism
#20
Lavender Yuen-Nam Fan, Paula Saavedra-García, Eric Wing-Fai Lam
The data presented in this article are related to the review article entitled 'Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis' (Saavedra-Garcia et al., 2017) [24]. Here, we have matched the DAF-16/FOXO3 downstream genes with their respective human orthologues and reviewed the roles of these targeted genes in FA metabolism. The list of genes listed in this article are precisely selected from literature reviews based on their functions in mammalian FA metabolism. The nematode Caenorhabditis elegans gene orthologues of the genes are obtained from WormBase, the online biological database of C...
April 2017: Data in Brief
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